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Select item 114885851.

USP10 promotes pancreatic ductal adenocarcinoma progression by attenuating FOXC1 protein degradation to activate the WNT signaling pathway

Jie Wang, Lang Gan, Fenghao Liu, Qin Yang, Qingsong Deng, Di Jiang, Chengcheng Zhang, LeiDa Zhang, XiaoJun Wang

Int J Biol Sci. 2024; 20(13): 5343–5362. Published online 2024 Sep 30. doi: 10.7150/ijbs.92278

PMCID:: PMC11488585

Abstract Article PDF–11M

Select item 112970992.

FOXC1 transcriptionally suppresses ABHD5 to inhibit the progression of renal cell carcinoma through AMPK/mTOR pathway

Jianfa Li, Shuangchen Chen, Jing Xiao, Jiayuan Ji, Chenchen Huang, Ge Shu

Cell Biol Toxicol. 2024; 40(1): 62. Published online 2024 Aug 2. doi: 10.1007/s10565-024-09899-w

PMCID:: PMC11297099

Abstract Article PDF–3.8M

Select item 111940933.

Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence

Bin Li, Weiyao Xiong, Wu Zuo, Yuanyuan Shi, Teng Wang, Lingling Chang, Yueheng Wu, Heng Ma, Qian Bian, Alex C Y Chang

Nucleic Acids Res. 2024 Jun 24; 52(11): 6269–6284. Published online 2024 Apr 18. doi: 10.1093/nar/gkae274

PMCID:: PMC11194093

Abstract Article PDF–2.7M

Select item 109597744.

Reciprocal regulation of forkhead box C1 and L1 cell adhesion molecule contributes to triple-negative breast cancer progression

Fan Zhang, Yue Xu, Jiediao Lin, Hongchao Pan, Armando E. Giuliano, Xiaojiang Cui, Yukun Cui

Breast Cancer Res Treat. 2024; 204(3): 465–474. Published online 2024 Jan 6. doi: 10.1007/s10549-023-07177-7

PMCID:: PMC10959774

Abstract Article PDF–1.7M

Select item 105302635.

FoxC1 activates limbal epithelial stem cells following corneal epithelial debridement

Wending Yang, Sun Kyong Lee, Ordan J Lehmann, Zhijian Wu, Suja Hiriyanna, Anand Swaroop, Robert M Lavker, Han Peng, Tsutomu Kume

Exp Eye Res. Author manuscript; available in PMC 2024 Sep 1.

Published in final edited form as: Exp Eye Res. 2023 Sep; 234: 109599. Published online 2023 Jul 22. doi: 10.1016/j.exer.2023.109599

PMCID:: PMC10530263

Abstract Article PDF–382K

Select item 101516156.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 97080867.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 95878528.

Clinical Significance of MAP-7 and FOXC1 in Egyptian Acute Myeloid Leukemia Patients

Safa Mohamed Nabawy, Lobna Ahmed Refaat, Hussam Mohamed Naser Aldin, Reham A Rashed

Asian Pac J Cancer Prev. 2022 May; 23(5): 1619–1626. doi: 10.31557/APJCP.2022.23.5.1619

PMCID:: PMC9587852

Abstract Article PDF–454K

Select item 95403459.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 943498710.

FOXC1-mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis via NF-κB signaling pathway

Yazhi Wei, Xinmin Huang, Yanmei Ma, Liping Dai

Mol Med Rep. 2022 Oct; 26(4): 304. Published online 2022 Aug 9. doi: 10.3892/mmr.2022.12820

PMCID:: PMC9434987

Abstract Article PDF–6.2M

Select item 939022711.

Comparison of Anterior Segment Abnormalities in Individuals With FOXC1 and PITX2 Variants

Mallika Prem Senthil, Lachlan S. W. Knight, Deepa Taranath, David A. Mackey, Jonathan B. Ruddle, Mark Y. Chiang, Owen M. Siggs, Emmanuelle Souzeau, Jamie E. Craig

Cornea. 2022 Aug; 41(8): 1009–1015. Published online 2022 Mar 30. doi: 10.1097/ICO.0000000000003020

PMCID:: PMC9390227

Abstract Article PDF–198K

Select item 929024112.

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Annamaria Salvati, Viola Melone, Assunta Sellitto, Francesca Rizzo, Roberta Tarallo, Tuula A. Nyman, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz

Breast Cancer Res. 2022; 24: 52. Published online 2022 Jul 18. doi: 10.1186/s13058-022-01547-7

PMCID:: PMC9290241

Abstract Article PDF–8.2M

Select item 906515513.

Somatic FOXC1 insertion mutation remodels the immune microenvironment and promotes the progression of childhood acute lymphoblastic leukemia

Yaping Wang, Xiaopeng Ma, Jie Huang, Xiaoyun Yang, Meiyun Kang, Xiaoyan Sun, Huimin Li, Yijun Wu, Heng Zhang, Yuting Zhu, Yao Xue, Yongjun Fang

Cell Death Dis. 2022 May; 13(5): 431. Published online 2022 May 3. doi: 10.1038/s41419-022-04873-y

PMCID:: PMC9065155

Abstract Article PDF–8.1M

Select item 894907614.

Variable Anterior Segment Dysgenesis and Cardiac Anomalies Caused by a Novel Truncating Variant of FOXC1

Mariya R. Ahmed, Saumil Sethna, Laura A. Krueger, Michael B. Yang, Robert B. Hufnagel

Genes (Basel) 2022 Mar; 13(3): 411. Published online 2022 Feb 24. doi: 10.3390/genes13030411

PMCID:: PMC8949076

Abstract Article PDF–26M

Select item 882889515.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 880653716.

MicroRNA miR-106a-5p targets forkhead box transcription factor FOXC1 to suppress the cell proliferation, migration, and invasion of ectopic endometrial stromal cells via the PI3K/Akt/mTOR signaling pathway

Xinyue Zhou, Zhenyu Chen, Lipeng Pei, Jingli Sun

Bioengineered. 2021; 12(1): 2203–2213. Published online 2021 Jun 4. doi: 10.1080/21655979.2021.1933679

PMCID:: PMC8806537

Abstract Article PDF–2.7M

Select item 870974817.

miR-149 Suppresses the Proliferation and Metastasis of Human Gastric Cancer Cells by Targeting FOXC1

Dan Li, Yunqing Zhang, Yulong Li, Xiaofei Wang, Fenghui Wang, Juan Du, Huahua Zhang, Haiyan Shi, Yanfeng Wang, Yi Gao, Yun Feng, Jing Yan, Yajuan Xue, Yang Yang, Jing Zhang

Biomed Res Int. 2021; 2021: 1503403. Published online 2021 Dec 17. doi: 10.1155/2021/1503403

PMCID:: PMC8709748

Abstract Article PDF–3.4M

Select item 855290718.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 851636019.

A novel tumour suppressor protein encoded by circMAPK14 inhibits progression and metastasis of colorectal cancer by competitively binding to MKK6

Lu Wang, Jiahui Zhou, Chuan Zhang, Ranran Chen, Qingyang Sun, Peng Yang, Chaofan Peng, Yuqian Tan, Chi Jin, Tuo Wang, Jiangzhou Ji, Yueming Sun

Clin Transl Med. 2021 Oct; 11(10): e613. Published online 2021 Oct 14. doi: 10.1002/ctm2.613

PMCID:: PMC8516360

Abstract Article PDF–5.6M

Select item 848028120.

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Fabrizio Simeoni, Isabel Romero-Camarero, Francesco Camera, Fabio M.R. Amaral, Oliver J. Sinclair, Evangelia K. Papachristou, Gary J. Spencer, Michael Lie-A-Ling, Georges Lacaud, Daniel H. Wiseman, Jason S. Carroll, Tim C.P. Somervaille

Cell Rep. 2021 Sep 21; 36(12): 109725. Published online 2021 Sep 21. doi: 10.1016/j.celrep.2021.109725