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Select item 113010741.

Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17

Guillaume Dolla, Sarah Nicolas, Ligia Ramos dos Santos, Alexandre Bourgeois, Raphaëlle Pardossi-Piquard, Franck Bihl, Christelle Zaghrini, Joana Justino, Christine Payré, Pascal Mansuelle, Christoph Garbers, Pierre Ronco, Frédéric Checler, Gérard Lambeau, Agnès Petit-Paitel

J Biol Chem. 2024 Jul; 300(7): 107480. Published online 2024 Jun 17. doi: 10.1016/j.jbc.2024.107480

PMCID:: PMC11301074

Abstract Article PDF–4.9M

Select item 112969142.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112099353.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111677764.

Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation

Aaron Babendreyer, Julia Kieselhorst, Cindy Rinkens, Anastasia M. Lyashenko, Stefan Düsterhöft, Holger Jahr, Rogerio B. Craveiro, Michael Wolf, Andreas Ludwig

Cell Commun Signal. 2024; 22: 322. Published online 2024 Jun 11. doi: 10.1186/s12964-024-01690-y

PMCID:: PMC11167776

Abstract Article PDF–11M

Select item 111588875.

Nuclear translocation of ADAM‐10 contributes to the pathogenesis and progression of human prostate cancer

Takashi Arima, Hideki Enokida, Hiroyuki Kubo, Ichiro Kagara, Ryouichirou Matsuda, Kazuki Toki, Hiroaki Nishimura, Takeshi Chiyomaru, Shuichi Tatarano, Toshihiko Idesako, Kenryu Nishiyama, Masayuki Nakagawa

Cancer Sci. 2007 Nov; 98(11): 1720–1726. Published online 2007 Aug 28. doi: 10.1111/j.1349-7006.2007.00601.x

PMCID:: PMC11158887

Abstract Article PDF–1.0M

Select item 111159266.

Ectodomain shedding of the receptor for advanced glycation end products: a novel therapeutic target for Alzheimer’s disease

Ling Zhang, Rolf Postina, Yingqun Wang

Cell Mol Life Sci. 2009 Dec; 66(24): 3923–3935. Published online 2009 Aug 12. doi: 10.1007/s00018-009-0121-4

PMCID:: PMC11115926

Abstract Article PDF–398K

Select item 111154867.

Human mesenchymal stem cells induce E-cadherin degradation in breast carcinoma spheroids by activating ADAM10

Angela Dittmer, Kristina Hohlfeld, Jana Lützkendorf, Lutz P. Müller, Jürgen Dittmer

Cell Mol Life Sci. 2009 Sep; 66(18): 3053–3065. Published online 2009 Jul 15. doi: 10.1007/s00018-009-0089-0

PMCID:: PMC11115486

Abstract Article PDF–834K

Select item 111054588.

Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer’s disease

Sven Reinhardt, Florian Schuck, Nicolai Stoye, Tobias Hartmann, Marcus O. W. Grimm, Gert Pflugfelder, Kristina Endres

Cell Mol Life Sci. 2019 Mar; 76(5): 1005–1025. Published online 2019 Jan 1. doi: 10.1007/s00018-018-2998-2

PMCID:: PMC11105458

Abstract Article PDF–2.6M

Select item 111050099.

Degradome of soluble ADAM10 and ADAM17 metalloproteases

Franka Scharfenberg, Andreas Helbig, Martin Sammel, Julia Benzel, Uwe Schlomann, Florian Peters, Rielana Wichert, Maximilian Bettendorff, Dirk Schmidt-Arras, Stefan Rose-John, Catherine Moali, Stefan F. Lichtenthaler, Claus U. Pietrzik, Jörg W. Bartsch, Andreas Tholey, Christoph Becker-Pauly

Cell Mol Life Sci. 2020 Jan; 77(2): 331–350. Published online 2019 Jun 17. doi: 10.1007/s00018-019-03184-4

PMCID:: PMC11105009

Abstract Article PDF–2.2M

Select item 1078980210.

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

Linnea Z. Drexhage, Shengpan Zhang, Maeva Dupont, Franziska Ragaller, Ellen Sjule, Jose Cabezas-Caballero, Lachlan P. Deimel, Helen Robertson, Rebecca A. Russell, Omer Dushek, Erdinc Sezgin, Niloofar Karaji, Quentin J. Sattentau

Nat Commun. 2024; 15: 541. Published online 2024 Jan 15. doi: 10.1038/s41467-023-44619-8

PMCID:: PMC10789802

Abstract Article PDF–1.8M

Select item 1056069811.

Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition

Conor B. Abraham, Lin Xu, George A. Pantelopulos, John E. Straub

Biophys J. 2023 Oct 3; 122(19): 3999–4010. Published online 2023 Sep 1. doi: 10.1016/j.bpj.2023.08.025

PMCID:: PMC10560698

Abstract Article PDF–5.6M

Select item 1052845212.

Structural basis for membrane-proximal proteolysis of substrates by ADAM10

Colin H. Lipper, Emily D. Egan, Khal-Hentz Gabriel, Stephen C. Blacklow

Cell. Author manuscript; available in PMC 2024 Aug 17.

Published in final edited form as: Cell. 2023 Aug 17; 186(17): 3632–3641.e10. Published online 2023 Jul 28. doi: 10.1016/j.cell.2023.06.026

PMCID:: PMC10528452

Abstract Article PDF–1.5M

Select item 1032933113.

Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

Ehsan Bahrami, Jan Philipp Schmid, Vindi Jurinovic, Martin Becker, Anna-Katharina Wirth, Romina Ludwig, Sophie Kreissig, Tania Vanessa Duque Angel, Diana Amend, Katharina Hunt, Rupert Öllinger, Roland Rad, Joris Maximilian Frenz, Maria Solovey, Frank Ziemann, Matthias Mann, Binje Vick, Christian Wichmann, Tobias Herold, Ashok Kumar Jayavelu, Irmela Jeremias

Mol Cancer. 2023; 22: 107. Published online 2023 Jul 8. doi: 10.1186/s12943-023-01803-0

PMCID:: PMC10329331

Abstract Article PDF–5.5M

Select item 1023742214.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1015286815.

ADAM10 Gene Polymorphism and Its Relationship to Hepatocellular Carcinoma in Egyptian HCV Patients Receiving Direct-Acting Antiviral Therapies (DAAs)

Samar Ghanem, Gamalat El Gedawy, Sania Yehia, Hanan Bedair, Samah Awad, Wael Abdel-Razek, Mostafa Elhelbawy, Dalia EL-Sabaawy, Ashraf Yousif Elfert

Asian Pac J Cancer Prev. 2023; 24(1): 149–155. doi: 10.31557/APJCP.2023.24.1.149

PMCID:: PMC10152868

Abstract Article PDF–327K

Select item 1013911416.

ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?

Sanne L. Maas, Marjo M. P. C. Donners, Emiel P. C. van der Vorst

Int J Mol Sci. 2023 Apr; 24(8): 7309. Published online 2023 Apr 15. doi: 10.3390/ijms24087309

PMCID:: PMC10139114

Abstract Article PDF–2.1M

Select item 1009829217.

Potential impact of ADAM‐10 genetic variants with the clinical features of oral squamous cell carcinoma

Yi‐Tzu Chen, Chiao‐Wen Lin, Ying‐Erh Chou, Shih‐Chi Su, Lun‐Ching Chang, Chia‐Yi Lee, Ming‐Ju Hsieh, Shun‐Fa Yang

J Cell Mol Med. 2023 Apr; 27(8): 1144–1152. Published online 2023 Mar 22. doi: 10.1111/jcmm.17728

PMCID:: PMC10098292

Abstract Article PDF–1.3M

Select item 1009392718.

ADAM10 Gene Variants in AD Patients and Their Relationship to CSF Protein Levels

Pablo Agüero-Rabes, Julián Pérez-Pérez, Lucía Cremades-Jimeno, María-Salud García-Ayllón, Adriana Gea-González, María José Sainz, Ignacio Mahillo-Fernández, Raquel Téllez, Blanca Cárdaba, Javier Sáez-Valero, Estrella Gómez-Tortosa

Int J Mol Sci. 2023 Apr; 24(7): 6113. Published online 2023 Mar 24. doi: 10.3390/ijms24076113

PMCID:: PMC10093927

Abstract Article PDF–1.3M

Select item 991700519.

Elevated Expression of ADAM10 in Skeletal Muscle of Patients with Idiopathic Inflammatory Myopathies Could Be Responsible for FNDC5/Irisin Unbalance

Roberta Zerlotin, Marco Fornaro, Mariella Errede, Patrizia Pignataro, Clelia Suriano, Maddalena Ruggieri, Silvia Colucci, Florenzo Iannone, Maria Grano, Graziana Colaianni

Int J Mol Sci. 2023 Feb; 24(3): 2469. Published online 2023 Jan 27. doi: 10.3390/ijms24032469

PMCID:: PMC9917005

Abstract Article PDF–3.8M

Select item 981354720.

ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non-redundantly to ADAM17

Miriam Zatovicova, Ivana Kajanova, Martina Takacova, Lenka Jelenska, Olga Sedlakova, Martina Labudova, Silvia Pastorekova

Oncol Rep. 2023 Feb; 49(2): 27. Published online 2022 Dec 15. doi: 10.3892/or.2022.8464

PMCID:: PMC9813547

Abstract Article PDF–1.2M

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