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Select item 110757441.

Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-R_KT

Akshay Bareja, David E. Lee, Tricia Ho, Greg Waitt, Lauren H. McKay, Sarah A. Hannou, Melissa C. Orenduff, Kristen M. McGreevy, Alexandra Binder, Calen P. Ryan, Erik J. Soderblom, Daniel W. Belsky, Luigi Ferrucci, Jayanta Kumar Das, Nirad Banskota, Virginia B. Kraus, Janet L. Huebner, William E. Kraus, Kim M. Huffman, Gurpreet S. Baht, Steve Horvath, Robert J. Parmer, Lindsey A. Miles, James P. White

Cell Rep. Author manuscript; available in PMC 2024 May 7.

Published in final edited form as: Cell Rep. 2024 Mar 26; 43(3): 113881. Published online 2024 Mar 4. doi: 10.1016/j.celrep.2024.113881

PMCID:: PMC11075744

Abstract Article PDF–2.7M

Select item 110160662.

Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson’s disease

Chunying Guo, Ting Wang, Haiyan Huang, Xiaolu Wang, Yugui Jiang, Jinan Li

Sci Rep. 2024; 14: 8581. Published online 2024 Apr 13. doi: 10.1038/s41598-024-59090-8

PMCID:: PMC11016066

Abstract Article PDF–4.1M

Select item 107662003.

Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression

Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick

Mol Oncol. 2024 Jan; 18(1): 113–135. Published online 2023 Nov 27. doi: 10.1002/1878-0261.13552

PMCID:: PMC10766200

Abstract Article PDF–16M

Select item 88653754.

Plasminogen regulates fracture repair by promoting the functions of periosteal mesenchymal progenitors

Luqiang Wang, Lutian Yao, Hao Duan, Fan Yang, Maohuan Lin, Rongxin Zhang, Zhenqiang He, Jaimo Ahn, Yi Fan, Ling Qin, Yanqing Gong

J Bone Miner Res. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: J Bone Miner Res. 2021 Nov; 36(11): 2229–2242. Published online 2021 Sep 8. doi: 10.1002/jbmr.4423

PMCID:: PMC8865375

Abstract Article PDF–3.3M

Select item 84618215.

Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice

Bernhard N. Bohnert, Irene Gonzalez-Menendez, Thomas Dörffel, Jonas C. Schneider, Mengyun Xiao, Andrea Janessa, M. Zaher Kalo, Birgit Fehrenbacher, Martin Schaller, Nicolas Casadei, Kerstin Amann, Christoph Daniel, Andreas L. Birkenfeld, Florian Grahammer, Lahoucine Izem, Edward F. Plow, Leticia Quintanilla-Martinez, Ferruh Artunc

Dis Model Mech. 2021 Sep 1; 14(9): dmm049038. Published online 2021 Sep 15. doi: 10.1242/dmm.049038

PMCID:: PMC8461821

Abstract Article

Select item 83799126.

Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus

Dejun Yang, Hongwei Yang, Gabrielle Luiselli, Charles Ogagan, Huijun Dai, Lucinda Chiu, Rona S. Carroll, Mark D. Johnson

Proc Natl Acad Sci U S A. 2021 Aug 17; 118(33): e2010528118. Published online 2021 Aug 11. doi: 10.1073/pnas.2010528118

PMCID:: PMC8379912

Abstract Article PDF–1.3M

Select item 83104297.

Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure

Michael W. Henderson, Erica M. Sparkenbaugh, Shaobin Wang, Anton Ilich, Denis F. Noubouossie, Reiner Mailer, Thomas Renné, Matthew J. Flick, James P. Luyendyk, Zu-Lin Chen, Sidney Strickland, R. Todd Stravitz, Keith R. McCrae, Nigel S. Key, Rafal Pawlinski

Blood. 2021 Jul 22; 138(3): 259–272. Prepublished online 2021 Apr 7. doi: 10.1182/blood.2020006198

PMCID:: PMC8310429

Abstract Article

Select item 79593888.

Ischemic stroke in PAR1 KO mice: Decreased brain plasmin and thrombin activity along with decreased infarct volume

Efrat Shavit-Stein, Ekaterina Mindel, Shany Guly Gofrit, Joab Chapman, Nicola Maggio

PLoS One. 2021; 16(3): e0248431. Published online 2021 Mar 15. doi: 10.1371/journal.pone.0248431

PMCID:: PMC7959388

Abstract Article PDF–1.1M

Select item 79387709.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 785231210.

CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets

Henrik J. Jürgensen, Lakmali M. Silva, Oliver Krigslund, Sander van Putten, Daniel H. Madsen, Niels Behrendt, Lars H. Engelholm, Thomas H. Bugge

Matrix Biol Plus. 2019 Feb; 1: 100003. Published online 2019 Mar 19. doi: 10.1016/j.mbplus.2019.03.002

PMCID:: PMC7852312

Abstract Article PDF–1.0M

Select item 737475411.

Selection of mutant µplasmin for amyloid-β cleavage in vivo

Dongying Yang, Wei Zhu, Yingjie Wang, Fangmei Tan, Zhiping Ma, Jiali Gao, Xinli Lin

Sci Rep. 2020; 10: 12117. Published online 2020 Jul 21. doi: 10.1038/s41598-020-69079-8

PMCID:: PMC7374754

Abstract Article PDF–4.8M

Select item 720581212.

A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice

Adam Miszta, Anna K. Kopec, Asmita Pant, Lori A. Holle, James R. Byrnes, Daniel A. Lawrence, Kirk C. Hansen, Matthew J. Flick, James P. Luyendyk, Bas de Laat, Alisa S. Wolberg

Blood. 2020 May 7; 135(19): 1704–1717. Prepublished online 2020 Feb 13. doi: 10.1182/blood.2019004267