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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107666172.

15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling T_reg cell function through IFN-β

A. Zamora, M. Nougué, L. Verdu, E. Balzan, T. Draia-Nicolau, E. Benuzzi, F. Pujol, V. Baillif, E. Lacazette, F. Morfoisse, J. Galitzky, A. Bouloumié, M. Dubourdeau, B. Chaput, N. Fazilleau, J. Malloizel-Delaunay, A. Bura-Rivière, A. C. Prats, B. Garmy-Susini

Nat Commun. 2024; 15: 221. Published online 2024 Jan 4. doi: 10.1038/s41467-023-43554-y

PMCID:: PMC10766617

Abstract Article PDF–6.9M

Select item 106856873.

Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system

Florian Reisch, Dagmar Heydeck, Marjann Schäfer, Michael Rothe, Jiaxing Yang, Sabine Stehling, Gerhard P. Püschel, Hartmut Kuhn

Cell Mol Biol Lett. 2023; 28: 97. Published online 2023 Nov 29. doi: 10.1186/s11658-023-00511-3

PMCID:: PMC10685687

Abstract Article PDF–4.3M

Select item 103933464.

Hematopoietic 12/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma

Mgayya Makullah, Diandra A. Ellis, MaryJane Jones, Chad Steele

Am J Physiol Lung Cell Mol Physiol. 2023 Aug 1; 325(2): L104–L113. Published online 2023 May 30. doi: 10.1152/ajplung.00090.2023

PMCID:: PMC10393346

Abstract Article

Select item 101515775.

12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis

Christa D. Jackson, Kinsey A. Hilliard, Charles R. Brown

Front Immunol. 2023; 14: 1144172. Published online 2023 Apr 18. doi: 10.3389/fimmu.2023.1144172

PMCID:: PMC10151577

Abstract Article PDF–4.5M

Select item 99458436.

Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE

Erwan Pernet, Sarah Sun, Nicole Sarden, Saideep Gona, Angela Nguyen, Nargis Khan, Martin Mawhinney, Kim A. Tran, Julia Chronopoulos, Dnyandeo Amberkar, Mina Sadeghi, Alexandre Grant, Shradha Wali, Renaud Prevel, Jun Ding, James G. Martin, Ajitha Thanabalasuriar, Bryan G. Yipp, Luis B. Barreiro, Maziar Divangahi

Nature. 2023; 614(7948): 530–538. Published online 2023 Jan 4. doi: 10.1038/s41586-022-05660-7

PMCID:: PMC9945843

Abstract Article PDF–44M

Select item 96466667.

Identification of a Feed-Forward Loop Between 15(S)-HETE and PGE2 in Human Amnion at Parturition

Fan Zhang, Kang Sun, Wang-Sheng Wang

J Lipid Res. 2022 Nov; 63(11): 100294. Published online 2022 Oct 4. doi: 10.1016/j.jlr.2022.100294

PMCID:: PMC9646666

Abstract Article PDF–4.1M

Select item 94561958.

Unbalanced Expression of Glutathione Peroxidase 4 and Arachidonate 15-Lipoxygenase Affects Acrosome Reaction and In Vitro Fertilization

Mariana Soria-Tiedemann, Geert Michel, Iris Urban, Maceler Aldrovandi, Valerie B. O’Donnell, Sabine Stehling, Hartmut Kuhn, Astrid Borchert

Int J Mol Sci. 2022 Sep; 23(17): 9907. Published online 2022 Aug 31. doi: 10.3390/ijms23179907

PMCID:: PMC9456195

Abstract Article PDF–3.0M

Select item 92977119.

Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes

Annie R. Piñeros, Abhishek Kulkarni, Hongyu Gao, Kara S. Orr, Lindsey Glenn, Fei Huang, Yunlong Liu, Maureen Gannon, Farooq Syed, Wenting Wu, Cara M. Anderson, Carmella Evans-Molina, Marcia McDuffie, Jerry L. Nadler, Margaret A. Morris, Raghavendra G. Mirmira, Sarah A. Tersey

Cell Rep. Author manuscript; available in PMC 2022 Jul 20.

Published in final edited form as: Cell Rep. 2022 Jun 28; 39(13): 111011. doi: 10.1016/j.celrep.2022.111011

PMCID:: PMC9297711

Abstract Article PDF–2.9M

Select item 929576010.

Vagus nerve stimulation promotes resolution of inflammation by a mechanism that involves Alox15 and requires the α7nAChR subunit

April S. Caravaca, Alessandro L. Gallina, Laura Tarnawski, Vladimir S. Shavva, Romain A. Colas, Jesmond Dalli, Stephen G. Malin, Henrik Hult, Hildur Arnardottir, Peder S. Olofsson

Proc Natl Acad Sci U S A. 2022 May 31; 119(22): e2023285119. Published online 2022 May 27. doi: 10.1073/pnas.2023285119

PMCID:: PMC9295760

Abstract Article PDF–1.5M

Select item 903249111.

Increased 12/15-Lipoxygenase Enhances Cell Growth, Fibronectin Deposition, and Neointimal Formation in Response to Carotid Injury

Hamid Deliri, Nahum Meller, Ajay Kadakkal, Rohit Malhotra, Jordan Brewster, Amanda C. Doran, Hong Pei, Stephanie N. Oldham, Marcus D. Skaflen, James C. Garmey, Coleen A. McNamara

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2022 Apr 22.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1): 110–116. Published online 2010 Oct 14. doi: 10.1161/ATVBAHA.110.212068

PMCID:: PMC9032491

Abstract Article PDF–878K

Select item 887648012.

P. aeruginosa augments irradiation injury via 15-lipoxygenase–catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis

Haider H. Dar, Michael W. Epperly, Vladimir A. Tyurin, Andrew A. Amoscato, Tamil S. Anthonymuthu, Austin B. Souryavong, Alexander A. Kapralov, Galina V. Shurin, Svetlana N. Samovich, Claudette M. St. Croix, Simon C. Watkins, Sally E. Wenzel, Rama K. Mallampalli, Joel S. Greenberger, Hülya Bayır, Valerian E. Kagan, Yulia Y. Tyurina

JCI Insight. 2022 Feb 22; 7(4): e156013. Published online 2022 Feb 22. doi: 10.1172/jci.insight.156013

PMCID:: PMC8876480

Abstract Article PDF–3.7M

Select item 876557013.

Suppression of Membranous LRP5 Recycling, Wnt/β-catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P

Fuyao Liu, Xiangsheng Zuo, Yi Liu, Yasunori Deguchi, Micheline J. Moussalli, Weidong Chen, Peiying Yang, Bo Wei, Lin Tan, Philip L. Lorenzi, Shen Gao, Jonathan C. Jaoude, Amir Mehdizadeh, Lovie Ann Valentin, Daoyan Wei, Imad Shureiqi

Cell Rep. Author manuscript; available in PMC 2022 Jan 18.

Published in final edited form as: Cell Rep. 2020 Aug 18; 32(7): 108049. doi: 10.1016/j.celrep.2020.108049

PMCID:: PMC8765570

Abstract Article PDF–3.1M

Select item 874272414.

15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction

John R. Montford, Colin Bauer, Jeremy Rahkola, Julie A. Reisz, Deanna Floyd, Katharina Hopp, Danielle E. Soranno, Jelena Klawitter, Mary C. M. Weiser-Evans, Raphael Nemenoff, Sarah Faubel, Seth B. Furgeson

Am J Physiol Renal Physiol. 2022 Jan 1; 322(1): F105–F119. Published online 2021 Dec 6. doi: 10.1152/ajprenal.00214.2021

PMCID:: PMC8742724

Abstract Article

Select item 872858515.

12/15–Lipoxygenase debilitates mitochondrial health in intermittent hypobaric hypoxia induced neuronal damage: An in vivo study

Richa Choudhary, Mukesh Kumar, Anju Katyal

Redox Biol. 2022 Feb; 49: 102228. Published online 2021 Dec 30. doi: 10.1016/j.redox.2021.102228

PMCID:: PMC8728585

Abstract Article PDF–14M

Select item 856731516.

Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery

Horst Penkert, Alix Bertrand, Vini Tiwari, Stephan Breimann, Stephan A. Müller, Paul M. Jordan, Mathias J. Gerl, Christian Klose, Ludovico Cantuti-Castelvetri, Mar Bosch-Queralt, Ilya Levental, Stefan F. Lichtenthaler, Oliver Werz, Mikael Simons

Cell Rep. 2021 Oct 26; 37(4): 109898. Published online 2021 Oct 26. doi: 10.1016/j.celrep.2021.109898

PMCID:: PMC8567315

Abstract Article

Select item 841007317.

12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes

Abhishek Kulkarni, Annie R. Pineros, Melissa A. Walsh, Isabel Casimiro, Sara Ibrahim, Marimar Hernandez-Perez, Kara S. Orr, Lindsey Glenn, Jerry L. Nadler, Margaret A. Morris, Sarah A. Tersey, Raghavendra G. Mirmira, Ryan M. Anderson

JCI Insight. 2021 Jul 22; 6(14): e147812. Published online 2021 Jul 22. doi: 10.1172/jci.insight.147812

PMCID:: PMC8410073

Abstract Article PDF–6.8M

Select item 831883218.

Marginating transitional B cells modulate neutrophils in the lung during inflammation and pneumonia

John Podstawka, Sarthak Sinha, Carlos H. Hiroki, Nicole Sarden, Elise Granton, Elodie Labit, Jung Hwan Kim, Graciela Andonegui, Yuefei Lou, Brendan D. Snarr, Donald C. Sheppard, Nicole L. Rosin, Jeff Biernaskie, Bryan G. Yipp

J Exp Med. 2021 Sep 6; 218(9): e20210409. Published online 2021 Jul 27. doi: 10.1084/jem.20210409

PMCID:: PMC8318832

Abstract Article PDF–5.8M

Select item 817030419.

12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice

Jun Miyata, Yoshiyuki Yokokura, Kazuyo Moro, Hiroyuki Arai, Koichi Fukunaga, Makoto Arita

Front Immunol. 2021; 12: 687192. Published online 2021 May 19. doi: 10.3389/fimmu.2021.687192

PMCID:: PMC8170304

Abstract Article PDF–1.6M

Select item 803899720.

Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD₂ in the kidney

Naohiro Takahashi, Hiroaki Kikuchi, Ayaka Usui, Taisuke Furusho, Takuya Fujimaru, Tamami Fujiki, Tomoki Yanagi, Yoshiaki Matsuura, Kenichi Asano, Kouhei Yamamoto, Fumiaki Ando, Koichiro Susa, Shintaro Mandai, Takayasu Mori, Tatemitsu Rai, Shinichi Uchida, Makoto Arita, Eisei Sohara

Clin Exp Nephrol. 2021; 25(5): 445–455. Published online 2021 Feb 17. doi: 10.1007/s10157-021-02021-y

PMCID:: PMC8038997

Abstract Article PDF–2.3M

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