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Select item 112905211.

ETV6::ACSL6 translocation-driven super-enhancer activation leads to eosinophilia in acute lymphoblastic leukemia through IL-3 overexpression

Wenqian Xu, Feng Tian, Xiaolu Tai, Gaoxian Song, Yuanfang Liu, Liquan Fan, Xiangqin Weng, Eunjeong Yang, Meng Wang, Martin Bornhäuser, Chao Zhang, Richard B. Lock, Jason W.H. Wong, Jin Wang, Duohui Jing, Jian-Qing Mi

Haematologica. 2024 Aug 1; 109(8): 2445–2458. Published online 2024 Feb 15. doi: 10.3324/haematol.2023.284121

PMCID:: PMC11290521

Abstract Article PDF–4.0M

Select item 105262282.

Interaction of S100A6 Protein with the Four-Helical Cytokines

Alexey S. Kazakov, Evgenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov

Biomolecules. 2023 Sep; 13(9): 1345. Published online 2023 Sep 4. doi: 10.3390/biom13091345

PMCID:: PMC10526228

Abstract Article PDF–13M

Select item 105248303.

Interleukin-3 coordinates glial–peripheral immune crosstalk to incite multiple sclerosis

Máté G. Kiss, John E. Mindur, Abi G. Yates, Donghoon Lee, John F. Fullard, Atsushi Anzai, Wolfram C. Poller, Kathleen A. Christie, Yoshiko Iwamoto, Vladimir Roudko, Jeffrey Downey, Christopher T. Chan, Pacific Huynh, Henrike Janssen, Achilles Ntranos, Jan D. Hoffmann, Walter Jacob, Sukanya Goswami, Sumnima Singh, David Leppert, Jens Kuhle, Seunghee Kim-Schulze, Matthias Nahrendorf, Benjamin P. Kleinstiver, Fay Probert, Panos Roussos, Filip K. Swirski, Cameron S. McAlpine

Immunity. Author manuscript; available in PMC 2024 Jul 11.

Published in final edited form as: Immunity. 2023 Jul 11; 56(7): 1502–1514.e8. Published online 2023 May 8. doi: 10.1016/j.immuni.2023.04.013

PMCID:: PMC10524830

Abstract Article PDF–1.8M

Select item 99961954.

Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming

Alan Bénard, Frederik J. Hansen, Florian Uhle, Bettina Klösch, Franziska Czubayko, Anke Mittelstädt, Anne Jacobsen, Paul David, Malgorzata J. Podolska, Anna Anthuber, Izabela Swierzy, Dominik Schaack, Petra Mühl-Zürbes, Alexander Steinkasserer, Michael Weyand, Markus A. Weigand, Thorsten Brenner, Christian Krautz, Robert Grützmann, Georg F. Weber

Front Immunol. 2023; 14: 1140630. Published online 2023 Feb 22. doi: 10.3389/fimmu.2023.1140630

PMCID:: PMC9996195

Abstract Article PDF–3.0M

Select item 95699905.

Calcium-Bound S100P Protein Is a Promiscuous Binding Partner of the Four-Helical Cytokines

Alexey S. Kazakov, Evgenia I. Deryusheva, Maria E. Permyakova, Andrey S. Sokolov, Victoria A. Rastrygina, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov

Int J Mol Sci. 2022 Oct; 23(19): 12000. Published online 2022 Oct 9. doi: 10.3390/ijms231912000

PMCID:: PMC9569990

Abstract Article PDF–3.2M

Select item 91063036.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 89341487.

Astrocyte-derived interleukin-3 reprograms microglia and limits Alzheimer’s disease

Cameron S. McAlpine, Joseph Park, Ana Griciuc, Eunhee Kim, Se Hoon Choi, Yoshiko Iwamoto, Máté G. Kiss, Kathleen A. Christie, Claudio Vinegoni, Wolfram C. Poller, John E. Mindur, Christopher T. Chan, Shun He, Henrike Janssen, Lai Ping Wong, Jeffrey Downey, Sumnima Singh, Atsushi Anzai, Florian Kahles, Mehdi Jorfi, Paolo Fumene Feruglio, Ruslan I. Sadreyev, Ralph Weissleder, Benjamin P. Kleinstiver, Matthias Nahrendorf, Rudolph E. Tanzi, Filip K. Swirski

Nature. Author manuscript; available in PMC 2022 Mar 19.

Published in final edited form as: Nature. 2021 Jul; 595(7869): 701–706. Published online 2021 Jul 14. doi: 10.1038/s41586-021-03734-6

PMCID:: PMC8934148

Abstract Article PDF–2.6M

Select item 89043518.

An Immunoregulatory Role of Interleukin-3 in Allergic Asthma

Susanne Krammer, Zuqin Yang, Theodor Zimmermann, Paraskevi Xepapadaki, Carol I. Geppert, Nikolaos G. Papadopoulos, Susetta Finotto

Front Immunol. 2022; 13: 821658. Published online 2022 Feb 23. doi: 10.3389/fimmu.2022.821658

PMCID:: PMC8904351

Abstract Article PDF–3.9M

Select item 89017799.

Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells

Yuzhi Yin, Yun Bai, Ana Olivera, Dean D. Metcalfe

J Allergy Clin Immunol. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: J Allergy Clin Immunol. 2022 Apr; 149(4): 1392–1401.e6. Published online 2021 Sep 8. doi: 10.1016/j.jaci.2021.09.003

PMCID:: PMC8901779

Abstract Article PDF–1.0M

Select item 857821410.

Persistent astrocytic IL-3 stimulation of microglia slows disease in Alzheimer’s: treatment perspectives for Alzheimer’s

Natja Haag, Hans Zempel

Signal Transduct Target Ther. 2021; 6: 388. Published online 2021 Nov 9. doi: 10.1038/s41392-021-00806-x

PMCID:: PMC8578214

Article PDF–676K

Select item 809410311.

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification

Mania Ackermann, Kathrin Haake, Henning Kempf, Paul Kaschutnig, Anna-Carina Weiss, Ariane H.H. Nguyen, Markus Abeln, Sylvia Merkert, Mark Phillip Kühnel, Dorothee Hartmann, Danny Jonigk, Thomas Thum, Andreas Kispert, Michael D. Milsom, Nico Lachmann

Haematologica. 2021 May 1; 106(5): 1354–1367. Published online 2020 Apr 23. doi: 10.3324/haematol.2019.228064

PMCID:: PMC8094103

Abstract Article PDF–2.3M

Select item 709880012.

The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity

Yao Tong, Travis B. Lear, John Evankovich, Yanwen Chen, James D. Londino, Michael M. Myerburg, Yingze Zhang, Iulia D. Popescu, John F. McDyer, Bryan J. McVerry, Karina C. Lockwood, Michael J. Jurczak, Yuan Liu, Bill B. Chen

JCI Insight. 2020 Feb 13; 5(3): e133652. Published online 2020 Feb 13. doi: 10.1172/jci.insight.133652

PMCID:: PMC7098800

Abstract Article PDF–5.8M

Select item 661600713.

Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared to Common Beta-Chain Cytokines IL-5 and GM-CSF

Ryan K. Nelson, Howard Brickner, Bharat Panwar, Ciro Ramirez Suastegui, Sara Herrera de la Mata, Neiman Liu, Damaris Diaz, Laura E. Crotty Alexander, Ferhat Ay, Pandurangan Vijayanand, Grégory Seumois, Praveen Akuthota

J Immunol. Author manuscript; available in PMC 2020 Jul 15.

Published in final edited form as: J Immunol. 2019 Jul 15; 203(2): 329–337. Published online 2019 Jun 7. doi: 10.4049/jimmunol.1801668

PMCID:: PMC6616007

Abstract Article PDF–1.4M

Select item 650630614.

Malignant Transformation of Fanconi Anemia Complementation Group D2-deficient (Fancd2−/−) Hematopoietic Progenitor Cells by a Single HPV16 Oncogene

XICHEN ZHANG, RENEE FISHER, DONNA SHIELDS, WEN HOU, DARCY FRANICOLA, HONG WANG, MICHAEL W. EPPERLY, LORA RIGATTI, JOEL S. GREENBERGER

In Vivo. 2019 Mar-Apr; 33(2): 303–311. Published online 2019 Mar 3. doi: 10.21873/invivo.11476

PMCID:: PMC6506306

Abstract Article PDF–740K

Select item 646661015.

Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles

Cheng-Hsuan Wu, Tsung-Hsien Lee, Shun-Fa Yang, Hui-Mei Tsao, Yu-Jun Chang, Chia-Hsuan Chou, Maw-Sheng Lee

Int J Environ Res Public Health. 2019 Mar; 16(6): 995. Published online 2019 Mar 19. doi: 10.3390/ijerph16060995

PMCID:: PMC6466610

Abstract Article PDF–320K

Select item 641222316.

Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease

Francesco Borriello, Maria Rosaria Galdiero, Gilda Varricchi, Stefania Loffredo, Giuseppe Spadaro, Gianni Marone

Int J Mol Sci. 2019 Feb; 20(4): 834. Published online 2019 Feb 15. doi: 10.3390/ijms20040834

PMCID:: PMC6412223

Abstract Article PDF–595K

Select item 633447917.

Role of interleukin-3 as a prognostic marker in septic patients

Isabela Nascimento Borges, Carolina Braga Resende, Érica Leandro Marciano Vieira, José Luiz Padilha da Silva, Marcus Vinícius Melo de Andrade, Andrea Jerusa de Souza, Eurípedes Badaró, Rafael Mourão Carneiro, Antônio Lúcio Teixeira Jr., Vandack Nobre

Rev Bras Ter Intensiva. 2018 Oct-Dec; 30(4): 443–452. doi: 10.5935/0103-507X.20180064

PMCID:: PMC6334479

Abstract Article PDF–791K

Select item 593871218.

IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils

Fabian Zellweger, Patrick Buschor, Gabriel Hobi, Daniel Brigger, Clemens Andreas Dahinden, Peter Matthias Villiger, Alexander Eggel

Cell Death Dis. 2018 May; 9(5): 510. Published online 2018 May 3. doi: 10.1038/s41419-018-0526-9

PMCID:: PMC5938712

Abstract Article PDF–1.5M

Select item 578597719.

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Sophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Winnie L. Kan, Emma F. Barry, Mara Dottore, Karen S. Cheung Tung Shing, Craig J. Morton, Urmi Dhagat, Matthew P. Hardy, Nicholas J. Wilson, Matthew T. Downton, Christine Schieber, Timothy P. Hughes, Angel F. Lopez, Michael W. Parker

Nat Commun. 2018; 9: 386. Published online 2018 Jan 26. doi: 10.1038/s41467-017-02633-7

PMCID:: PMC5785977

Abstract Article PDF–6.3M

Select item 565095220.

DPP4 Truncated GM-CSF & IL-3 Manifest Distinct Receptor Binding & Regulatory Functions Compared to their Full Length Forms

Heather Ann O’Leary, Maegan Capitano, Scott Cooper, Charlie Mantel, H. Scott Boswell, Reuben Kapur, Baskar Ramdas, Rebecca Chan, Lisa Deng, Cheng-Kui Qu, Hal E. Broxmeyer

Leukemia. Author manuscript; available in PMC 2017 Nov 2.

Published in final edited form as: Leukemia. 2017 Nov; 31(11): 2468–2478. Published online 2017 Mar 27. doi: 10.1038/leu.2017.98

PMCID:: PMC5650952

Abstract Article PDF–990K

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