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Select item 115879321.

Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders

C. Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Berichel, Matthew D. Park, Camille Bigenwald, George R. Heaton, Pauline Hamon, Leanna Troncoso, Brooks P. Scull, Diana Dangoor, Aymeric Silvin, Ryan Fleischmann, Meriem Belabed, Howard Lin, Elias Merad Taouli, Steffen Boettcher, Long Li, Antonio Aubry, Markus G. Manz, Julia K. Kofler, Zhenyu Yue, Sergio A. Lira, Florent Ginhoux, John F. Crary, Kenneth L. McClain, Jennifer L. Picarsic, Scott J. Russo, Carl E. Allen, Miriam Merad

Immunity. Author manuscript; available in PMC 2024 Dec 12.

Published in final edited form as: Immunity. 2023 Dec 12; 56(12): 2790–2802.e6. doi: 10.1016/j.immuni.2023.11.011

PMCID:: PMC11587932

Abstract Article PDF–2.8M

Select item 115141572.

Development of a novel immunocompetent murine tumor model for urothelial carcinoma using in vivo electroporation

Stefan Soleder, Nicolas Gengenbacher, Carolin Mogler, Markus Eckstein, Anja Runge, Maximilian C. Kriegmair, Hellmut G. Augustin

Sci Rep. 2024; 14: 25619. Published online 2024 Oct 27. doi: 10.1038/s41598-024-77178-z

PMCID:: PMC11514157

Abstract Article PDF–3.7M

Select item 112985413.

Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy

Yinshen Wee, Junhua Wang, Emily C. Wilson, Coulson P. Rich, Aaron Rogers, Zongzhong Tong, Evelyn DeGroot, Y. N. Vashisht Gopal, Michael A. Davies, H. Atakan Ekiz, Joshua K. H. Tay, Chris Stubben, Kenneth M. Boucher, Juan M. Oviedo, Keke C. Fairfax, Matthew A. Williams, Sheri L. Holmen, Roger K. Wolff, Allie H. Grossmann

Nat Commun. 2024; 15: 6613. Published online 2024 Aug 4. doi: 10.1038/s41467-024-50881-1

PMCID:: PMC11298541

Abstract Article PDF–5.5M

Select item 112080454.

FAK loss reduces BRAF^V600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

Chenxi Gao, Huaibin Ge, Shih-Fan Kuan, Chunhui Cai, Xinghua Lu, Farzad Esni, Robert E Schoen, Jing H Wang, Edward Chu, Jing Hu

eLife. 2024; 13: RP94605. Published online 2024 Jun 26. doi: 10.7554/eLife.94605

PMCID:: PMC11208045

Abstract Article PDF–5.3M

Select item 111711015.

Single-Cell Profiling Reveals the Impact of Genetic Alterations on the Differentiation of Inflammation-Induced Murine Colon Tumors

Ahmed H. Ghobashi, Rosie Lanzloth, Christopher A. Ladaika, Ashiq Masood, Heather M. O’Hagan

Cancers (Basel) 2024 Jun; 16(11): 2040. Published online 2024 May 28. doi: 10.3390/cancers16112040

PMCID:: PMC11171101

Abstract Article PDF–9.3M

Select item 111287136.

Targeting miR‐31 represses tumourigenesis and dedifferentiation of BRAF^V600E‐associated thyroid carcinoma

Peitao Zhang, Lizhao Guan, Wei Sun, Yu Zhang, Yaying Du, Shukai Yuan, Xiaolong Cao, Zhengquan Yu, Qiang Jia, Xiangqian Zheng, Zhaowei Meng, Xingrui Li, Li Zhao

Clin Transl Med. 2024 May; 14(5): e1694. Published online 2024 May 26. doi: 10.1002/ctm2.1694

PMCID:: PMC11128713

Abstract Article PDF–8.1M

Select item 110961767.

Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis

Zhenlei Zhang, Yufan Wu, Jinrong Fu, Xiujie Yu, Yang Su, Shikai Jia, Huili Cheng, Yan Shen, Xianghui He, Kai Ren, Xiangqian Zheng, Haixia Guan, Feng Rao, Li Zhao

Nat Commun. 2024; 15: 4108. Published online 2024 May 15. doi: 10.1038/s41467-024-48173-9

Correction in:: Nat Commun. 2024; 15: 4936.

PMCID:: PMC11096176

Abstract Article PDF–5.7M

Select item 110298048.

Noncovalently particle-anchored cytokines with prolonged tumor retention safely elicit potent antitumor immunity

Liqian Niu, Eungyo Jang, Ai Lin Chin, Ziyu Huo, Wenbo Wang, Wenjun Cai, Rong Tong

Sci Adv. 2024 Apr 19; 10(16): eadk7695. Published online 2024 Apr 19. doi: 10.1126/sciadv.adk7695

PMCID:: PMC11029804

Abstract Article PDF–6.9M

Select item 107974269.

HSPA8 Activates Wnt/β‐Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA‐Mediated CAV1 Degradation

Bowen Li, Hui Ming, Siyuan Qin, Li Zhou, Zhao Huang, Ping Jin, Liyuan Peng, Maochao Luo, Tingting Zhang, Kui Wang, Rui Liu, Yih‐Cherng Liou, Edouard C. Nice, Jingwen Jiang, Canhua Huang

Adv Sci (Weinh) 2024 Jan; 11(3): 2306535. Published online 2023 Nov 16. doi: 10.1002/advs.202306535

PMCID:: PMC10797426

Abstract Article PDF–6.3M

Select item 1078672310.

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids

Hélène Lasolle, Andrea Schiavo, Adrien Tourneur, Pierre Gillotay, Bárbara de Faria da Fonseca, Lucieli Ceolin, Olivier Monestier, Benilda Aganahi, Laura Chomette, Marina Malta Letro Kizys, Lieven Haenebalcke, Tim Pieters, Steven Goossens, Jody Haigh, Vincent Detours, Ana Luiza Silva Maia, Sabine Costagliola, Mírian Romitti

Oncogene. 2024; 43(3): 155–170. Published online 2023 Nov 20. doi: 10.1038/s41388-023-02889-y

PMCID:: PMC10786723

Abstract Article PDF–14M

Select item 1077189111.

BRAF^V600E mutation and DSS treatment synergize to induce cecal tumor formation in mice

Chenxi Gao, Farzad Esni, Edward Chu, Jing Hu

Biochem Biophys Rep. 2024 Mar; 37: 101634. Published online 2024 Jan 1. doi: 10.1016/j.bbrep.2023.101634

PMCID:: PMC10771891

Abstract Article PDF–6.0M

Select item 1074039112.

Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis

Nneoma Adaku, Benjamin N. Ostendorf, Wenbin Mei, Sohail F. Tavazoie

Cancer Res. Author manuscript; available in PMC 2023 Dec 22.

Published in final edited form as: Cancer Res. 2023 Sep 15; 83(18): 3013–3025. doi: 10.1158/0008-5472.CAN-23-1252

PMCID:: PMC10740391

Abstract Article PDF–1.7M

Select item 1058575013.

BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8⁺ T cell infiltration in colorectal cancer

Wenjing Li, Chenyi Zhao, Wenhui Li, Yang Gong, Kaili Ma, Yujie Lu, Xiaowei Liu, Lianjun Zhang, Feng Guo

J Transl Med. 2023; 21: 737. Published online 2023 Oct 18. doi: 10.1186/s12967-023-04606-5

PMCID:: PMC10585750

Abstract Article PDF–16M

Select item 1057578114.

GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation

Koei Shinzawa, Shinji Matsumoto, Ryota Sada, Akikazu Harada, Kaori Saitoh, Keiko Kato, Satsuki Ikeda, Akiyoshi Hirayama, Kazunori Yokoi, Atsushi Tanemura, Keisuke Nimura, Masahito Ikawa, Tomoyoshi Soga, Akira Kikuchi

Oncogene. 2023; 42(42): 3142–3156. Published online 2023 Sep 1. doi: 10.1038/s41388-023-02803-6

PMCID:: PMC10575781

Abstract Article PDF–5.0M

Select item 1057032315.

Oncogenic context shapes the fitness landscape of tumor suppression

Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters

Nat Commun. 2023; 14: 6422. Published online 2023 Oct 12. doi: 10.1038/s41467-023-42156-y

PMCID:: PMC10570323

Abstract Article PDF–6.1M

Select item 1052119516.

Multiplexed screens identify RAS paralogs HRAS and NRAS as suppressors of KRAS-driven lung cancer growth

Rui Tang, Emily G. Shuldiner, Marcus Kelly, Christopher W. Murray, Jess D. Hebert, Laura Andrejka, Min K. Tsai, Nicholas W. Hughes, Mitchell I Parker, Hongchen Cai, Yao-Cheng Li, Geoffrey M. Wahl, Roland L Dunbrack, Peter K. Jackson, Dmitri A. Petrov, Monte M. Winslow

Nat Cell Biol. Author manuscript; available in PMC 2023 Sep 26.

Published in final edited form as: Nat Cell Biol. 2023 Jan; 25(1): 159–169. Published online 2023 Jan 12. doi: 10.1038/s41556-022-01049-w

PMCID:: PMC10521195

Abstract Article PDF–6.8M

Select item 1051433217.

BRAF^V600E-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism

Paulina Rzasa, Sarah Whelan, Pooyeh Farahmand, Hong Cai, Inna Guterman, Raquel Palacios-Gallego, Shanthi S. Undru, Lauren Sandford, Caleb Green, Catherine Andreadi, Maria Mintseva, Emma Parrott, Hong Jin, Fiona Hey, Susan Giblett, Nicolas B. Sylvius, Natalie S. Allcock, Anna Straatman-Iwanowska, Roberto Feuda, Cristina Tufarelli, Karen Brown, Catrin Pritchard, Alessandro Rufini

Commun Biol. 2023; 6: 962. Published online 2023 Sep 21. doi: 10.1038/s42003-023-05331-x

PMCID:: PMC10514332

Abstract Article PDF–4.5M

Select item 1047396118.

Microenvironmental Snail1-induced immunosuppression promotes melanoma growth

Marta Arumi-Planas, Francisco Javier Rodriguez-Baena, Francisco Cabello-Torres, Francisco Gracia, Cristina Lopez-Blau, M. Angela Nieto, Berta Sanchez-Laorden

Oncogene. 2023; 42(36): 2659–2672. Published online 2023 Jul 29. doi: 10.1038/s41388-023-02793-5

PMCID:: PMC10473961

Abstract Article PDF–3.9M

Select item 1046813719.

TERT accelerates BRAF mutant–induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis

Pengcheng Yu, Ning Qu, Rui Zhu, Jiaqian Hu, Peizhen Han, Jiahao Wu, Licheng Tan, Hualei Gan, Cong He, Chuantao Fang, Yubin Lei, Jian Li, Chenxi He, Fei Lan, Xiao Shi, Wenjun Wei, Yu Wang, Qinghai Ji, Fa-Xing Yu, Yu-Long Wang

Sci Adv. 2023 Sep; 9(35): eadg7125. Published online 2023 Aug 30. doi: 10.1126/sciadv.adg7125

PMCID:: PMC10468137

Abstract Article PDF–3.1M

Select item 1045719820.

UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease

Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Naoya Takayama, Naoki Itokawa, Shuhei Koide, Asuka Shibamiya, Yurie Miyamoto-Nagai, Mohamed Rizk, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Changshan Wang, Atsunori Saraya, Ryoji Ito, Masanori Seimiya, Mariko Watanabe, Satoshi Yamasaki, Tatsuhiro Shibata, Kiyoshi Yamaguchi, Yoichi Furukawa, Tetsuhiro Chiba, Emiko Sakaida, Chiaki Nakaseko, Jun-ichi Tamaru, Yu-Tzu Tai, Kenneth C. Anderson, Hiroaki Honda, Atsushi Iwama

Leukemia. 2023; 37(9): 1895–1907. Published online 2023 May 17. doi: 10.1038/s41375-023-01928-7

Correction in:: Leukemia. 2023; 37(9): 1952.

PMCID:: PMC10457198

Abstract Article PDF–4.0M

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