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Select item 111586761.

Ataxia‐telangiectasia‐mutated dependent phosphorylation of Artemis in response to DNA damage

Ling Chen, Tomohiro Morio, Yoshiyuki Minegishi, Shin‐Ichiro Nakada, Masayuki Nagasawa, Kenshi Komatsu, Luciana Chessa, Anna Villa, Daniele Lecis, Domenico Delia, Shuki Mizutani

Cancer Sci. 2005 Feb; 96(2): 134–141. Published online 2005 Feb 21. doi: 10.1111/j.1349-7006.2005.00019.x

PMCID:: PMC11158676

Abstract Article PDF–271K

Select item 99406332.

Dynamics of the Artemis and DNA-PKcs Complex in the Repair of Double-Strand Breaks

Go Watanabe, Michael R. Lieber

J Mol Biol. Author manuscript; available in PMC 2023 Dec 15.

Published in final edited form as: J Mol Biol. 2022 Dec 15; 434(23): 167858. Published online 2022 Oct 19. doi: 10.1016/j.jmb.2022.167858

PMCID:: PMC9940633

Abstract Article PDF–1023K

Select item 98844873.

Lentiviral Gene Therapy for Artemis-Deficient SCID

Morton J. Cowan, Jason Yu, Janelle Facchino, Carol Fraser-Browne, Ukina Sanford, Misako Kawahara, Jasmeen Dara, Janel Long-Boyle, Jess Oh, Wendy Chan, Shivali Chag, Lori Broderick, Deepak Chellapandian, Hélène Decaluwe, Catherine Golski, Diana Hu, Caroline Y. Kuo, Holly K. Miller, Aleksandra Petrovic, Robert Currier, Joan F. Hilton, Divya Punwani, Christopher C. Dvorak, Harry L. Malech, R. Scott McIvor, Jennifer M. Puck

N Engl J Med. Author manuscript; available in PMC 2023 Jan 29.

Published in final edited form as: N Engl J Med. 2022 Dec 22; 387(25): 2344–2355. doi: 10.1056/NEJMoa2206575

PMCID:: PMC9884487

Abstract Article PDF–1.2M

Select item 93032824.

Structural analysis of the basal state of the Artemis:DNA-PKcs complex

Go Watanabe, Michael R Lieber, Dewight R Williams

Nucleic Acids Res. 2022 Jul 22; 50(13): 7697–7720. Published online 2022 Jul 8. doi: 10.1093/nar/gkac564

PMCID:: PMC9303282

Abstract Article PDF–16M

Select item 82716205.

Staring at the Naked Goddess: Unraveling the Structure and Reactivity of Artemis Endonuclease Interacting with a DNA Double Strand

Cécilia Hognon, Antonio Monari

Molecules. 2021 Jul; 26(13): 3986. Published online 2021 Jun 29. doi: 10.3390/molecules26133986

PMCID:: PMC8271620

Abstract Article PDF–2.3M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 76572337.

Artemis‐dependent DNA double‐strand break formation at stalled replication forks

Junya Unno, Masatoshi Takagi, Jinhua Piao, Masataka Sugimoto, Fumiko Honda, Daisuke Maeda, Mitsuko Masutani, Tohru Kiyono, Fumiaki Watanabe, Tomohiro Morio, Hirobumi Teraoka, Shuki Mizutani

Cancer Sci. 2013 Jun; 104(6): 703–710. Published online 2013 Apr 15. doi: 10.1111/cas.12144

PMCID:: PMC7657233

Abstract Article PDF–1.6M

Select item 74588168.

Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features

Md Fazlul Karim, Shanshan Liu, Adrian R. Laciak, Leah Volk, Mary Koszelak-Rosenblum, Michael R. Lieber, Mousheng Wu, Rory Curtis, Nian N. Huang, Grant Carr, Guangyu Zhu

J Biol Chem. 2020 Aug 28; 295(35): 12368–12377. Published online 2020 Jun 23. doi: 10.1074/jbc.RA120.014136

PMCID:: PMC7458816

Abstract Article PDF–2.6M

Select item 74273279.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 705010310.

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair

Zhen Chen, Chao Wang, Antrix Jain, Mrinal Srivastava, Mengfan Tang, Huimin Zhang, Xu Feng, Litong Nie, Dan Su, Yun Xiong, Sung Yun Jung, Jun Qin, Junjie Chen

Mol Cell Proteomics. 2020 Mar; 19(3): 467–477. Published online 2020 Jan 3. doi: 10.1074/mcp.RA119.001794

PMCID:: PMC7050103

Abstract Article PDF–1.8M

Select item 689239311.

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

Kristen Mengwasser, Richard Adeyemi, Yumei Leng, Mei Yuk Choi, Connor Clairmont, Alan D’Andrea, Stephen J. Elledge

Mol Cell. Author manuscript; available in PMC 2019 Dec 4.

Published in final edited form as: Mol Cell. 2019 Mar 7; 73(5): 885–899.e6. Published online 2019 Jan 24. doi: 10.1016/j.molcel.2018.12.008

PMCID:: PMC6892393

Abstract Article PDF–1.7M

Select item 615874812.

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining

Ajinkya S Kawale, Konstantin Akopiants, Kristoffer Valerie, Brian Ruis, Eric A Hendrickson, Shar-yin N Huang, Yves Pommier, Lawrence F Povirk

Nucleic Acids Res. 2018 Sep 28; 46(17): 8926–8939. Published online 2018 Aug 3. doi: 10.1093/nar/gky694

PMCID:: PMC6158748

Abstract Article PDF–3.2M

Select item 608506913.

DNA replication stress triggers rapid DNA replication fork breakage by Artemis and XPF

Rémy Bétous, Théo Goullet de Rugy, Alessandra Luiza Pelegrini, Sophie Queille, Jean-Pierre de Villartay, Jean-Sébastien Hoffmann

PLoS Genet. 2018 Jul; 14(7): e1007541. Published online 2018 Jul 30. doi: 10.1371/journal.pgen.1007541

PMCID:: PMC6085069

Abstract Article PDF–3.6M

Select item 557292714.

Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity

Christina A. Gerodimos, Howard H. Y. Chang, Go Watanabe, Michael R. Lieber

J Biol Chem. 2017 Aug 25; 292(34): 13914–13924. Published online 2017 Jul 10. doi: 10.1074/jbc.M117.798850

PMCID:: PMC5572927

Abstract Article PDF–2.0M

Select item 553161115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 533616816.

Autoinhibition of the Nuclease ARTEMIS Is Mediated by a Physical Interaction between Its Catalytic and C-terminal Domains

Doris Niewolik, Ingrid Peter, Carmen Butscher, Klaus Schwarz

J Biol Chem. 2017 Feb 24; 292(8): 3351–3365. Published online 2017 Jan 12. doi: 10.1074/jbc.M116.770461

PMCID:: PMC5336168

Abstract Article PDF–2.8M

Select item 503757117.

Clinical Application of Whole Genome Sequencing In Patients with Primary Immunodeficiency

Talal Mousallem, Thomas J. Urban, K. Melodi McSweeney, Sarah E. Kleinstein, Mingfu Zhu, Mehdi Adeli, Roberta E. Parrott, Joseph L. Roberts, Brian Krueger, Rebecca H. Buckley, David B Goldstein

J Allergy Clin Immunol. Author manuscript; available in PMC 2016 Sep 27.

Published in final edited form as: J Allergy Clin Immunol. 2015 Aug; 136(2): 476–9.e6. Published online 2015 May 14. doi: 10.1016/j.jaci.2015.02.040

PMCID:: PMC5037571

Abstract Article PDF–204K

Select item 466417218.

DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency

Timo Volk, Ulrich Pannicke, Ismail Reisli, Alla Bulashevska, Julia Ritter, Andrea Björkman, Alejandro A. Schäffer, Manfred Fliegauf, Esra H. Sayar, Ulrich Salzer, Paul Fisch, Dietmar Pfeifer, Michela Di Virgilio, Hongzhi Cao, Fang Yang, Karin Zimmermann, Sevgi Keles, Zafer Caliskaner, S¸ükrü Güner, Detlev Schindler, Lennart Hammarström, Marta Rizzi, Michael Hummel, Qiang Pan-Hammarström, Klaus Schwarz, Bodo Grimbacher

Hum Mol Genet. 2015 Dec 20; 24(25): 7361–7372. Published online 2015 Oct 16. doi: 10.1093/hmg/ddv437

PMCID:: PMC4664172

Abstract Article PDF–519K

Select item 464794119.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 461721120.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

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