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Items: 1 to 20 of 51

1.
Increase in TPSB2 and TPSD1 Expression in Synovium of Hip Osteoarthritis Patients Who Are Overweight
Maho Tsuchiya, Kensuke Fukushima, Ken Takata, Yoshihisa Ohashi, Katsufumi Uchiyama, Naonobu Takahira, Hiroki Saito, Ayumi Tsukada, Gen Inoue, Masashi Takaso, Kentaro Uchida
Int J Mol Sci. 2023 Jul; 24(14): 11532. Published online 2023 Jul 16. doi: 10.3390/ijms241411532
PMCID:
PMC10380195
AbstractArticlePDF–1.0M
2.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
3.
Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA
Sultan Alanazi, Mirjana Grujic, Maria Lampinen, Ola Rollman, Christian P. Sommerhoff, Gunnar Pejler, Fabio Rabelo Melo
Int J Mol Sci. 2020 Jul; 21(14): 5065. Published online 2020 Jul 17. doi: 10.3390/ijms21145065
PMCID:
PMC7404274
AbstractArticlePDF–2.4M
4.
The mutational constraint spectrum quantified from variation in 141,456 humans
Konrad J. Karczewski, Laurent C. Francioli, Grace Tiao, Beryl B. Cummings, Jessica Alföldi, Qingbo Wang, Ryan L. Collins, Kristen M. Laricchia, Andrea Ganna, Daniel P. Birnbaum, Laura D. Gauthier, Harrison Brand, Matthew Solomonson, Nicholas A. Watts, Daniel Rhodes, Moriel Singer-Berk, Eleina M. England, Eleanor G. Seaby, Jack A. Kosmicki, Raymond K. Walters, Katherine Tashman, Yossi Farjoun, Eric Banks, Timothy Poterba, Arcturus Wang, Cotton Seed, Nicola Whiffin, Jessica X. Chong, Kaitlin E. Samocha, Emma Pierce-Hoffman, Zachary Zappala, Anne H. O’Donnell-Luria, Eric Vallabh Minikel, Ben Weisburd, Monkol Lek, James S. Ware, Christopher Vittal, Irina M. Armean, Louis Bergelson, Kristian Cibulskis, Kristen M. Connolly, Miguel Covarrubias, Stacey Donnelly, Steven Ferriera, Stacey Gabriel, Jeff Gentry, Namrata Gupta, Thibault Jeandet, Diane Kaplan, Christopher Llanwarne, Ruchi Munshi, Sam Novod, Nikelle Petrillo, David Roazen, Valentin Ruano-Rubio, Andrea Saltzman, Molly Schleicher, Jose Soto, Kathleen Tibbetts, Charlotte Tolonen, Gordon Wade, Michael E. Talkowski, Genome Aggregation Database Consortium, Benjamin M. Neale, Mark J. Daly, Daniel G. MacArthur
Nature. 2020; 581(7809): 434–443. Published online 2020 May 27. doi: 10.1038/s41586-020-2308-7
Correction in:
Nature. 2021; 590(7846): E53.
PMCID:
PMC7334197
AbstractArticlePDF–3.1M
5.
Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes
Antonio Rausell, Yufei Luo, Marie Lopez, Yoann Seeleuthner, Franck Rapaport, Antoine Favier, Peter D. Stenson, David N. Cooper, Etienne Patin, Jean-Laurent Casanova, Lluis Quintana-Murci, Laurent Abel
Proc Natl Acad Sci U S A. 2020 Jun 16; 117(24): 13626–13636. Published online 2020 Jun 2. doi: 10.1073/pnas.1917993117
PMCID:
PMC7306792
AbstractArticlePDF–1.0M
6.
Hereditary α tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis
Georg Greiner, Bettina Sprinzl, Aleksandra Górska, Franz Ratzinger, Michael Gurbisz, Nadine Witzeneder, Klaus G. Schmetterer, Bettina Gisslinger, Goekhan Uyanik, Emir Hadzijusufovic, Harald Esterbauer, Karoline V. Gleixner, Maria T. Krauth, Michael Pfeilstöcker, Felix Keil, Heinz Gisslinger, Boguslaw Nedoszytko, Marek Niedoszytko, Wolfgang R. Sperr, Peter Valent, Gregor Hoermann
Blood. Author manuscript; available in PMC 2022 Jan 14.
Published in final edited form as: Blood. 2021 Jan 14; 137(2): 238–247. doi: 10.1182/blood.2020006157
PMCID:
PMC7116780
AbstractArticlePDF–1.1M
7.
Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia
Quang T. Le, Jonathan J. Lyons, Andrea N. Naranjo, Ana Olivera, Robert A. Lazarus, Dean D. Metcalfe, Joshua D. Milner, Lawrence B. Schwartz
J Exp Med. 2019 Oct 7; 216(10): 2348–2361. Published online 2019 Jul 23. doi: 10.1084/jem.20190701
PMCID:
PMC6780998
AbstractArticlePDF–2.2M
8.
Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold
Brian S. Finlin, Amy L. Confides, Beibei Zhu, Mary C. Boulanger, Hasiyet Memetimin, Kyle W. Taylor, Zachary R. Johnson, Philip M. Westgate, Esther E. Dupont-Versteegden, Philip A. Kern
Sci Rep. 2019; 9: 8658. Published online 2019 Jun 17. doi: 10.1038/s41598-019-45136-9
PMCID:
PMC6572779
AbstractArticlePDF–2.0M
9.
BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression
Lei Yu, Natee Jearawiriyapaisarn, Mary P. Lee, Tomonori Hosoya, Qingqing Wu, Greggory Myers, Kim-Chew Lim, Ryo Kurita, Yukio Nakamura, Anne B. Vojtek, Jean-François Rual, James Douglas Engel
Genes Dev. 2018 Dec 1; 32(23-24): 1537–1549. doi: 10.1101/gad.318436.118
PMCID:
PMC6295165
AbstractArticlePDF–3.5M
10.
Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer
Henry R. Maun, Peter S. Liu, Yvonne Franke, Charles Eigenbrot, William F. Forrest, Lawrence B. Schwartz, Robert A. Lazarus
J Biol Chem. 2018 Jun 22; 293(25): 9614–9628. Published online 2018 Apr 16. doi: 10.1074/jbc.M117.812016
PMCID:
PMC6016454
AbstractArticlePDF–1.4M
11.
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
Kyuho Han, Edwin E. Jeng, Gaelen T. Hess, David W. Morgens, Amy Li, Michael C. Bassik
Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 20.
Published in final edited form as: Nat Biotechnol. 2017 May; 35(5): 463–474. Published online 2017 Mar 20. doi: 10.1038/nbt.3834
PMCID:
PMC5557292
AbstractArticlePDF–3.4M
12.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
13.
Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number
Jonathan J Lyons, Xiaomin Yu, Jason D Hughes, Quang T Le, Ali Jamil, Yun Bai, Nancy Ho, Ming Zhao, Yihui Liu, Michael P O’Connell, Neil N Trivedi, Celeste Nelson, Thomas DiMaggio, Nina Jones, Helen Matthews, Katie L Lewis, Andrew J Oler, Ryan J Carlson, Peter D Arkwright, Celine Hong, Sherene Agama, Todd M Wilson, Sofie Tucker, Yu Zhang, Joshua J McElwee, Maryland Pao, Sarah C Glover, Marc E Rothenberg, Robert J Hohman, Kelly D Stone, George H Caughey, Theo Heller, Dean D Metcalfe, Leslie G Biesecker, Lawrence B Schwartz, Joshua D Milner
Nat Genet. Author manuscript; available in PMC 2017 Dec 1.
Published in final edited form as: Nat Genet. 2016 Dec; 48(12): 1564–1569. Published online 2016 Oct 17. doi: 10.1038/ng.3696
PMCID:
PMC5397297
AbstractArticlePDF–484K
14.
Glycoproteomics Reveals Decorin Peptides with Anti-Myostatin Activity in Human Atrial Fibrillation
Javier Barallobre-Barreiro, Shashi K. Gupta, Anna Zoccarato, Rika Kitazume-Taneike, Marika Fava, Xiaoke Yin, Tessa Werner, Marc N Hirt, Anna Zampetaki, Alessandro Viviano, Mei Chong, Marshall Bern, Antonios Kourliouros, Nieves Domenech, Peter Willeit, Ajay M Shah, Marjan Jahangiri, Liliana Schaefer, Jens W. Fischer, Renato V. Iozzo, Rosa Viner, Thomas Thum, Joerg Heineke, Antoine Kichler, Kinya Otsu, Manuel Mayr
Circulation. Author manuscript; available in PMC 2017 Mar 13.
Published in final edited form as: Circulation. 2016 Sep 13; 134(11): 817–832. Published online 2016 Aug 24. doi: 10.1161/CIRCULATIONAHA.115.016423
PMCID:
PMC5081096
AbstractArticlePDF–2.5M
15.
Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis
Melody C. Carter, Sarah T. Clayton, Hirsh D. Komarow, Erica H. Brittain, Linda M. Scott, Daly Cantave, Donna M. Gaskins, Irina Maric, Dean D. Metcalfe
J Allergy Clin Immunol. Author manuscript; available in PMC 2016 Dec 1.
Published in final edited form as: J Allergy Clin Immunol. 2015 Dec; 136(6): 1673–79.e1-3. Published online 2015 Jun 1. doi: 10.1016/j.jaci.2015.04.024
PMCID:
PMC4984538
AbstractArticlePDF–636K
16.
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins
Javier Barallobre-Barreiro, Rahmi Oklu, Marc Lynch, Marika Fava, Ferheen Baig, Xiaoke Yin, Temo Barwari, David N. Potier, Hassan Albadawi, Marjan Jahangiri, Karen E. Porter, Michael T. Watkins, Sanjay Misra, Julianne Stoughton, Manuel Mayr
Cardiovasc Res. 2016 Jun 1; 110(3): 419–430. Published online 2016 Apr 11. doi: 10.1093/cvr/cvw075
PMCID:
PMC4872879
AbstractArticlePDF–1.1M
17.
Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report
Lukasz Lewicki, Janusz Siebert, Natalia Marek-Trzonkowska, Emilia Masiewicz, Tomasz Kolinski, Magdalena Reiwer-Gostomska, Radoslaw Targonski, Piotr Trzonkowski
Mediators Inflamm. 2015; 2015: 395173. Published online 2015 May 18. doi: 10.1155/2015/395173
PMCID:
PMC4452104
AbstractArticlePDF–634K
18.
Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma
A M Abdelmotelb, M J Rose-Zerilli, S J Barton, S T Holgate, A F Walls, J W Holloway
Clin Exp Allergy. 2013 Jun; 44(6): 822–830. Published online 2013 May 24. doi: 10.1111/cea.12259
PMCID:
PMC4282335
AbstractArticlePDF–300K
19.
Development of Mast Cells and Importance of Their Tryptase and Chymase Serine Proteases in Inflammation and Wound Healing
Jeffrey Douaiher, Julien Succar, Luca Lancerotto, Michael F. Gurish, Dennis P. Orgill, Matthew J. Hamilton, Steven A. Krilis, Richard L. Stevens
Adv Immunol. Author manuscript; available in PMC 2014 Jul 29.
Published in final edited form as: Adv Immunol. 2014; 122: 211–252. doi: 10.1016/B978-0-12-800267-4.00006-7
PMCID:
PMC4115062
AbstractArticlePDF–821K
20.
Tryptase - PAR2 axis in Experimental Autoimmune Prostatitis, a model for Chronic Pelvic Pain Syndrome
Kenny Roman, Joseph D. Done, Anthony J. Schaeffer, Stephen F. Murphy, Praveen Thumbikat
Pain. Author manuscript; available in PMC 2015 Jul 1.
Published in final edited form as: Pain. 2014 Jul; 155(7): 1328–1338. Published online 2014 Apr 13. doi: 10.1016/j.pain.2014.04.009
PMCID:
PMC4089501
AbstractArticlePDF–789K

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