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Items: 1 to 20 of 32

1.
Repeated Measurement of the Novel Atrial Biomarker BMP10 (Bone Morphogenetic Protein 10) Refines Risk Stratification in Anticoagulated Patients With Atrial Fibrillation: Insights From the ARISTOTLE Trial
Konstantinos I. Gkarmiris, Johan Lindbäck, John H. Alexander, Christopher B. Granger, Peter Kastner, Renato D. Lopes, André Ziegler, Jonas Oldgren, Agneta Siegbahn, Lars Wallentin, Ziad Hijazi
J Am Heart Assoc. 2024 Apr 2; 13(7): e033720. Published online 2024 Mar 26. doi: 10.1161/JAHA.123.033720
PMCID:
PMC11179770
AbstractArticlePDF–2.8M
2.
Bone morphogenetic protein‐10 (BMP‐10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer
Lin Ye, Sivan Bokobza, Jin Li, Muhammad Moazzam, Jinfeng Chen, Robert E. Mansel, Wen G. Jiang
Cancer Sci. 2010 Oct; 101(10): 2137–2144. Published online 2010 Jun 14. doi: 10.1111/j.1349-7006.2010.01648.x
PMCID:
PMC11158251
AbstractArticlePDF–568K
3.
Bone Morphogenetic Protein 10—A Novel Biomarker to Predict Adverse Outcomes in Patients With Atrial Fibrillation
Elisa Hennings, Steffen Blum, Stefanie Aeschbacher, Michael Coslovsky, Sven Knecht, Ceylan Eken, Mirko Lischer, Rebecca E. Paladini, Philipp Krisai, Tobias Reichlin, Nicolas Rodondi, Jürg H. Beer, Peter Ammann, Giulio Conte, Maria Luisa De Perna, Richard Kobza, Manuel R. Blum, Matthias Bossard, Peter Kastner, André Ziegler, Christian Müller, Leo H. Bonati, Otmar Pfister, Christine S. Zuern, David Conen, Michael Kühne, Stefan Osswald, the Swiss‐AF Investigators
J Am Heart Assoc. 2023 Mar 21; 12(6): e028255. Published online 2023 Mar 16. doi: 10.1161/JAHA.122.028255
PMCID:
PMC10111531
AbstractArticlePDF–2.7M
4.
Assessment of community efforts to advance network-based prediction of protein–protein interactions
Xu-Wen Wang, Lorenzo Madeddu, Kerstin Spirohn, Leonardo Martini, Adriano Fazzone, Luca Becchetti, Thomas P. Wytock, István A. Kovács, Olivér M. Balogh, Bettina Benczik, Mátyás Pétervári, Bence Ágg, Péter Ferdinandy, Loan Vulliard, Jörg Menche, Stefania Colonnese, Manuela Petti, Gaetano Scarano, Francesca Cuomo, Tong Hao, Florent Laval, Luc Willems, Jean-Claude Twizere, Marc Vidal, Michael A. Calderwood, Enrico Petrillo, Albert-László Barabási, Edwin K. Silverman, Joseph Loscalzo, Paola Velardi, Yang-Yu Liu
Nat Commun. 2023; 14: 1582. Published online 2023 Mar 22. doi: 10.1038/s41467-023-37079-7
PMCID:
PMC10033937
AbstractArticlePDF–1.5M
5.
Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation
Ziad Hijazi, Alexander P Benz, Johan Lindbäck, John H Alexander, Stuart J Connolly, John W Eikelboom, Christopher B Granger, Peter Kastner, Renato D Lopes, André Ziegler, Jonas Oldgren, Agneta Siegbahn, Lars Wallentin
Eur Heart J. 2023 Jan 14; 44(3): 208–218. Published online 2022 Nov 16. doi: 10.1093/eurheartj/ehac632
PMCID:
PMC9839419
AbstractArticlePDF–1.6M
6.
Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10
Jingxu Guo, Bin Liu, Midory Thorikay, Minmin Yu, Xiaoyan Li, Zhen Tong, Richard M. Salmon, Randy J. Read, Peter ten Dijke, Nicholas W. Morrell, Wei Li
Nat Commun. 2022; 13: 2395. Published online 2022 May 3. doi: 10.1038/s41467-022-30111-2
PMCID:
PMC9064986
AbstractArticlePDF–3.5M
7.
Homozygous GDF2 nonsense mutations result in a loss of circulating BMP9 and BMP10 and are associated with either PAH or an “HHT‐like” syndrome in children
Joshua Hodgson, Lidia Ruiz‐Llorente, Jamie McDonald, Oliver Quarrell, Kelechi Ugonna, James Bentham, Rebecca Mason, Jennifer Martin, David Moore, Katie Bergstrom, Pinar Bayrak‐Toydemir, Whitney Wooderchak‐Donahue, Nicholas W. Morrell, Robin Condliffe, Carmelo Bernabeu, Paul D. Upton
Mol Genet Genomic Med. 2021 Dec; 9(12): e1685. Published online 2021 Apr 9. doi: 10.1002/mgg3.1685
PMCID:
PMC8683697
AbstractArticlePDF–1.2M
8.
Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10
Nicola E. Owen, Duuamene Nyimanu, Rhoda E. Kuc, Paul D. Upton, Nicholas W. Morrell, Graeme J. Alexander, Janet J. Maguire, Anthony P. Davenport
Peptides. 2021 Feb; 136: 170440. doi: 10.1016/j.peptides.2020.170440
PMCID:
PMC7883214
AbstractArticlePDF–1.1M
9.
In Search of “Hepatic Factor”: Lack of Evidence for ALK1 Ligands BMP9 and BMP10
Teresa L. Capasso, Sara M. Trucco, Morgan Hindes, Tristin Schwartze, Jamie L. Bloch, Jacqueline Kreutzer, Stephen C. Cook, Cynthia S. Hinck, Davide Treggiari, Brian Feingold, Andrew P. Hinck, Beth L. Roman
Am J Respir Crit Care Med. 2021 Jan 15; 203(2): 249–251. Published online 2021 Jan 15. doi: 10.1164/rccm.202005-1937LE
PMCID:
PMC7874408
ArticlePDF–623K
10.
Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation
Jasmeet S. Reyat, Winnie Chua, Victor R. Cardoso, Anika Witten, Peter M. Kastner, S. Nashitha Kabir, Moritz F. Sinner, Robin Wesselink, Andrew P. Holmes, Davor Pavlovic, Monika Stoll, Stefan Kääb, Georgios V. Gkoutos, Joris R. de Groot, Paulus Kirchhof, Larissa Fabritz
JCI Insight. 2020 Aug 20; 5(16): e139179. Published online 2020 Aug 20. doi: 10.1172/jci.insight.139179
PMCID:
PMC7455124
AbstractArticlePDF–3.1M
11.
Endothelial protective factors BMP9 and BMP10 inhibit CCL2 release by human vascular endothelial cells
Paul D. Upton, John E. S. Park, Patricia M. De Souza, Rachel J. Davies, Mark J. D. Griffiths, Stephen J. Wort, Nicholas W. Morrell
J Cell Sci. 2020 Jul 15; 133(14): jcs239715. Published online 2020 Jul 21. doi: 10.1242/jcs.239715
PMCID:
PMC7390625
AbstractArticle
12.
BMP9/10 in Pulmonary Vascular Complications of Liver Disease
Elizabeth R. Rochon, Michael J. Krowka, Sonja Bartolome, Gustavo A. Heresi, Todd Bull, Kari Roberts, Anna Hemnes, Kimberly A. Forde, Karen L. Krok, Mamta Patel, Grace Lin, Megan McNeil, Nadine Al-Naamani, Beth L. Roman, Paul B. Yu, Michael B. Fallon, Mark T. Gladwin, , For the PVCLD2 Study Group
Am J Respir Crit Care Med. 2020 Jun 15; 201(12): 1575–1578. Published online 2020 Jun 15. doi: 10.1164/rccm.201912-2514LE
PMCID:
PMC7301744
ArticlePDF–599K
13.
Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis
Nicola E. Owen, Graeme J. Alexander, Sambit Sen, Katherine Bunclark, Gary Polwarth, Joanna Pepke-Zaba, Anthony P. Davenport, Nicholas, W. Morrell, Paul. D. Upton
EBioMedicine. 2020 Jun; 56: 102794. Published online 2020 May 23. doi: 10.1016/j.ebiom.2020.102794
PMCID:
PMC7248419
AbstractArticlePDF–4.6M
14.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
15.
Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension
Joshua Hodgson, Emilia M. Swietlik, Richard M. Salmon, Charaka Hadinnapola, Ivana Nikolic, John Wharton, Jingxu Guo, James Liley, Matthias Haimel, Marta Bleda, Laura Southgate, Rajiv D. Machado, Jennifer M. Martin, Carmen M. Treacy, Katherine Yates, Louise C. Daugherty, Olga Shamardina, Deborah Whitehorn, Simon Holden, Harm J. Bogaard, Colin Church, Gerry Coghlan, Robin Condliffe, Paul A. Corris, Cesare Danesino, Mélanie Eyries, Henning Gall, Stefano Ghio, Hossein-Ardeschir Ghofrani, J. Simon R. Gibbs, Barbara Girerd, Arjan C. Houweling, Luke Howard, Marc Humbert, David G. Kiely, Gabor Kovacs, Allan Lawrie, Robert V. MacKenzie Ross, Shahin Moledina, David Montani, Andrea Olschewski, Horst Olschewski, Willem H. Ouwehand, Andrew J. Peacock, Joanna Pepke-Zaba, Inga Prokopenko, Christopher J. Rhodes, Laura Scelsi, Werner Seeger, Florent Soubrier, Jay Suntharalingam, Mark R. Toshner, Richard C. Trembath, Anton Vonk Noordegraaf, Stephen J. Wort, Martin R. Wilkins, Paul B. Yu, Wei Li, Stefan Gräf, Paul D. Upton, Nicholas W. Morrell
Am J Respir Crit Care Med. 2020 Mar 1; 201(5): 575–585. Published online 2019 Oct 29. doi: 10.1164/rccm.201906-1141OC
PMCID:
PMC7047445
AbstractArticlePDF–929K
16.
BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways
Xiuxia Qu, Ying Liu, Dayan Cao, Jinghai Chen, Zhuo Liu, Hongrui Ji, Yuwen Chen, Wenjun Zhang, Ping Zhu, Deyong Xiao, Xiaohui Li, Weinian Shou, Hanying Chen
J Biol Chem. 2019 Dec 27; 294(52): 19877–19888. Published online 2019 Nov 11. doi: 10.1074/jbc.RA119.010943
PMCID:
PMC6937579
AbstractArticlePDF–3.4M
17.
Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2
Claudia-Gabriela Mitrofan, Sarah L. Appleby, Gerard B. Nash, Ziad Mallat, Edwin R. Chilvers, Paul D. Upton, Nicholas W. Morrell
J Biol Chem. 2017 Aug 18; 292(33): 13714–13726. Published online 2017 Jun 23. doi: 10.1074/jbc.M117.778506
PMCID:
PMC5566526
AbstractArticlePDF–2.8M
18.
The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells
He Jiang, Richard M. Salmon, Paul D. Upton, Zhenquan Wei, Aleksandra Lawera, Anthony P. Davenport, Nicholas W. Morrell, Wei Li
J Biol Chem. 2016 Feb 5; 291(6): 2954–2966. Published online 2015 Dec 2. doi: 10.1074/jbc.M115.683292
PMCID:
PMC4742757
AbstractArticlePDF–3.0M
19.
Expression analysis of BMP2, BMP5, BMP10 in human colon tissues from Hirschsprung disease patients
Mei Wu, Wenwen Chen, Jie Mi, Dong Chen, Weilin Wang, Hong Gao
Int J Clin Exp Pathol. 2014; 7(2): 529–536. Published online 2014 Jan 15.
PMCID:
PMC3925897
AbstractArticlePDF–1.3M
20.
Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex
Sharon A. Townson, Erik Martinez-Hackert, Chloe Greppi, Patricia Lowden, Dianne Sako, June Liu, Jeffrey A. Ucran, Katia Liharska, Kathryn W. Underwood, Jasbir Seehra, Ravindra Kumar, Asya V. Grinberg
J Biol Chem. 2012 Aug 10; 287(33): 27313–27325. Published online 2012 Jun 20. doi: 10.1074/jbc.M112.377960
PMCID:
PMC3431715
AbstractArticlePDF–5.7M

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