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Items: 1 to 20 of 265

1.
Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status
Patricia Marqués, Jesús Burillo, Carlos González-Blanco, Beatriz Jiménez, Gema García, Ana García-Aguilar, Sarai Iglesias-Fortes, Ángela Lockwood, Carlos Guillén
Sci Rep. 2024; 14: 12521. Published online 2024 May 31. doi: 10.1038/s41598-024-63525-7
PMCID:
PMC11143182
AbstractArticlePDF–1.6M
2.
Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling
Susan M. Lin, Ryan Rue, Alexander R. Mukhitov, Akansha Goel, Maria C. Basil, Kseniya Obraztsova, Apoorva Babu, Slaven Crnkovic, Owen A. Ledwell, Laura T. Ferguson, Joseph D. Planer, Ana N. Nottingham, Kanth Swaroop Vanka, Carly J. Smith, Edward Cantu, III, Grazyna Kwapiszewska, Edward E. Morrisey, Jillian F. Evans, Vera P. Krymskaya
J Clin Invest. 2024 Feb 15; 134(4): e172116. Published online 2023 Dec 20. doi: 10.1172/JCI172116
PMCID:
PMC10866655
AbstractArticlePDF–16M
3.
TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex
Nicola Alesi, Damir Khabibullin, Dean M. Rosenthal, Elie W. Akl, Pieter M. Cory, Michel Alchoueiry, Samer Salem, Melissa Daou, William F. Gibbons, Jennifer A. Chen, Long Zhang, Harilaos Filippakis, Laura Graciotti, Caterina Miceli, Jlenia Monfregola, Claudia Vilardo, Manrico Morroni, Chiara Di Malta, Gennaro Napolitano, Andrea Ballabio, Elizabeth P. Henske
Nat Commun. 2024; 15: 406. Published online 2024 Jan 9. doi: 10.1038/s41467-023-44229-4
PMCID:
PMC10776564
AbstractArticlePDF–5.7M
4.
Tsc2 coordinates neuroprogenitor differentiation
Victoria A. Riley, Vijay Shankar, Jennie C. Holmberg, Aidan M. Sokolov, Victoria N. Neckles, Kaitlyn Williams, Rachel Lyman, Trudy F.C. Mackay, David M. Feliciano
iScience. 2023 Dec 15; 26(12): 108442. Published online 2023 Nov 14. doi: 10.1016/j.isci.2023.108442
PMCID:
PMC10724693
AbstractArticlePDF–6.0M
5.
TSC2 S1365A mutation potently regulates CD8+ T cell function and differentiation and improves adoptive cellular cancer therapy
Chirag H. Patel, Yi Dong, Navid Koleini, Xiaoxu Wang, Brittany L. Dunkerly-Eyring, Jiayu Wen, Mark J. Ranek, Laura M. Bartle, Daniel B. Henderson, Jason Sagert, David A. Kass, Jonathan D. Powell
JCI Insight. 2023 Nov 8; 8(21): e167829. Published online 2023 Nov 8. doi: 10.1172/jci.insight.167829
PMCID:
PMC10721258
AbstractArticlePDF–7.8M
6.
Duodenal macrophages control dietary iron absorption via local degradation of transferrin
Nyamdelger Sukhbaatar, Maria Schöller, Stephanie Deborah Fritsch, Monika Linke, Stefanie Horer, Manuela Träger, Mario Mazić, Stephan Forisch, Karine Gonzales, Jan Pascal Kahler, Carina Binder, Caroline Lassnig, Birgit Strobl, Mathias Müller, Barbara Scheiber-Mojdehkar, Claudia Gundacker, Stefanie Dabsch, Renate Kain, Markus Hengstschläger, Steven H. L. Verhelst, Günter Weiss, Igor Theurl, Thomas Weichhart
Blood. 2023 Jun 8; 141(23): 2878–2890. Published online 2023 Apr 7. doi: 10.1182/blood.2022016632
PMCID:
PMC10646810
AbstractArticle
7.
Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve
Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylène Brunelle, Nicolas Gévry, Bruce D. Murphy
Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2220849120. Published online 2023 Jul 26. doi: 10.1073/pnas.2220849120
PMCID:
PMC10410717
AbstractArticlePDF–3.9M
8.
Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness
Yixiao Wang, Aaron Snell, Frank M. Dyka, Elizabeth R. Colvin, Cristhian Ildefonso, John D. Ash, Ekaterina S. Lobanova
Sci Adv. 2023 Jul; 9(28): eadd5479. Published online 2023 Jul 14. doi: 10.1126/sciadv.add5479
PMCID:
PMC10348684
AbstractArticlePDF–2.1M
9.
Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model Via Induction of Apoptosis
Uchenna Unachukwu, Jarrod Sonett, Denzel Woode, Takayuki Shiomi, Kiran Chada, Jeanine M. D'Armiento
Mol Cancer Ther. 2023 Jul 5; 22(7): 844–858. Published online 2023 May 1. doi: 10.1158/1535-7163.MCT-22-0224
PMCID:
PMC10320481
AbstractArticlePDF–9.0M
10.
Reversal of memory and autism-related phenotypes in Tsc2+/− mice via inhibition of Nlgn1
Kleanthi Chalkiadaki, Elpida Statoulla, Maria Zafeiri, Nabila Haji, Jean-Claude Lacaille, Craig M. Powell, Seyed Mehdi Jafarnejad, Arkady Khoutorsky, Christos G. Gkogkas
Front Cell Dev Biol. 2023; 11: 1205112. Published online 2023 May 24. doi: 10.3389/fcell.2023.1205112
PMCID:
PMC10244498
AbstractArticlePDF–2.3M
11.
Estradiol Augments Tumor-Induced Neutrophil Production to Promote Tumor Cell Actions in Lymphangioleiomyomatosis Models
Briaunna M N Minor, Dana LeMoine, Christina Seger, Erin Gibbons, Jules Koudouovoh, Manisha Taya, Daniel Kurtz, Yan Xu, Stephen R Hammes
Endocrinology. 2023 Jun; 164(6): bqad061. Published online 2023 Apr 12. doi: 10.1210/endocr/bqad061
PMCID:
PMC10164661
AbstractArticle
12.
Microtubule Cytoskeletal Network Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders
Magdalena Gąssowska-Dobrowolska, Grzegorz A. Czapski, Magdalena Cieślik, Karolina Zajdel, Małgorzata Frontczak-Baniewicz, Lidia Babiec, Agata Adamczyk
Int J Mol Sci. 2023 Apr; 24(8): 7303. Published online 2023 Apr 15. doi: 10.3390/ijms24087303
PMCID:
PMC10138344
AbstractArticlePDF–6.3M
13.
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion
Heng-Jia Liu, Heng Du, Damir Khabibullin, Mahsa Zarei, Kevin Wei, Gordon J. Freeman, David J. Kwiatkowski, Elizabeth P. Henske
Nat Commun. 2023; 14: 1214. Published online 2023 Mar 3. doi: 10.1038/s41467-023-36881-7
PMCID:
PMC9984496
AbstractArticlePDF–5.7M
14.
Neurovascular Development in Pten and Tsc2 Mouse Mutants
Mary Dusing, Candi L. LaSarge, Angela White, Lilian G. Jerow, Christina Gross, Steve C. Danzer
eNeuro. 2023 Feb; 10(2): ENEURO.0340-22.2023. Prepublished online 2023 Feb 9. Published online 2023 Feb 22. doi: 10.1523/ENEURO.0340-22.2023
PMCID:
PMC9953070
AbstractArticlePDF–5.3M
15.
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation
Thomas Krausgruber, Anna Redl, Daniele Barreca, Konstantin Doberer, Daria Romanovskaia, Lina Dobnikar, Maria Guarini, Luisa Unterluggauer, Lisa Kleissl, Denise Atzmüller, Carolina Mayerhofer, Aglaja Kopf, Simona Saluzzo, Clarice X. Lim, Praveen Rexie, Thomas Weichhart, Christoph Bock, Georg Stary
Immunity. 2023 Feb 14; 56(2): 289–306.e7. doi: 10.1016/j.immuni.2023.01.014
PMCID:
PMC9942876
AbstractArticle
16.
Identification of an Electrogenic 2Cl−/H+ Exchanger, ClC5, as a Chloride-Secreting Transporter Candidate in Kidney Cyst Epithelium in Tuberous Sclerosis
Sharon Barone, Marybeth Brooks, Kamyar Zahedi, L. Shannon Holliday, John Bissler, Jane J. Yu, Manoocher Soleimani
Am J Pathol. 2023 Feb; 193(2): 191–200. doi: 10.1016/j.ajpath.2022.10.007
PMCID:
PMC9926528
AbstractArticlePDF–4.5M
17.
Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex
Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Ikeda
Hum Genomics. 2023; 17: 4. Published online 2023 Feb 2. doi: 10.1186/s40246-023-00450-2
PMCID:
PMC9893559
AbstractArticlePDF–5.2M
18.
Crosstalk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension
Yuanjun Shen, Dmitry A. Goncharov, Andressa Pena, Jeffrey Baust, Andres Chavez Barragan, Arnab Ray, Analise Rode, Timothy N. Bachman, Baojun Chang, Lifeng Jiang, Paul Dieffenbach, Laura E. Fredenburgh, Mauricio Rojas, Horace DeLisser, Ana L. Mora, Tatiana V. Kudryashova, Elena. A. Goncharova
Sci Signal. Author manuscript; available in PMC 2023 Dec 6.
Published in final edited form as: Sci Signal. 2022 Dec 6; 15(763): eabn2743. Published online 2022 Dec 6. doi: 10.1126/scisignal.abn2743
PMCID:
PMC9869933
AbstractArticlePDF–3.1M
19.
Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity
Jennifer M. Brazill, David Shin, Kristann Magee, Anurag Majumdar, Ivana R. Shen, Valeria Cavalli, Erica L. Scheller
Mol Metab. 2023 Feb; 68: 101664. Published online 2022 Dec 28. doi: 10.1016/j.molmet.2022.101664
PMCID:
PMC9841058
AbstractArticlePDF–5.0M
20.
mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome
Zhengping Huang, Xiaomeng You, Liang Chen, Yan Du, Kailey Brodeur, Hyuk Jee, Qiang Wang, Grace Linder, Roxane Darbousset, Pierre Cunin, Margaret H. Chang, Alexandra Wactor, Brian M. Wauford, Marc J. C. Todd, Kevin Wei, Ying Li, Anais Levescot, Yoichiro Iwakura, Virginia Pascual, Nicole E. Baldwin, Pierre Quartier, Tianwang Li, Maria T. Gianatasio, Robert P. Hasserjian, Lauren A. Henderson, David B. Sykes, Elizabeth D. Mellins, Scott W. Canna, Julia F. Charles, Peter A. Nigrovic, Pui Y. Lee
Nat Commun. 2022; 13: 6915. Published online 2022 Nov 28. doi: 10.1038/s41467-022-34480-6
PMCID:
PMC9705324
AbstractArticlePDF–4.6M

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