PMC Links for GEO Profiles (Select 126832861) - PMC

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108056704.

The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway

Yuhong Huang, Yi Fan Wang, Xiong Zhong Ruan, Chi Wai Lau, Li Wang, Yu Huang

J Lipid Res. 2024 Jan; 65(1): 100472. Published online 2023 Nov 9. doi: 10.1016/j.jlr.2023.100472

PMCID:: PMC10805670

Abstract Article PDF–3.4M

Select item 107193135.

Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis

Yu Muta, Juan F. Linares, Anxo Martinez-Ordoñez, Angeles Duran, Tania Cid-Diaz, Hiroto Kinoshita, Xiao Zhang, Qixiu Han, Yuki Nakanishi, Naoko Nakanishi, Thekla Cordes, Gurpreet K. Arora, Marc Ruiz-Martinez, Miguel Reina-Campos, Hiroaki Kasashima, Masakazu Yashiro, Kiyoshi Maeda, Ana Albaladejo-Gonzalez, Daniel Torres-Moreno, José García-Solano, Pablo Conesa-Zamora, Giorgio Inghirami, Christian M. Metallo, Timothy F. Osborne, Maria T. Diaz-Meco, Jorge Moscat

Nat Commun. 2023; 14: 8075. Published online 2023 Dec 13. doi: 10.1038/s41467-023-43690-5

PMCID:: PMC10719313

Abstract Article PDF–7.4M

Select item 106162316.

Contextual fear memory impairment in Angelman syndrome model mice is associated with altered transcriptional responses

Wenyue Su, Yan Liu, Aileen Lam, Xiaoning Hao, Michel Baudry, Xiaoning Bi

Sci Rep. 2023; 13: 18647. Published online 2023 Oct 30. doi: 10.1038/s41598-023-45769-x

PMCID:: PMC10616231

Abstract Article PDF–4.0M

Select item 105304567.

Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice

Lei Xing, Jeremy M. Simon, Travis S. Ptacek, Jason J. Yi, Lipin Loo, Hanqian Mao, Justin M. Wolter, Eric S. McCoy, Smita R. Paranjape, Bonnie Taylor-Blake, Mark J. Zylka

Cell Rep. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112706. Published online 2023 Jun 28. doi: 10.1016/j.celrep.2023.112706

PMCID:: PMC10530456

Abstract Article PDF–4.5M

Select item 104765618.

UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells

Yanyan Luo, Yun Yang, Cong Yang, Chuanyin Li, Ronggui Hu, Wujun Geng, Xianhui Kang, Hai Lin

FEBS Open Bio. 2023 Sep; 13(9): 1756–1771. Published online 2023 Jul 28. doi: 10.1002/2211-5463.13675

PMCID:: PMC10476561

Abstract Article PDF–5.1M

Select item 104681309.

Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells

Weilian Bao, Yan You, Jiahui Ni, Hui Hou, Jiaren Lyu, Guize Feng, Yirui Wang, Keyuan You, Sulin Zhang, Lijie Zhang, Xinyue Cao, Xu Wang, Haidong Li, Hong Li, Jiake Xu, Chenying Liu, Xiaomin Luo, Peng Du, Daofeng Chen, Xiaoyan Shen

Sci Adv. 2023 Sep; 9(35): eadh5016. Published online 2023 Aug 30. doi: 10.1126/sciadv.adh5016

Correction in:: Sci Adv. 2024 Apr 12; 10(15): eadp3968.

PMCID:: PMC10468130

Abstract Article PDF–23M

Select item 1036238110.

A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions in Angelman syndrome mice

Jinhui Li, Zhixin Shen, Yajing Liu, Zixiang Yan, Yuanhua Liu, Xiang Lin, Junjie Tang, Ruimin Lv, Guannan Geng, Zhi-Qi Xiong, Changyang Zhou, Hui Yang

Mol Ther. 2023 Jul 5; 31(7): 2286–2295. Published online 2023 Feb 18. doi: 10.1016/j.ymthe.2023.02.015

PMCID:: PMC10362381

Abstract Article PDF–3.3M

Select item 1035933011.

IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation

Vishwas Mishra, Anna Crespo-Puig, Callum McCarthy, Tereza Masonou, Izabela Glegola-Madejska, Alice Dejoux, Gabriella Dow, Matthew J. G. Eldridge, Luciano H. Marinelli, Meihan Meng, Shijie Wang, Daniel J. Bennison, Rebecca Morrison, Avinash R. Shenoy

Nat Commun. 2023; 14: 4385. Published online 2023 Jul 20. doi: 10.1038/s41467-023-40054-x

PMCID:: PMC10359330

Abstract Article PDF–3.3M

Select item 1027653912.

Excessive protein accumulation and impaired autophagy in the hippocampus of Angelman syndrome modeled in mice

Francesca Aria, Kiran Pandey, Cristina M. Alberini

Biol Psychiatry. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: Biol Psychiatry. 2023 Jul 1; 94(1): 68–83. Published online 2022 Dec 5. doi: 10.1016/j.biopsych.2022.11.016

PMCID:: PMC10276539

Abstract Article PDF–2.7M

Select item 1011716513.

Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway—implications for Parkinson’s disease

Willcyn Tang, John Thundyil, Grace Gui Yin Lim, Teddy J W Tng, Sean Qing Zhang Yeow, Aditya Nair, Chou Chai, Tso-Pang Yao, Kah-Leong Lim

Hum Mol Genet. 2023 May 1; 32(9): 1466–1482. Published online 2022 Nov 26. doi: 10.1093/hmg/ddac297

Correction in:: Hum Mol Genet. 2023 Jun 1; 32(11): 1943.

PMCID:: PMC10117165

Abstract Article PDF–2.3M

Select item 1011060314.

Imbalanced expression of cation-chloride cotransporters as a potential therapeutic target in an Angelman syndrome mouse model

Kiyoshi Egawa, Miho Watanabe, Hideaki Shiraishi, Daisuke Sato, Yukitoshi Takahashi, Saori Nishio, Atsuo Fukuda

Sci Rep. 2023; 13: 5685. Published online 2023 Apr 17. doi: 10.1038/s41598-023-32376-z

PMCID:: PMC10110603

Abstract Article PDF–2.5M

Select item 1007759515.

Effects of UBE3A on Cell and Liver Metabolism through the Ubiquitination of PDHA1 and ACAT1

Kangli Peng, Shirong Wang, Ruochuan Liu, Li Zhou, Geon H. Jeong, In Ho Jeong, Xianpeng Liu, Hiroaki Kiyokawa, Bingzhong Xue, Bo Zhao, Hang Shi, Jun Yin

Biochemistry. 2023 Apr 4; 62(7): 1274–1286. Published online 2023 Mar 15. doi: 10.1021/acs.biochem.2c00624

PMCID:: PMC10077595

Abstract Article PDF–7.0M

Select item 1007334416.

UBE3A deficiency-induced autophagy is associated with activation of AMPK-ULK1 and p53 pathways

Xiaoning Hao, Jiandong Sun, Li Zhong, Michel Baudry, Xiaoning Bi

Exp Neurol. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Exp Neurol. 2023 May; 363: 114358. Published online 2023 Feb 26. doi: 10.1016/j.expneurol.2023.114358

PMCID:: PMC10073344

Abstract Article PDF–1.7M

Select item 1004062317.

Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis

Xuwen Tang, Qingxin Qin, Wenjing Xu, Xuezhen Zhang

Diabetes Metab J. 2023 Mar; 47(2): 267–286. Published online 2023 Jan 19. doi: 10.4093/dmj.2021.0216

PMCID:: PMC10040623

Abstract Article PDF–4.6M

Select item 997796318.

Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome

Luis O. Romero, Rebeca Caires, A. Kaitlyn Victor, Juanma Ramirez, Francisco J. Sierra-Valdez, Patrick Walsh, Vincent Truong, Jungsoo Lee, Ugo Mayor, Lawrence T. Reiter, Valeria Vásquez, Julio F. Cordero-Morales

Nat Commun. 2023; 14: 1167. Published online 2023 Mar 1. doi: 10.1038/s41467-023-36818-0

PMCID:: PMC9977963

Abstract Article PDF–33M

Select item 997751019.

UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation

Diana C. Rotaru, Ilse Wallaard, Maud de Vries, Julia van der Bie, Ype Elgersma

JCI Insight. 2023 Feb 22; 8(4): e166073. Published online 2023 Feb 22. doi: 10.1172/jci.insight.166073

PMCID:: PMC9977510

Abstract Article PDF–4.3M

Select item 990712620.

Gut flora disequilibrium promotes the initiation of liver cancer by modulating tryptophan metabolism and up-regulating SREBP2

Wen Chen, Liang Wen, Yingying Bao, Zengwei Tang, Jianhui Zhao, Xiaozhen Zhang, Tao Wei, Jian Zhang, Tao Ma, Qi Zhang, Xiao Zhi, Jin Li, Cheng Zhang, Lei Ni, Muchun Li, Tingbo Liang

Proc Natl Acad Sci U S A. 2022 Dec 27; 119(52): e2203894119. Published online 2022 Dec 19. doi: 10.1073/pnas.2203894119

PMCID:: PMC9907126

Abstract Article PDF–37M

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