PMC Links for GEO Profiles (Select 127030580) - PMC

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 102499014.

Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver

Hitoshi Tsugawa, Takuto Ohki, Shogo Tsubaki, Rika Tanaka, Juntaro Matsuzaki, Hidekazu Suzuki, Katsuto Hozumi

PLoS Pathog. 2023 Jun; 19(6): e1011139. Published online 2023 Jun 8. doi: 10.1371/journal.ppat.1011139

PMCID:: PMC10249901

Abstract Article PDF–4.0M

Select item 102090175.

AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells

Oltin-Tiberiu Pop, Anne Geng, Emilio Flint, Arjuna Singanayagam, Caner Ercan, Lucia Possamai, Vishal C. Patel, Patrizia Kuenzler, Marie-Anne Meier, Savas Soysal, Petr Hruz, Otto Kollmar, Kate C. Tatham, Josie K. Ward, Beat Müllhaupt, Achim Weber, Julia Wendon, Jan Hendrik Niess, Markus Heim, David Semela, Christopher Weston, Charalambos G. Antoniades, Luigi Maria Terracciano, Evangelos Triantafyllou, Robert G. Brenig, Christine Bernsmeier

Cell Mol Gastroenterol Hepatol. 2023; 16(1): 17–37. Published online 2023 Mar 31. doi: 10.1016/j.jcmgh.2023.03.007

PMCID:: PMC10209017

Abstract Article PDF–7.9M

Select item 101916226.

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

Zihao Yao, Weizhong Qi, Hongbo Zhang, Zhicheng Zhang, Liangliang Liu, Yan Shao, Hua Zeng, Jianbin Yin, Haoyan Pan, Xiongtian Guo, Anling Liu, Daozhang Cai, Xiaochun Bai, Haiyan Zhang

eLife. 2023; 12: e83069. Published online 2023 May 5. doi: 10.7554/eLife.83069

PMCID:: PMC10191622

Abstract Article PDF–19M

Select item 95643257.

Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling

Youtong Huang, Greg Lemke

Proc Natl Acad Sci U S A. 2022 Oct 11; 119(41): e2204306119. Published online 2022 Oct 3. doi: 10.1073/pnas.2204306119

PMCID:: PMC9564325

Abstract Article PDF–1.6M

Select item 93044088.

Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex

Tamar Sapir, Aditya Kshirsagar, Anna Gorelik, Tsviya Olender, Ziv Porat, Ingrid E. Scheffer, David B. Goldstein, Orrin Devinsky, Orly Reiner

Nat Commun. 2022; 13: 4209. Published online 2022 Jul 21. doi: 10.1038/s41467-022-31752-z

PMCID:: PMC9304408

Abstract Article PDF–13M

Select item 88228389.

Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer’s disease

Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott, M. Kerry O’Banion

J Neuroinflammation. 2022; 19: 38. Published online 2022 Feb 7. doi: 10.1186/s12974-022-02397-y

Correction in:: J Neuroinflammation. 2023; 20: 254.

PMCID:: PMC8822838

Abstract Article PDF–3.1M

Select item 878683610.

Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development

Margaret E. Magaletta, Macrina Lobo, Eric M. Kernfeld, Hananeh Aliee, Jack D. Huey, Teagan J. Parsons, Fabian J. Theis, René Maehr

Nat Commun. 2022; 13: 457. Published online 2022 Jan 24. doi: 10.1038/s41467-022-28067-4

PMCID:: PMC8786836

Abstract Article PDF–5.6M

Select item 835171411.

GAS6 ameliorates advanced age-associated meiotic defects in mouse oocytes by modulating mitochondrial function

Kyeoung-Hwa Kim, Eun-Young Kim, Kyung-Ah Lee

Aging (Albany NY) 2021 Jul 31; 13(14): 18018–18032. Published online 2021 Jul 26. doi: 10.18632/aging.203328

PMCID:: PMC8351714

Abstract Article PDF–1.5M

Select item 831323912.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 801583613.

Growth arrest‐specific 6 modulates adiponectin expression and insulin resistance in adipose tissue

Sheng‐Chiang Su, Chi‐Fu Chiang, Chang‐Hsun Hsieh, Giieh‐Hua Lu, Jhih‐Syuan Liu, Yi‐Shing Shieh, Yi‐Jen Hung, Chien‐Hsing Lee

J Diabetes Investig. 2021 Apr; 12(4): 485–492. Published online 2020 Oct 13. doi: 10.1111/jdi.13412

PMCID:: PMC8015836

Abstract Article PDF–981K

Select item 793877014.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 761194215.

AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia

Irene Tirado-Gonzalez, Arnaud Descot, Devona Soetopo, Aleksandra Nevmerzhitskaya, Alexander Schäffer, Ivan-Maximilano Kur, Ewelina Czlonka, Carolin Wachtel, Ioanna Tsoukala, Luise Müller, Anna-Lena Schäfer, Maresa Weitmann, Petra Dinse, Emily Alberto, Michèle C. Buck, Jonathan JM. Landry, Bianka Baying, Julia Slotta-Huspenina, Jenny Roesler, Patrick N. Harter, Anne-Sophie Kubasch, Jörn Meinel, Eiman Elwakeel, Elisabeth Strack, Christine Tran Quang, Omar Abdel-Wahab, Marc Schmitz, Andreas Weigert, Tobias Schmid, Uwe Platzbecker, Vladimir Benes, Jacques Ghysdael, Halvard Bonig, Katharina S. Götze, Carla V. Rothlin, Sourav Ghosh, Hind Medyouf

Cancer Discov. 2021 Nov 1; 11(11): 2924–2943. Published online 2021 Jun 8. doi: 10.1158/2159-8290.CD-20-1378

PMCID:: PMC7611942

Abstract Article PDF–32M

Select item 726003516.

Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization

Takehiko Shibata, Airi Makino, Ruiko Ogata, Shigeki Nakamura, Toshihiro Ito, Kisaburo Nagata, Yoshihiko Terauchi, Taku Oishi, Mikiya Fujieda, Yoshimasa Takahashi, Manabu Ato

J Clin Invest. 2020 Jun 1; 130(6): 3021–3037. Published online 2020 May 4. doi: 10.1172/JCI125505

PMCID:: PMC7260035

Abstract Article PDF–26M

Select item 725244317.

HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure

Beth A Firulli, Rajani M George, Jade Harkin, Kevin P Toolan, Hongyu Gao, Yunlong Liu, Wenjun Zhang, Loren J Field, Ying Liu, Weinian Shou, Ronald Mark Payne, Michael Rubart-von der Lohe, Anthony B Firulli

Cardiovasc Res. 2020 Mar 1; 116(3): 605–618. Published online 2019 Jul 9. doi: 10.1093/cvr/cvz182

PMCID:: PMC7252443

Abstract Article PDF–1.8M

Select item 669779718.

STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation

Saroj Nepal, Chinnaswamy Tiruppathi, Yoshikazu Tsukasaki, Joseph Farahany, Manish Mittal, Jalees Rehman, Darwin J. Prockop, Asrar B. Malik

Proc Natl Acad Sci U S A. 2019 Aug 13; 116(33): 16513–16518. Published online 2019 Jul 30. doi: 10.1073/pnas.1821601116

PMCID:: PMC6697797

Abstract Article PDF–1.4M

Select item 667861419.

Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE₂, PGD₂ and Their Receptors

Jihye Jung, Ye-Ji Lee, Youn-Hee Choi, Eun-Mi Park, Hee-Sun Kim, Jihee L. Kang

Cells. 2019 Jul; 8(7): 643. Published online 2019 Jun 26. doi: 10.3390/cells8070643

PMCID:: PMC6678614

Abstract Article PDF–3.4M

Select item 667527220.

Gas6/Axl Signaling Activates the Phosphatidylinositol 3-Kinase/Akt1 Survival Pathway to Protect Oligodendrocytes from Tumor Necrosis Factorα-Induced Apoptosis

Sai Latha Shankar, Kathleen O’Guin, Mimi Kim, Brian Varnum, Greg Lemke, Celia F. Brosnan, Bridget Shafit-Zagardo

J Neurosci. 2006 May 24; 26(21): 5638–5648. doi: 10.1523/JNEUROSCI.5063-05.2006

PMCID:: PMC6675272

Abstract Article PDF–753K

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