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Select item 114424701.

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

Mengqi Li, Yu Wang, Xiaoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu, Yongliang Wang, Yan-Hui Liu, Jinye Xiong, Qi Qu, Yan Chen, Xiao Tian, Luming Yao, Renxiang Xie, Xiaomin Li, Siwei Chen, Xi Huang, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Baoding Zhang, Bin Jiang, Zhi-Chao Wang, Qinxi Li, Gang Li, Shu-Yong Lin, Li Yu, Hai-Long Piao, Xianming Deng, Jiahuai Han, Chen-Song Zhang, Sheng-Cai Lin

Cell Res. 2024 Oct; 34(10): 683–706. Published online 2024 Jun 19. doi: 10.1038/s41422-024-00985-6

PMCID:: PMC11442470

Abstract Article PDF–6.2M

Select item 112455432.

Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer

Taijin Lan, Sara Arastu, Jarrick Lam, Hyungsin Kim, Wenping Wang, Samuel Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Hu, Michael Sun, Xuefei Luo, Jonathan M. Ghergurovich, Xiaoyang Su, Joshua D. Rabinowitz, Eileen White, Jessie Yanxiang Guo

Nat Commun. 2024; 15: 5857. Published online 2024 Jul 12. doi: 10.1038/s41467-024-50157-8

PMCID:: PMC11245543

Abstract Article PDF–3.3M

Select item 111612013.

MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma

Yu Qian, Ana Galan-Cobo, Irene Guijarro, Minghao Dang, David Molkentine, Alissa Poteete, Fahao Zhang, Qi Wang, Jing Wang, Edwin Parra, Apekshya Panda, Jacy Fang, Ferdinandos Skoulidis, Ignacio I. Wistuba, Svena Verma, Taha Merghoub, Jedd D. Wolchok, Kwok-Kin Wong, Ralph J. DeBerardinis, John D. Minna, Natalie I. Vokes, Catherine B. Meador, Justin F. Gainor, Linghua Wang, Alexandre Reuben, John V. Heymach

Cancer Cell. Author manuscript; available in PMC 2024 Jun 7.

Published in final edited form as: Cancer Cell. 2023 Jul 10; 41(7): 1363–1380.e7. Published online 2023 Jun 15. doi: 10.1016/j.ccell.2023.05.015

PMCID:: PMC11161201

Abstract Article PDF–1.8M

Select item 111597134.

Hepatocellular carcinoma development induced by conditional β‐catenin activation in Lkb1^+/− mice

Hiroyuki Miyoshi, Atsuko Deguchi, Masayuki Nakau, Yasushi Kojima, Akira Mori, Masanobu Oshima, Masahiro Aoki, Makoto Mark Taketo

Cancer Sci. 2009 Nov; 100(11): 2046–2053. Published online 2009 Jul 10. doi: 10.1111/j.1349-7006.2009.01284.x

PMCID:: PMC11159713

Abstract Article PDF–647K

Select item 111292755.

TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition

Yun Xue, Yuting Chen, Sijia Sun, Xinyuan Tong, Yujia Chen, Shijie Tang, Xue Wang, Simin Bi, Yuqin Qiu, Qiqi Zhao, Zhen Qin, Qin Xu, Yingjie Ai, Leilei Chen, Beizhen Zhang, Zhijie Liu, Minbiao Ji, Meidong Lang, Luonan Chen, Guoliang Xu, Liang Hu, Dan Ye, Hongbin Ji

J Exp Med. 2024 Jul 1; 221(7): e20240111. Published online 2024 May 28. doi: 10.1084/jem.20240111

Correction in:: J Exp Med. 2024 Jul 1; 221(7): e2024011106032024c.

PMCID:: PMC11129275

Abstract Article PDF–8.2M

Select item 111176346.

Palmitic Acid Exerts Anti-Tumorigenic Activities by Modulating Cellular Stress and Lipid Droplet Formation in Endometrial Cancer

Ziyi Zhao, Jiandong Wang, Weimin Kong, Meredith A. Newton, Wesley C. Burkett, Wenchuan Sun, Lindsey Buckingham, Jillian O’Donnell, Hongyan Suo, Boer Deng, Xiaochang Shen, Xin Zhang, Tianran Hao, Chunxiao Zhou, Victoria L. Bae-Jump

Biomolecules. 2024 May; 14(5): 601. Published online 2024 May 20. doi: 10.3390/biom14050601

PMCID:: PMC11117634

Abstract Article PDF–11M

Select item 108677867.

NRF2 activation promotes aggressive lung cancer and associates with poor clinical outcomes

Anju Singh, Anneleen Daemen, Dorothee Nickles, Sang-Min Jeon, Oded Foreman, Kuladeep Sudini, Florian Gnad, Stephane Lajoie, Naina Gour, Wayne Mitzner, Samit Chatterjee, Eun-Ji Choi, Buvana Ravishankar, Amy Rappaport, Namrata Patil, Mark McCleland, Leisa Johnson, George Acquaah-Mensah, Edward Gabrielson, Shyam Biswal, Georgia Hatzivassiliou

Clin Cancer Res. Author manuscript; available in PMC 2024 Feb 15.

Published in final edited form as: Clin Cancer Res. 2021 Feb 1; 27(3): 877–888. Published online 2020 Oct 19. doi: 10.1158/1078-0432.CCR-20-1985

PMCID:: PMC10867786

Abstract Article PDF–2.5M

Select item 107418748.

Development of a Genetically Engineered Mouse Model Recapitulating LKB1 and PTEN Deficiency in Gastric Cancer Pathogenesis

Kuan-Te Fang, Hsin Hung, Nga Yin Sadonna Lau, Jou-Hsi Chi, Deng-Chyang Wu, Kuang-Hung Cheng

Cancers (Basel) 2023 Dec; 15(24): 5893. Published online 2023 Dec 18. doi: 10.3390/cancers15245893

PMCID:: PMC10741874

Abstract Article PDF–4.1M

Select item 105151409.

Fully accessible fitness landscape of oncogene-negative lung adenocarcinoma

Maryam Yousefi, Laura Andrejka, Márton Szamecz, Monte M. Winslow, Dmitri A. Petrov, Gábor Boross

Proc Natl Acad Sci U S A. 2023 Sep 19; 120(38): e2303224120. Published online 2023 Sep 11. doi: 10.1073/pnas.2303224120

PMCID:: PMC10515140

Abstract Article PDF–646K

Select item 1048049910.

MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention

Bin Qiu, Ahmed Lawan, Chrysovalantou E. Xirouchaki, Jae-Sung Yi, Marie Robert, Lei Zhang, Wendy Brown, Carlos Fernández-Hernando, Xiaoyong Yang, Tony Tiganis, Anton M. Bennett

Nat Commun. 2023; 14: 5405. Published online 2023 Sep 5. doi: 10.1038/s41467-023-41145-5

PMCID:: PMC10480499

Abstract Article PDF–6.7M

Select item 1044476211.

Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6

Qiming Deng, Hongxuan Li, Xiaolin Yue, Chenghu Guo, Yuanyuan Sun, Chang Ma, Jiangang Gao, Yue Wu, Bin Du, Jianmin Yang, Cheng Zhang, Wencheng Zhang

Cell Death Dis. 2023 Aug; 14(8): 542. Published online 2023 Aug 22. doi: 10.1038/s41419-023-06054-x

PMCID:: PMC10444762

Abstract Article PDF–11M

Select item 1042279412.

STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

Jan Pencik, Cecile Philippe, Michaela Schlederer, Emine Atas, Matteo Pecoraro, Sandra Grund-Gröschke, Wen (Jess) Li, Amanda Tracz, Isabel Heidegger, Sabine Lagger, Karolína Trachtová, Monika Oberhuber, Ellen Heitzer, Osman Aksoy, Heidi A. Neubauer, Bettina Wingelhofer, Anna Orlova, Nadine Witzeneder, Thomas Dillinger, Elisa Redl, Georg Greiner, David D’Andrea, Johnny R. Östman, Simone Tangermann, Ivana Hermanova, Georg Schäfer, Felix Sternberg, Elena E. Pohl, Christina Sternberg, Adam Varady, Jaqueline Horvath, Dagmar Stoiber, Tim I. Malcolm, Suzanne D. Turner, Eileen E. Parkes, Brigitte Hantusch, Gerda Egger, Stefan Rose-John, Valeria Poli, Suneil Jain, Chris W. D. Armstrong, Gregor Hoermann, Vincent Goffin, Fritz Aberger, Richard Moriggl, Arkaitz Carracedo, Cathal McKinney, Richard D. Kennedy, Helmut Klocker, Michael R. Speicher, Dean G. Tang, Ali A. Moazzami, David M. Heery, Marcus Hacker, Lukas Kenner

Mol Cancer. 2023; 22: 133. Published online 2023 Aug 12. doi: 10.1186/s12943-023-01825-8

PMCID:: PMC10422794

Abstract Article PDF–3.9M

Select item 1035471613.

LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model

Brigida Boccanegra, Paola Mantuano, Elena Conte, Alessandro Giovanni Cerchiara, Lisamaura Tulimiero, Raffaella Quarta, Erika Caputo, Francesca Sanarica, Monica Forino, Valeria Spadotto, Ornella Cappellari, Gianluca Fossati, Christian Steinkühler, Annamaria De Luca

Dis Model Mech. 2023 Jul 1; 16(7): dmm049930. Published online 2023 Jul 10. doi: 10.1242/dmm.049930

PMCID:: PMC10354716

Abstract Article

Select item 1026767914.

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

Janine M. DeBlasi, Aimee Falzone, Samantha Caldwell, Nicolas Prieto-Farigua, Justin R. Prigge, Edward E. Schmidt, Iok In Christine Chio, Florian A. Karreth, Gina M. DeNicola

Cancer Res. 2023 Jun 15; 83(12): 1953–1967. Published online 2023 Apr 16. doi: 10.1158/0008-5472.CAN-22-3848

PMCID:: PMC10267679

Abstract Article PDF–43M

Select item 1024382015.

Tumor loss-of-function mutations in STK11/LKB1 induce cachexia

Puneeth Iyengar, Aakash Y. Gandhi, Jorge Granados, Tong Guo, Arun Gupta, Jinhai Yu, Ernesto M. Llano, Faya Zhang, Ang Gao, Asha Kandathil, Dorothy Williams, Boning Gao, Luc Girard, Venkat S. Malladi, John M. Shelton, Bret M. Evers, Raquibul Hannan, Chul Ahn, John D. Minna, Rodney E. Infante

JCI Insight. 2023 Apr 24; 8(8): e165419. Published online 2023 Apr 24. doi: 10.1172/jci.insight.165419

PMCID:: PMC10243820

Abstract Article PDF–6.8M

Select item 1015364916.

Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

Liping Xie, Yanmei Yuan, Simiao Xu, Sijia Lu, Jinyang Gu, Yanping Wang, Yibing Wang, Xianjing Zhang, Suzhen Chen, Jian Li, Junxi Lu, Honglin Sun, Ruixiang Hu, Hailong Piao, Wen Wang, Cunchuan Wang, Jing Wang, Na Li, Morris F. White, Liu Han, Weiping Jia, Ji Miao, Junli Liu

Cell Rep. Author manuscript; available in PMC 2023 May 2.

Published in final edited form as: Cell Rep. 2022 Oct 18; 41(3): 111498. doi: 10.1016/j.celrep.2022.111498

PMCID:: PMC10153649

Abstract Article PDF–1.6M

Select item 1006844917.

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

Benjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos, Miriam Sindelar, Bryan Ngo, Steven S. Gross, Reuben J. Shaw, Chen Zhang, John M. Asara, Raymond E. Moellering, Harold Varmus, Lewis C. Cantley

Cancer Discov. 2023 Apr 3; 13(4): 1002–1025. Published online 2023 Jan 30. doi: 10.1158/2159-8290.CD-22-0805

PMCID:: PMC10068449

Abstract Article PDF–13M

Select item 992552118.

Loss of Lkb1 in CD11c⁺ myeloid cells protects mice from diet-induced obesity while enhancing glucose intolerance and IL-17/IFN-γ imbalance

Yunyan Sun, Bing Wang, Qianwen Hu, Haixiao Zhang, Xun Lai, Tier Wang, Chunxiao Zhao, Jiali Wang, Xi Zhang, Qing Niu, Baolin He, Erlie Jiang, Mingxia Shi, Xiaoming Feng, Yuechen Luo

Cell Mol Life Sci. 2023 Mar; 80(3): 63. Published online 2023 Feb 13. doi: 10.1007/s00018-023-04707-w

PMCID:: PMC9925521

Abstract Article PDF–4.4M

Select item 990009319.

Lkb1 loss in regulatory T cells leads to dysregulation of hematopoietic stem cell expansion and differentiation in bone marrow

Jiadi Chen, Jingru Liu, Huifang Huang

FEBS Open Bio. 2023 Feb; 13(2): 270–278. Published online 2023 Jan 4. doi: 10.1002/2211-5463.13536

PMCID:: PMC9900093

Abstract Article PDF–2.1M

Select item 987998120.

Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors

Vrushank Bhatt, Taijin Lan, Wenping Wang, Jerry Kong, Eduardo Cararo Lopes, Jianming Wang, Khoosheh Khayati, Akash Raju, Michael Rangel, Enrique Lopez, Zhixian Sherrie Hu, Xuefei Luo, Xiaoyang Su, Jyoti Malhotra, Wenwei Hu, Sharon R. Pine, Eileen White, Jessie Yanxiang Guo

Cell Death Dis. 2023 Jan; 14(1): 61. Published online 2023 Jan 26. doi: 10.1038/s41419-023-05592-8

PMCID:: PMC9879981

Abstract Article PDF–5.9M

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