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Items: 1 to 20 of 29

1.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
2.
A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis
Gregory Swan, Jia Geng, Eunchong Park, Quanquan Ding, John Zhou, Ciana Walcott, Junyi J. Zhang, Hsin-I Huang, Gianna Elena Hammer, Donghai Wang
Front Immunol. 2021; 12: 641188. Published online 2021 Mar 22. doi: 10.3389/fimmu.2021.641188
Correction in:
Front Immunol. 2021; 12: 687135.
PMCID:
PMC8019753
AbstractArticlePDF–4.8M
3.
Protein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells
Wei Su, Nicole M. Chapman, Jun Wei, Hu Zeng, Yogesh Dhungana, Hao Shi, Jordy Saravia, Peipei Zhou, Lingyun Long, Sherri Rankin, KC Anil, Peter Vogel, Hongbo Chi
Cell Metab. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: Cell Metab. 2020 Dec 1; 32(6): 996–1011.e7. Published online 2020 Nov 17. doi: 10.1016/j.cmet.2020.10.022
PMCID:
PMC7887758
AbstractArticlePDF–2.6M
4.
Prenylation of Axonally Translated Rac1 Controls NGF-Dependent Axon Growth
Emily Scott-Solomon, Rejji Kuruvilla
Dev Cell. Author manuscript; available in PMC 2021 Jun 22.
Published in final edited form as: Dev Cell. 2020 Jun 22; 53(6): 691–705.e7. Published online 2020 Jun 12. doi: 10.1016/j.devcel.2020.05.020
PMCID:
PMC7362586
AbstractArticlePDF–2.7M
5.
Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress
Xingrong Du, Hu Zeng, Shaofeng Liu, Cliff Guy, Yogesh Dhungana, Geoffrey Neale, Martin O. Bergo, Hongbo Chi
J Exp Med. 2020 Feb 3; 217(2): e20190969. Published online 2019 Nov 13. doi: 10.1084/jem.20190969
PMCID:
PMC7041713
AbstractArticlePDF–4.8M
6.
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Murali K. Akula, Mohamed X. Ibrahim, Emil G. Ivarsson, Omar M. Khan, Israiel T. Kumar, Malin Erlandsson, Christin Karlsson, Xiufeng Xu, Mikael Brisslert, Cord Brakebusch, Donghai Wang, Maria Bokarewa, Volkan I. Sayin, Martin O. Bergo
Nat Commun. 2019; 10: 3975. Published online 2019 Sep 4. doi: 10.1038/s41467-019-11606-x
PMCID:
PMC6726657
AbstractArticlePDF–1.4M
7.
Systemic or Forebrain Neuron Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density
David Hottman, Shaowu Cheng, Andrea Gram, Kyle LeBlanc, Li-Lian Yuan, Ling Li
Neuroscience. Author manuscript; available in PMC 2019 Mar 1.
Published in final edited form as: Neuroscience. 2018 Mar 1; 373: 207–217. Published online 2018 Feb 2. doi: 10.1016/j.neuroscience.2018.01.026
PMCID:
PMC5816690
AbstractArticlePDF–958K
8.
Upregulation of μ3A Drives Homeostatic Plasticity by Re-Routing AMPAR into the Recycling Endosomal Pathway
Celine C. Steinmetz, Vedakumar Tatavarty, Ken Sugino, Yasuyuki Shima, Anne Joseph, Heather Lin, Michael Rutlin, Mary Lambo, Chris M. Hempel, Benjamin W. Okaty, Suzanne Paradis, Sacha B. Nelson, Gina G. Turrigiano
Cell Rep. Author manuscript; available in PMC 2017 Jan 11.
Published in final edited form as: Cell Rep. 2016 Sep 6; 16(10): 2711–2722. Published online 2016 Aug 25. doi: 10.1016/j.celrep.2016.08.009
PMCID:
PMC5226429
AbstractArticlePDF–2.1M
9.
Control of the innate immune response by the mevalonate pathway
Murali K. Akula, Man Shi, Zhaozhao Jiang, Celia E. Foster, David Miao, Annie S. Li, Xiaoman Zhang, Ruth M. Gavin, Sorcha D. Forde, Gail Germain, Susan Carpenter, Charles V. Rosadini, Kira Gritsman, Jae Jin Chae, Randolph Hampton, Neal Silverman, Ellen M. Gravallese, Jonathan C. Kagan, Katherine A. Fitzgerald, Daniel L. Kastner, Douglas T. Golenbock, Martin O. Bergo, Donghai Wang
Nat Immunol. Author manuscript; available in PMC 2016 Dec 6.
Published in final edited form as: Nat Immunol. 2016 Aug; 17(8): 922–929. Published online 2016 Jun 6. doi: 10.1038/ni.3487
PMCID:
PMC4955724
AbstractArticlePDF–1.7M
10.
Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation
Rocío López-Posadas, Christoph Becker, Claudia Günther, Stefan Tenzer, Kerstin Amann, Ulrike Billmeier, Raja Atreya, Gionata Fiorino, Stefania Vetrano, Silvio Danese, Arif B. Ekici, Stefan Wirtz, Veronika Thonn, Alastair J.M. Watson, Cord Brakebusch, Martin Bergö, Markus F. Neurath, Imke Atreya
J Clin Invest. 2016 Feb 1; 126(2): 611–626. Published online 2016 Jan 11. doi: 10.1172/JCI80997
PMCID:
PMC4731169
AbstractArticlePDF–11M
11.
Impaired Geranylgeranyltransferase-I Regulation Reduces Membrane-Associated Rho-Protein Levels in Aged Mouse Brain
Sarah Afshordel, W. Gibson Wood, Urule Igbavboa, Walter E. Muller, Gunter P. Eckert
J Neurochem. Author manuscript; available in PMC 2015 May 1.
Published in final edited form as: J Neurochem. 2014 May; 129(4): 732–742. Published online 2014 Feb 7. doi: 10.1111/jnc.12654
PMCID:
PMC3999261
AbstractArticlePDF–4.5M
12.
Targeting GGTase-I Activates RHOA, Increases Macrophage Reverse Cholesterol Transport, and Reduces Atherosclerosis in Mice
Omar M. Khan, Murali K. Akula, Kristina Skålen, Christin Karlsson, Marcus Ståhlman, Stephen G. Young, Jan Borén, Martin O. Bergo
Circulation. Author manuscript; available in PMC 2014 Mar 3.
Published in final edited form as: Circulation. 2013 Feb 19; 127(7): 782–790. Published online 2013 Jan 18. doi: 10.1161/CIRCULATIONAHA.112.000588
PMCID:
PMC3940160
AbstractArticlePDF–968K
13.
Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease
Shaowu Cheng, Dongfeng Cao, David A. Hottman, LiLian Yuan, Martin O. Bergo, Ling Li
J Biol Chem. 2013 Dec 13; 288(50): 35952–35960. Published online 2013 Oct 17. doi: 10.1074/jbc.M113.503904
PMCID:
PMC3861644
AbstractArticlePDF–1.9M
14.
Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases
Shao H. Yang, Sandy Y. Chang, Yiping Tu, Gregory W. Lawson, Martin O. Bergo, Loren G. Fong, Stephen G. Young
J Lipid Res. 2012 Jan; 53(1): 77–86. doi: 10.1194/jlr.M021220
PMCID:
PMC3243483
AbstractArticlePDF–2.8M
15.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
16.
Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice
Omar M. Khan, Mohamed X. Ibrahim, Ing-Marie Jonsson, Christin Karlsson, Meng Liu, Anna-Karin M. Sjogren, Frida J. Olofsson, Mikael Brisslert, Sofia Andersson, Claes Ohlsson, Lillemor Mattsson Hultén, Maria Bokarewa, Martin O. Bergo
J Clin Invest. 2011 Feb 1; 121(2): 628–639. Published online 2011 Jan 25. doi: 10.1172/JCI43758
PMCID:
PMC3026725
AbstractArticlePDF–1.0M
17.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
18.
Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer
Meng Liu, Anna-Karin M. Sjogren, Christin Karlsson, Mohamed X. Ibrahim, Karin M. E. Andersson, Frida J. Olofsson, Annika M. Wahlstrom, Martin Dalin, Huiming Yu, Zhenggang Chen, Shao H. Yang, Stephen G. Young, Martin O. Bergo
Proc Natl Acad Sci U S A. 2010 Apr 6; 107(14): 6471–6476. Published online 2010 Mar 22. doi: 10.1073/pnas.0908396107
PMCID:
PMC2852017
AbstractArticlePDF–984K
19.
Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes
Roger Lee, Sandy Y. Chang, Hung Trinh, Yiping Tu, Andrew C. White, Brandon S.J. Davies, Martin O. Bergo, Loren G. Fong, William E. Lowry, Stephen G. Young
Hum Mol Genet. 2010 Apr 15; 19(8): 1603–1617. Published online 2010 Jan 27. doi: 10.1093/hmg/ddq036
PMCID:
PMC2846164
AbstractArticlePDF–1.3M
20.
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells
Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin
Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108
PMCID:
PMC2556270
AbstractArticlePDF–493K

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