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Select item 103280791.

LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity

Tania Christova, Stephanie KY Ho, Ying Liu, Mandeep Gill, Liliana Attisano

EMBO Rep. 2023 Jul; 24(7): e56937. Published online 2023 Jun 9. doi: 10.15252/embr.202356937

PMCID:: PMC10328079

Abstract Article PDF–8.3M

Select item 89354832.

Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice

Hannah Kohler, Soeren Latteyer, Georg Sebastian Hönes, Sarah Theurer, Xiao-Hui Liao, Sandra Christoph, Denise Zwanziger, Johannes H. Schulte, Jukka Kero, Hendrik Undeutsch, Samuel Refetoff, Kurt W. Schmid, Dagmar Führer, Lars C. Moeller

Thyroid. 2019 Oct 1; 29(10): 1438–1446. Published online 2019 Oct 15. doi: 10.1089/thy.2018.0526

PMCID:: PMC8935483

Abstract Article PDF–894K

Select item 87584903.

Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation

Jisu Park, Hyunwoo Choi, Young Doo Kim, Seo-Hyun Kim, Youbin Kim, Youngdae Gwon, Dong Young Lee, Sung-Hye Park, Won Do Heo, Yong-Keun Jung

Mol Psychiatry. 2021; 26(10): 5542–5556. Published online 2021 Jan 15. doi: 10.1038/s41380-020-01003-y

PMCID:: PMC8758490

Abstract Article PDF–3.9M

Select item 84880234.

Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1–Dependent Myeloid Cells

Lee-Ann Van de Velde, E. Kaitlynn Allen, Jeremy Chase Crawford, Taylor L. Wilson, Clifford S. Guy, Marion Russier, Leonie Zeitler, Armita Bahrami, David Finkelstein, Stephane Pelletier, Stacey Schultz-Cherry, Paul G. Thomas, Peter J. Murray

Cancer Res. 2021 Oct 1; 81(19): 5047–5059. Published online 2021 Jul 23. doi: 10.1158/0008-5472.CAN-21-0691

PMCID:: PMC8488023

Abstract Article PDF–1.6M

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 78487496.

A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells

Kazuhiro Murakami, Yumi Terakado, Kikue Saito, Yoshie Jomen, Haruna Takeda, Masanobu Oshima, Nick Barker

Proc Natl Acad Sci U S A. 2021 Jan 26; 118(4): e2016806118. Published online 2021 Jan 21. doi: 10.1073/pnas.2016806118

PMCID:: PMC7848749

Abstract Article PDF–3.2M

Select item 76857267.

ALK-transformed mature T lymphocytes restore early thymus progenitor features

Annabelle Congras, Coralie Hoareau-Aveilla, Nina Caillet, Marie Tosolini, Patrick Villarese, Agata Cieslak, Laura Rodriguez, Vahid Asnafi, Elisabeth Macintyre, Gerda Egger, Pierre Brousset, Laurence Lamant, Fabienne Meggetto

J Clin Invest. 2020 Dec 1; 130(12): 6395–6408. Published online 2020 Nov 3. doi: 10.1172/JCI134990

PMCID:: PMC7685726

Abstract Article PDF–12M

Select item 71840288.

Oncogenic ALK^F1174L drives tumorigenesis in cutaneous squamous cell carcinoma

Marco Gualandi, Maria Iorio, Olivia Engeler, André Serra-Roma, Giuseppe Gasparre, Johannes H Schulte, Daniel Hohl, Olga Shakhova

Life Sci Alliance. 2020 Jun; 3(6): e201900601. Published online 2020 Apr 20. doi: 10.26508/lsa.201900601

PMCID:: PMC7184028

Abstract Article PDF–3.2M

Select item 63813889.

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System

Fatima Memic, Viktoria Knoflach, Khomgrit Morarach, Rebecca Sadler, Catia Laranjeira, Jens Hjerling-Leffler, Erik Sundström, Vassilis Pachnis, Ulrika Marklund

Gastroenterology. 2018 Feb; 154(3): 624–636. doi: 10.1053/j.gastro.2017.10.005

PMCID:: PMC6381388

Abstract Article

Select item 616845610.

Activated ALK signals through the ERK–ETV5–RET pathway to drive neuroblastoma oncogenesis

Lucille Lopez-Delisle, Cécile Pierre-Eugène, Caroline Louis-Brennetot, Didier Surdez, Virginie Raynal, Sylvain Baulande, Valentina Boeva, Sandrine Grossetête-Lalami, Valérie Combaret, Michel Peuchmaur, Olivier Delattre, Isabelle Janoueix-Lerosey

Oncogene. 2018; 37(11): 1417–1429. Published online 2018 Jan 11. doi: 10.1038/s41388-017-0039-5

PMCID:: PMC6168456

Abstract Article PDF–1.4M

Select item 585913311.

Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus

Sandra G. Gonzalez Malagon, Anna M. Lopez Muñoz, Daniel Doro, Triòna G. Bolger, Evon Poon, Elizabeth R. Tucker, Hadeel Adel Al-Lami, Matthias Krause, Christopher J. Phiel, Louis Chesler, Karen J. Liu

Nat Commun. 2018; 9: 1126. Published online 2018 Mar 19. doi: 10.1038/s41467-018-03512-5

PMCID:: PMC5859133

Abstract Article PDF–12M

Select item 550273612.

The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model

Jiaxiong Lu, Shan Guan, Yanlin Zhao, Yang Yu, Sarah E. Woodfield, Huiyuan Zhang, Kristine L. Yang, Shayahati Bieerkehazhi, Lin Qi, Xiaonan Li, Jerry Gu, Xin Xu, Jinling Jin, Jodi A. Muscal, Tianshu Yang, Guo-Tong Xu, Jianhua Yang

Cancer Lett. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Cancer Lett. 2017 Aug 1; 400: 61–68. Published online 2017 Apr 26. doi: 10.1016/j.canlet.2017.04.022

PMCID:: PMC5502736

Abstract Article PDF–1.6M

Select item 547945313.

Role of the p55-gamma subunit of PI3K in ALK-induced cell migration: RNAi-based selection of cell migration regulators

Minchul Seo, Jong-Heon Kim, Kyoungho Suk

Cell Adh Migr. 2017; 11(3): 205–210. Published online 2016 Jun 20. doi: 10.1080/19336918.2016.1202385

PMCID:: PMC5479453

Abstract Article PDF–672K

Select item 501502914.

Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma

Shunpei Satoh, Atsushi Takatori, Atsushi Ogura, Kenichi Kohashi, Ryota Souzaki, Yoshiaki Kinoshita, Tomoaki Taguchi, Md. Shamim Hossain, Miki Ohira, Yohko Nakamura, Akira Nakagawara

Sci Rep. 2016; 6: 32682. Published online 2016 Sep 8. doi: 10.1038/srep32682

PMCID:: PMC5015029

Abstract Article PDF–1.8M

Select item 494030415.

Anaplastic lymphoma kinase (ALK) regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area

John W. Dutton, III, Hu Chen, Chang You, Mark S. Brodie, Amy W. Lasek

Addict Biol. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Addict Biol. 2017 May; 22(3): 665–678. Published online 2016 Jan 11. doi: 10.1111/adb.12358

PMCID:: PMC4940304

Abstract Article PDF–2.0M

Select item 491288316.

Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice

Paul Schweitzer, Chelsea Cates-Gatto, Florence P. Varodayan, Tali Nadav, Marisa Roberto, Amy W. Lasek, Amanda J. Roberts

Neuropharmacology. Author manuscript; available in PMC 2017 Aug 1.

Published in final edited form as: Neuropharmacology. 2016 Aug; 107: 1–8. Published online 2016 Mar 2. doi: 10.1016/j.neuropharm.2016.03.003

PMCID:: PMC4912883

Abstract Article PDF–2.0M

Select item 461808417.

Ethanol activates Midkine and Anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brain

Donghong He, Hu Chen, Hisako Muramatsu, Amy W. Lasek

J Neurochem. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: J Neurochem. 2015 Nov; 135(3): 508–521. Published online 2015 Aug 11. doi: 10.1111/jnc.13252

PMCID:: PMC4618084

Abstract Article PDF–1.4M

Select item 442549418.

Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism

Barbara Witek, Abeer El Wakil, Christoffer Nord, Ulf Ahlgren, Maria Eriksson, Emma Vernersson-Lindahl, Åslaug Helland, Oleg A. Alexeyev, Bengt Hallberg, Ruth H. Palmer

PLoS One. 2015; 10(5): e0123542. Published online 2015 May 8. doi: 10.1371/journal.pone.0123542

PMCID:: PMC4425494

Abstract Article PDF–7.6M

Select item 431955919.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 405803820.

Hyperactivation of Alk induces neonatal lethality in knock-in Alk^F1178L mice

Lucille Lopez-Delisle, Cécile Pierre-Eugène, Evelyne Bloch-Gallego, Marie-Christine Birling, Jean-Loup Duband, Estelle Durand, Thomas Bourgeois, Boris Matrot, Tania Sorg, Michel Huerre, Hamid Meziane, Michel J. Roux, Marie-France Champy, Jorge Gallego, Olivier Delattre, Isabelle Janoueix-Lerosey

Oncotarget. 2014 May; 5(9): 2703–2713. Published online 2014 Apr 2. doi: 10.18632/oncotarget.1882

PMCID:: PMC4058038

Abstract Article PDF–5.6M

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