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Items: 1 to 20 of 28

1.
The deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases
Leah Rie Varner, Taro Chaya, Yamato Maeda, Ryotaro Tsutsumi, Shanshan Zhou, Toshinori Tsujii, Daisuke Okuzaki, Takahisa Furukawa
iScience. 2024 Apr 19; 27(4): 109380. Published online 2024 Mar 1. doi: 10.1016/j.isci.2024.109380
PMCID:
PMC10951987
AbstractArticlePDF–8.4M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Ovarian Tumor Domain‐Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel‐Like Factor 4
Bin‐Bin Du, Jie‐Lei Zhang, Ling‐Yao Kong, Hui‐Ting Shi, Dian‐Hong Zhang, Xing Wang, Chun‐Lei Yang, Peng‐Cheng Li, Rui Yao, Cui Liang, Lei‐Ming Wu, Zhen Huang
J Am Heart Assoc. 2023 Dec 19; 12(24): e029745. Published online 2023 Dec 12. doi: 10.1161/JAHA.123.029745
PMCID:
PMC10863784
AbstractArticlePDF–17M
4.
The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2
Kunjan Harit, Rituparna Bhattacharjee, Kai Matuschewski, Jennifer Becker, Ulrich Kalinke, Dirk Schlüter, Gopala Nishanth
Cell Death Dis. 2023 Jul; 14(7): 480. Published online 2023 Jul 29. doi: 10.1038/s41419-023-06014-5
PMCID:
PMC10387084
AbstractArticlePDF–3.8M
5.
Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling
Weiwei An, Le A Luong, Neil P Bowden, Mei Yang, Wei Wu, Xinmiao Zhou, Chenxin Liu, Kaiyuan Niu, Jun Luo, Cheng Zhang, Xiaolei Sun, Robin Poston, Li Zhang, Paul C Evans, Qingzhong Xiao
Cardiovasc Res. 2022 Feb; 118(2): 638–653. Published online 2021 Feb 18. doi: 10.1093/cvr/cvab056
PMCID:
PMC8803089
AbstractArticlePDF–2.2M
6.
OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis
Zhicheng Gong, Aicun Li, Jiancheng Ding, Qing Li, Lei Zhang, Yuanpei Li, Zhe Meng, Fei Chen, Jialiang Huang, Dawang Zhou, Ronggui Hu, Jing Ye, Wen Liu, Han You
Adv Sci (Weinh) 2021 Aug; 8(15): 2004504. Published online 2021 May 29. doi: 10.1002/advs.202004504
PMCID:
PMC8336515
AbstractArticlePDF–6.5M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination
Le A. Luong, Maria Fragiadaki, Jennifer Smith, Joseph Boyle, Jens Lutz, Jonathan L. E. Dean, Sarah Harten, Margaret Ashcroft, Sarah Walmsley, Dorian O. Haskard, Patrick H. Maxwell, Henning Walczak, Charles Pusey, Paul C. Evans
Circ Res. Author manuscript; available in PMC 2021 Jun 23.
Published in final edited form as: Circ Res. 2013 Jun 7; 112(12): 1583–91. Published online 2013 Apr 5. doi: 10.1161/CIRCRESAHA.111.300119
PMCID:
PMC7611065
AbstractArticlePDF–2.0M
9.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
10.
Placentation defects are highly prevalent in embryonic lethal mouse mutants
Vicente Perez-Garcia, Elena Fineberg, Robert Wilson, Alexander Murray, Cecilia Icoresi Mazzeo, Catherine Tudor, Arnold Sienerth, Jacqueline K. White, Elizabeth Tuck, Edward J. Ryder, Diane Gleeson, Emma Siragher, Hannah Wardle-Jones, Nicole Staudt, Neha Wali, John Collins, Stefan Geyer, Elisabeth M. Busch-Nentwich, Antonella Galli, James C. Smith, Elizabeth Robertson, David J. Adams, Wolfgang J. Weninger, Timothy Mohun, Myriam Hemberger
Nature. Author manuscript; available in PMC 2018 Sep 14.
Published in final edited form as: Nature. 2018 Mar 22; 555(7697): 463–468. Published online 2018 Mar 14. doi: 10.1038/nature26002
PMCID:
PMC5866719
AbstractArticlePDF–7.4M
11.
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
Bin Wang, Zuliang Jie, Donghyun Joo, Alban Ordureau, Pengda Liu, Wenjian Gan, Jianping Guo, Jinfang Zhang, Brian J. North, Xiangpeng Dai, Xuhong Cheng, Xiuwu Bian, Lingqiang Zhang, J. Wade Harper, Shao-Cong Sun, Wenyi Wei
Nature. Author manuscript; available in PMC 2017 Nov 20.
Published in final edited form as: Nature. 2017 May 18; 545(7654): 365–369. Published online 2017 May 10. doi: 10.1038/nature22344
PMCID:
PMC5695540
AbstractArticlePDF–2.8M
12.
Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma
Jia-hong Wang, Xiao-ping Zhong, Yong-fa Zhang, Xiao-liang Wu, Shao-hua Li, Pei-en Jian, Yi-hong Ling, Ming Shi, Min-shan Chen, Wei Wei, Rong-ping Guo
Cell Death Dis. 2017 Sep; 8(9): e3043. Published online 2017 Sep 7. doi: 10.1038/cddis.2017.428
PMCID:
PMC5636974
AbstractArticlePDF–3.0M
13.
Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice
Robert Wilson, Stefan H. Geyer, Lukas Reissig, Julia Rose, Dorota Szumska, Emily Hardman, Fabrice Prin, Christina McGuire, Ramiro Ramirez-Solis, Jacqui White, Antonella Galli, Catherine Tudor, Elizabeth Tuck, Cecilia Icoresi Mazzeo, James C. Smith, Elizabeth Robertson, David J. Adams, Timothy Mohun, Wolfgang J. Weninger
Version 2. Wellcome Open Res. 2016; 1: 1. Published online 2017 Feb 27. doi: 10.12688/wellcomeopenres.9899.2
PMCID:
PMC5159622
AbstractArticlePDF–7.4M
14.
Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination
Hongbo Hu, Hui Wang, Yichuan Xiao, Jin Jin, Jae-Hoon Chang, Qiang Zou, Xiaoping Xie, Xuhong Cheng, Shao-Cong Sun
J Exp Med. 2016 Mar 7; 213(3): 399–414. doi: 10.1084/jem.20151426
PMCID:
PMC4813674
AbstractArticlePDF–2.8M
15.
Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner
Anja Bremm, Sonia Moniz, Julia Mader, Sonia Rocha, David Komander
EMBO Rep. 2014 Dec; 15(12): 1268–1277. Published online 2014 Oct 29. doi: 10.15252/embr.201438850
PMCID:
PMC4264929
AbstractArticlePDF–823K
16.
Otud7b controls noncanonical NF-?B activation via deubiquitination of TRAF3
Hongbo Hu, George C. Brittain, Jae-Hoon Chang, Nahum Puebla-Osorio, Jin Jin, Anna Zal, Yichuan Xiao, Xuhong Cheng, Mikyoung Chang, Yang-Xin Fu, Tomasz Zal, Chengming Zhu, Shao-Cong Sun
Nature. Author manuscript; available in PMC 2013 Aug 21.
Published in final edited form as: Nature. 2013 Feb 21; 494(7437): 371–374. Published online 2013 Jan 20. doi: 10.1038/nature11831
PMCID:
PMC3578967
AbstractArticlePDF–1.4M
17.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
18.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
19.
DJ-1 Enhances Cell Survival through the Binding of Cezanne, a Negative Regulator of NF-κB
R. Sean McNally, Beckley K. Davis, Casey M. Clements, Mary Ann Accavitti-Loper, Tak W. Mak, Jenny P.-Y. Ting
J Biol Chem. 2011 Feb 11; 286(6): 4098–4106. Published online 2010 Nov 19. doi: 10.1074/jbc.M110.147371
PMCID:
PMC3039338
AbstractArticlePDF–939K
20.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M

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