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Select item 112085471.

Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells

Adélaïde Gélineau, Geneviève Marcelin, Melissa Ouhachi, Sébastien Dussaud, Lise Voland, Raoul Manuel, Ines Baba, Christine Rouault, Laurent Yvan-Charvet, Karine Clément, Roxane Tussiwand, Thierry Huby, Emmanuel L. Gautier

Nat Commun. 2024; 15: 5413. Published online 2024 Jun 26. doi: 10.1038/s41467-024-49820-x

PMCID:: PMC11208547

Abstract Article PDF–2.4M

Select item 110990792.

Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions

Kyoko Ochiai, Hiroki Shima, Toru Tamahara, Nao Sugie, Ryo Funayama, Keiko Nakayama, Tomohiro Kurosaki, Kazuhiko Igarashi

EMBO J. 2024 May; 43(10): 1947–1964. Published online 2024 Apr 11. doi: 10.1038/s44318-024-00077-6

PMCID:: PMC11099079

Abstract Article PDF–4.6M

Select item 110980523.

Control of nutrient uptake by IRF4 orchestrates innate immune memory

Endi K. Santosa, Hyunu Kim, Timo Rückert, Jean-Benoît Le Luduec, Aamna J. Abbasi, Claire K. Wingert, Lila Peters, Joe N. Frost, Katharine C. Hsu, Chiara Romagnani, Joseph C. Sun

Nat Immunol. Author manuscript; available in PMC 2024 May 16.

Published in final edited form as: Nat Immunol. 2023 Oct; 24(10): 1685–1697. Published online 2023 Sep 11. doi: 10.1038/s41590-023-01620-z

PMCID:: PMC11098052

Abstract Article PDF–4.9M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109129075.

Site-specific regulation of Th2 differentiation within lymph node microenvironments

Miranda R. Lyons-Cohen, Elya A. Shamskhou, Michael Y. Gerner

J Exp Med. 2024 Apr 1; 221(4): e20231282. Published online 2024 Mar 4. doi: 10.1084/jem.20231282

PMCID:: PMC10912907

Abstract Article PDF–10M

Select item 108274826.

Type I interferon activates MHC class I-dressed CD11b⁺ conventional dendritic cells to promote protective anti-tumor CD8⁺ T cell immunity

Ellen Duong, Tim B. Fessenden, Emi Lutz, Teresa Dinter, Leon Yim, Sarah Blatt, Arjun Bhutkar, Karl Dane Wittrup, Stefani Spranger

Immunity. Author manuscript; available in PMC 2024 Jan 30.

Published in final edited form as: Immunity. 2022 Feb 8; 55(2): 308–323.e9. Published online 2021 Nov 19. doi: 10.1016/j.immuni.2021.10.020

PMCID:: PMC10827482

Abstract Article PDF–2.4M

Select item 107774897.

IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3

Ying Zhu, Langyue He, Yue Zhu, Huici Yao, Jianfeng Jiang, Hongyan Lu

Mol Med. 2024; 30: 6. Published online 2024 Jan 9. doi: 10.1186/s10020-023-00770-y

PMCID:: PMC10777489

Abstract Article PDF–3.2M

Select item 106837928.

TRANSITIONAL DENDRITIC CELLS ARE DISTINCT FROM CONVENTIONAL DC2 PRECURSORS AND MEDIATE PRO-INFLAMMATORY ANTIVIRAL RESPONSES

Fernando Bandeira Sulczewski, Raul A. Maqueda-Alfaro, Marcela Alcántara-Hernández, Oriana A. Perez, Sanjana Saravanan, Tae Jin Yun, David Seong, Rebeca Arroyo Hornero, Hayley M. Raquer-McKay, Eduardo Esteva, Zachary R. Lanzar, Rebecca A. Leylek, Nicholas M. Adams, Annesa Das, Adeeb H. Rahman, Andres Gottfried-Blackmore, Boris Reizis, Juliana Idoyaga

Nat Immunol. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Nat Immunol. 2023 Aug; 24(8): 1265–1280. Published online 2023 Jul 6. doi: 10.1038/s41590-023-01545-7

PMCID:: PMC10683792

Abstract Article PDF–8.1M

Select item 106201279.

Pellino 3 promotes the colitis‐associated colorectal cancer through suppression of IRF4‐mediated negative regulation of TLR4 signalling

Young‐Mi Kim, Hye‐Youn Kim, Huyen Trang Ha Thi, Jooyoung Kim, Young Jae Lee, Seong‐Jin Kim, Suntaek Hong

Mol Oncol. 2023 Nov; 17(11): 2380–2395. Published online 2023 Jun 27. doi: 10.1002/1878-0261.13475

PMCID:: PMC10620127

Abstract Article PDF–2.2M

Select item 1058539310.

AIM2 promotes T_H17 cells differentiation by regulating RORγt transcription activity

Jefferson Antônio Leite, Luísa Menezes, Eloisa Martins, Tamara Silva Rodrigues, Lucas Tavares, Anna Ebering, Carsten Schelmbauer, Guilherme C. Martelossi Cebinelli, Valeriya Zinina, Artemiy Golden, Natalia Soshnikova, Dario S. Zamboni, Fernando Q. Cunha, Magdalena Huber, João Santana Silva, Ari Waisman, Daniela Carlos, Niels Olsen Saraiva Câmara

iScience. 2023 Nov 17; 26(11): 108134. Published online 2023 Oct 4. doi: 10.1016/j.isci.2023.108134

PMCID:: PMC10585393

Abstract Article PDF–5.0M

Select item 1058304911.

The transcription factor IRF4 determines the anti-tumor immunity of CD8⁺ T cells

Hui Yan, Yulin Dai, Xiaolong Zhang, Hedong Zhang, Xiang Xiao, Jinfei Fu, Dawei Zou, Anze Yu, Tao Jiang, Xian C. Li, Zhongming Zhao, Wenhao Chen

iScience. 2023 Nov 17; 26(11): 108087. Published online 2023 Sep 28. doi: 10.1016/j.isci.2023.108087

PMCID:: PMC10583049

Abstract Article PDF–5.9M

Select item 1052495612.

T-bet-expressing B cells contribute to the autoreactive plasma cell pool in Lyn−/− mice

Kristina Ottens, Jalyn Schneider, Anne B. Satterthwaite

Eur J Immunol. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Eur J Immunol. 2023 Aug; 53(8): e2250300. Published online 2023 May 14. doi: 10.1002/eji.202250300

PMCID:: PMC10524956

Abstract Article PDF–1.5M

Select item 1035298313.

IRF4 is required for migration of CD4⁺ T cells to the intestine but not for Th2 and Th17 cell maintenance

Constantin Schmidt, Aenne Harberts, Daniel Reimers, Tabea Bertram, Leonie Caroline Voß, Joanna Schmid, Niels Christian Lory, Michael Spohn, Friedrich Koch-Nolte, Samuel Huber, Friederike Raczkowski, Minka Breloer, Hans-Willi Mittrücker

Front Immunol. 2023; 14: 1182502. Published online 2023 Jul 3. doi: 10.3389/fimmu.2023.1182502

PMCID:: PMC10352983

Abstract Article PDF–11M

Select item 1020295114.

A T follicular helper cell origin for T regulatory type 1 cells

Patricia Solé, Jun Yamanouchi, Josep Garnica, Muhammad Myn Uddin, Robert Clarke, Joel Moro, Nahir Garabatos, Shari Thiessen, Mireia Ortega, Santiswarup Singha, Debajyoti Mondal, César Fandos, Julio Saez-Rodriguez, Yang Yang, Pau Serra, Pere Santamaria

Cell Mol Immunol. 2023 May; 20(5): 489–511. Published online 2023 Mar 27. doi: 10.1038/s41423-023-00989-z

PMCID:: PMC10202951

Abstract Article PDF–13M

Select item 967545815.

IRF4 expression by lung dendritic cells drives acute but not Trm cell–dependent memory Th2 responses

Daniel F. Camacho, Tania E. Velez, Maile K. Hollinger, Esther Wang, Chanie L. Howard, Eli P. Darnell, Domenick E. Kennedy, Paulette A. Krishack, Cara L. Hrusch, Marcus R. Clark, James J. Moon, Anne I. Sperling

JCI Insight. 2022 Nov 8; 7(21): e140384. Published online 2022 Nov 8. doi: 10.1172/jci.insight.140384

PMCID:: PMC9675458

Abstract Article PDF–4.3M

Select item 963008716.

Obese Skeletal Muscle–Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome

Ting Yao, Hongmei Yan, Xiaopeng Zhu, Qiongyue Zhang, Xingyu Kong, Shanshan Guo, Yonghao Feng, Hui Wang, Yinghui Hua, Jing Zhang, Steven D. Mittelman, Peter Tontonoz, Zhenqi Zhou, Tiemin Liu, Xingxing Kong

Diabetes. 2022 Nov; 71(11): 2256–2271. Published online 2022 Jun 17. doi: 10.2337/db22-0260

Correction in:: Diabetes. 2023 Feb; 72(2): 309.

PMCID:: PMC9630087

Abstract Article PDF–3.4M

Select item 961366017.

IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

Dennis Das Gupta, Christoph Paul, Nadine Samel, Maria Bieringer, Daniel Staudenraus, Federico Marini, Hartmann Raifer, Lisa Menke, Lea Hansal, Bärbel Camara, Edith Roth, Patrick Daum, Michael Wanzel, Marco Mernberger, Andrea Nist, Uta-Maria Bauer, Frederik Helmprobst, Malte Buchholz, Katrin Roth, Lorenz Bastian, Alina M. Hartmann, Claudia Baldus, Koichi Ikuta, Andreas Neubauer, Andreas Burchert, Hans-Martin Jäck, Matthias Klein, Tobias Bopp, Thorsten Stiewe, Axel Pagenstecher, Michael Lohoff

Cell Death Differ. 2022 Nov; 29(11): 2163–2176. Published online 2022 Apr 22. doi: 10.1038/s41418-022-01005-z

PMCID:: PMC9613660

Abstract Article PDF–5.8M

Select item 955018818.

Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B-cell response

Qianwen Hu, Tingting Xu, Min Zhang, Heng Zhang, Yongbo Liu, Hua-bing Li, Chiqi Chen, Junke Zheng, Zhen Zhang, Fubin Li, Nan Shen, Wenqian Zhang, Ari Melnick, Chuanxin Huang

Cell Rep. Author manuscript; available in PMC 2022 Oct 10.

Published in final edited form as: Cell Rep. 2022 Jul 5; 40(1): 111035. doi: 10.1016/j.celrep.2022.111035

PMCID:: PMC9550188

Abstract Article PDF–971K

Select item 949450919.

Jmjd3/IRF4 axis aggravates myeloid fibroblast activation and m2 macrophage to myofibroblast transition in renal fibrosis

Hua Liang, Benquan Liu, Ying Gao, Jiayi Nie, Shuyun Feng, Wenqiang Yu, Shihong Wen, Xi Su

Front Immunol. 2022; 13: 978262. Published online 2022 Sep 8. doi: 10.3389/fimmu.2022.978262

PMCID:: PMC9494509

Abstract Article PDF–7.4M

Select item 941722620.

Regulation of microglial activation in stroke in aged mice: a translational study

Conelius Ngwa, Abdullah Al Mamun, Shaohua Qi, Romana Sharmeen, Yan Xu, Fudong Liu

Aging (Albany NY) 2022 Aug 15; 14(15): 6047–6065. Published online 2022 Aug 12. doi: 10.18632/aging.204216

PMCID:: PMC9417226

Abstract Article PDF–1.7M

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