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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 101192332.

Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties

Timothy Sargis, Seock-Won Youn, Krishna Thakkar, L. A. Naiche, Na Yoon Paik, Kostandin V. Pajcini, Jan K. Kitajewski

Angiogenesis. 2023; 26(2): 249–263. Published online 2022 Nov 15. doi: 10.1007/s10456-022-09861-6

PMCID:: PMC10119233

Abstract Article PDF–5.8M

Select item 100354633.

Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis in Mice

Kiyoshi Saeki, Wanglong Qiu, Richard A. Friedman, Samuel Pan, Jordan Lu, Shu Ichimiya, Iok In Christine Chio, Carrie J. Shawber, Jan Kitajewski, Jianhua Hu, Gloria H. Su

Cancer Res Commun. 2022 Dec; 2(12): 1601–1616. Published online 2022 Dec 12. doi: 10.1158/2767-9764.CRC-22-0106

PMCID:: PMC10035463

Abstract Article PDF–51M

Select item 97207434.

Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility

Mariam Rusidzé, Mélanie C. Faure, Pierre Sicard, Isabelle Raymond-Letron, Frank Giton, Emilie Vessieres, Vincent Prevot, Daniel Henrion, Jean-François Arnal, Charlotte A. Cornil, Françoise Lenfant

Development. 2022 Oct 1; 149(19): dev200683. Published online 2022 Oct 13. doi: 10.1242/dev.200683

PMCID:: PMC9720743

Abstract Article

Select item 96242625.

Endothelial loss of ETS1 impairs coronary vascular development and leads to ventricular non-compaction

Lu Wang, Lizhu Lin, Hui Qi, Ju Chen, Paul Grossfeld

Circ Res. Author manuscript; available in PMC 2023 Aug 19.

Published in final edited form as: Circ Res. 2022 Aug 19; 131(5): 371–387. Published online 2022 Jul 27. doi: 10.1161/CIRCRESAHA.121.319955

PMCID:: PMC9624262

Abstract Article PDF–4.5M

Select item 95751356.

Delta‐like ligand‐4 regulates Notch‐mediated maturation of second heart field progenitor‐derived pharyngeal arterial endothelial cells

Prashan De Zoysa, Omar Toubat, Drayton C. Harvey, Christopher Yi, Jiang Liu, Susana Cavallero, Young‐Kwon Hong, Henry M. Sucov, Subramanyan Ram Kumar

J Cell Mol Med. 2022 Oct; 26(20): 5181–5194. Published online 2022 Sep 9. doi: 10.1111/jcmm.17542

PMCID:: PMC9575135

Abstract Article PDF–19M

Select item 94328417.

JAG1-NOTCH4 mechanosensing drives atherosclerosis

Celine Souilhol, Blanca Tardajos Ayllon, Xiuying Li, Mannekomba R. Diagbouga, Ziqi Zhou, Lindsay Canham, Hannah Roddie, Daniela Pirri, Emily V. Chambers, Mark J. Dunning, Mark Ariaans, Jin Li, Yun Fang, Helle F. Jørgensen, Michael Simons, Rob Krams, Johannes Waltenberger, Maria Fragiadaki, Victoria Ridger, Sarah De Val, Sheila E. Francis, Timothy JA Chico, Jovana Serbanovic-Canic, Paul C. Evans

Sci Adv. 2022 Sep; 8(35): eabo7958. Published online 2022 Aug 31. doi: 10.1126/sciadv.abo7958

PMCID:: PMC9432841

Abstract Article PDF–2.6M

Select item 90548798.

Unique functions for Notch4 in murine embryonic lymphangiogenesis

Ajit Muley, Minji Kim Uh, Glicella Salazar-De Simone, Bhairavi Swaminathan, Jennifer M. James, Aino Murtomaki, Seock Won Youn, Joseph D. McCarron, Chris Kitajewski, Maria Gnarra Buethe, Gloria Riitano, Yoh-suke Mukouyama, Jan Kitajewski, Carrie J. Shawber

Angiogenesis. 2022; 25(2): 205–224. Published online 2021 Oct 19. doi: 10.1007/s10456-021-09822-5

PMCID:: PMC9054879

Abstract Article PDF–6.8M

Select item 89880089.

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia

Ann-Helen Rosendahl, Mia Monnius, Anu Laitala, Antti Railo, Ilkka Miinalainen, Ritva Heljasvaara, Joni M. Mäki, Johanna Myllyharju

J Biol Chem. 2022 Apr; 298(4): 101787. Published online 2022 Mar 2. doi: 10.1016/j.jbc.2022.101787

PMCID:: PMC8988008

Abstract Article PDF–6.1M

Select item 867116010.

NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling

Susana López-López, María José Romero de Ávila, Natalia Carolina Hernández de León, Francisco Ruiz-Marcos, Victoriano Baladrón, María Luisa Nueda, Jorge Laborda, José Javier García-Ramírez, Eva M. Monsalve, María José M. Díaz-Guerra

Front Immunol. 2021; 12: 734966. Published online 2021 Dec 1. doi: 10.3389/fimmu.2021.734966

PMCID:: PMC8671160

Abstract Article PDF–3.9M

Select item 861717611.

Cell-fate transition and determination analysis of mouse male germ cells throughout development

Jiexiang Zhao, Ping Lu, Cong Wan, Yaping Huang, Manman Cui, Xinyan Yang, Yuqiong Hu, Yi Zheng, Ji Dong, Mei Wang, Shu Zhang, Zhaoting Liu, Shuhui Bian, Xiaoman Wang, Rui Wang, Shaofang Ren, Dazhuang Wang, Zhaokai Yao, Gang Chang, Fuchou Tang, Xiao-Yang Zhao

Nat Commun. 2021; 12: 6839. Published online 2021 Nov 25. doi: 10.1038/s41467-021-27172-0

PMCID:: PMC8617176

Abstract Article PDF–14M

Select item 831323912.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 812707613.

The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling

Monica Corada, Daniel Nyqvist, Fabrizio Orsenigo, Andrea Caprini, Costanza Giampietro, Makoto M. Taketo, M. Luisa Iruela-Arispe, Ralf H. Adams, Elisabetta Dejana

Dev Cell. Author manuscript; available in PMC 2021 May 17.

Published in final edited form as: Dev Cell. 2010 Jun 15; 18(6): 938–949. doi: 10.1016/j.devcel.2010.05.006

PMCID:: PMC8127076

Abstract Article PDF–3.6M

Select item 811123714.

Maternal Cripto is required for proper uterine decidualization and peri-implantation uterine remodeling

Shiva Shafiei, Omar Farah, Daniel Dufort

Biol Reprod. 2021 May; 104(5): 1045–1057. Published online 2021 Feb 16. doi: 10.1093/biolre/ioab020

PMCID:: PMC8111237

Abstract Article PDF–1.9M

Select item 808041615.

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

Hani Harb, Mehdi Benamar, Peggy S. Lai, Paola Contini, Jason W. Griffith, Elena Crestani, Klaus Schmitz-Abe, Qian Chen, Jason Fong, Luca Marri, Gilberto Filaci, Genny Del Zotto, Novalia Pishesha, Stephen Kolifrath, Achille Broggi, Sreya Ghosh, Metin Yusuf Gelmez, Fatma Betul Oktelik, Esin Aktas Cetin, Ayca Kiykim, Murat Kose, Ziwei Wang, Ye Cui, Xu G. Yu, Jonathan Z. Li, Lorenzo Berra, Emmanuel Stephen-Victor, Louis-Marie Charbonnier, Ivan Zanoni, Hidde Ploegh, Gunnur Deniz, Raffaele De Palma, Talal A. Chatila

Immunity. 2021 Jun 8; 54(6): 1186–1199.e7. Published online 2021 Apr 28. doi: 10.1016/j.immuni.2021.04.002

PMCID:: PMC8080416

Abstract Article PDF–5.5M

Select item 793877016.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 790543717.

Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice

Madhulika Sharma, Sireesha Yerrathota, Mackenzie M Thornton, Sumedha Gunewardena

Data Brief. 2021 Apr; 35: 106873. Published online 2021 Feb 13. doi: 10.1016/j.dib.2021.106873

PMCID:: PMC7905437

Abstract Article PDF–290K

Select item 757817418.

A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma

Hani Harb, Emmanuel Stephen-Victor, Elena Crestani, Mehdi Benamar, Amir Massoud, Ye Cui, Louis-Marie Charbonnier, Sena Arbag, Safa Baris, Amparito Cunnigham, Juan Manuel Leyva-Castillo, Raif S. Geha, Amirhosein J. Mousavi, Boris Guennewig, Klaus Schmitz-Abe, Constantinos Sioutas, Wanda Phipatanakul, Talal A. Chatila

Nat Immunol. Author manuscript; available in PMC 2021 Mar 14.

Published in final edited form as: Nat Immunol. 2020 Nov; 21(11): 1359–1370. Published online 2020 Sep 14. doi: 10.1038/s41590-020-0777-3

PMCID:: PMC7578174

Abstract Article PDF–6.1M

Select item 691875419.

Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy

Rajni Vaid Puri, Sireesha Yerrathota, Trisha Home, Jessica Y. Idowu, V. Praveen Chakravarthi, Christopher J. Ward, Pravin C. Singhal, Gregory B. Vanden Heuvel, Timothy A. Fields, Madhulika Sharma

Dis Model Mech. 2019 Dec 1; 12(12): dmm040642. Published online 2019 Dec 17. doi: 10.1242/dmm.040642

PMCID:: PMC6918754

Abstract Article

Select item 617365620.

A Jagged 1–Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles

Mingcan Xia, Hani Harb, Arian Saffari, Constantinos Sioutas, Talal A. Chatila

J Allergy Clin Immunol. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: J Allergy Clin Immunol. 2018 Oct; 142(4): 1243–1256.e17. Published online 2018 Apr 5. doi: 10.1016/j.jaci.2018.03.009

PMCID:: PMC6173656

Abstract Article PDF–1.6M

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