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Select item 98985371.

CCN3/NOV promotes metastasis and tumor progression via GPNMB-induced EGFR activation in triple-negative breast cancer

Seogho Son, Hyungjoo Kim, Hogeun Lim, Joo-hyung Lee, Kyung-min Lee, Incheol Shin

Cell Death Dis. 2023 Feb; 14(2): 81. Published online 2023 Feb 3. doi: 10.1038/s41419-023-05608-3

PMCID:: PMC9898537

Abstract Article PDF–7.6M

Select item 97382752.

Elevated Expression of CCN3 in Articular Cartilage Induces Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing

Kazuki Hirose, Miho Kuwahara, Eiji Nakata, Tomonori Tetsunaga, Kazuki Yamada, Kenta Saiga, Masaharu Takigawa, Toshifumi Ozaki, Satoshi Kubota, Takako Hattori

Int J Mol Sci. 2022 Dec; 23(23): 15311. Published online 2022 Dec 4. doi: 10.3390/ijms232315311

PMCID:: PMC9738275

Abstract Article PDF–3.1M

Select item 92316233.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 90486014.

Downregulation of CCN3 expression as a potential mechanism for melanoma progression

M Fukunaga-Kalabis, G Martinez, S M Telson, Z-J Liu, K Balint, I Juhasz, D E Elder, B Perbal, M Herlyn

Oncogene. Author manuscript; available in PMC 2022 Apr 28.

Published in final edited form as: Oncogene. 2008 Apr 17; 27(18): 2552–2560. Published online 2007 Oct 29. doi: 10.1038/sj.onc.1210896

PMCID:: PMC9048601

Abstract Article PDF–1.5M

Select item 86218785.

NOV/CCN3 Promotes Cell Migration and Invasion in Intrahepatic Cholangiocarcinoma via miR-92a-3p

Tingming Liang, Lulu Shen, Yaya Ji, Lin Jia, Yuyang Dou, Li Guo

Genes (Basel) 2021 Nov; 12(11): 1659. Published online 2021 Oct 21. doi: 10.3390/genes12111659

PMCID:: PMC8621878

Abstract Article PDF–9.1M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80459327.

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition

Yahya Benslimane, María Sánchez‐Osuna, Jasmin Coulombe‐Huntington, Thierry Bertomeu, Danielle Henry, Caroline Huard, Éric Bonneil, Pierre Thibault, Mike Tyers, Lea Harrington

Aging Cell. 2021 Apr; 20(4): e13331. Published online 2021 Mar 4. doi: 10.1111/acel.13331

PMCID:: PMC8045932

Abstract Article PDF–1.9M

Select item 77012188.

CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta

Liyan Duan, Manuela Schimmelmann, Yuqing Wu, Beatrix Reisch, Marijke Faas, Rainer Kimmig, Elke Winterhager, Angela Köninger, Alexandra Gellhaus

Front Endocrinol (Lausanne) 2020; 11: 597549. Published online 2020 Nov 16. doi: 10.3389/fendo.2020.597549

PMCID:: PMC7701218

Abstract Article PDF–13M

Select item 76819749.

CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis

Michelle Naughton, Jill Moffat, George Eleftheriadis, Nira de la Vega Gallardo, Andrew Young, John Falconer, Kristen Hawkins, Ben Pearson, Bernard Perbal, Andrew Hogan, Paul Moynagh, Sam Loveless, Neil P. Robertson, Bruno Gran, Rachael Kee, Stella Hughes, Gavin McDonnell, Owain Howell, Denise C. Fitzgerald

J Neuroinflammation. 2020; 17: 349. Published online 2020 Nov 22. doi: 10.1186/s12974-020-02025-7

PMCID:: PMC7681974

Abstract Article PDF–1.5M

Select item 723266710.

Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis

Yingying Wei, Linan Peng, Yi Li, Na Zhang, Ke Shang, Lihua Duan, Jixin Zhong, Jie Chen

J Immunol Res. 2020; 2020: 3891425. Published online 2020 May 9. doi: 10.1155/2020/3891425

PMCID:: PMC7232667

Abstract Article PDF–623K

Select item 716998311.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 705782512.

Regulatory mechanism of NOV/CCN3 in the inflammation and apoptosis of lung epithelial alveolar cells upon lipopolysaccharide stimulation

Hai-Ping Zhu, Hui-Ya Huang, Deng-Min Wu, Nian Dong, Li Dong, Cheng-Shui Chen, Chao-Lei Chen, Yu-Guo Chen

Mol Med Rep. 2020 Apr; 21(4): 1872–1880. Published online 2019 Sep 9. doi: 10.3892/mmr.2019.10655

PMCID:: PMC7057825

Abstract Article PDF–893K

Select item 689667113.

Remodeling of hepatic stellate cells orchestrated the stroma-derived oxaliplatin-resistance through CCN3 paracrine in hepatocellular carcinoma

Xia Liao, Yang Bu, Fan Chang, Fengan Jia, Ge Song, Xuelian Xiao, Mei Zhang, Pengbo Ning, Qingan Jia

BMC Cancer. 2019; 19: 1192. Published online 2019 Dec 5. doi: 10.1186/s12885-019-6362-1

PMCID:: PMC6896671

Abstract Article PDF–10M

Select item 681582414.

NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway

Xiaojian Huang, Bowei Ni, Zekai Mao, Yang Xi, Xiangyu Chu, Rui Zhang, Xiaohu Ma, Hongbo You

J Cell Mol Med. 2019 Nov; 23(11): 7525–7534. Published online 2019 Aug 27. doi: 10.1111/jcmm.14621

PMCID:: PMC6815824

Abstract Article PDF–1.5M

Select item 675209715.

The Predictive Role of Tenascin-C and Cellular Communication Network Factor 3 (CCN3) in Post Hepatectomy Liver Failure in a Rat Model and 50 Patients Following Partial Hepatectomy

Hao Li, Xinlan Ge, Ke Pan, Minghao Sui, Huayong Cai, Chao Cui, Chonghui Li, Shichun Lu

Med Sci Monit. 2019; 25: 6755–6766. Published online 2019 Sep 8. doi: 10.12659/MSM.917331

PMCID:: PMC6752097

Abstract Article PDF–1.7M

Select item 665180516.

CCN3 Facilitates Runx2 and Osterix Expression by Inhibiting miR-608 through PI3K/Akt Signaling in Osteoblasts

Po-Chun Chen, Ju-Fang Liu, Yi-Chin Fong, Yuan-Lin Huang, Chia-Chia Chao, Chih-Hsin Tang

Int J Mol Sci. 2019 Jul; 20(13): 3300. Published online 2019 Jul 5. doi: 10.3390/ijms20133300

PMCID:: PMC6651805

Abstract Article PDF–1.7M

Select item 648699017.

Paracrine effects of CCN3 from non-cancerous hepatic cells increase signaling and progression of hepatocellular carcinoma

Weimin Li, Xia Liao, Pengbo Ning, Yu Cao, Mei Zhang, Yang Bu, Jun Lv, Qingan Jia

BMC Cancer. 2019; 19: 395. Published online 2019 Apr 27. doi: 10.1186/s12885-019-5603-7

PMCID:: PMC6486990

Abstract Article PDF–4.5M

Select item 565386918.

CCN3 is a therapeutic target relating enhanced stemness and coagulation in hepatocellular carcinoma

Qingan Jia, Tongchun Xue, Qiangbo Zhang, Wei Cheng, Chun Zhang, Jingwei Ma, Yang Bu, Songning Yu, Qingguang Liu

Sci Rep. 2017; 7: 13846. Published online 2017 Oct 23. doi: 10.1038/s41598-017-14087-4

PMCID:: PMC5653869

Abstract Article PDF–12M

Select item 553161119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 543225220.

Reduced NOV expression correlates with disease progression in colorectal cancer and is associated with survival, invasion and chemoresistance of cancer cells

Jun Li, Lin Ye, Ping-Hui Sun, Fei Zheng, Fiona Ruge, Lucy K. Satherley, Yi Feng, Huishan Zhao, Guifang Du, Tingting Wang, Yao Yang, Xuemei Ma, Shan Cheng, Xiaomei Yang, Hefen Yu, Xu Teng, Yang Si, Zhongtao Zhang, Wen G. Jiang

Oncotarget. 2017 Apr 18; 8(16): 26231–26244. Published online 2017 Feb 17. doi: 10.18632/oncotarget.15439

PMCID:: PMC5432252

Abstract Article PDF–3.2M

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