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Select item 108929661.

Beyond Impairment of Virion Infectivity: New Activities of the Anti-HIV Host Cell Factor SERINC5

Samy Sid Ahmed, Kathrin Bajak, Oliver T. Fackler

Viruses. 2024 Feb; 16(2): 284. Published online 2024 Feb 12. doi: 10.3390/v16020284

PMCID:: PMC10892966

Abstract Article PDF–1.6M

Select item 106175082.

Relative resistance of patient-derived envelope sequences to SERINC5-mediated restriction of HIV-1 infectivity

Emmanuel Nkuwi, George P. Judicate, Toong Seng Tan, Godfrey Barabona, Mako Toyoda, Bruno Sunguya, Doreen Kamori, Takamasa Ueno

J Virol. 2023 Oct; 97(10): e00823-23. Published online 2023 Sep 28. doi: 10.1128/jvi.00823-23

PMCID:: PMC10617508

Abstract Article PDF–974K

Select item 104846243.

Nef enhances HIV-1 replication and infectivity independently of SERINC5 in CEM T cells

Peter W. Ramirez, Thomas Vollbrecht, Francisco M. Acosta, Marissa Suarez, Aaron O. Angerstein, Jared Wallace, Ryan M. O’ Connell, John Guatelli

Virology. Author manuscript; available in PMC 2023 Sep 7.

Published in final edited form as: Virology. 2023 Jan; 578: 154–162. Published online 2022 Dec 23. doi: 10.1016/j.virol.2022.12.008

PMCID:: PMC10484624

Abstract Article PDF–1.2M

Select item 101276074.

SERINC5 Mediates a Postintegration Block to HIV-1 Gene Expression in Macrophages

Pavitra Ramdas, Ajit Chande

mBio. 2023 Mar-Apr; 14(2): e00166-23. Published online 2023 Mar 28. doi: 10.1128/mbio.00166-23

Correction in:: mBio. 2023 Jul-Aug; 14(4): e01222-23.

PMCID:: PMC10127607

Abstract Article PDF–3.0M

Select item 99732675.

AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4

Balaji Olety, Yoshiko Usami, Yuanfei Wu, Paul Peters, Heinrich Göttlinger

mBio. 2023 Jan-Feb; 14(1): e03382-22. Published online 2023 Jan 9. doi: 10.1128/mbio.03382-22

PMCID:: PMC9973267

Abstract Article PDF–3.5M

Select item 97654696.

Restriction of Influenza A Virus by SERINC5

Kin Kui Lai, James B. Munro, Guoli Shi, Saliha Majdoul, Alex A. Compton, Alan Rein

mBio. 2022 Nov-Dec; 13(6): e02923-22. Published online 2022 Nov 21. doi: 10.1128/mbio.02923-22

PMCID:: PMC9765469

Abstract Article PDF–2.2M

Select item 95497017.

SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways

Cong Zeng, Abdul A. Waheed, Tianliang Li, Jingyou Yu, Yi-Min Zheng, Jacob S. Yount, Haitao Wen, Eric O. Freed, Shan-Lu Liu

Sci Signal. Author manuscript; available in PMC 2022 Oct 10.

Published in final edited form as: Sci Signal. 2021 Sep 14; 14(700): eabc7611. Published online 2021 Sep 14. doi: 10.1126/scisignal.abc7611

PMCID:: PMC9549701

Abstract Article PDF–2.5M

Select item 93327838.

SERINC5-Mediated Restriction of HIV-1 Infectivity Correlates with Resistance to Cholesterol Extraction but Not with Lipid Order of Viral Membrane

Gokul Raghunath, Yen-Cheng Chen, Mariana Marin, Hui Wu, Gregory B. Melikyan

Viruses. 2022 Aug; 14(8): 1636. Published online 2022 Jul 27. doi: 10.3390/v14081636

PMCID:: PMC9332783

Abstract Article PDF–1.8M

Select item 90428229.

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction

Sunan Li, Rongrong Li, Iqbal Ahmad, Xiaomeng Liu, Silas F. Johnson, Liangliang Sun, Yong-Hui Zheng

Nat Commun. 2022; 13: 2242. Published online 2022 Apr 26. doi: 10.1038/s41467-022-30026-y

PMCID:: PMC9042822

Abstract Article PDF–7.5M

Select item 838564510.

HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity

Qingqing Chai, Sunan Li, Morgan K. Collins, Rongrong Li, Iqbal Ahmad, Silas F. Johnson, Dylan A. Frabutt, Zhichang Yang, Xiaojing Shen, Liangliang Sun, Jian Hu, Judd F. Hultquist, B. Matija Peterlin, Yong-Hui Zheng

Cell Rep. Author manuscript; available in PMC 2021 Aug 25.

Published in final edited form as: Cell Rep. 2021 Aug 10; 36(6): 109514. doi: 10.1016/j.celrep.2021.109514

PMCID:: PMC8385645

Abstract Article PDF–2.1M

Select item 831018211.

Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity

William E. Diehl, Mehmet H. Guney, Teresa Vanzo, Pyae P. Kyawe, Judith M. White, Massimo Pizzato, Jeremy Luban

Viruses. 2021 Jul; 13(7): 1279. Published online 2021 Jun 30. doi: 10.3390/v13071279

PMCID:: PMC8310182

Abstract Article PDF–8.3M

Select item 827444812.

Super-Resolution Fluorescence Imaging Reveals That Serine Incorporator Protein 5 Inhibits Human Immunodeficiency Virus Fusion by Disrupting Envelope Glycoprotein Clusters

Yen-Cheng Chen, Chetan Sood, Mariana Marin, Jesse Aaron, Enrico Gratton, Khalid Salaita, Gregory B. Melikyan

ACS Nano. Author manuscript; available in PMC 2021 Jul 12.

Published in final edited form as: ACS Nano. 2020 Sep 22; 14(9): 10929–10943. Published online 2020 Jun 1. doi: 10.1021/acsnano.0c02699

PMCID:: PMC8274448

Abstract Article PDF–2.1M

Select item 816616313.

HIV envelope tail truncation confers resistance to SERINC5 restriction

Tafhima Haider, Xenia Snetkov, Clare Jolly

Proc Natl Acad Sci U S A. 2021 May 25; 118(21): e2101450118. Published online 2021 May 17. doi: 10.1073/pnas.2101450118

PMCID:: PMC8166163

Abstract Article PDF–1.3M

Select item 810409514.

SERINC5 Can Enhance Proinflammatory Cytokine Production by Primary Human Myeloid Cells in Response to Challenge with HIV-1 Particles

Virginia Pierini, Lara Gallucci, Christina M. Stürzel, Frank Kirchhoff, Oliver T. Fackler

J Virol. 2021 May; 95(9): e02372-20. Prepublished online 2021 Feb 17. Published online 2021 Apr 12. doi: 10.1128/JVI.02372-20

PMCID:: PMC8104095

Abstract Article PDF–3.2M

Select item 790078015.

SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation

Ariane Zutz, Christian Schölz, Stephanie Schneider, Virginia Pierini, Maximilian Münchhoff, Kathrin Sutter, Georg Wittmann, Ulf Dittmer, Rika Draenert, Johannes R. Bogner, Oliver T. Fackler, Oliver T. Keppler

J Innate Immun. 2020 Sep; 12(5): 399–409. Published online 2020 Jan 14. doi: 10.1159/000504888

PMCID:: PMC7900780

Abstract Article PDF–4.1M

Select item 766798416.

Nef homodimers down-regulate SERINC5 by AP-2–mediated endocytosis to promote HIV-1 infectivity

Ryan P. Staudt, Thomas E. Smithgall

J Biol Chem. 2020 Nov 13; 295(46): 15540–15552. Published online 2020 Sep 1. doi: 10.1074/jbc.RA120.014668

PMCID:: PMC7667984

Abstract Article PDF–2.9M

Select item 765625017.

Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals

Mako Toyoda, Doreen Kamori, Toong Seng Tan, Kageaki Goebuchi, Jun Ohashi, Jonathan Carlson, Ai Kawana-Tachikawa, Hiroyuki Gatanaga, Shinichi Oka, Massimo Pizzato, Takamasa Ueno

Sci Rep. 2020; 10: 19416. Published online 2020 Nov 10. doi: 10.1038/s41598-020-76375-w

PMCID:: PMC7656250

Abstract Article PDF–1.1M

Select item 765025218.

HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy

Amanda E. Ward, Volker Kiessling, Owen Pornillos, Judith M. White, Barbie K. Ganser-Pornillos, Lukas K. Tamm

J Biol Chem. 2020 Nov 6; 295(45): 15183–15195. Published online 2020 Aug 11. doi: 10.1074/jbc.RA120.014466

PMCID:: PMC7650252

Abstract Article PDF–2.9M

Select item 753152219.

Novel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous and virion-associated SERINC5

Sebastian Molnar, Lindsay Wieczorek, Michelle Zemil, Bianca Schulte, Elizabeth Martinez, Syna Gift, Lan Tang, Hendrik Streeck, Robert A. Gramzinski, Nelson L. Michael, Gordon Joyce, Victoria R. Polonis

MAbs. 2020 Jan-Dec; 12(1): 1802187. Published online 2020 Aug 23. doi: 10.1080/19420862.2020.1802187