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Items: 1 to 20 of 32

1.
Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling
Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia G Hsu, Vyacheslav A Korshunov, Xiaochun Long, Peter A Knight, Bradford C Berk, Chen Yan
Cardiovasc Res. 2022 Aug; 118(12): 2703–2717. Published online 2021 Sep 22. doi: 10.1093/cvr/cvab304
Correction in:
Cardiovasc Res. 2023 Mar; 119(3): 879.
PMCID:
PMC9890476
AbstractArticlePDF–2.0M
2.
Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer
Rebecca M. Borneman, Elaine Gavin, Alla Musiyenko, Wito Richter, Kevin J. Lee, David K. Crossman, Joel F. Andrews, Annelise M. Wilhite, Steven McClellan, Ileana Aragon, Antonio B. Ward, Xi Chen, Adam B. Keeton, Kristy Berry, Gary A. Piazza, Jennifer M. Scalici, Luciana Madeira da Silva
J Ovarian Res. 2022; 15: 120. Published online 2022 Nov 2. doi: 10.1186/s13048-022-01050-9
PMCID:
PMC9632086
AbstractArticlePDF–8.2M
3.
Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry
Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang
Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118
PMCID:
PMC8364181
AbstractArticlePDF–3.0M
4.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
5.
Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease
Reagan Farmer, Steven D. Burbano, Neema S. Patel, Angelo Sarmiento, Abigail J. Smith, Michy P. Kelly
Cell Signal. Author manuscript; available in PMC 2021 Jun 1.
Published in final edited form as: Cell Signal. 2020 Jun; 70: 109592. Published online 2020 Feb 29. doi: 10.1016/j.cellsig.2020.109592
PMCID:
PMC7153982
AbstractArticlePDF–2.6M
6.
Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme
Gonzalo S. Tejeda, Ellanor L. Whiteley, Tarek Z. Deeb, Roland W. Bürli, Stephen J. Moss, Eamonn Sheridan, Nicholas J. Brandon, George S. Baillie
Proc Natl Acad Sci U S A. 2020 Jan 7; 117(1): 677–688. Published online 2019 Dec 23. doi: 10.1073/pnas.1916398117
PMCID:
PMC6955301
AbstractArticlePDF–2.4M
7.
Phosphodiesterase 10A IgG: A novel biomarker of paraneoplastic neurologic autoimmunity
Anastasia Zekeridou, Thomas Kryzer, Yong Guo, Anhar Hassan, Vanda Lennon, Claudia F. Lucchinetti, Sean Pittock, Andrew McKeon
Neurology. 2019 Aug 20; 93(8): e815–e822. doi: 10.1212/WNL.0000000000007971
PMCID:
PMC6711657
AbstractArticlePDF–856K
8.
Interplay of Palmitoylation and Phosphorylation in the Trafficking and Localization of Phosphodiesterase 10A: Implications for the Treatment of Schizophrenia
Erik I. Charych, Li-Xin Jiang, Frederick Lo, Kelly Sullivan, Nicholas J. Brandon
J Neurosci. 2010 Jul 7; 30(27): 9027–9037. doi: 10.1523/JNEUROSCI.1635-10.2010
PMCID:
PMC6632485
AbstractArticlePDF–1.9M
9.
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy
Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown
Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115
PMCID:
PMC6077722
AbstractArticlePDF–2.4M
10.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
11.
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing
Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown
Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114
PMCID:
PMC5495225
AbstractArticlePDF–1.3M
12.
Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain
Kai-Chun Yang, Vladimir Stepanov, Nahid Amini, Stefan Martinsson, Akihiro Takano, Jacob Nielsen, Christoffer Bundgaard, Benny Bang-Andersen, Sarah Grimwood, Christer Halldin, Lars Farde, Sjoerd J. Finnema
Eur J Nucl Med Mol Imaging. 2017; 44(2): 308–320. Published online 2016 Nov 5. doi: 10.1007/s00259-016-3544-9
PMCID:
PMC5215309
AbstractArticlePDF–736K
13.
A novel thermoregulatory role for PDE10A in mouse and human adipocytes
Mohammed K Hankir, Mathias Kranz, Thorsten Gnad, Juliane Weiner, Sally Wagner, Winnie Deuther‐Conrad, Felix Bronisch, Karen Steinhoff, Julia Luthardt, Nora Klöting, Swen Hesse, John P Seibyl, Osama Sabri, John T Heiker, Matthias Blüher, Alexander Pfeifer, Peter Brust, Wiebke K Fenske
EMBO Mol Med. 2016 Jul; 8(7): 796–812. Published online 2016 May 31. doi: 10.15252/emmm.201506085
PMCID:
PMC4931292
AbstractArticlePDF–1.4M
14.
Novel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder
C M MacMullen, K Vick, R Pacifico, M Fallahi-Sichani, R L Davis
Transl Psychiatry. 2016 Feb; 6(2): e742. Published online 2016 Feb 23. doi: 10.1038/tp.2016.3
PMCID:
PMC4872433
AbstractArticlePDF–1.0M
15.
Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy
Christine P. Diggle, Stacey J. Sukoff Rizzo, Michael Popiolek, Reetta Hinttala, Jan-Philip Schülke, Manju A. Kurian, Ian M. Carr, Alexander F. Markham, David T. Bonthron, Christopher Watson, Saghira Malik Sharif, Veronica Reinhart, Larry C. James, Michelle A. Vanase-Frawley, Erik Charych, Melanie Allen, John Harms, Christopher J. Schmidt, Joanne Ng, Karen Pysden, Christine Strick, Päivi Vieira, Katariina Mankinen, Hannaleena Kokkonen, Matti Kallioinen, Raija Sormunen, Juha O. Rinne, Jarkko Johansson, Kati Alakurtti, Laura Huilaja, Tiina Hurskainen, Kaisa Tasanen, Eija Anttila, Tiago Reis Marques, Oliver Howes, Marius Politis, Somayyeh Fahiminiya, Khanh Q. Nguyen, Jacek Majewski, Johanna Uusimaa, Eamonn Sheridan, Nicholas J. Brandon
Am J Hum Genet. 2016 Apr 7; 98(4): 735–743. Published online 2016 Apr 7. doi: 10.1016/j.ajhg.2016.03.015
PMCID:
PMC4833436
AbstractArticlePDF–654K
16.
De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions
Niccolò E. Mencacci, Erik-Jan Kamsteeg, Kosuke Nakashima, Lea R’Bibo, David S. Lynch, Bettina Balint, Michèl A.A.P. Willemsen, Matthew E. Adams, Sarah Wiethoff, Kazunori Suzuki, Ceri H. Davies, Joanne Ng, Esther Meyer, Liana Veneziano, Paola Giunti, Deborah Hughes, F. Lucy Raymond, Miryam Carecchio, Giovanna Zorzi, Nardo Nardocci, Chiara Barzaghi, Barbara Garavaglia, Vincenzo Salpietro, John Hardy, Alan M. Pittman, Henry Houlden, Manju A. Kurian, Haruhide Kimura, Lisenka E.L.M. Vissers, Nicholas W. Wood, Kailash P. Bhatia
Am J Hum Genet. 2016 Apr 7; 98(4): 763–771. Published online 2016 Apr 7. doi: 10.1016/j.ajhg.2016.02.015
PMCID:
PMC4833291
AbstractArticlePDF–1.2M
17.
Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10
Nan Li, Xi Chen, Bing Zhu, Verónica Ramírez-Alcántara, Joshua C. Canzoneri, Kevin Lee, Sara Sigler, Bernard Gary, Yonghe Li, Wei Zhang, Mary P. Moyer, E. Alan Salter, Andrzej Wierzbicki, Adam B. Keeton, Gary A. Piazza
Oncotarget. 2015 Sep 29; 6(29): 27403–27415. Published online 2015 Jul 25. doi: 10.18632/oncotarget.4741
PMCID:
PMC4694998
AbstractArticlePDF–2.8M
18.
Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and ß-catenin-dependent TCF transcriptional activity
Nan Li, Kevin Lee, Yaguang Xi, Bing Zhu, Bernard D. Gary, Verónica Ramírez-Alcántara, Evrim Gurpinar, Joshua C. Canzoneri, Alexandra Fajardo, Sara Sigler, John T. Piazza, Xi Chen, Joel Andrews, Meagan Thomas, Wenyan Lu, Yonghe Li, Danuel J. Laan, Mary P. Moyer, Suzanne Russo, Brian T. Eberhardt, Larry Yet, Adam B. Keeton, William E. Grizzle, Gary A. Piazza
Oncogene. Author manuscript; available in PMC 2015 Sep 19.
Published in final edited form as: Oncogene. 2015 Mar 19; 34(12): 1499–1509. Published online 2014 Apr 7. doi: 10.1038/onc.2014.94
PMCID:
PMC4212019
AbstractArticlePDF–2.1M
19.
Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate
Alexis C. Frazier-Wood, Stella Aslibekyan, Ingrid B. Borecki, Paul N. Hopkins, Chao-Qiang Lai, Jose M. Ordovas, Robert J. Straka, Hemant K. Tiwari, Donna K. Arnett
Pharmacogenet Genomics. Author manuscript; available in PMC 2013 Oct 1.
Published in final edited form as: Pharmacogenet Genomics. 2012 Oct; 22(10): 750–757. doi: 10.1097/FPC.0b013e328357f6af
PMCID:
PMC3760420
AbstractArticlePDF–723K
20.
HPRT-Deficiency Dysregulates cAMP-PKA Signaling and Phosphodiesterase 10A Expression: Mechanistic Insight and Potential Target for Lesch-Nyhan Disease?
Ghiabe-Henri Guibinga, Fiona Murray, Nikki Barron
PLoS One. 2013; 8(5): e63333. Published online 2013 May 14. doi: 10.1371/journal.pone.0063333
PMCID:
PMC3653951
AbstractArticlePDF–962K

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