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Items: 1 to 20 of 60

1.
Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD
Zhenfeng Song, Pattaraporn Thepsuwan, Woosuk Steve Hur, Mauricio Torres, Shuangcheng Alivia Wu, Xiaoqiong Wei, Nusrat Jahan Tushi, Juncheng Wei, Francesca Ferraresso, Adrienne W. Paton, James C. Paton, Ze Zheng, Kezhong Zhang, Deyu Fang, Christian J. Kastrup, Sunil Jaiman, Matthew James Flick, Shengyi Sun
Nat Commun. 2024; 15: 9244. Published online 2024 Oct 26. doi: 10.1038/s41467-024-53639-x
PMCID:
PMC11512042
AbstractArticlePDF–23M
2.
HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion
Xuzi Zhao, Deshun Liu, Yan Zhao, Zhecheng Wang, Yue Wang, Zhao Chen, Shili Ning, Guangzhi Wang, Lu Meng, Jihong Yao, Xiaofeng Tian
Cell Death Dis. 2024 Feb; 15(2): 154. Published online 2024 Feb 20. doi: 10.1038/s41419-024-06504-0
PMCID:
PMC10879504
AbstractArticlePDF–5.2M
3.
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex
Liangguang Leo Lin, Huilun Helen Wang, Brent Pederson, Xiaoqiong Wei, Mauricio Torres, You Lu, Zexin Jason Li, Xiaodan Liu, Hancheng Mao, Hui Wang, Linyao Elina Zhou, Zhen Zhao, Shengyi Sun, Ling Qi
Nat Commun. 2024; 15: 1440. Published online 2024 Feb 16. doi: 10.1038/s41467-024-45633-0
Correction in:
Nat Commun. 2024; 15: 3241.
PMCID:
PMC10873344
AbstractArticlePDF–7.3M
4.
Exogenous H2S promotes ubiquitin‐mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S‐sulfhydration
Shiwu Zhang, Mengyi Wang, Hongxia Li, Qianzhu Li, Ning Liu, Shiyun Dong, Yajun Zhao, Kemiao Pang, Jiayi Huang, Cheng Ren, Yan Wang, Zhen Tian, Fanghao Lu, Weihua Zhang
J Cachexia Sarcopenia Muscle. 2023 Dec; 14(6): 2719–2732. Published online 2023 Oct 30. doi: 10.1002/jcsm.13347
PMCID:
PMC10751422
AbstractArticlePDF–3.4M
5.
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
Bing Dai, Si Liu, Wenxin Shen, Li Chen, Qianlan Zhou, Lina Han, Qinzhen Zhang, Lishen Shan
Biol Res. 2023; 56: 64. Published online 2023 Dec 2. doi: 10.1186/s40659-023-00478-7
PMCID:
PMC10693155
AbstractArticlePDF–5.2M
6.
SYVN1 Promotes STAT3 Protein Ubiquitination and Exerts Antiangiogenesis Effects in Retinopathy of Prematurity Development
Shimei Chen, Jian Zhang, Dandan Sun, Yidong Wu, Junwei Fang, Xiaoling Wan, Shenping Li, Shuchang Zhang, Qing Gu, Qing Shao, Jun Dong, Xun Xu, Fang Wei, Qiao Sun
Invest Ophthalmol Vis Sci. 2023 Aug; 64(11): 8. Published online 2023 Aug 4. doi: 10.1167/iovs.64.11.8
PMCID:
PMC10408771
AbstractArticlePDF–8.1M
7.
Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland
Xiaohan Zhang, Crystal Young, Xiao-Hui Liao, Samuel Refetoff, Mauricio Torres, Yaron Tomer, Mihaela Stefan-Lifshitz, Hao Zhang, Dennis Larkin, Deyu Fang, Ling Qi, Peter Arvan
JCI Insight. 2023 Jun 22; 8(12): e169937. Published online 2023 Jun 22. doi: 10.1172/jci.insight.169937
PMCID:
PMC10371246
AbstractArticlePDF–18M
8.
HRD1 functions as a tumor suppressor in ovarian cancer by facilitating ubiquitination-dependent SLC7A11 degradation
Yanyan Wang, Shanfeng Wang, Wenjuan Zhang
Cell Cycle. 2023; 22(9): 1116–1126. Published online 2023 Feb 21. doi: 10.1080/15384101.2023.2178102
PMCID:
PMC10081055
AbstractArticlePDF–2.2M
9.
The effects of 4-Phenylbutyric acid on ER stress during mouse tooth development
Eui-Seon Lee, Yam Prasad Aryal, Tae-Young Kim, Elina Pokharel, Ji-Youn Kim, Hitoshi Yamamoto, Chang-Hyeon An, Seo-Young An, Jae-Kwang Jung, Youngkyun Lee, Jung-Hong Ha, Wern-Joo Sohn, Jae-Young Kim
Front Physiol. 2022; 13: 1079355. Published online 2023 Jan 4. doi: 10.3389/fphys.2022.1079355
PMCID:
PMC9848431
AbstractArticlePDF–4.4M
10.
O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development
Sanjiv Neupane, Steven J. Berardinelli, Daniel C. Cameron, Richard C. Grady, David E. Komatsu, Christopher J. Percival, Megumi Takeuchi, Atsuko Ito, Ta-Wei Liu, Alison V. Nairn, Kelley W. Moremen, Robert S. Haltiwanger, Bernadette C. Holdener
Matrix Biol. Author manuscript; available in PMC 2022 Oct 27.
Published in final edited form as: Matrix Biol. 2022 Mar; 107: 77–96. Published online 2022 Feb 12. doi: 10.1016/j.matbio.2022.02.002
PMCID:
PMC9606722
AbstractArticlePDF–6.7M
11.
SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer
Asmita Bhattacharya, Juncheng Wei, Wenxin Song, Beixue Gao, Chunyan Tian, Shuangcheng Alivia Wu, Jian Wang, Ligong Chen, Deyu Fang, Ling Qi
iScience. 2022 Oct 21; 25(10): 105183. Published online 2022 Sep 24. doi: 10.1016/j.isci.2022.105183
PMCID:
PMC9550610
AbstractArticlePDF–6.4M
12.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
13.
HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease
Juncheng Wei, Bryan T. Harada, Dan Lu, Ruihua Ma, Beixue Gao, Yanan Xu, Elena Montauti, Nikita Mani, Shuvam Chaudhuri, Shana Gregory, Samuel Weinberg, Donna Zhang, Richard Green, Chuan He, Deyu Fang
Mol Cell. Author manuscript; available in PMC 2022 Dec 16.
Published in final edited form as: Mol Cell. 2021 Dec 16; 81(24): 5052–5065.e6. Published online 2021 Nov 29. doi: 10.1016/j.molcel.2021.10.028
PMCID:
PMC8751812
AbstractArticlePDF–2.3M
14.
Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease
Sandra Franco-Iborra, Ainhoa Plaza-Zabala, Marta Montpeyo, David Sebastian, Miquel Vila, Marta Martinez-Vicente
Autophagy. 2021; 17(3): 672–689. Published online 2020 Feb 24. doi: 10.1080/15548627.2020.1728096
PMCID:
PMC8032238
AbstractArticlePDF–6.1M
15.
Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program
Hyunbae Kim, Juncheng Wei, Zhenfeng Song, Emilio Mottillo, Lobelia Samavati, Ren Zhang, Li Li, Xuequn Chen, Bhanu P. Jena, Jiandie D. Lin, Deyu Fang, Kezhong Zhang
Mol Metab. 2021 Jul; 49: 101192. Published online 2021 Feb 13. doi: 10.1016/j.molmet.2021.101192
PMCID:
PMC7966871
AbstractArticlePDF–4.5M
16.
Downregulation of XBP1 protects kidney against ischemia-reperfusion injury via suppressing HRD1-mediated NRF2 ubiquitylation
Ji Zhang, Jiasi Zhang, Haiqiang Ni, Yanfeng Wang, Gaurav Katwal, Yuanyuan Zhao, Kailun Sun, Mengqin Wang, Qingwen Li, Gen Chen, Yun Miao, Nianqiao Gong
Cell Death Discov. 2021; 7: 44. Published online 2021 Mar 2. doi: 10.1038/s41420-021-00425-z
PMCID:
PMC7925512
AbstractArticlePDF–7.3M
17.
Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression
Ya Fan, Jia Wang, Yuemei Xu, Yipin Wang, Tao Song, Xiubin Liang, Feng Jin, Dongming Su
Cell Commun Signal. 2021; 19: 18. Published online 2021 Feb 15. doi: 10.1186/s12964-020-00679-7
Correction in:
Cell Commun Signal. 2021; 19: 111.
PMCID:
PMC7883444
AbstractArticlePDF–4.9M
18.
The role of Hrd1 in ultraviolet (UV) radiation induced photoaging
Yi Jin, Xianye Cheng, Xin Huang, Fan Ding, Sae Rom Lee, Fengdi Wang, Xiaoyi Lu, Dongming Su, Bin Chen
Aging (Albany NY) 2020 Nov 15; 12(21): 21273–21289. Published online 2020 Nov 9. doi: 10.18632/aging.103851
PMCID:
PMC7695362
AbstractArticlePDF–1.7M
19.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
20.
Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling
Neha Shrestha, Tongyu Liu, Yewei Ji, Rachel B. Reinert, Mauricio Torres, Xin Li, Maria Zhang, Chih-Hang Anthony Tang, Chih-Chi Andrew Hu, Chengyang Liu, Ali Naji, Ming Liu, Jiandie D. Lin, Sander Kersten, Peter Arvan, Ling Qi
J Clin Invest. 2020 Jul 1; 130(7): 3499–3510. Published online 2020 May 26. doi: 10.1172/JCI134874
PMCID:
PMC7324191
AbstractArticlePDF–18M

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