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Select item 112041841.

REDD1 Deletion Suppresses NF-κB Signaling in Cardiomyocytes and Prevents Deficits in Cardiac Function in Diabetic Mice

Shaunaci A. Stevens, Siddharth Sunilkumar, Sandeep M. Subrahmanian, Allyson L. Toro, Omer Cavus, Efosa V. Omorogbe, Elisa A. Bradley, Michael D. Dennis

Int J Mol Sci. 2024 Jun; 25(12): 6461. Published online 2024 Jun 12. doi: 10.3390/ijms25126461

PMCID:: PMC11204184

Abstract Article PDF–3.2M

Select item 109814462.

NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β

Christopher M. McCurry, Siddharth Sunilkumar, Sandeep M. Subrahmanian, Esma I. Yerlikaya, Allyson L. Toro, Ashley M. VanCleave, Shaunaci A. Stevens, Alistair J. Barber, Jeffery M. Sundstrom, Michael D. Dennis

Invest Ophthalmol Vis Sci. 2024 Mar; 65(3): 34. Published online 2024 Mar 28. doi: 10.1167/iovs.65.3.34

PMCID:: PMC10981446

Abstract Article PDF–2.5M

Select item 104074323.

REDD1-dependent GSK3β dephosphorylation promotes NF-κB activation and macrophage infiltration in the retina of diabetic mice

Siddharth Sunilkumar, Ashley M. VanCleave, Christopher M. McCurry, Allyson L. Toro, Shaunaci A. Stevens, Scot R. Kimball, Michael D. Dennis

J Biol Chem. 2023 Aug; 299(8): 104991. Published online 2023 Jun 29. doi: 10.1016/j.jbc.2023.104991

PMCID:: PMC10407432

Abstract Article PDF–1.7M

Select item 103926974.

REDD1 deletion attenuates cancer cachexia in mice

Brian A. Hain, Haifang Xu, Ashley M. VanCleave, Bradley S. Gordon, Scot R. Kimball, David L. Waning

J Appl Physiol (1985) 2021 Dec 1; 131(6): 1718–1730. Published online 2021 Oct 21. doi: 10.1152/japplphysiol.00536.2021

PMCID:: PMC10392697

Abstract Article

Select item 98705775.

PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice

Shaunaci A. Stevens, Maria K. Gonzalez Aguiar, Allyson L. Toro, Esma I. Yerlikaya, Siddharth Sunilkumar, Ashley M. VanCleave, Jessica Pfleger, Elisa A. Bradley, Scot R. Kimball, Michael D. Dennis

Am J Physiol Endocrinol Metab. 2023 Jan 1; 324(1): E62–E72. Published online 2022 Nov 16. doi: 10.1152/ajpendo.00238.2022

PMCID:: PMC9870577

Abstract Article

Select item 97509466.

Activation of Disulfide Redox Switch in REDD1 Promotes Oxidative Stress Under Hyperglycemic Conditions

William P. Miller, Congzhou M. Sha, Siddharth Sunilkumar, Allyson L. Toro, Ashley M. VanCleave, Scot R. Kimball, Nikolay V. Dokholyan, Michael D. Dennis

Diabetes. 2022 Dec; 71(12): 2764–2776. Published online 2022 Sep 28. doi: 10.2337/db22-0355

PMCID:: PMC9750946

Abstract Article PDF–6.8M

Select item 96941147.

Stress response protein REDD1 promotes diabetes-induced retinal inflammation by sustaining canonical NF-κB signaling

Siddharth Sunilkumar, Allyson L. Toro, Christopher M. McCurry, Ashley M. VanCleave, Shaunaci A. Stevens, William P. Miller, Scot R. Kimball, Michael D. Dennis

J Biol Chem. 2022 Dec; 298(12): 102638. Published online 2022 Oct 26. doi: 10.1016/j.jbc.2022.102638

PMCID:: PMC9694114

Abstract Article PDF–2.0M

Select item 96300838.

REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice

Siddharth Sunilkumar, Esma I. Yerlikaya, Allyson L. Toro, William P. Miller, Han Chen, Kebin Hu, Scot R. Kimball, Michael D. Dennis

Diabetes. 2022 Nov; 71(11): 2412–2425. Published online 2022 Aug 19. doi: 10.2337/db22-0402

PMCID:: PMC9630083

Abstract Article PDF–14M

Select item 95880129.

REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation

Dong-Keon Lee, Taesam Kim, Junyoung Byeon, Minsik Park, Suji Kim, Joohwan Kim, Seunghwan Choi, Gihwan Lee, Chanin Park, Keun Woo Lee, Yong Jung Kwon, Jeong-Hyung Lee, Young-Guen Kwon, Young-Myeong Kim

Nat Commun. 2022; 13: 6303. Published online 2022 Oct 22. doi: 10.1038/s41467-022-34110-1

PMCID:: PMC9588012

Abstract Article PDF–3.8M

Select item 879451910.

miR-222-3p is involved in neural tube closure by directly targeting Ddit4 in RA induced NTDs mouse model

Yuqing Sun, Juan Zhang, Yufei Wang, Lei Wang, Meiyan Song, Ajab Khan, Li Zhang, Bo Niu, Hong Zhao, Meining Li, Tiane Luo, Qiwei He, Xianghui Xie, Zhizhen Liu, Jun Xie

Cell Cycle. 2021; 20(22): 2372–2386. Published online 2021 Nov 15. doi: 10.1080/15384101.2021.1982506

PMCID:: PMC8794519

Abstract Article PDF–2.2M

Select item 876229311.

Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

Satoshi Yamaguchi, Dongxiao Zhang, Akihiro Katayama, Naoko Kurooka, Ryosuke Sugawara, Haya Hamed Hassan Albuayjan, Atsuko Nakatsuka, Jun Eguchi, Jun Wada

Front Endocrinol (Lausanne) 2021; 12: 750261. Published online 2022 Jan 3. doi: 10.3389/fendo.2021.750261

PMCID:: PMC8762293

Abstract Article PDF–10M

Select item 871809212.

Loss of REDD1 prevents chemotherapy‐induced muscle atrophy and weakness in mice

Brian A. Hain, Haifang Xu, David L. Waning

J Cachexia Sarcopenia Muscle. 2021 Dec; 12(6): 1597–1612. Published online 2021 Oct 19. doi: 10.1002/jcsm.12795

PMCID:: PMC8718092

Abstract Article PDF–22M

Select item 831323913.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 823606114.

An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models

Mengyuan Niu, Li Li, Zhonglan Su, Lulu Wei, Wenyuan Pu, Chen Zhao, Yibing Ding, Junaid Wazir, Wangsen Cao, Shiyu Song, Qian Gao, Hongwei Wang

Cell Death Dis. 2021 Jul; 12(7): 652. Published online 2021 Jun 26. doi: 10.1038/s41419-021-03932-0

PMCID:: PMC8236061

Abstract Article PDF–4.8M

Select item 820287715.

Redd1 knockdown prevents doxorubicin-induced cardiac senescence

Pianpian Huang, Lijuan Bai, Lihua Liu, Jun Fu, Kefei Wu, Hongxia Liu, Yun Liu, Benming Qi, Benling Qi

Aging (Albany NY) 2021 May 31; 13(10): 13788–13806. Published online 2021 May 6. doi: 10.18632/aging.202972

PMCID:: PMC8202877

Abstract Article PDF–1.8M

Select item 810907816.

lncRNA C2dat2 facilitates autophagy and apoptosis via the miR-30d-5p/DDIT4/mTOR axis in cerebral ischemia-reperfusion injury

Qian Xu, Ma Guohui, Dandan Li, Fanghui Bai, Jintao Fang, Gui Zhang, Yuxin Xing, Jiawei Zhou, Yugang Guo, Yunchao Kan

Aging (Albany NY) 2021 Apr 30; 13(8): 11315–11335. Published online 2021 Apr 4. doi: 10.18632/aging.202824

PMCID:: PMC8109078

Abstract Article PDF–2.8M

Select item 785701717.

DDIT4 licenses only healthy cells to proliferate during injury-induced metaplasia

Zhi-Feng Miao, Jing-Xu Sun, Mahliyah Adkins-Threats, Min-Jiao Pang, Jun-Hua Zhao, Xin Wang, Kai-Wen Tang, Zhen-Ning Wang, Jason C. Mills

Gastroenterology. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: Gastroenterology. 2021 Jan; 160(1): 260–271.e10. Published online 2020 Sep 19. doi: 10.1053/j.gastro.2020.09.016

PMCID:: PMC7857017

Abstract Article PDF–4.1M

Select item 776315318.

REDD1 Is Involved in Amyloid β-Induced Synaptic Dysfunction and Memory Impairment

Jee Hyun Yi, Huiyoung Kwon, Eunbi Cho, Jieun Jeon, Jeongwon Lee, Young Choon Lee, Jong Hyun Cho, Mira Jun, Minho Moon, Jong Hoon Ryu, Ji-Su Kim, Ji Woong Choi, Se Jin Park, Seungheon Lee, Dong Hyun Kim

Int J Mol Sci. 2020 Dec; 21(24): 9482. Published online 2020 Dec 13. doi: 10.3390/ijms21249482

PMCID:: PMC7763153

Abstract Article PDF–1.8M

Select item 760676419.

A dedicated evolutionarily conserved molecular network licenses differentiated cells to return to the cell cycle

Zhi-Feng Miao, Mark A. Lewis, Charles J. Cho, Mahliyah Adkins-Threats, Dongkook Park, Jeffrey W. Brown, Jing-Xu Sun, Joseph R. Burclaff, Susan Kennedy, Jianyun Lu, Marcus Mahar, Ilja Vietor, Lukas A. Huber, Nicholas O. Davidson, Valeria Cavalli, Deborah C. Rubin, Zhen-Ning Wang, Jason C. Mills

Dev Cell. Author manuscript; available in PMC 2021 Oct 26.

Published in final edited form as: Dev Cell. 2020 Oct 26; 55(2): 178–194.e7. Published online 2020 Aug 7. doi: 10.1016/j.devcel.2020.07.005

PMCID:: PMC7606764

Abstract Article PDF–4.5M

Select item 739882720.

REDD1 (regulated in development and DNA damage 1) prevents dermal adipocyte differentiation and is required for hair cycle-dependent dermal adipose expansion

Guillermo C. Rivera-Gonzalez, Anna Klopot, Kaitlyn Sabin, Gleb Baida, Valerie Horsley, Irina Budunova

J Invest Dermatol. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: J Invest Dermatol. 2020 Sep; 140(9): 1698–1705.e1. Published online 2020 Feb 4. doi: 10.1016/j.jid.2019.12.033

PMCID:: PMC7398827

Abstract Article PDF–1.4M

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