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Items: 1 to 20 of 157

1.
A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice
David Brenner, Kirsten Sieverding, Jahnavi Srinidhi, Susanne Zellner, Christopher Secker, Rüstem Yilmaz, Julia Dyckow, Shady Amr, Anna Ponomarenko, Esra Tunaboylu, Yasmin Douahem, Joana S. Schlag, Lucía Rodríguez Martínez, Georg Kislinger, Cornelia Niemann, Karsten Nalbach, Wolfgang P. Ruf, Jonathan Uhl, Johanna Hollenbeck, Lucas Schirmer, Alberto Catanese, Christian S. Lobsiger, Karin M. Danzer, Deniz Yilmazer-Hanke, Christian Münch, Philipp Koch, Axel Freischmidt, Martina Fetting, Christian Behrends, Rosanna Parlato, Jochen H. Weishaupt
J Exp Med. 2024 May 6; 221(5): e20221190. Published online 2024 Mar 22. doi: 10.1084/jem.20221190
PMCID:
PMC10959724
AbstractArticlePDF–7.3M
2.
Ubiquitin specific protease 38 aggravates pathological cardiac remodeling by stabilizing phospho-TBK1
Zheng Xiao, Chang Dai, Tingting Yu, Jun Zhu, Yucheng Pan, Wei Shuai, Bin Kong, He Huang
Int J Biol Sci. 2024; 20(5): 1815–1832. Published online 2024 Feb 25. doi: 10.7150/ijbs.85562
PMCID:
PMC10929191
AbstractArticlePDF–16M
3.
Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response
Sarah A. Kazzaz, Kashif A. Shaikh, Jesse White, Qinjie Zhou, Wade H. Powell, Edward W. Harhaj
J Biol Chem. 2024 Jan; 300(1): 105525. Published online 2023 Dec 1. doi: 10.1016/j.jbc.2023.105525
PMCID:
PMC10792245
AbstractArticlePDF–2.8M
4.
IKKε and TBK1 prevent RIPK1 dependent and independent inflammation
Remzi Onur Eren, Göksu Gökberk Kaya, Robin Schwarzer, Manolis Pasparakis
Nat Commun. 2024; 15: 130. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44372-y
PMCID:
PMC10761900
AbstractArticlePDF–6.9M
5.
Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS
Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, Kotaro Oiwa, Mai Horiuchi, Yohei Iguchi, Okiru Komine, Akira Sobue, Masahisa Katsuno, Tomoo Ogi, Koji Yamanaka
Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47): e2315347120. Published online 2023 Nov 15. doi: 10.1073/pnas.2315347120
PMCID:
PMC10666035
AbstractArticlePDF–8.9M
6.
SARS-COV-2 protein NSP9 promotes cytokine production by targeting TBK1
Yihua Zhang, Bowen Xin, Yinan Liu, Wenyi Jiang, Wendong Han, Jian Deng, Peihui Wang, Xiaowu Hong, Dapeng Yan
Front Immunol. 2023; 14: 1211816. Published online 2023 Oct 2. doi: 10.3389/fimmu.2023.1211816
PMCID:
PMC10580797
AbstractArticlePDF–3.6M
7.
ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1
Weihong Xie, Chenqiu Zhang, Zheyu Wang, Hui Chen, Tonghui Gu, Tao Zhou, Yaoxing Wu, Fan Xia, Min Li, Jun Wang, Renjie Jiao, Jun Cui, Shouheng Jin
Autophagy. 2023; 19(11): 2853–2868. Published online 2023 Jul 11. doi: 10.1080/15548627.2023.2233846
PMCID:
PMC10549193
AbstractArticlePDF–3.0M
8.
Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma
Lizhi Pang, Madeline Dunterman, Wenjing Xuan, Annette Gonzalez, Yiyun Lin, Wen-Hao Hsu, Fatima Khan, Robert S. Hagan, William A. Muller, Amy B. Heimberger, Peiwen Chen
Cell Rep. Author manuscript; available in PMC 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Feb 28; 42(2): 112127. Published online 2023 Feb 14. doi: 10.1016/j.celrep.2023.112127
PMCID:
PMC10423747
AbstractArticlePDF–2.6M
9.
TBK1 Knockdown Alleviates Axonal Transport Deficits in Retinal Ganglion Cells Via mTORC1 Activation in a Retinal Damage Mouse Model
Meng Ye, Yuanyuan Hu, Bowen Zhao, Qianxue Mou, Yueqi Ni, Jing Luo, Lu Li, Hong Zhang, Yin Zhao
Invest Ophthalmol Vis Sci. 2023 Jul; 64(10): 1. Published online 2023 Jul 3. doi: 10.1167/iovs.64.10.1
PMCID:
PMC10324417
AbstractArticlePDF–5.1M
10.
DTX3L Enhances Type I Interferon Antiviral Response by Promoting the Ubiquitination and Phosphorylation of TBK1
Jiaqi Huang, Zhengrong Chen, Yunfei Ye, Yu Shao, Peijie Zhu, Xiaoping Li, Yu Ma, Fei Xu, Ji Zhou, Mengyun Wu, Xiu Gao, Yi Yang, Jinping Zhang, Chuangli Hao
J Virol. 2023 Jun; 97(6): e00687-23. Published online 2023 May 31. doi: 10.1128/jvi.00687-23
PMCID:
PMC10308958
AbstractArticlePDF–4.8M
11.
VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation
Zhiqiang Hu, Yingchao Xie, Jiansen Lu, Jianwu Yang, Jiahuan Zhang, Huaji Jiang, Hongyu Li, Yufeng Zhang, Dan Wu, Ke Zeng, Xiaochun Bai, Xiao Yu
Sci Adv. 2023 Jun; 9(25): eadg2339. Published online 2023 Jun 23. doi: 10.1126/sciadv.adg2339
PMCID:
PMC10289648
AbstractArticlePDF–2.6M
12.
Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration
Wei Shao, Tiffany W. Todd, Yanwei Wu, Caroline Y. Jones, Jimei Tong, Karen Jansen-West, Lillian M. Daughrity, Jinyoung Park, Yuka Koike, Aishe Kurti, Mei Yue, Monica Castanedes-Casey, Giulia del Rosso, Judith A. Dunmore, Desiree Zanetti Alepuz, Björn Oskarsson, Dennis W. Dickson, Casey N. Cook, Mercedes Prudencio, Tania F. Gendron, John D. Fryer, Yong-Jie Zhang, Leonard Petrucelli
Science. Author manuscript; available in PMC 2023 Apr 7.
Published in final edited form as: Science. 2022 Oct 7; 378(6615): 94–99. Published online 2022 Oct 6. doi: 10.1126/science.abq7860
PMCID:
PMC9942492
AbstractArticlePDF–748K
13.
SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15
Lei Li, Jialiang Luo, Zhengyumeng Zhu, Qishan Xu, Ping Wang, Bo Chang, Di Wang, Lu Yu, Xiao Lu, Jia Zhou, Daming Zuo, Qingyun Chen
Microbiol Spectr. 2022 Nov-Dec; 10(6): e02028-22. Published online 2022 Nov 7. doi: 10.1128/spectrum.02028-22
PMCID:
PMC9769732
AbstractArticlePDF–4.3M
14.
TBK1-mTOR Signaling Attenuates Obesity-Linked Hyperglycemia and Insulin Resistance
Cagri Bodur, Dubek Kazyken, Kezhen Huang, Aaron Seth Tooley, Kae Won Cho, Tammy M. Barnes, Carey N. Lumeng, Martin G. Myers, Jr., Diane C. Fingar
Diabetes. 2022 Nov; 71(11): 2297–2312. Published online 2022 Aug 19. doi: 10.2337/db22-0256
PMCID:
PMC9630091
AbstractArticlePDF–82M
15.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
16.
TBK1 Is Required for Host Defense Functions Distinct from Type I IFN Expression and Myeloid Cell Recruitment in Murine Streptococcus pneumoniae Pneumonia
Robert S. Hagan, John C. Gomez, Jose Torres-Castillo, Jessica R. Martin, Claire M. Doerschuk
Am J Respir Cell Mol Biol. 2022 Jun; 66(6): 671–681. Published online 2022 Mar 31. doi: 10.1165/rcmb.2020-0311OC
PMCID:
PMC9163639
AbstractArticlePDF–1009K
17.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
18.
Silence of TANK-binding kinase 1 (TBK1) regulates extracellular matrix degradation of chondrocyte in osteoarthritis by janus kinase (JAK)-signal transducer of activators of transcription (STAT) signaling
Peng Sun, Yuan Xue
Bioengineered. 2022; 13(1): 1872–1879. Published online 2022 Feb 7. doi: 10.1080/21655979.2021.2018976
PMCID:
PMC8973840
AbstractArticlePDF–1.2M
19.
DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis
Yanchuan Li, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y. Konopleva, Xuhong Cheng, Shao-Cong Sun
Blood. 2021 Dec 9; 138(23): 2360–2371. doi: 10.1182/blood.2021011247
PMCID:
PMC8832461
AbstractArticle
20.
Myeloid cell TBK1 restricts inflammatory responses
Tianxiao Gao, Ting Liu, Chun-Jung Ko, Lingyun Zhang, Donghyun Joo, Xiaoping Xie, Lele Zhu, Yanchuan Li, Xuhong Cheng, Shao-Cong Sun
Proc Natl Acad Sci U S A. 2022 Jan 25; 119(4): e2107742119. Published online 2022 Jan 24. doi: 10.1073/pnas.2107742119
PMCID:
PMC8794809
AbstractArticlePDF–1.6M

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