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Select item 112888521.

Protective role of the CD73-A2AR axis in cirrhotic cardiomyopathy through negative feedback regulation of the NF-κB pathway

Ning Zhao, Zhenhao Shao, Guoqing Xia, Huanhuan Liu, Lei Zhang, Xiaoxi Zhao, Shipeng Dang, Lingling Qian, Wentao Xu, Zhiming Yu, Ruxing Wang

Front Immunol. 2024; 15: 1428551. Published online 2024 Jul 17. doi: 10.3389/fimmu.2024.1428551

PMCID:: PMC11288852

Abstract Article PDF–7.4M

Select item 112863462.

Retrograde adenosine/A_2A receptor signaling facilitates excitatory synaptic transmission and seizures

Kaoutsar Nasrallah, Coralie Berthoux, Yuki Hashimotodani, Andrés E. Chávez, Michelle Gulfo, Rafael Luján, Pablo E. Castillo

Cell Rep. Author manuscript; available in PMC 2024 Jul 30.

Published in final edited form as: Cell Rep. 2024 Jul 23; 43(7): 114382. Published online 2024 Jun 19. doi: 10.1016/j.celrep.2024.114382

PMCID:: PMC11286346

Abstract Article PDF–3.8M

Select item 111893723.

Feedback facilitation by adenosine A_2A receptors of ATP release from mouse hippocampal nerve terminals

Francisco Q. Gonçalves, Pedro Valada, Marco Matos, Rodrigo A. Cunha, Angelo R. Tomé

Purinergic Signal. 2024 Jun; 20(3): 247–255. Published online 2023 Mar 31. doi: 10.1007/s11302-023-09937-y

PMCID:: PMC11189372

Abstract Article PDF–873K

Select item 111832504.

Nociceptive adenosine A_2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma

Lanxin Jiang, Ying Zhou, Shijie Tang, Dan Yang, Yixin Zhang, Jiuge Zhang, Fan Yang, Tong Zhou, Xiaoqiang Xia, Qianming Chen, Lu Jiang, Yuchen Jiang, Xiaodong Feng

Int J Oral Sci. 2024; 16: 46. Published online 2024 Jun 18. doi: 10.1038/s41368-024-00308-w

PMCID:: PMC11183250

Abstract Article PDF–2.5M

Select item 111801885.

Intra-islet α-cell Gs signaling promotes glucagon release

Liu Liu, Kimberley El, Diptadip Dattaroy, Luiz F. Barella, Yinghong Cui, Sarah M. Gray, Carla Guedikian, Min Chen, Lee S. Weinstein, Emily Knuth, Erli Jin, Matthew J. Merrins, Jeffrey Roman, Klaus H. Kaestner, Nicolai Doliba, Jonathan E. Campbell, Jürgen Wess

Nat Commun. 2024; 15: 5129. Published online 2024 Jun 15. doi: 10.1038/s41467-024-49537-x

Correction in:: Nat Commun. 2024; 15: 6383.

PMCID:: PMC11180188

Abstract Article PDF–3.0M

Select item 109884426.

Cardiovascular and respiratory evaluation in adenosine A_2A receptor knockout mice submitted to short‐term sustained hypoxia

Juliana R. Souza, Benedito H. Machado

Exp Physiol. 2023 Nov; 108(11): 1434–1445. Published online 2023 Aug 26. doi: 10.1113/EP091221

PMCID:: PMC10988442

Abstract Article PDF–1.9M

Select item 109176607.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108054708.

Inhibition of the interaction between microglial adenosine 2A receptor and NLRP3 inflammasome attenuates neuroinflammation posttraumatic brain injury

Hao Du, Chang‐Hong Li, Ruo‐Bing Gao, Yan Tan, Bo Wang, Yan Peng, Nan Yang, Ya‐Lei Ning, Ping Li, Yan Zhao, Yuan‐Guo Zhou

CNS Neurosci Ther. 2024 Jan; 30(1): e14408. Published online 2023 Aug 11. doi: 10.1111/cns.14408

PMCID:: PMC10805470

Abstract Article PDF–20M

Select item 107759509.

Targeted deletion of adenosine A₃ receptors augments adenosine-induced coronary flow in isolated mouse heart

M. A. HASSAN TALUKDER, R. RAY MORRISON, MARLENE A. JACOBSON, KENNETH A. JACOBSON, CATHERINE LEDENT, S. JAMAL MUSTAFA

Am J Physiol Heart Circ Physiol. Author manuscript; available in PMC 2024 Jan 9.

Published in final edited form as: Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6): H2183–H2189. doi: 10.1152/ajpheart.00964.2001

PMCID:: PMC10775950

Abstract Article PDF–644K

Select item 1062040310.

A_2AR eGFP reporter mouse enables elucidation of A_2AR expression dynamics during anti-tumor immune responses

Kirsten L. Todd, Junyun Lai, Kevin Sek, Yu-Kuan Huang, Dane M. Newman, Emily B. Derrick, Hui-Fern Koay, Dat Nguyen, Thang X. Hoang, Emma V. Petley, Cheok Weng Chan, Isabelle Munoz, Imran G. House, Joel N. Lee, Joelle S. Kim, Jasmine Li, Junming Tong, Maria N. de Menezes, Christina M. Scheffler, Kah Min Yap, Amanda X. Y. Chen, Phoebe A. Dunbar, Brandon Haugen, Ian A. Parish, Ricky W. Johnstone, Phillip K. Darcy, Paul A. Beavis

Nat Commun. 2023; 14: 6990. Published online 2023 Nov 1. doi: 10.1038/s41467-023-42734-0

PMCID:: PMC10620403

Abstract Article PDF–4.9M

Select item 1061433911.

Blockade of adenosine A_2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells

Qi Ji, Yang Yang, Yun Xiong, Ying-Jie Zhang, Jun Jiang, Li-Ping Zhou, Xiao-Hui Du, Chun-Xiang Wang, Zhi-Ru Zhu

Alzheimers Res Ther. 2023; 15: 187. Published online 2023 Oct 30. doi: 10.1186/s13195-023-01337-z

PMCID:: PMC10614339

Abstract Article PDF–11M

Select item 1061359612.

Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A_2A receptors

Daniela Madeira, Joana Domingues, Cátia R. Lopes, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho

Cell Mol Life Sci. 2023 Nov; 80(11): 340. Published online 2023 Oct 29. doi: 10.1007/s00018-023-04983-6

PMCID:: PMC10613596

Abstract Article PDF–3.5M

Select item 1051862713.

Adenosine A2A receptor is a tumor suppressor of NASH-associated hepatocellular carcinoma

Bertrand Allard, Célia Jacoberger-Foissac, Isabelle Cousineau, Yacine Bareche, Laurence Buisseret, Pavel Chrobak, David Allard, Sandra Pommey, Franck Ah-Pine, Sebastien Duquenne, Fabien Picard, John Stagg

Cell Rep Med. 2023 Sep 19; 4(9): 101188. Published online 2023 Sep 19. doi: 10.1016/j.xcrm.2023.101188

PMCID:: PMC10518627

Abstract Article PDF–7.0M

Select item 1045225014.

Adenosine A_2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ_1–42 to Model Early Alzheimer’s Disease

Cátia R. Lopes, António C. Silva, Henrique B. Silva, Paula M. Canas, Paula Agostinho, Rodrigo A. Cunha, João Pedro Lopes

Biomolecules. 2023 Aug; 13(8): 1173. Published online 2023 Jul 28. doi: 10.3390/biom13081173

PMCID:: PMC10452250

Abstract Article PDF–1.8M

Select item 1038209015.

Adenosine A_2A Receptor Regulates microRNA‐181b Expression in Aorta: Therapeutic Implications for Large‐Artery Stiffness

Kei Akiyoshi, Tomonari Fujimori, Xiuping Fu, Aparna P. Shah, Atsushi Yamaguchi, Charles Steenbergen, Lakshmi Santhanam, Dan Berkowitz, Eric Tuday, Jay M. Baraban, Samarjit Das

J Am Heart Assoc. 2023 Jul 18; 12(14): e028421. Published online 2023 Jul 8. doi: 10.1161/JAHA.122.028421

PMCID:: PMC10382090

Abstract Article PDF–1.7M

Select item 1004485216.

Adenosine 2A receptor contributes to the facilitation of post-infectious irritable bowel syndrome by γδ T cells via the PKA/CREB/NF-κB signaling pathway

Li-Wei Dong, Yi-Yao Chen, Chao-Chao Chen, Zhi-Chao Ma, Jiao Fu, Bai-Li Huang, Fu-Jin Liu, Dong-Chun Liang, De-Ming Sun, Cheng Lan

World J Gastroenterol. 2023 Mar 7; 29(9): 1475–1491. Published online 2023 Mar 7. doi: 10.3748/wjg.v29.i9.1475

PMCID:: PMC10044852

Abstract Article PDF–5.7M

Select item 965384017.

CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A_2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity

Ana Patrícia Simões, Francisco Q. Gonçalves, Daniel Rial, Samira G. Ferreira, João Pedro Lopes, Paula M. Canas, Rodrigo A. Cunha

Int J Mol Sci. 2022 Nov; 23(21): 12826. Published online 2022 Oct 24. doi: 10.3390/ijms232112826

PMCID:: PMC9653840

Abstract Article PDF–3.4M

Select item 945229418.

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine

Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y. Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E. Müller, Anke Tönjes, Christian Schlein, Azin Jafari, Holger K. Eltzschig, Thorsten Gnad, Matthias Blüher, Natalie Krahmer, Peter Kovacs, Joerg Heeren, Alexander Pfeifer

Nature. 2022; 609(7926): 361–368. Published online 2022 Jul 5. doi: 10.1038/s41586-022-05041-0

PMCID:: PMC9452294

Abstract Article PDF–29M

Select item 943600619.

The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

Ingmar Mederacke, Aveline Filliol, Silvia Affo, Ajay Nair, Celine Hernandez, Qiuyan Sun, Florian Hamberger, Francesco Brundu, Yu Chen, Aashreya Ravichandra, Peter Huebener, Helena Anke, Hongxue Shi, Raquel A. Martínez García de la Torre, James R. Smith, Neil C. Henderson, Florian W. R. Vondran, Carla V. Rothlin, Heike Baehre, Ira Tabas, Pau Sancho-Bru, Robert F. Schwabe

Sci Transl Med. Author manuscript; available in PMC 2022 Oct 6.

Published in final edited form as: Sci Transl Med. 2022 Apr 6; 14(639): eabe5795. Published online 2022 Apr 6. doi: 10.1126/scitranslmed.abe5795

PMCID:: PMC9436006

Abstract Article PDF–2.7M

Select item 942420820.

Adenosine A_2A receptors control synaptic remodeling in the adult brain

Xinli Xu, Rui O. Beleza, Francisco Q. Gonçalves, Sergio Valbuena, Sofia Alçada-Morais, Nélio Gonçalves, Joana Magalhães, João M. M. Rocha, Sofia Ferreira, Ana S. G. Figueira, Juan Lerma, Rodrigo A. Cunha, Ricardo J. Rodrigues, Joana M. Marques

Sci Rep. 2022; 12: 14690. Published online 2022 Aug 29. doi: 10.1038/s41598-022-18884-4

PMCID:: PMC9424208

Abstract Article PDF–12M

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