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Select item 115879321.

Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders

C. Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Berichel, Matthew D. Park, Camille Bigenwald, George R. Heaton, Pauline Hamon, Leanna Troncoso, Brooks P. Scull, Diana Dangoor, Aymeric Silvin, Ryan Fleischmann, Meriem Belabed, Howard Lin, Elias Merad Taouli, Steffen Boettcher, Long Li, Antonio Aubry, Markus G. Manz, Julia K. Kofler, Zhenyu Yue, Sergio A. Lira, Florent Ginhoux, John F. Crary, Kenneth L. McClain, Jennifer L. Picarsic, Scott J. Russo, Carl E. Allen, Miriam Merad

Immunity. Author manuscript; available in PMC 2024 Dec 12.

Published in final edited form as: Immunity. 2023 Dec 12; 56(12): 2790–2802.e6. doi: 10.1016/j.immuni.2023.11.011

PMCID:: PMC11587932

Article PDF–2.8M

Select item 115141572.

Development of a novel immunocompetent murine tumor model for urothelial carcinoma using in vivo electroporation

Stefan Soleder, Nicolas Gengenbacher, Carolin Mogler, Markus Eckstein, Anja Runge, Maximilian C. Kriegmair, Hellmut G. Augustin

Sci Rep. 2024; 14: 25619. Published online 2024 Oct 27. doi: 10.1038/s41598-024-77178-z

PMCID:: PMC11514157

Article PDF–3.7M

Select item 112985413.

Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy

Yinshen Wee, Junhua Wang, Emily C. Wilson, Coulson P. Rich, Aaron Rogers, Zongzhong Tong, Evelyn DeGroot, Y. N. Vashisht Gopal, Michael A. Davies, H. Atakan Ekiz, Joshua K. H. Tay, Chris Stubben, Kenneth M. Boucher, Juan M. Oviedo, Keke C. Fairfax, Matthew A. Williams, Sheri L. Holmen, Roger K. Wolff, Allie H. Grossmann

Nat Commun. 2024; 15: 6613. Published online 2024 Aug 4. doi: 10.1038/s41467-024-50881-1

PMCID:: PMC11298541

Article PDF–5.5M

Select item 112080454.

FAK loss reduces BRAF^V600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

Chenxi Gao, Huaibin Ge, Shih-Fan Kuan, Chunhui Cai, Xinghua Lu, Farzad Esni, Robert E Schoen, Jing H Wang, Edward Chu, Jing Hu

eLife. 2024; 13: RP94605. Published online 2024 Jun 26. doi: 10.7554/eLife.94605

PMCID:: PMC11208045

Article PDF–5.3M

Select item 111711015.

Single-Cell Profiling Reveals the Impact of Genetic Alterations on the Differentiation of Inflammation-Induced Murine Colon Tumors

Ahmed H. Ghobashi, Rosie Lanzloth, Christopher A. Ladaika, Ashiq Masood, Heather M. O’Hagan

Cancers (Basel) 2024 Jun; 16(11): 2040. Published online 2024 May 28. doi: 10.3390/cancers16112040

PMCID:: PMC11171101

Article PDF–9.3M

Select item 111287136.

Targeting miR‐31 represses tumourigenesis and dedifferentiation of BRAF^V600E‐associated thyroid carcinoma

Peitao Zhang, Lizhao Guan, Wei Sun, Yu Zhang, Yaying Du, Shukai Yuan, Xiaolong Cao, Zhengquan Yu, Qiang Jia, Xiangqian Zheng, Zhaowei Meng, Xingrui Li, Li Zhao

Clin Transl Med. 2024 May; 14(5): e1694. Published online 2024 May 26. doi: 10.1002/ctm2.1694

PMCID:: PMC11128713

Article PDF–8.1M

Select item 110961767.

Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis

Zhenlei Zhang, Yufan Wu, Jinrong Fu, Xiujie Yu, Yang Su, Shikai Jia, Huili Cheng, Yan Shen, Xianghui He, Kai Ren, Xiangqian Zheng, Haixia Guan, Feng Rao, Li Zhao

Nat Commun. 2024; 15: 4108. Published online 2024 May 15. doi: 10.1038/s41467-024-48173-9

Correction in:: Nat Commun. 2024; 15: 4936.

PMCID:: PMC11096176

Article PDF–5.7M

Select item 110298048.

Noncovalently particle-anchored cytokines with prolonged tumor retention safely elicit potent antitumor immunity

Liqian Niu, Eungyo Jang, Ai Lin Chin, Ziyu Huo, Wenbo Wang, Wenjun Cai, Rong Tong

Sci Adv. 2024 Apr 19; 10(16): eadk7695. Published online 2024 Apr 19. doi: 10.1126/sciadv.adk7695

PMCID:: PMC11029804

Article PDF–6.9M

Select item 108693579.

Tissue-location-specific transcription programs drive tumor dependencies in colon cancer

Lijing Yang, Lei Tu, Shilpa Bisht, Yiqing Mao, Daniel Petkovich, Sara-Jayne Thursby, Jinxiao Liang, Nibedita Patel, Ray-Whay Chiu Yen, Tina Largent, Cynthia Zahnow, Malcolm Brock, Kathy Gabrielson, Kevan J. Salimian, Stephen B. Baylin, Hariharan Easwaran

Nat Commun. 2024; 15: 1384. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45605-4

PMCID:: PMC10869357

Article PDF–10M

Select item 1079742610.

HSPA8 Activates Wnt/β‐Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA‐Mediated CAV1 Degradation

Bowen Li, Hui Ming, Siyuan Qin, Li Zhou, Zhao Huang, Ping Jin, Liyuan Peng, Maochao Luo, Tingting Zhang, Kui Wang, Rui Liu, Yih‐Cherng Liou, Edouard C. Nice, Jingwen Jiang, Canhua Huang

Adv Sci (Weinh) 2024 Jan; 11(3): 2306535. Published online 2023 Nov 16. doi: 10.1002/advs.202306535

PMCID:: PMC10797426

Article PDF–6.3M

Select item 1078672311.

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids

Hélène Lasolle, Andrea Schiavo, Adrien Tourneur, Pierre Gillotay, Bárbara de Faria da Fonseca, Lucieli Ceolin, Olivier Monestier, Benilda Aganahi, Laura Chomette, Marina Malta Letro Kizys, Lieven Haenebalcke, Tim Pieters, Steven Goossens, Jody Haigh, Vincent Detours, Ana Luiza Silva Maia, Sabine Costagliola, Mírian Romitti

Oncogene. 2024; 43(3): 155–170. Published online 2023 Nov 20. doi: 10.1038/s41388-023-02889-y

PMCID:: PMC10786723

Article PDF–14M

Select item 1077189112.

BRAF^V600E mutation and DSS treatment synergize to induce cecal tumor formation in mice

Chenxi Gao, Farzad Esni, Edward Chu, Jing Hu

Biochem Biophys Rep. 2024 Mar; 37: 101634. Published online 2024 Jan 1. doi: 10.1016/j.bbrep.2023.101634

PMCID:: PMC10771891

Article PDF–6.0M

Select item 1074039113.

Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis

Nneoma Adaku, Benjamin N. Ostendorf, Wenbin Mei, Sohail F. Tavazoie

Cancer Res. Author manuscript; available in PMC 2023 Dec 22.

Published in final edited form as: Cancer Res. 2023 Sep 15; 83(18): 3013–3025. doi: 10.1158/0008-5472.CAN-23-1252

PMCID:: PMC10740391

Article PDF–1.7M

Select item 1058575014.

BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8⁺ T cell infiltration in colorectal cancer

Wenjing Li, Chenyi Zhao, Wenhui Li, Yang Gong, Kaili Ma, Yujie Lu, Xiaowei Liu, Lianjun Zhang, Feng Guo

J Transl Med. 2023; 21: 737. Published online 2023 Oct 18. doi: 10.1186/s12967-023-04606-5

PMCID:: PMC10585750

Article PDF–16M

Select item 1057578115.

GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation

Koei Shinzawa, Shinji Matsumoto, Ryota Sada, Akikazu Harada, Kaori Saitoh, Keiko Kato, Satsuki Ikeda, Akiyoshi Hirayama, Kazunori Yokoi, Atsushi Tanemura, Keisuke Nimura, Masahito Ikawa, Tomoyoshi Soga, Akira Kikuchi

Oncogene. 2023; 42(42): 3142–3156. Published online 2023 Sep 1. doi: 10.1038/s41388-023-02803-6

PMCID:: PMC10575781

Article PDF–5.0M

Select item 1057032316.

Oncogenic context shapes the fitness landscape of tumor suppression

Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters

Nat Commun. 2023; 14: 6422. Published online 2023 Oct 12. doi: 10.1038/s41467-023-42156-y

PMCID:: PMC10570323

Article PDF–6.1M

Select item 1052119517.

Multiplexed screens identify RAS paralogs HRAS and NRAS as suppressors of KRAS-driven lung cancer growth

Rui Tang, Emily G. Shuldiner, Marcus Kelly, Christopher W. Murray, Jess D. Hebert, Laura Andrejka, Min K. Tsai, Nicholas W. Hughes, Mitchell I Parker, Hongchen Cai, Yao-Cheng Li, Geoffrey M. Wahl, Roland L Dunbrack, Peter K. Jackson, Dmitri A. Petrov, Monte M. Winslow

Nat Cell Biol. Author manuscript; available in PMC 2023 Sep 26.

Published in final edited form as: Nat Cell Biol. 2023 Jan; 25(1): 159–169. Published online 2023 Jan 12. doi: 10.1038/s41556-022-01049-w

PMCID:: PMC10521195

Article PDF–6.8M

Select item 1051433218.

BRAF^V600E-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism

Paulina Rzasa, Sarah Whelan, Pooyeh Farahmand, Hong Cai, Inna Guterman, Raquel Palacios-Gallego, Shanthi S. Undru, Lauren Sandford, Caleb Green, Catherine Andreadi, Maria Mintseva, Emma Parrott, Hong Jin, Fiona Hey, Susan Giblett, Nicolas B. Sylvius, Natalie S. Allcock, Anna Straatman-Iwanowska, Roberto Feuda, Cristina Tufarelli, Karen Brown, Catrin Pritchard, Alessandro Rufini

Commun Biol. 2023; 6: 962. Published online 2023 Sep 21. doi: 10.1038/s42003-023-05331-x

PMCID:: PMC10514332

Article PDF–4.5M

Select item 1047396119.

Microenvironmental Snail1-induced immunosuppression promotes melanoma growth

Marta Arumi-Planas, Francisco Javier Rodriguez-Baena, Francisco Cabello-Torres, Francisco Gracia, Cristina Lopez-Blau, M. Angela Nieto, Berta Sanchez-Laorden

Oncogene. 2023; 42(36): 2659–2672. Published online 2023 Jul 29. doi: 10.1038/s41388-023-02793-5

PMCID:: PMC10473961

Article PDF–3.9M

Select item 1046813720.

TERT accelerates BRAF mutant–induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis

Pengcheng Yu, Ning Qu, Rui Zhu, Jiaqian Hu, Peizhen Han, Jiahao Wu, Licheng Tan, Hualei Gan, Cong He, Chuantao Fang, Yubin Lei, Jian Li, Chenxi He, Fei Lan, Xiao Shi, Wenjun Wei, Yu Wang, Qinghai Ji, Fa-Xing Yu, Yu-Long Wang

Sci Adv. 2023 Sep; 9(35): eadg7125. Published online 2023 Aug 30. doi: 10.1126/sciadv.adg7125

PMCID:: PMC10468137

Article PDF–3.1M

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