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Items: 1 to 20 of 245

1.
Sexually dimorphic renal expression of mouse Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b
Jakub Jankowski, Hye Kyung Lee, Chengyu Liu, Julia Wilflingseder, Lothar Hennighausen
Commun Biol. 2024; 7: 1142. Published online 2024 Sep 14. doi: 10.1038/s42003-024-06855-6
PMCID:
PMC11401919
AbstractArticlePDF–2.2M
2.
Inhibition of EZH2 Reduces Aging-Related Decline in Interstitial Cells of Cajal of the Mouse Stomach
Negar Taheri, Egan L. Choi, Vy Truong Thuy Nguyen, Yuebo Zhang, Nick M. Huynh, Todd A. Kellogg, Andre J. van Wijnen, Tamas Ordog, Yujiro Hayashi
Cell Mol Gastroenterol Hepatol. 2024; 18(4): 101376. Published online 2024 Jul 3. doi: 10.1016/j.jcmgh.2024.101376
PMCID:
PMC11359770
AbstractArticlePDF–5.3M
3.
Knockout of the longevity gene Klotho perturbs aging and Alzheimer’s disease-linked brain microRNAs and tRNA fragments
Serafima Dubnov, Estelle R. Bennett, Nadav Yayon, Or Yakov, David A. Bennett, Sudha Seshadri, Elliott Mufson, Yonat Tzur, David Greenberg, Makoto Kuro-o, Iddo Paldor, Carmela R. Abraham, Hermona Soreq
Commun Biol. 2024; 7: 720. Published online 2024 Jun 11. doi: 10.1038/s42003-024-06407-y
PMCID:
PMC11166644
AbstractArticlePDF–2.8M
4.
Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases
R. Nagai*, Y. Saito, Y. Ohyama, H. Aizawa, T. Suga, T. Nakamura, M. Kurabayashi, M. Kuro-o
Cell Mol Life Sci. 2000 May; 57(5): 738–746. doi: 10.1007/s000180050038
PMCID:
PMC11147118
AbstractPDF–289K
5.
Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse
H. Kawaguchi*, N. Manabe, H. Chikuda, K. Nakamura, M. Kuro-o
Cell Mol Life Sci. 2000 May; 57(5): 731–737. doi: 10.1007/s000180050037
PMCID:
PMC11146784
AbstractPDF–1.6M
6.
ABI3BP promotes renal aging through Klotho-mediated ferroptosis
Ren Ji, Lin Wei, Yuxin Zan, Xiao Li, Shinan Ma, Liming Ma, Xiju He, Li Wang, Yan Ding
J Transl Med. 2024; 22: 514. Published online 2024 May 29. doi: 10.1186/s12967-024-05300-w
PMCID:
PMC11134664
AbstractArticlePDF–2.2M
7.
Klotho is highly expressed in the chief sites of regulated potassium secretion, and it is stimulated by potassium intake
Hyun Jun Jung, Truyen D. Pham, Xiao-Tong Su, Teodora Veronica Grigore, Joost G. Hoenderop, Hannes Olauson, Susan M. Wall, David H. Ellison, Paul A. Welling, Lama Al-Qusairi
Sci Rep. 2024; 14: 10740. Published online 2024 May 10. doi: 10.1038/s41598-024-61481-w
PMCID:
PMC11087591
AbstractArticlePDF–5.9M
8.
Zona Glomerulosa–Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice
Arezoo Daryadel, Cong Tang, Ye Xie, Mirko Peitzsch, Viktoria Fisi, Constanze Hantel, Dominique Loffing-Cueni, David T Breault, David Penton, Johannes Loffing, Felix Beuschlein
Endocrinology. 2024 May; 165(5): bqae040. Published online 2024 Apr 4. doi: 10.1210/endocr/bqae040
PMCID:
PMC11002783
AbstractArticle
9.
Absence of the Klotho Function Causes Cornea Degeneration with Specific Features Resembling Fuchs Endothelial Corneal Dystrophy and Bullous Keratopathy
Chun-Yen Wu, Da-Fong Song, Zhi-Jia Chen, Chao-Sheng Hu, David Pei-Cheng Lin, Han-Hsin Chang
Biology (Basel) 2024 Mar; 13(3): 133. Published online 2024 Feb 20. doi: 10.3390/biology13030133
PMCID:
PMC10968125
AbstractArticlePDF–12M
10.
Relationship of the bone phenotype of the Klotho mutant mouse model of accelerated aging to changes in skeletal architecture that occur with chronological aging
Lieve Verlinden, Shanshan Li, Vaishali Veldurthy, Geert Carmeliet, Sylvia Christakos
Front Endocrinol (Lausanne) 2024; 15: 1310466. Published online 2024 Jan 30. doi: 10.3389/fendo.2024.1310466
PMCID:
PMC10861770
AbstractArticlePDF–1.9M
11.
Klotho regulates the myogenic response of muscle to mechanical loading and exercise
Eisuke Ochi, Alice Barrington, Michelle Wehling‐Henricks, Marcus Avila, Makoto Kuro‐o, James G. Tidball
Exp Physiol. 2023 Dec; 108(12): 1531–1547. Published online 2023 Oct 20. doi: 10.1113/EP091263
PMCID:
PMC10841225
AbstractArticlePDF–1.8M
12.
Klotho-derived peptide KP1 ameliorates SARS-CoV-2-associated acute kidney injury
Jie Xu, Enqing Lin, Xue Hong, Li Li, Jun Gu, Jinghong Zhao, Youhua Liu
Front Pharmacol. 2023; 14: 1333389. Published online 2024 Jan 3. doi: 10.3389/fphar.2023.1333389
PMCID:
PMC10795167
AbstractArticlePDF–5.1M
13.
Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulation
Xiaoyao Zhang, Li Li, Huishi Tan, Xue Hong, Qian Yuan, Fan Fan Hou, Lili Zhou, Youhua Liu
Theranostics. 2024; 14(1): 420–435. Published online 2024 Jan 1. doi: 10.7150/thno.89105
PMCID:
PMC10750200
AbstractArticlePDF–11M
14.
Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease
Wei Jiang, Chun Gan, Xindi Zhou, Qing Yang, Dan Chen, Han Xiao, Lujun Dai, Yaxi Chen, Mo Wang, Haiping Yang, Qiu Li
Cardiovasc Diabetol. 2023; 22: 293. Published online 2023 Oct 27. doi: 10.1186/s12933-023-02025-w
PMCID:
PMC10612302
AbstractArticlePDF–6.4M
15.
Klotho Null Mutation Indirectly Leads to Age-Related Lacrimal Gland Degeneration in Mutant Mice
Chun-Yen Wu, Da-Fong Song, Tsung-Han Lu, Zhi-Jia Chen, Su-Min Tsai, Ya-Jing Liu, Han-Hsin Chang, David Pei-Cheng Lin
Biology (Basel) 2023 Oct; 12(10): 1328. Published online 2023 Oct 11. doi: 10.3390/biology12101328
PMCID:
PMC10604155
AbstractArticlePDF–4.2M
16.
Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis
Ya-Yun Wang, Ying-Hung Lin, Vin-Cent Wu, Yu-Hua Lin, Chia-Yen Huang, Wei-Chi Ku, Chiao-Yin Sun
Antioxidants (Basel) 2023 Sep; 12(9): 1671. Published online 2023 Aug 25. doi: 10.3390/antiox12091671
PMCID:
PMC10526093
AbstractArticlePDF–8.9M
17.
Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice
Cana Park, Oliver Hahn, Shweta Gupta, Arturo J. Moreno, Francesca Marino, Blen Kedir, Dan Wang, Saul A. Villeda, Tony Wyss-Coray, Dena B. Dubal
Nat Aging. 2023; 3(9): 1067–1078. Published online 2023 Aug 16. doi: 10.1038/s43587-023-00468-0
PMCID:
PMC10501899
AbstractArticlePDF–9.2M
18.
Klotho increases antioxidant defenses in astrocytes and ubiquitin–proteasome activity in neurons
Ana Maria Orellana, Caio Henrique Mazucanti, Leticia Pavan dos Anjos, Larissa de Sá Lima, Elisa Mitiko Kawamoto, Cristoforo Scavone
Sci Rep. 2023; 13: 15080. Published online 2023 Sep 12. doi: 10.1038/s41598-023-41166-6
PMCID:
PMC10497516
AbstractArticlePDF–1.8M
19.
Extracellular Vesicles in Young Serum Contribute to the Restoration of Age-Related Brain Transcriptomes and Cognition in Old Mice
Nicholas F. Fitz, Amrita Sahu, Yi Lu, Fabrisia Ambrosio, Iliya Lefterov, Radosveta Koldamova
Int J Mol Sci. 2023 Aug; 24(16): 12550. Published online 2023 Aug 8. doi: 10.3390/ijms241612550
PMCID:
PMC10454174
AbstractArticlePDF–3.7M
20.
Insulin-Like Growth Factor1 Preserves Gastric Pacemaker Cells and Motor Function in Aging via ERK1/2 Activation
Vy Truong Thuy Nguyen, Negar Taheri, Egan L. Choi, Todd A. Kellogg, David R. Linden, Yujiro Hayashi
Cell Mol Gastroenterol Hepatol. 2023; 16(3): 369–383. Published online 2023 Jun 8. doi: 10.1016/j.jcmgh.2023.06.002
PMCID:
PMC10372898
AbstractArticlePDF–4.0M

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