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Select item 111788421.

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics

Ken Hashimoto, Momoko Ohira, Aya Kodama, Misaki Kimoto, Mariko Inoue, Shigenobu Toné, Yuu Usui, Akira Hanashima, Takato Goto, Yuhei Ogura, Yoshihiro Ujihara, Satoshi Mohri

Sci Rep. 2024; 14: 13727. Published online 2024 Jun 14. doi: 10.1038/s41598-024-64608-1

PMCID:: PMC11178842

Abstract Article PDF–5.4M

Select item 110226832.

An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor

Oscar E. Reyes Gaido, Nikoleta Pavlaki, Jonathan M. Granger, Olurotimi O. Mesubi, Bian Liu, Brian L. Lin, Alan Long, David Walker, Joshua Mayourian, Kate L. Schole, Chantelle E. Terrillion, Lubika J. Nkashama, Mohit M. Hulsurkar, Lauren E. Dorn, Kimberly M. Ferrero, Richard L. Huganir, Frank U. Müller, Xander H. T. Wehrens, Jun O. Liu, Elizabeth D. Luczak, Vassilios J. Bezzerides, Mark E. Anderson

Sci Transl Med. Author manuscript; available in PMC 2024 Apr 17.

Published in final edited form as: Sci Transl Med. 2023 Jun 21; 15(701): eabq7839. Published online 2023 Jun 21. doi: 10.1126/scitranslmed.abq7839

PMCID:: PMC11022683

Abstract Article PDF–2.2M

Select item 109535653.

Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes

Changzhu Li, Yang Zhang, Jingling Shen, Hairong Bao, Yue Zhao, Desheng Li, Sijia Li, Yining Liu, Jiming Yang, Zhiwen Zhou, Kangyi Gao, Lexin Zhao, Yao Pei, Yanjie Lu, Zhenwei Pan, Benzhi Cai

Adv Sci (Weinh) 2024 Mar; 11(11): 2305992. Published online 2024 Jan 9. doi: 10.1002/advs.202305992

PMCID:: PMC10953565

Abstract Article PDF–5.8M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109130195.

Whole-exome sequencing in familial type 2 diabetes identifies an atypical missense variant in the RyR2 gene

Vikas Bansal, Bernhard R. Winkelmann, Johannes W. Dietrich, Bernhard O. Boehm

Front Endocrinol (Lausanne) 2024; 15: 1258982. Published online 2024 Feb 20. doi: 10.3389/fendo.2024.1258982

PMCID:: PMC10913019

Abstract Article PDF–591K

Select item 108838516.

Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers

Parisa Asghari, David R.L. Scriven, Saba Shahrasebi, Hector H. Valdivia, Katherina M. Alsina, Carmen R. Valdivia, J. Alberto Navarro-Garcia, Xander H.T. Wehrens, Edwin D.W. Moore

J Gen Physiol. 2024 Apr 1; 156(4): e202213108. Published online 2024 Feb 22. doi: 10.1085/jgp.202213108

PMCID:: PMC10883851

Abstract Article PDF–5.1M

Select item 107211467.

Foxp3-mediated blockage of ryanodine receptor 2 underlies contact-based suppression by regulatory T cells

Xiaobo Wang, Shuang Geng, Junchen Meng, Ning Kang, Xinyi Liu, Yanni Xu, Huiyun Lyu, Ying Xu, Xun Xu, Xinrong Song, Bin Zhang, Xin Wang, Nuerdida Nuerbulati, Ze Zhang, Di Zhai, Xin Mao, Ruya Sun, Xiaoting Wang, Ruiwu Wang, Jie Guo, S.R. Wayne Chen, Xuyu Zhou, Tie Xia, Hai Qi, Xiaoyu Hu, Yan Shi

J Clin Invest. 2023 Dec 15; 133(24): e163470. Published online 2023 Dec 15. doi: 10.1172/JCI163470

PMCID:: PMC10721146

Abstract Article PDF–1.5M

Select item 106819108.

A dual-targeted drug inhibits cardiac ryanodine receptor Ca²⁺ leak but activates SERCA2a Ca²⁺ uptake

Jörg W Wegener, Gyuzel Y Mitronova, Lina ElShareif, Christine Quentin, Vladimir Belov, Tatiana Pochechueva, Gerd Hasenfuss, Lutz Ackermann, Stephan E Lehnart

Life Sci Alliance. 2024 Feb; 7(2): e202302278. Published online 2023 Nov 27. doi: 10.26508/lsa.202302278

PMCID:: PMC10681910

Abstract Article PDF–2.8M

Select item 104004329.

Heart failure-induced cognitive dysfunction is mediated by intracellular Ca²⁺ leak through ryanodine receptor type 2

Haikel Dridi, Yang Liu, Steven Reiken, Xiaoping Liu, Elentina K. Argyrousi, Qi Yuan, Marco C. Miotto, Leah Sittenfeld, Andrei Meddar, Rajesh Kumar Soni, Ottavio Arancio, Alain Lacampagne, Andrew R. Marks

Nat Neurosci. 2023; 26(8): 1365–1378. Published online 2023 Jul 10. doi: 10.1038/s41593-023-01377-6

PMCID:: PMC10400432

Abstract Article PDF–18M

Select item 1023330510.

Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation

Yuxuan Guo, Yangpo Cao, Blake D Jardin, Xiaoran Zhang, Pingzhu Zhou, Silvia Guatimosim, Junsen Lin, Zhan Chen, Yueyang Zhang, Neil Mazumdar, Fujian Lu, Qing Ma, Yao-Wei Lu, Mingming Zhao, Da-Zhi Wang, Erdan Dong, William T Pu

Cardiovasc Res. 2023 Jan; 119(1): 221–235. Published online 2022 May 16. doi: 10.1093/cvr/cvac077

PMCID:: PMC10233305

Abstract Article PDF–2.0M

Select item 998757211.

A Gating Mutation in Ryanodine Receptor Type 2 Rescues Phenotypes of Alzheimer’s Disease Mouse Models by Upregulating Neuronal Autophagy

Hua Zhang, Caitlynn Knight, S.R. Wayne Chen, Ilya Bezprozvanny

J Neurosci. 2023 Feb 22; 43(8): 1441–1454. doi: 10.1523/JNEUROSCI.1820-22.2022

PMCID:: PMC9987572

Abstract Article PDF–3.1M

Select item 985651512.

Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease

Arpita Deb, Brian D. Tow, You Qing, Madelyn Walker, Emmanuel R. Hodges, James A. Stewart, Jr., Björn C. Knollmann, Yi Zheng, Ying Wang, Bin Liu

Cells. 2023 Jan; 12(2): 204. Published online 2023 Jan 4. doi: 10.3390/cells12020204

PMCID:: PMC9856515

Abstract Article PDF–3.8M

Select item 963615013.

Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function

Yinuo Wang, Adel Elsherbiny, Linda Kessler, Julio Cordero, Haojie Shi, Heike Serke, Olga Lityagina, Felix A. Trogisch, Mona Malek Mohammadi, Ibrahim El-Battrawy, Johannes Backs, Thomas Wieland, Joerg Heineke, Gergana Dobreva

Nat Commun. 2022; 13: 6663. Published online 2022 Nov 4. doi: 10.1038/s41467-022-34366-7

PMCID:: PMC9636150

Abstract Article PDF–8.9M

Select item 944076314.

Nebivolol Suppresses Cardiac Ryanodine Receptor Mediated Spontaneous Ca²⁺ Release and Catecholaminergic Polymorphic Ventricular Tachycardia

Zhen Tan, Zhichao Xiao, Jinhong Wei, Jingqun Zhang, Qiang Zhou, Chris D. Smith, Alma Nani, Guogen Wu, Long-Sheng Song, Thomas G. Back, Michael Fill, S.R. Wayne Chen

Biochem J. Author manuscript; available in PMC 2022 Sep 3.

Published in final edited form as: Biochem J. 2016 Nov 15; 473(22): 4159–4172. Published online 2016 Sep 13. doi: 10.1042/BCJ20160620

PMCID:: PMC9440763

Abstract Article PDF–2.5M

Select item 941070915.

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

Xin Shen, Jonas van den Brink, Anna Bergan-Dahl, Terje R Kolstad, Einar S Norden, Yufeng Hou, Martin Laasmaa, Yuriana Aguilar-Sanchez, Ann P Quick, Emil KS Espe, Ivar Sjaastad, Xander HT Wehrens, Andrew G Edwards, Christian Soeller, William E Louch

eLife. 2022; 11: e77725. Published online 2022 Aug 1. doi: 10.7554/eLife.77725

PMCID:: PMC9410709

Abstract Article PDF–16M

Select item 911673516.

RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development

Peiheng Gan, Zhaoning Wang, Maria Gabriela Morales, Yu Zhang, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson

Dev Cell. Author manuscript; available in PMC 2023 Apr 25.

Published in final edited form as: Dev Cell. 2022 Apr 25; 57(8): 959–973.e7. doi: 10.1016/j.devcel.2022.03.017

PMCID:: PMC9116735

Abstract Article PDF–3.1M

Select item 902352417.

CMYA5 establishes cardiac dyad architecture and positioning

Fujian Lu, Qing Ma, Wenjun Xie, Carter L. Liou, Donghui Zhang, Mason E. Sweat, Blake D. Jardin, Francisco J. Naya, Yuxuan Guo, Heping Cheng, William T. Pu

Nat Commun. 2022; 13: 2185. Published online 2022 Apr 21. doi: 10.1038/s41467-022-29902-4

PMCID:: PMC9023524

Abstract Article PDF–4.2M

Select item 899637418.

The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca²⁺ and Mg²⁺

Abigail D. Wilson, Jianshu Hu, Charalampos Sigalas, Elisa Venturi, Héctor H. Valdivia, Carmen R. Valdivia, Ming Lei, Maria Musgaard, Rebecca Sitsapesan

J Physiol. Author manuscript; available in PMC 2022 Apr 11.

Published in final edited form as: J Physiol. 2021 Dec; 599(23): 5179–5201. Published online 2021 Nov 9. doi: 10.1113/JP281707

PMCID:: PMC8996374

Abstract Article PDF–4.1M

Select item 888858819.

Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory

Florian Hiess, Jinjing Yao, Zhenpeng Song, Bo Sun, Zizhen Zhang, Junting Huang, Lina Chen, Adam Institoris, John Paul Estillore, Ruiwu Wang, Henk E. D. J. ter Keurs, Peter K. Stys, Grant R. Gordon, Gerald W. Zamponi, Anutosh Ganguly, S. R. Wayne Chen

Commun Biol. 2022; 5: 183. Published online 2022 Mar 1. doi: 10.1038/s42003-022-03124-2

PMCID:: PMC8888588

Abstract Article PDF–27M

Select item 869626220.

The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool

Jörg W. Wegener, Ahmed Wagdi, Eva Wagner, Dörthe M. Katschinski, Gerd Hasenfuss, Tobias Bruegmann, Stephan E. Lehnart

Front Physiol. 2021; 12: 777770. Published online 2021 Dec 9. doi: 10.3389/fphys.2021.777770

PMCID:: PMC8696262

Abstract Article PDF–13M

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