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Select item 114982251.

Acute contact with profibrotic macrophages mechanically activates fibroblasts via αvβ3 integrin–mediated engagement of Piezo1

Maya Ezzo, Katrin Spindler, Jun Bo Wang, Dahea Lee, Gilbert Pecoraro, Justin Cowen, Pardis Pakshir, Boris Hinz

Sci Adv. 2024 Oct 25; 10(43): eadp4726. Published online 2024 Oct 23. doi: 10.1126/sciadv.adp4726

PMCID:: PMC11498225

Abstract Article PDF–16M

Select item 113945372.

The Role of αvβ3 Integrin in Lamina Cribrosa Cell Mechanotransduction in Glaucoma

Mustapha Irnaten, Ellen Gaynor, Colm O’Brien

Cells. 2024 Sep; 13(17): 1487. Published online 2024 Sep 5. doi: 10.3390/cells13171487

PMCID:: PMC11394537

Abstract Article PDF–2.1M

Select item 113546413.

Targeting ITGβ3 to Overcome Trastuzumab Resistance through Epithelial–Mesenchymal Transition Regulation in HER2-Positive Breast Cancer

Asiye Busra Boz Er, Idris Er

Int J Mol Sci. 2024 Aug; 25(16): 8640. Published online 2024 Aug 8. doi: 10.3390/ijms25168640

PMCID:: PMC11354641

Abstract Article PDF–3.7M

Select item 113390324.

Role of TSP-1 and its receptor ITGB3 in the renal tubulointerstitial injury of focal segmental glomerulosclerosis

Yun Fan, Shihui Dong, Yuanyuan Xia, Xue Yang, Qunjuan Lei, Feng Xu, Dandan Liang, Shaoshan Liang, Mingchao Zhang, Fan Yang, Yan Jing, Lijuan Li, Xiaodong Zhu, Hao Bao, Zhaohong Chen, Caihong Zeng

J Biol Chem. 2024 Aug; 300(8): 107516. Published online 2024 Jul 1. doi: 10.1016/j.jbc.2024.107516

PMCID:: PMC11339032

Abstract Article PDF–6.6M

Select item 112379305.

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein

Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo

J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390

PMCID:: PMC11237930

Abstract Article PDF–3.8M

Select item 111584946.

Up‐regulation of integrin β3 in radioresistant pancreatic cancer impairs adenovirus‐mediated gene therapy

Takuya Egami, Kenoki Ohuchida, Takaharu Yasui, Kazuhiro Mizumoto, Manabu Onimaru, Hiroki Toma, Norihiro Sato, Kunio Matsumoto, Masao Tanaka

Cancer Sci. 2009 Oct; 100(10): 1902–1907. Published online 2009 Jun 17. doi: 10.1111/j.1349-7006.2009.01245.x

PMCID:: PMC11158494

Abstract Article PDF–2.1M

Select item 110960687.

Integrin αvβ3 upregulation in response to nutrient stress promotes lung cancer cell metabolic plasticity

Arin Nam, Shashi Jain, Chengsheng Wu, Alejandro Campos, Ryan M. Shepard, Ziqi Yu, Joshua P. Reddy, Tami Von Schalscha, Sara M. Weis, Mark Onaitis, Hiromi I. Wettersten, David A. Cheresh

Cancer Res. Author manuscript; available in PMC 2024 Nov 15.

Published in final edited form as: Cancer Res. 2024 May 15; 84(10): 1630–1642. doi: 10.1158/0008-5472.CAN-23-2700

PMCID:: PMC11096068

Abstract Article PDF–2.4M

Select item 110656948.

Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity

Megat H. B. A. Hamid, Pablo F. Cespedes, Chen Jin, Ji-Li Chen, Uzi Gileadi, Elie Antoun, Zhu Liang, Fei Gao, Renuka Teague, Nikita Manoharan, David Maldonado-Perez, Nasullah Khalid-Alham, Lucia Cerundolo, Raul Ciaoca, Svenja S. Hester, Adán Pinto-Fernández, Simeon D. Draganov, Iolanda Vendrell, Guihai Liu, Xuan Yao, Audun Kvalvaag, Delaney C. C. Dominey-Foy, Charunya Nanayakkara, Nikolaos Kanellakis, Yi-Ling Chen, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Najib M. Rahman, Clare Verrill, Benedikt M. Kessler, Graham Ogg, Ricardo A. Fernandes, Roman Fisher, Yanchun Peng, Michael L. Dustin, Tao Dong

Nat Immunol. 2024; 25(5): 834–846. Published online 2024 Apr 1. doi: 10.1038/s41590-024-01802-3

PMCID:: PMC11065694

Abstract Article PDF–24M

Select item 109424679.

Mitochondrial Raf1 Regulates Glutamine Catabolism

Ronald L. Shanderson, Ian D. Ferguson, Zurab Siprashvili, Luca Ducoli, Albert M. Li, Weili Miao, Suhas Srinivasan, Mary Grace Velasco, Yang Li, Jiangbin Ye, Paul A. Khavari

Version 1. bioRxiv. Preprint. 2024 Mar 9. doi: 10.1101/2024.03.08.581297

PMCID:: PMC10942467

Abstract Article PDF–6.5M

Select item 1091686610.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 1070227311.

Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance

William Echavidre, Jérôme Durivault, Célia Gotorbe, Thays Blanchard, Marina Pagnuzzi, Valérie Vial, Florian Raes, Alexis Broisat, Rémy Villeneuve, Régis Amblard, Nicolas Garnier, Cécile Ortholan, Marc Faraggi, Benjamin Serrano, Vincent Picco, Christopher Montemagno

Cancer Res Commun. 2023 Dec; 3(12): 2483–2496. Published online 2023 Dec 7. doi: 10.1158/2767-9764.CRC-23-0298

PMCID:: PMC10702273

Abstract Article PDF–16M

Select item 1033821112.

A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia

Sevasti B. Koukouritaki, Aye Myat M. Thinn, Katrina J. Ashworth, Juan Fang, Haley S. Slater, Lily M. Du, Huong Thi Thu Nguyen, Xavier Pillois, Alan T. Nurden, Christopher J. Ng, Jorge Di Paola, Jieqing Zhu, David A. Wilcox

Blood Adv. 2023 Jul 11; 7(13): 3180–3191. Published online 2023 Mar 11. doi: 10.1182/bloodadvances.2022009495

PMCID:: PMC10338211

Abstract Article PDF–2.3M

Select item 1024444513.

Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3

Jeevan B. Gc, Justin Chen, Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Peter Obi, Paul Panipinto, Smarajit Bandyopadhyay, Santanu Bose, Senthil Natesan

Sci Rep. 2023; 13: 9166. Published online 2023 Jun 6. doi: 10.1038/s41598-023-36040-4

PMCID:: PMC10244445

Abstract Article PDF–2.6M

Select item 1013436214.

ITGB3 promotes cisplatin resistance in osteosarcoma tumors

Qian Li, Guangyou Chen, Huachai Jiang, Haoping Dai, Dongdong Li, Kai Zhu, Kaiquan Zhang, Huarui Shen, Houping Xu, Sen Li

Cancer Med. 2023 Apr; 12(7): 8452–8463. Published online 2023 Feb 11. doi: 10.1002/cam4.5585

PMCID:: PMC10134362

Abstract Article PDF–18M

Select item 1013074815.

The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand

Yoko K Takada, Scott I Simon, Yoshikazu Takada

Life Sci Alliance. 2023 Jul; 6(7): e202201747. Published online 2023 Apr 25. doi: 10.26508/lsa.202201747

PMCID:: PMC10130748

Abstract Article PDF–3.6M

Select item 1010367816.

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions

He-Wei Jiang, Hong Chen, Yun-Xiao Zheng, Xue-Ning Wang, Qingfeng Meng, Jin Xie, Jiong Zhang, ChangSheng Zhang, Zhao-Wei Xu, Zi-Qing Chen, Lei Wang, Wei-Sha Kong, Kuan Zhou, Ming-Liang Ma, Hai-Nan Zhang, Shu-Juan Guo, Jun-Biao Xue, Jing-Li Hou, Zhe-Yi Liu, Wen-Xue Niu, Fang-Jun Wang, Tao Wang, Wei Li, Rui-Na Wang, Yong-Jun Dang, Daniel M. Czajkowsky, JianFeng Pei, Jia-Jia Dong, Sheng-Ce Tao

Sci China Life Sci. 2023 Apr 14 : 1–19. doi: 10.1007/s11427-023-2316-2 [Epub ahead of print]