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Items: 1 to 20 of 137

1.
Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability
Ramoji Kosuru, Olivier Romito, Guru Prasad Sharma, Francesca Ferraresso, Behshid Ghadrdoost Nakhchi, Kai Yang, Tadanori Mammoto, Akiko Mammoto, Christian J. Kastrup, David X. Zhang, Paul H. Goldspink, Mohamed Trebak, Magdalena Chrzanowska
Arterioscler Thromb Vasc Biol. 2024 Nov; 44(11): 2271–2287. Published online 2024 Sep 26. doi: 10.1161/ATVBAHA.124.321458
PMCID:
PMC11495542
AbstractArticlePDF–3.6M
2.
TRF2–RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM–DNA2-dependent 5′-end resection
Fengshan Liang, Rekha Rai, Tori Sodeinde, Sandy Chang
Nucleic Acids Res. 2024 Sep 9; 52(16): 9695–9709. Published online 2024 Jul 31. doi: 10.1093/nar/gkae642
PMCID:
PMC11381343
AbstractArticlePDF–2.3M
3.
Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis
Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley
J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295
PMCID:
PMC10641524
AbstractArticlePDF–3.8M
4.
C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains
Julia Jülg, Dieter Edbauer, Christian Behrends
EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895
PMCID:
PMC10398660
AbstractArticlePDF–2.4M
5.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
6.
The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse
Inbar Azoulay-Alfaguter, Marianne Strazza, Michael Peled, Hila K. Novak, James Muller, Michael L. Dustin, Adam Mor
Sci Signal. Author manuscript; available in PMC 2022 Sep 2.
Published in final edited form as: Sci Signal. 2017 Aug 8; 10(491): eaal2880. Published online 2017 Aug 8. doi: 10.1126/scisignal.aal2880
PMCID:
PMC9437928
AbstractArticlePDF–1.8M
7.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
8.
Natural Killer Cell Transcript 4 promotes the development of Sjögren’s Syndrome via activation of Rap1 on B cells
Peng Qu, Todd Wuest, Yongfen Min, Ilias Alevizos, Howard A. Young, P. Charles Lin
J Autoimmun. Author manuscript; available in PMC 2022 Jul 8.
Published in final edited form as: J Autoimmun. 2021 Jan; 116: 102559. Published online 2020 Oct 19. doi: 10.1016/j.jaut.2020.102559
PMCID:
PMC9264267
AbstractArticlePDF–2.2M
9.
ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak
Alamzeb Khan, Weiming Ni, Tania Baltazar, F. Lopez-Giraldez, Jordan S. Pober, Richard W. Pierce
FASEB J. Author manuscript; available in PMC 2023 Apr 1.
Published in final edited form as: FASEB J. 2022 Apr; 36(4): e22254. doi: 10.1096/fj.202101873RR
PMCID:
PMC9103844
AbstractArticlePDF–1.9M
10.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
11.
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo
Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396
PMCID:
PMC8552907
AbstractArticlePDF–3.9M
12.
Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma
Verónica Freire-Benéitez, Nicola Pomella, Thomas O Millner, Anaëlle A Dumas, Maria Victoria Niklison-Chirou, Eleni Maniati, Jun Wang, Vinothini Rajeeve, Pedro Cutillas, Silvia Marino
NAR Cancer. 2021 Mar; 3(1): zcab009. Published online 2021 Mar 22. doi: 10.1093/narcan/zcab009
Correction in:
NAR Cancer. 2021 Jun; 3(2): zcab020.
PMCID:
PMC8210184
AbstractArticlePDF–3.4M
13.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
14.
Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis
Liliana Perdomo, Xavier Vidal-Gómez, Raffaella Soleti, Luisa Vergori, Lucie Duluc, Maggy Chwastyniak, Malik Bisserier, Soazig Le Lay, Alexandre Villard, Gilles Simard, Olivier Meilhac, Frank Lezoualc’h, Ilya Khantalin, Reuben Veerapen, Séverine Dubois, Jérôme Boursier, Samir Henni, Frédéric Gagnadoux, Florence Pinet, Ramaroson Andriantsitohaina, M. Carmen Martínez
Circ Res. Author manuscript; available in PMC 2021 Mar 25.
Published in final edited form as: Circ Res. 2020 Aug 28; 127(6): 747–760. Published online 2020 Jun 16. doi: 10.1161/CIRCRESAHA.120.317086
PMCID:
PMC7992112
AbstractArticlePDF–2.2M
15.
Identification of Radil as a Ras binding partner and putative activator
Byeong Hyeok Choi, Ziyue Kou, Tania Marlyn Colon, Chih-Hong Chen, Yuan Chen, Wei Dai
J Biol Chem. 2021 Jan-Jun; 296: 100314. Published online 2021 Jan 20. doi: 10.1016/j.jbc.2021.100314
PMCID:
PMC7949112
AbstractArticlePDF–2.7M
16.
Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Polo-Like Kinase (Plk2) alters the Ratio of Its GAP Activity toward HRas, Rap1 and Rap2 GTPases
Ward G. Walkup, 4th, Michael J. Sweredoski, Robert L. Graham, Sonja Hess, Mary B. Kennedy
Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Feb 19.
Published in final edited form as: Biochem Biophys Res Commun. 2018 Sep 10; 503(3): 1599–1604. Published online 2018 Jul 24. doi: 10.1016/j.bbrc.2018.07.087
PMCID:
PMC7894274
AbstractArticlePDF–1016K
17.
Functional and structural characterization of allosteric activation of phospholipase Cε by Rap1A
Monita Sieng, Arielle F. Selvia, Elisabeth E. Garland-Kuntz, Jesse B. Hopkins, Isaac J. Fisher, Andrea T. Marti, Angeline M. Lyon
J Biol Chem. 2020 Dec 4; 295(49): 16562–16571. Published online 2021 Jan 13. doi: 10.1074/jbc.RA120.015685
PMCID:
PMC7864056
AbstractArticlePDF–2.2M
18.
AMPK, a key regulator of metabolism and autophagy, is activated by lysosomal damage via a novel galectin-directed ubiquitin signal transduction system
Jingyue Jia, Bhawana Bissa, Lukas Brecht, Lee Allers, Seong Won Choi, Yuexi Gu, Mark Zbinden, Mark R. Burge, Graham Timmins, Kenneth Hallows, Christian Behrends, Vojo Deretic
Mol Cell. Author manuscript; available in PMC 2021 Mar 5.
Published in final edited form as: Mol Cell. 2020 Mar 5; 77(5): 951–969.e9. Published online 2020 Jan 28. doi: 10.1016/j.molcel.2019.12.028
PMCID:
PMC7785494
AbstractArticlePDF–2.9M
19.
CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage
Marie-Christine Albert, Kerstin Brinkmann, Wojciech Pokrzywa, Saskia Diana Günther, Martin Krönke, Thorsten Hoppe, Hamid Kashkar
Cell Death Dis. 2020 Sep; 11(9): 740. Published online 2020 Sep 10. doi: 10.1038/s41419-020-02923-x
PMCID:
PMC7484759
AbstractArticlePDF–2.6M
20.
A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn’s Disease in Japanese Individuals
Yoichi Kakuta, Yosuke Kawai, Takeo Naito, Atsushi Hirano, Junji Umeno, Yuta Fuyuno, Zhenqiu Liu, Dalin Li, Takeru Nakano, Yasuhiro Izumiyama, Ryo Ichikawa, Daisuke Okamoto, Hiroshi Nagai, Shin Matsumoto, Katsutoshi Yamamoto, Naonobu Yokoyama, Hirofumi Chiba, Yusuke Shimoyama, Motoyuki Onodera, Rintaro Moroi, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Kenichi Negoro, Jun Yasuda, Motohiro Esaki, Katsushi Tokunaga, Minoru Nakamura, Takayuki Matsumoto, Dermot P B McGovern, Masao Nagasaki, Yoshitaka Kinouchi, Tooru Shimosegawa, Atsushi Masamune
J Crohns Colitis. 2019 Apr; 13(5): 648–658. Published online 2018 Nov 29. doi: 10.1093/ecco-jcc/jjy197
PMCID:
PMC7458277
AbstractArticlePDF–1.4M

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