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Select item 108508181.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 99501833.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 88970224.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 83529645.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79370287.

Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis

Ittai B Muller, Marry Lin, Willem F Lems, Marieke M ter Wee, Anna Wojtuszkiewicz, Michael T Nurmohamed, Jacqueline Cloos, Yehuda G Assaraf, Gerrit Jansen, Robert de Jonge

Rheumatology (Oxford) 2021 Mar; 60(3): 1273–1281. Published online 2020 Sep 17. doi: 10.1093/rheumatology/keaa428

PMCID:: PMC7937028

Abstract Article PDF–296K

Select item 77376108.

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy

Amelia E Ohnstad, Jose M Delgado, Brian J North, Isha Nasa, Arminja N Kettenbach, Sebastian W Schultz, Christopher J Shoemaker

EMBO J. 2020 Dec 15; 39(24): e104948. Published online 2020 Nov 23. doi: 10.15252/embj.2020104948

PMCID:: PMC7737610

Abstract Article PDF–3.7M

Select item 75668819.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 747271510.

Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia

Morten Tulstrup, Takaya Moriyama, Chuang Jiang, Marie Grosjean, Jacob Nersting, Jonas Abrahamsson, Kathrine Grell, Lisa Lyngsie Hjalgrim, Ólafur Gísli Jónsson, Jukka Kanerva, Bendik Lund, Stine Nygaard Nielsen, Rikke Linnemann Nielsen, Ulrik Overgaard, Petter Quist-Paulsen, Kaie Pruunsild, Goda Vaitkeviciene, Benjamin Ole Wolthers, Hui Zhang, Ramneek Gupta, Jun J. Yang, Kjeld Schmiegelow

Blood. 2020 Sep 3; 136(10): 1161–1168. Prepublished online 2020 May 11. doi: 10.1182/blood.2020005064

PMCID:: PMC7472715

Abstract Article

Select item 745069611.

Effects of folylpolyglutamate synthase modulation on global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells

Sung-Eun Kim, Toshinori Hinoue, Michael S. Kim, Kyoung-Jin Sohn, Robert C. Cho, Daniel J. Weisenberger, Peter W. Laird, Young-In Kim

J Nutr Biochem. Author manuscript; available in PMC 2020 Aug 27.

Published in final edited form as: J Nutr Biochem. 2016 Mar; 29: 27–35. Published online 2015 Nov 17. doi: 10.1016/j.jnutbio.2015.10.019

PMCID:: PMC7450696

Abstract Article PDF–1.0M

Select item 737408712.

FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia

Sung-Liang Yu, Hui Zhang, Bing-Ching Ho, Chih-Hsiang Yu, Chia-Ching Chang, Yin-Chen Hsu, Yu-Ling Ni, Kai-Hsin Lin, Shiann-Tarng Jou, Meng-Yao Lu, Shu-Huey Chen, Kang-Hsi Wu, Shih-Chung Wang, Hsiu-Hao Chang, Ching-Hon Pui, Jun J. Yang, Jinghui Zhang, Dong-Tsamn Lin, Shu-Wha Lin, Xiaotu Ma, Yung-Li Yang

Sci Rep. 2020; 10: 12074. Published online 2020 Jul 21. doi: 10.1038/s41598-020-69059-y

PMCID:: PMC7374087

Abstract Article PDF–1.4M

Select item 734901713.

Association of NUDT15 c.415C>T and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia

Sunitha Kodidela, Patchava Dorababu, Dimpal N. Thakkar, Biswajit Dubashi, Rajan Sundaram, Niveditha Muralidharan, Ravi Prasad Nidanapu, Anil Aribandi, Suresh Chandra Pradhan, Chakradhara Rao Satyanarayana Uppugunduri

Genes (Basel) 2020 Jun; 11(6): 594. Published online 2020 May 28. doi: 10.3390/genes11060594

PMCID:: PMC7349017

Abstract Article PDF–605K

Select item 573541914.

Correlation Between Polymorphisms of the Reduced Folate Carrier Gene (SLC19A1) and Survival After Pemetrexed-Based Therapy in Non-small Cell Lung Cancer: A North Central Cancer Treatment Group-Based Exploratory Study

Araba A. Adjei, Oreste E. Salavaggione, Sumithra J. Mandrekar, Grace K. Dy, Katie L. Allen Ziegler, Chiaki Endo, Julian R. Molina, Steven E. Schild, Alex A. Adjei

J Thorac Oncol. Author manuscript; available in PMC 2017 Dec 19.

Published in final edited form as: J Thorac Oncol. 2010 Sep; 5(9): 1346–1353. doi: 10.1097/JTO.0b013e3181ec18c4

PMCID:: PMC5735419

Abstract Article PDF–1.3M

Select item 567858115.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 553358516.

The human cytoplasmic dynein interactome reveals novel activators of motility

William B Redwine, Morgan E DeSantis, Ian Hollyer, Zaw Min Htet, Phuoc Tien Tran, Selene K Swanson, Laurence Florens, Michael P Washburn, Samara L Reck-Peterson

eLife. 2017; 6: e28257. Published online 2017 Jul 18. doi: 10.7554/eLife.28257

PMCID:: PMC5533585

Abstract Article PDF–5.9M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 539090718.

Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma

Chengli Miao, Ding Liu, Feng Zhang, Youxin Wang, Yanbin Zhang, Junhui Yu, Zhanzhi Zhang, Gang Liu, Bing Li, Xing Liu, Chenghua Luo

Sci Rep. 2015; 5: 9079. Published online 2015 Mar 13. doi: 10.1038/srep09079

PMCID:: PMC5390907

Abstract Article PDF–706K

Select item 518972219.

Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia

Zhen Huang, Hong-Fei Tong, Yuan Li, Jiang-Chao Qian, Ju-Xiang Wang, Zhe Wang, Ji-Chen Ruan

Med Sci Monit. 2016; 22: 4967–4971. Published online 2016 Dec 17. doi: 10.12659/MSM.899021

PMCID:: PMC5189722

Abstract Article PDF–737K

Select item 500447520.

The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia

Anna Wojtuszkiewicz, Yehuda G. Assaraf, Mirthe Hoekstra, Rocco Sciarrillo, Gerrit Jansen, Godefridus J. Peters, Rob Pieters, Edwin Sonneveld, Gabriele Escherich, Gertjan J.L. Kaspers, Jacqueline Cloos

Haematologica. 2016 Jul; 101(7): e291–e294. doi: 10.3324/haematol.2016.142794

PMCID:: PMC5004475

Article PDF–329K

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