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Items: 1 to 20 of 35

1.
The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection
Milton Pereira, Theresa Ramalho, Warrison A. Andrade, Danielle F. Durso, Maria C. Souza, Katherine A. Fitzgerald, Douglas T. Golenbock, Neal Silverman, Ricardo T. Gazzinelli
Cell Rep. Author manuscript; available in PMC 2024 Nov 13.
Published in final edited form as: Cell Rep. 2024 Feb 27; 43(2): 113795. Published online 2024 Feb 15. doi: 10.1016/j.celrep.2024.113795
PMCID:
PMC11559090
AbstractArticlePDF–3.2M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy
Meng-Yuan Jiang, Wan-Rong Man, Xue-Bin Zhang, Xiao-Hua Zhang, Yu Duan, Jie Lin, Yan Zhang, Yang Cao, De-Xi Wu, Xiao-Fei Shu, Lei Xin, Hao Wang, Xiao Zhang, Cong-Ye Li, Xiao-Ming Gu, Xuan Zhang, Dong-Dong Sun
Mil Med Res. 2023; 10: 63. Published online 2023 Dec 11. doi: 10.1186/s40779-023-00493-5
PMCID:
PMC10712050
AbstractArticlePDF–13M
4.
IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models
Francesca Ferraro, Anja Steinle, Harini Narasimhan, Andreas Bleilevens, Paula-Marie Stolzenberg, Till Braunschweig, Elmar Stickeler, Jochen Maurer
Int J Mol Sci. 2023 Feb; 24(3): 2520. Published online 2023 Jan 28. doi: 10.3390/ijms24032520
PMCID:
PMC9917074
AbstractArticlePDF–2.8M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes
Hao Zhou, Han Wang, Minjia Yu, Rebecca C. Schugar, Wen Qian, Fangqiang Tang, Weiwei Liu, Hui Yang, Ruth E. McDowell, Junjie Zhao, Ji Gao, Ashok Dongre, Julie A. Carman, Mei Yin, Judith A. Drazba, Robert Dent, Christopher Hine, Yeong-Renn Chen, Jonathan D. Smith, Paul L. Fox, J. Mark Brown, Xiaoxia Li
Nat Immunol. Author manuscript; available in PMC 2021 Feb 10.
Published in final edited form as: Nat Immunol. 2020 Oct; 21(10): 1219–1231. Published online 2020 Aug 10. doi: 10.1038/s41590-020-0750-1
PMCID:
PMC7566776
AbstractArticlePDF–6.5M
7.
lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p
Ting Xiao, Chuihua Sun, Ying Xiao, Yunbao Li
Biol Open. 2020 Jun 15; 9(6): bio049353. Published online 2020 Jun 24. doi: 10.1242/bio.049353
PMCID:
PMC7327994
AbstractArticlePDF–2.0M
8.
Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins
Sirish K. Ippagunta, Julie A. Pollock, Naina Sharma, Wenwei Lin, Taosheng Chen, Kazuki Tawaratsumida, Anthony A. High, Jaeki Min, Yizhe Chen, R. Kiplin Guy, Vanessa Redecke, John A. Katzenellenbogen, Hans Häcker
Sci Signal. Author manuscript; available in PMC 2020 May 2.
Published in final edited form as: Sci Signal. 2018 Aug 14; 11(543): eaaq1077. Published online 2018 Aug 14. doi: 10.1126/scisignal.aaq1077
PMCID:
PMC7195875
AbstractArticlePDF–1.7M
9.
IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs
Hao Zhou, Katarzyna Bulek, Xiao Li, Tomasz Herjan, Minjia Yu, Wen Qian, Han Wang, Gao Zhou, Xing Chen, Hui Yang, Lingzi Hong, Junjie Zhao, Luke Qin, Koichi Fukuda, Annette Flotho, Ji Gao, Ashok Dongre, Julie A Carman, Zizhen Kang, Bing Su, Timothy S Kern, Jonathan D Smith, Thomas A Hamilton, Frauke Melchior, Paul L Fox, Xiaoxia Li
eLife. 2017; 6: e29630. Published online 2017 Oct 9. doi: 10.7554/eLife.29630
PMCID:
PMC5675595
AbstractArticlePDF–5.9M
10.
An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-Like Receptor Signaling
Philipp Mertins, Dariusz Przybylski, Nir Yosef, Jana Qiao, Karl Clauser, Raktima Raychowdhury, Thomas M. Eisenhaure, Tanja Maritzen, Volker Haucke, Takashi Satoh, Shizuo Akira, Steven A. Carr, Aviv Regev, Nir Hacohen, Nicolas Chevrier
Cell Rep. Author manuscript; available in PMC 2017 Aug 10.
Published in final edited form as: Cell Rep. 2017 Jun 27; 19(13): 2853–2866. doi: 10.1016/j.celrep.2017.06.016
PMCID:
PMC5551420
AbstractArticlePDF–4.1M
11.
Comprehensive siRNA-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use
Jing Sun, Ning Li, Kyu-Seon Oh, Bhaskar Dutta, Sharat J. Vayttaden, Bin Lin, Thomas S. Ebert, Dominic De Nardo, Joie Davis, Rustam Bagirzadeh, Nicolas W. Lounsbury, Chandrashekhar Pasare, Eicke Latz, Veit Hornung, Iain D. C. Fraser
Sci Signal. Author manuscript; available in PMC 2017 Apr 5.
Published in final edited form as: Sci Signal. 2016 Jan 5; 9(409): ra3. Published online 2016 Jan 5. doi: 10.1126/scisignal.aab2191
PMCID:
PMC5381726
AbstractArticlePDF–1.5M
12.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
13.
The Tumor Necrosis Family Member 4-1BBL Sustains Inflammation by Interacting with Mediators of Toll-Like Receptor Signaling
Jianhui Ma, Bo-Ram Bang, Jiawei Lu, So-Young Eun, Motoyuki Otsuka, Michael Croft, Peter Tobias, Jiahuai Han, Osamu Takeuchi, Shizuo Akira, Michael Karin, Hideo Yagita, Young Jun Kang
Sci Signal. Author manuscript; available in PMC 2014 Apr 29.
Published in final edited form as: Sci Signal. 2013 Oct 1; 6(295): ra87. Published online 2013 Oct 1. doi: 10.1126/scisignal.2004431
PMCID:
PMC4004444
AbstractArticlePDF–1.4M
14.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
15.
Novel Protein Interactions with Endoglin and Activin Receptor-like Kinase 1: Potential Role in Vascular Networks
Guoxiong Xu, Miriam Barrios-Rodiles, Mirjana Jerkic, Andrei L. Turinsky, Robert Nadon, Sonia Vera, Despina Voulgaraki, Jeffrey L. Wrana, Mourad Toporsian, Michelle Letarte
Mol Cell Proteomics. 2014 Feb; 13(2): 489–502. Published online 2013 Dec 7. doi: 10.1074/mcp.M113.033464
PMCID:
PMC3916649
AbstractArticlePDF–4.1M
16.
Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice
Eduardo Pauls, Sambit K. Nanda, Hilary Smith, Rachel Toth, J. Simon C. Arthur, Philip Cohen
J Immunol. Author manuscript; available in PMC 2014 Mar 1.
Published in final edited form as: J Immunol. 2013 Sep 1; 191(5): 10.4049/jimmunol.1203268. Published online 2013 Aug 5. doi: 10.4049/jimmunol.1203268
Correction in:
volume 191 on page 5317
PMCID:
PMC3849919
AbstractArticlePDF–9.5M
17.
Interleukin-1 Receptor-Associated Kinase-2 (IRAK2) Is a Critical Mediator of Endoplasmic Reticulum (ER) Stress Signaling
Samir Benosman, Palaniyandi Ravanan, Ricardo G. Correa, Ying-Chen Hou, Minjia Yu, Muhammet Fatih Gulen, Xiaoxia Li, James Thomas, Michael Cuddy, Yasuko Matsuzawa, Renata Sano, Paul Diaz, Shu-ichi Matsuzawa, John C. Reed
PLoS One. 2013; 8(5): e64256. Published online 2013 May 28. doi: 10.1371/journal.pone.0064256
PMCID:
PMC3665826
AbstractArticlePDF–1.7M
18.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
19.
Interleukin-1 Receptor-Associated Kinase 2- and Protein Kinase D1-Dependent Regulation of IRAK-Monocyte Expression by CpG DNA
Young-In Kim, Jeoung-Eun Park, Ki Han Kwon, Cheol Yi Hong, Ae-Kyung Yi
PLoS One. 2012; 7(8): e43970. Published online 2012 Aug 23. doi: 10.1371/journal.pone.0043970
PMCID:
PMC3426515
AbstractArticlePDF–727K
20.
IRAK-2 Regulates IL-1-Mediated Pathogenic Th17 Cell Development in Helminthic Infection
Patrick M. Smith, Berri Jacque, James R. Conner, Alexander Poltorak, Miguel J. Stadecker
PLoS Pathog. 2011 Oct; 7(10): e1002272. Published online 2011 Oct 6. doi: 10.1371/journal.ppat.1002272
PMCID:
PMC3188523
AbstractArticlePDF–1.2M

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