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Select item 113799751.

ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy

Yuan-Mei Wang, Huang Tang, Ya-Jie Tang, Juan Liu, Yu-Fang Yin, Ya-Ling Tang, Yao-Guang Feng, Hong-Feng Gu

J Adv Res. 2024 Sep; 63: 195–206. Published online 2023 Nov 4. doi: 10.1016/j.jare.2023.11.004

PMCID:: PMC11379975

Abstract Article PDF–4.2M

Select item 112691852.

Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury

Ke Lai, Iva Pritišanac, Zhen-Qi Liu, Han-Wei Liu, Li-Na Gong, Ming-Xian Li, Jian-Fei Lu, Xin Qi, Tian-Le Xu, Julie Forman-Kay, Hai-Bo Shi, Lu-Yang Wang, Shan-Kai Yin

Nature. 2024; 631(8022): 826–834. Published online 2024 Jul 10. doi: 10.1038/s41586-024-07684-7

PMCID:: PMC11269185

Abstract Article PDF–17M

Select item 111397143.

Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BK_Ca channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells

Karolos-Philippos Pissas, Stefan Gründer, Yuemin Tian

Pflugers Arch. 2024; 476(6): 923–937. Published online 2024 Apr 16. doi: 10.1007/s00424-024-02964-7

PMCID:: PMC11139714

Abstract Article PDF–4.9M

Select item 109902774.

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton

Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012

PMCID:: PMC10990277

Abstract Article PDF–3.9M

Select item 107174415.

The roles of acid-sensing ion channel 1a and ovarian cancer G protein-coupled receptor 1 on passive Mg²⁺ transport across intestinal epithelium-like Caco-2 monolayers

Narongrit Thongon, Pattamaporn Ketkeaw, Chanin Nuekchob

J Physiol Sci. 2014 Mar; 64(2): 129–139. Published online 2013 Dec 28. doi: 10.1007/s12576-013-0301-8

PMCID:: PMC10717441

Abstract Article PDF–1.2M

Select item 100698166.

ASIC1a Involves the Acid-Mediated Activation of Pancreatic Stellate Cells Associated With Autophagy Induction

Tao WANG, Qianqian WANG, Guixia PAN, Guorong JIA, Xiao LI, Chao WANG, Liming ZHANG, Changjing ZUO

Physiol Res. 2023 Feb; 72(1): 49–57. Published online 2022 Dec 22. doi: 10.33549/physiolres.934950

PMCID:: PMC10069816

Abstract Article PDF–1.1M

Select item 91197367.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 90978448.

ASIC1a stimulates the resistance of human hepatocellular carcinoma by promoting EMT via the AKT/GSK3β/Snail pathway driven by TGFβ/Smad signals

Yinci Zhang, Niandie Cao, Jiafeng Gao, Jiaojiao Liang, Yong Liang, Yinghai Xie, Shuping Zhou, Xiaolong Tang

J Cell Mol Med. 2022 May; 26(10): 2777–2792. Published online 2022 Apr 14. doi: 10.1111/jcmm.17288

PMCID:: PMC9097844

Abstract Article PDF–54M

Select item 87159819.

Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD

Xu Han, Yawen Zhang, Allen Lee, Zhaoshen Li, Jun Gao, Xiaoyin Wu, Jiulong Zhao, Hui Wang, Di Chen, Duowu Zou, Chung Owyang

FASEB J. 2022 Jan; 36(1): e22083. Published online 2021 Dec 17. doi: 10.1096/fj.202100606R

PMCID:: PMC8715981

Abstract Article PDF–1.6M

Select item 855290710.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 844854411.

Regulation of gliomagenesis and stemness through acid sensor ASIC1a

Pendelton King, Jingwei Wan, Alyssa Aihui Guo, Shanchun Guo, Yugang Jiang, Mingli Liu

Int J Oncol. 2021 Oct; 59(4): 82. Published online 2021 Sep 10. doi: 10.3892/ijo.2021.5262

PMCID:: PMC8448544

Abstract Article PDF–2.4M

Select item 831858912.

Structure and analysis of nanobody binding to the human ASIC1a ion channel

Yangyu Wu, Zhuyuan Chen, Fred J Sigworth, Cecilia M Canessa

eLife. 2021; 10: e67115. Published online 2021 Jul 28. doi: 10.7554/eLife.67115

PMCID:: PMC8318589

Abstract Article PDF–5.7M

Select item 819964413.

Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors

Kirsten Ackermann, Susanne Wallner, Christoph Brochhausen, Stephan Schreml

Int J Mol Sci. 2021 Jun; 22(11): 6024. Published online 2021 Jun 2. doi: 10.3390/ijms22116024

PMCID:: PMC8199644

Abstract Article PDF–68M

Select item 816788914.

Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1

Matthew L. Rook, Megan Miaro, Tyler Couch, Dana L. Kneisley, Maria Musgaard, David M. MacLean

J Gen Physiol. 2021 Aug 2; 153(8): e202012855. Published online 2021 Jun 1. doi: 10.1085/jgp.202012855

PMCID:: PMC8167889

Abstract Article PDF–3.2M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011