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Select item 104535821.

The Transcription Factor HOXA5: Novel Insights into Metabolic Diseases and Adipose Tissue Dysfunction

Luca Parrillo, Rosa Spinelli, Michele Longo, Federica Zatterale, Gianluca Santamaria, Alessia Leone, Michele Campitelli, Gregory Alexander Raciti, Francesco Beguinot

Cells. 2023 Aug; 12(16): 2090. Published online 2023 Aug 18. doi: 10.3390/cells12162090

PMCID:: PMC10453582

Abstract Article PDF–722K

Select item 103211032.

HOXA5 is a key regulator of class 3 semaphorins expression in the synovium of rheumatoid arthritis patients

Sara Martínez-Ramos, Carlos Rafael-Vidal, Beatriz Malvar-Fernández, Angela Rodriguez-Trillo, Douglas Veale, Ursula Fearon, Carmen Conde, Javier Conde-Aranda, Timothy R D J Radstake, Jose María Pego-Reigosa, Kris A Reedquist, Samuel García

Rheumatology (Oxford) 2023 Jul; 62(7): 2621–2630. Published online 2022 Nov 18. doi: 10.1093/rheumatology/keac654

PMCID:: PMC10321103

Abstract Article PDF–883K

Select item 98811363.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 97619644.

CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug

Yanping Liang, Junjie Cen, Yong Huang, Yong Fang, Yunfei Wang, Guannan Shu, Yihui Pan, Kangbo Huang, Jiaqi Dong, Mi Zhou, Yi Xu, Junhang Luo, Min Liu, Jiaxing Zhang

Mol Cancer. 2022; 21: 224. Published online 2022 Dec 19. doi: 10.1186/s12943-022-01694-7

Correction in:: Mol Cancer. 2023; 22: 14.

PMCID:: PMC9761964

Abstract Article PDF–14M

Select item 91714115.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 89643306.

Expression Landscape and Functional Roles of HOXA4 and HOXA5 in Lung Adenocarcinoma

Li Gao, Rong-Quan He, Zhi-Guang Huang, Guo-Sheng Li, Jiang-Hui Zeng, Jia-Yin Hou, Jia-Yuan Luo, Yi-Wu Dang, Hua-Fu Zhou, Jin-Liang Kong, Da-Ping Yang, Zhen-Bo Feng, Gang Chen

Int J Med Sci. 2022; 19(3): 572–587. Published online 2022 Mar 6. doi: 10.7150/ijms.70445

PMCID:: PMC8964330

Abstract Article PDF–3.6M

Select item 89230577.

Transcription Factor Protein Interactomes Reveal Genetic Determinants in Heart Disease

Barbara Gonzalez-Teran, Maureen Pittman, Franco Felix, Reuben Thomas, Desmond Richmond-Buccola, Ruth Hüttenhain, Krishna Choudhary, Elisabetta Moroni, Mauro W. Costa, Yu Huang, Arun Padmanabhan, Michael Alexanian, Clara Youngna Lee, Bonnie E. J. Maven, Kaitlen Samse-Knapp, Sarah U. Morton, Michael McGregor, Casey A. Gifford, J. G. Seidman, Christine E. Seidman, Bruce D. Gelb, Giorgio Colombo, Bruce R. Conklin, Brian L. Black, Benoit G. Bruneau, Nevan J. Krogan, Katherine S. Pollard, Deepak Srivastava

Cell. Author manuscript; available in PMC 2023 Mar 3.

Published in final edited form as: Cell. 2022 Mar 3; 185(5): 794–814.e30. Published online 2022 Feb 18. doi: 10.1016/j.cell.2022.01.021

PMCID:: PMC8923057

Abstract Article PDF–2.5M

Select item 88706348.

Epigenetic Dysregulation of the Homeobox A5 (HOXA5) Gene Associates with Subcutaneous Adipocyte Hypertrophy in Human Obesity

Luca Parrillo, Rosa Spinelli, Mattia Costanzo, Pasqualina Florese, Serena Cabaro, Antonella Desiderio, Immacolata Prevenzano, Gregory Alexander Raciti, Ulf Smith, Claudia Miele, Pietro Formisano, Raffaele Napoli, Francesco Beguinot

Cells. 2022 Feb; 11(4): 728. Published online 2022 Feb 18. doi: 10.3390/cells11040728

PMCID:: PMC8870634

Abstract Article PDF–1.5M

Select item 88288959.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 880626410.

Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression

Danyan Chen, Zhaonan Shen, Xi Cheng, Qi Wang, Junlin Zhou, Fang Ren, Yue Sun, Hongman Wang, Rongxi Huang

Bioengineered. 2021; 12(1): 1964–1975. Published online 2021 May 23. doi: 10.1080/21655979.2021.1924545

PMCID:: PMC8806264

Abstract Article PDF–4.4M

Select item 855290711.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 849052512.

Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI

Yin Ni, Bang-Chuan Hu, Guo-Hua Wu, Zi-Qiang Shao, Yang Zheng, Run Zhang, Jun Jin, Jun Hong, Xiang-Hong Yang, Ren-Hua Sun, Jin-Quan Liu, Shi-Jing Mo

Theranostics. 2021; 11(19): 9431–9451. Published online 2021 Sep 13. doi: 10.7150/thno.61902

PMCID:: PMC8490525

Abstract Article PDF–3.8M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 800904814.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 795028315.

An aging and p53 related marker: HOXA5 promoter methylation negatively correlates with mRNA and protein expression in old age

Laura-Kim Feiner, Sascha Tierling, Sebastian Holländer, Matthias Glanemann, Claudia Rubie

Aging (Albany NY) 2021 Feb 28; 13(4): 4831–4849. Published online 2021 Feb 5. doi: 10.18632/aging.202621

PMCID:: PMC7950283

Abstract Article PDF–899K

Select item 794150216.

Aberrant DNA methylation at HOXA4 and HOXA5 genes are associated with resistance to imatinib mesylate among chronic myeloid leukemia patients

Marjanu Hikmah Elias, Husin Azlan, Sarina Sulong, Abdul Aziz Baba, Ravindran Ankathil

Cancer Rep (Hoboken) 2018 Aug; 1(2): e1111. Published online 2018 Jul 27. doi: 10.1002/cnr2.1111

PMCID:: PMC7941502

Abstract Article PDF–445K

Select item 779113317.

HOXA5 counteracts the function of pathological scar-derived fibroblasts by partially activating p53 signaling

Yimin Liang, Renpeng Zhou, Xiujun Fu, Chen Wang, Danru Wang

Cell Death Dis. 2021 Jan; 12(1): 40. Published online 2021 Jan 5. doi: 10.1038/s41419-020-03323-x

PMCID:: PMC7791133

Abstract Article PDF–3.8M

Select item 727241818.

HOXA5 inhibits the proliferation and neoplasia of cervical cancer cells via downregulating the activity of the Wnt/β-catenin pathway and transactivating TP53

Hong-Mei Ma, Nan Cui, Peng-Sheng Zheng

Cell Death Dis. 2020 Jun; 11(6): 420. Published online 2020 Jun 4. doi: 10.1038/s41419-020-2629-3

PMCID:: PMC7272418

Abstract Article PDF–4.0M

Select item 716998319.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 714552620.

The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21

Lucia A Torres-Fernández, Bettina Jux, Maximilian Bille, Yasmine Port, Karin Schneider, Matthias Geyer, Günter Mayer, Waldemar Kolanus

Nucleic Acids Res. 2019 Dec 16; 47(22): 11861–11879. Published online 2019 Nov 16. doi: 10.1093/nar/gkz1057

PMCID:: PMC7145526

Abstract Article PDF–7.0M

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