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Items: 1 to 20 of 33

1.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
2.
GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2
Ritian Lin, Wei Wu, Huimin Chen, Han Gao, Xiaohan Wu, Gengfeng Li, Qiong He, Huiying Lu, Mingming Sun, Zhanju Liu
Clin Transl Med. 2022 Mar; 12(3): e771. Published online 2022 Mar 28. doi: 10.1002/ctm2.771
PMCID:
PMC8958354
AbstractArticlePDF–6.6M
3.
NUAK2 silencing inhibits the proliferation, migration and epithelial-to-mesenchymal transition of cervical cancer cells via upregulating CYFIP2
Yuxia Li, Xiaohui Song, Liping Liu, Lei Yue
Mol Med Rep. 2021 Nov; 24(5): 817. Published online 2021 Sep 22. doi: 10.3892/mmr.2021.12457
PMCID:
PMC8477169
AbstractArticlePDF–11M
4.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
5.
lncRNA FGD5-AS1 promotes breast cancer progression by regulating the hsa-miR-195-5p/NUAK2 axis
Kun Fang, Zheng-Jie Xu, Su-Xiao Jiang, De-Sheng Tang, Chang-Sheng Yan, You-Yuan Deng, Fu-Ying Zhao
Mol Med Rep. 2021 Jun; 23(6): 460. Published online 2021 Apr 16. doi: 10.3892/mmr.2021.12099
PMCID:
PMC8072314
AbstractArticlePDF–7.3M
6.
A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling
Carine Bonnard, Naveenan Navaratnam, Kakaly Ghosh, Puck Wee Chan, Thong Teck Tan, Oz Pomp, Alvin Yu Jin Ng, Sumanty Tohari, Rishita Changede, David Carling, Byrappa Venkatesh, Umut Altunoglu, Hülya Kayserili, Bruno Reversade
J Exp Med. 2020 Dec 7; 217(12): e20191561. Published online 2020 Aug 25. doi: 10.1084/jem.20191561
PMCID:
PMC7953732
AbstractArticlePDF–4.7M
7.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
8.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
9.
Sucrose Nonfermenting-Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans
Jie Li, Bin Feng, Yaohui Nie, Ping Jiao, Xiaochen Lin, Mengna Huang, Ran An, Qin He, Huilin Emily Zhou, Arthur Salomon, Kirsten S. Sigrist, Zhidan Wu, Simin Liu, Haiyan Xu
Diabetes. 2018 Mar; 67(3): 400–411. Published online 2018 Jan 3. doi: 10.2337/db17-0745
PMCID:
PMC5828454
AbstractArticlePDF–2.7M
10.
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu
Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0
PMCID:
PMC5826926
AbstractArticlePDF–2.3M
11.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
12.
NUAK2 amplification coupled with PTEN deficiency promote melanoma development via CDK activation
Takeshi Namiki, Tomonori Yaguchi, Kenta Nakamura, Julio C. Valencia, Sergio G. Coelho, Lanlan Yin, Masakazu Kawaguchi, Wilfred D. Vieira, Yasuhiko Kaneko, Atsushi Tanemura, Ichiro Katayama, Hiroo Yokozeki, Yutaka Kawakami, Vincent J. Hearing
Cancer Res. Author manuscript; available in PMC 2016 Jul 1.
Published in final edited form as: Cancer Res. 2015 Jul 1; 75(13): 2708–2715. Published online 2015 Apr 1. doi: 10.1158/0008-5472.CAN-13-3209
PMCID:
PMC4490056
AbstractArticlePDF–1.0M
13.
Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase
Sourav Banerjee, Anna Zagórska, Maria Deak, David G. Campbell, Alan R. Prescott, Dario R. Alessi
Biochem J. 2014 Jul 15; 461(Pt 2): 233–245. Prepublished online 2014 May 2. Published online 2014 Jun 26. doi: 10.1042/BJ20140408
PMCID:
PMC4109838
AbstractArticlePDF–1.8M
14.
Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
Mikko Taipale, Irina Krykbaeva, Martina Koeva, Can Kayatekin, Kenneth D. Westover, Georgios I. Karras, Susan Lindquist
Cell. Author manuscript; available in PMC 2014 Jan 17.
Published in final edited form as: Cell. 2012 Aug 31; 150(5): 987–1001. doi: 10.1016/j.cell.2012.06.047
PMCID:
PMC3894786
AbstractArticlePDF–5.0M
15.
The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling
Kaku Goto, Wenyu Lin, Leiliang Zhang, Nikolaus Jilg, Run-Xuan Shao, Esperance A.K. Schaefer, Hong Zhao, Dahlene N. Fusco, Lee F. Peng, Naoya Kato, Raymond T. Chung
J Hepatol. Author manuscript; available in PMC 2014 Nov 1.
Published in final edited form as: J Hepatol. 2013 Nov; 59(5): 10.1016/j.jhep.2013.06.025. Published online 2013 Jul 2. doi: 10.1016/j.jhep.2013.06.025
PMCID:
PMC3866804
AbstractArticlePDF–590K
16.
Activation of AMP-activated protein kinase alleviates high glucose-induced dysfunction of brain microvascular endothelial cell tight junction dynamics
Chao Liu, Jiliang Wu, Ming-hui Zou
Free Radic Biol Med. Author manuscript; available in PMC 2013 Sep 15.
Published in final edited form as: Free Radic Biol Med. 2012 Sep 15; 53(6): 1213–1221. Published online 2012 Jul 14. doi: 10.1016/j.freeradbiomed.2012.07.003
PMCID:
PMC3437014
AbstractArticlePDF–1.4M
17.
NUAK2: an emerging acral melanoma oncogene
Takeshi Namiki, Sergio G. Coelho, Vincent J. Hearing
Oncotarget. 2011 Sep; 2(9): 695–704. Published online 2011 Sep 10. doi: 10.18632/oncotarget.325
PMCID:
PMC3248218
AbstractArticlePDF–628K
18.
Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN
Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi
J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907
PMCID:
PMC3190826
AbstractArticlePDF–5.7M
19.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
20.
AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma
Takeshi Namiki, Atsushi Tanemura, Julio C. Valencia, Sergio G. Coelho, Thierry Passeron, Masakazu Kawaguchi, Wilfred D. Vieira, Masashi Ishikawa, Wataru Nishijima, Toshiyuki Izumo, Yasuhiko Kaneko, Ichiro Katayama, Yuji Yamaguchi, Lanlan Yin, Eric C. Polley, Hongfang Liu, Yutaka Kawakami, Yoshinobu Eishi, Eishi Takahashi, Hiroo Yokozeki, Vincent J. Hearing
Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16): 6597–6602. Published online 2011 Apr 1. doi: 10.1073/pnas.1007694108
PMCID:
PMC3081019
AbstractArticlePDF–473K

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