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Select item 102374221.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 99531332.

Acid Ceramidase Deficiency: Bridging Gaps between Clinical Presentation, Mouse Models, and Future Therapeutic Interventions

Annie Kleynerman, Jitka Rybova, Mary L. Faber, William M. McKillop, Thierry Levade, Jeffrey A. Medin

Biomolecules. 2023 Feb; 13(2): 274. Published online 2023 Feb 1. doi: 10.3390/biom13020274

PMCID:: PMC9953133

Abstract Article PDF–910K

Select item 92792853.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 92778534.

A functional reference map of the RNF8 interactome in cancer

Chuanyang Liu, Jingyu Kuang, Yuxuan Wang, Ting Duan, Lu Min, Chenyu Lu, Tianyi Zhang, Ruifen Chen, Ying Wu, Lingyun Zhu

Biol Direct. 2022; 17: 17. Published online 2022 Jul 13. doi: 10.1186/s13062-022-00331-z

PMCID:: PMC9277853

Abstract Article PDF–5.9M

Select item 91197365.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 89515566.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 82663297.

Acid ceramidase promotes senescent cell survival

Rachel Munk, Carlos Anerillas, Martina Rossi, Dimitrios Tsitsipatis, Jennifer L. Martindale, Allison B. Herman, Jen-Hao Yang, Jackson A. Roberts, Vijay R. Varma, Poonam R. Pandey, Madhav Thambisetty, Myriam Gorospe, Kotb Abdelmohsen

Aging (Albany NY) 2021 Jun 30; 13(12): 15750–15769. Published online 2021 Jun 8. doi: 10.18632/aging.203170

PMCID:: PMC8266329

Abstract Article PDF–1.9M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80819939.

N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production

Parmanand Malvi, Radoslav Janostiak, Arvindhan Nagarajan, Xuchen Zhang, Narendra Wajapeyee

Mol Metab. 2021 Jun; 48: 101217. Published online 2021 Mar 23. doi: 10.1016/j.molmet.2021.101217

PMCID:: PMC8081993

Abstract Article PDF–3.4M

Select item 776542110.

Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer

Rachael E. Clifford, Naren Govindarajah, David Bowden, Paul Sutton, Mark Glenn, Mahnaz Darvish-Damavandi, Simon Buczacki, Ultan McDermott, Zdzislaw Szulc, Besim Ogretmen, Jason L. Parsons, Dale Vimalachandran

Cells. 2020 Dec; 9(12): 2693. Published online 2020 Dec 15. doi: 10.3390/cells9122693

PMCID:: PMC7765421

Abstract Article PDF–2.2M

Select item 760717411.

Rho‐associated protein kinase‐dependent moesin phosphorylation is required for PD‐L1 stabilization in breast cancer

Fanbiao Meng, Yang Su, Bo Xu

Mol Oncol. 2020 Nov; 14(11): 2701–2712. Published online 2020 Oct 3. doi: 10.1002/1878-0261.12804

PMCID:: PMC7607174

Abstract Article PDF–4.2M

Select item 739249112.

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination

Gangliang Wang, Shuai Chen, Ziang Xie, Shuying Shen, Wenbin Xu, Wenxiang Chen, Xiang Li, Yizheng Wu, Liangping Li, Bin Liu, Xianjun Ding, An Qin, Shunwu Fan

Ann Rheum Dis. 2020 Aug; 79(8): 1111–1120. Published online 2020 May 14. doi: 10.1136/annrheumdis-2019-216911

PMCID:: PMC7392491

Abstract Article PDF–14M

Select item 739233413.

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

Seung W. Ryu, Rose Stewart, D. Chase Pectol, Nicolette A. Ender, Oshadi Wimalarathne, Ji-Hoon Lee, Carlos P. Zanini, Antony Harvey, Jon M. Huibregtse, Peter Mueller, Tanya T. Paull

PLoS Biol. 2020 Jul; 18(7): e3000606. Published online 2020 Jul 20. doi: 10.1371/journal.pbio.3000606

PMCID:: PMC7392334

Abstract Article PDF–2.7M

Select item 708452914.

Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content

Kalia Kyriakou, Carsten W. Lederer, Marina Kleanthous, Anthi Drousiotou, Anna Malekkou

Int J Mol Sci. 2020 Mar; 21(5): 1607. Published online 2020 Feb 26. doi: 10.3390/ijms21051607

PMCID:: PMC7084529

Abstract Article PDF–6.4M

Select item 660213715.

Genetic and pharmacological inhibition of acid ceramidase prevents asymmetric cell division by neosis

Shai White-Gilbertson, Ping Lu, James S. Norris, Christina Voelkel-Johnson

J Lipid Res. 2019 Jul; 60(7): 1225–1235. Published online 2019 Apr 15. doi: 10.1194/jlr.M092247

PMCID:: PMC6602137

Abstract Article PDF–1.5M

Select item 631425716.

Overexpression of acid ceramidase (ASAH1) protects retinal cells (ARPE19) from oxidative stress

Eriko Sugano, Genea Edwards, Saikat Saha, Lynda A. Wilmott, Richard C. Grambergs, Koushik Mondal, Hui Qi, Megan Stiles, Hiroshi Tomita, Nawajes Mandal

J Lipid Res. 2019 Jan; 60(1): 30–43. Published online 2018 Nov 9. doi: 10.1194/jlr.M082198

PMCID:: PMC6314257

Abstract Article PDF–1.4M

Select item 620727917.

Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment

Mel Pilar Espaillat, Ashley J. Snider, Zhijuan Qiu, Breana Channer, Nicolas Coant, Edward H. Schuchman, Richard R. Kew, Brian S. Sheridan, Yusuf A. Hannun, Lina M. Obeid

FASEB J. 2018 May; 32(5): 2339–2353. Published online 2018 Jan 8. doi: 10.1096/fj.201700585R

PMCID:: PMC6207279

Abstract Article

Select item 591559818.

Structural basis for the activation of acid ceramidase

Ahmad Gebai, Alexei Gorelik, Zixian Li, Katalin Illes, Bhushan Nagar

Nat Commun. 2018; 9: 1621. Published online 2018 Apr 24. doi: 10.1038/s41467-018-03844-2

PMCID:: PMC5915598

Abstract Article PDF–2.7M

Select item 588910919.

Whole-transcriptome sequencing in blood provides a diagnosis of spinal muscular atrophy with progressive myoclonic epilepsy

Kristin D. Kernohan, Laure Frésard, Zachary Zappala, Taila Hartley, Kevin S. Smith, Justin Wagner, Hongbin Xu, Arran McBride, Pierre R. Bourque, Care4Rare Canada Consortium, Steffany A. L. Bennett, David A. Dyment, Kym M. Boycott, Stephen B. Montgomery, Jodi Warman Chardon

Hum Mutat. Author manuscript; available in PMC 2018 Jun 1.

Published in final edited form as: Hum Mutat. 2017 Jun; 38(6): 611–614. Published online 2017 Mar 28. doi: 10.1002/humu.23211

PMCID:: PMC5889109

Abstract Article PDF–508K

Select item 583915820.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

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