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Select item 115496761.

The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro

Michiaki Kojima, Kanami Machida, Sumie Cho, Daichi Watanabe, Hiroyuki Seki, Miyuki Shimoji, Ayuko Imaoka, Hiroshi Yamazaki, F. Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto, Takeshi Akiyoshi, Hisakazu Ohtani

Xenobiotica. Author manuscript; available in PMC 2024 Nov 9.

Published in final edited form as: Xenobiotica. 2023 May; 53(5): 357–365. Published online 2023 Aug 23. doi: 10.1080/00498254.2023.2248498

PMCID:: PMC11549676

Abstract Article PDF–836K

Select item 111594332.

Phase I pharmacokinetic and pharmacogenomic study of E7070 administered once every 21 days

Yasuhide Yamada, Noboru Yamamoto, Tatsu Shimoyama, Atsushi Horiike, Yasuhito Fujisaka, Kyoko Takayama, Terumi Sakamoto, Yuki Nishioka, Sanae Yasuda, Tomohide Tamura

Cancer Sci. 2005 Oct; 96(10): 721–728. Published online 2005 Oct 13. doi: 10.1111/j.1349-7006.2005.00109.x

PMCID:: PMC11159433

Abstract Article PDF–208K

Select item 105655373.

Effects of CYP3A4 and CYP2C9 genotype on systemic anastrozole and fulvestrant concentrations in SWOG S0226

Delaney V Rutherford, Sarah Medley, Nicholas C Henderson, Christina L Gersch, Ted A Vandenberg, Kathy S Albain, Shaker R Dakhil, Nagendra R Tirumali, Julie R Gralow, Gabriel N Hortobagyi, Lajos Pusztai, Rita S Mehta, Daniel F Hayes, Kelley M Kidwell, N Lynn Henry, William E Barlow, James M Rae, Daniel L Hertz

Pharmacogenomics. 2023 Aug; 24(12): 665–673. Published online 2023 Aug 23. doi: 10.2217/pgs-2023-0097

PMCID:: PMC10565537

Abstract Article PDF–784K

Select item 103789784.

Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes related to the metabolism of Warfarin in healthy donors from Cali, Colombia

Sebastian Giraldo-Ocampo, Lorena Diaz-Ordoñez, Yisther Katherine Silva-Cuero, Juan David Gutierrez-Medina, Estephania Candelo, Javier A. Diaz, Harry Pachajoa

Medicine (Baltimore) 2023 Jul 28; 102(30): e34204. Published online 2023 Jul 28. doi: 10.1097/MD.0000000000034204

PMCID:: PMC10378978

Abstract Article PDF–630K

Select item 102424345.

The frequency of major ABCG2, SLCO1B1 and CYP2C9 variants in Asian, Native Hawaiian and Pacific Islander women subgroups: implications for personalized statins dosing

Khalifa Alrajeh, Ola AlAzzeh, Youssef Roman

Pharmacogenomics. 2023 May; 24(7): 381–398. Published online 2023 May 24. doi: 10.2217/pgs-2023-0043

PMCID:: PMC10242434

Abstract Article PDF–628K

Select item 102048956.

Prevalence of CYP2C9 and CYP2C19 variants and the impact on clopidogrel efficacy in patients having CYPC19*2 variant

Meha P. Mehta, Normi D. Gajjar, Rutvi J. Patel, Lipi P. Joshi, Gaurang B. Shah

Indian J Pharmacol. 2023 Jan-Feb; 55(1): 27–33. Published online 2023 Mar 20. doi: 10.4103/ijp.ijp_706_22

PMCID:: PMC10204895

Abstract Article

Select item 100524107.

Identification and in vitro functional assessment of 10 CYP2C9 variants found in Chinese Han subjects

Qing Zhang, Yuying Qi, Shuanghu Wang, Fangling Zhao, Lili Zou, Quan Zhou, Peiwu Geng, Yun Hong, Hang Yang, Qingfeng Luo, Jianping Cai, Hualan Wu, Dongxu Wang, Hao Chen, Jiefu Yang, Dapeng Dai

Front Endocrinol (Lausanne) 2023; 14: 1139805. Published online 2023 Mar 15. doi: 10.3389/fendo.2023.1139805

PMCID:: PMC10052410

Abstract Article PDF–3.1M

Select item 100062458.

CYP2C9 Polymorphisms and the Risk of Cardiovascular Events in Patients Treated with Clopidogrel: Combined Data from the POPular Genetics and POPular AGE Trials

Wout W. A. van den Broek, Nabil Mani, Jaouad Azzahhafi, Jurriën M. ten Berg

Am J Cardiovasc Drugs. 2023; 23(2): 165–172. Published online 2023 Feb 14. doi: 10.1007/s40256-022-00565-2

PMCID:: PMC10006245

Abstract Article PDF–1.3M

Select item 99906319.

The role of CYP2C9*2, CYP2C9*3 and VKORC1-1639 variants on the susceptibility of upper gastrointestinal bleeding: A full case-control study

Marcela Forgerini, Gustavo Urbano, Tales Rubens De Nadai, Sabrina Setembre Batah, Alexandre Todorovic Fabro, Patrícia De Carvalho Mastroianni

J Pharm Pharm Sci. 2023; 26: 11136. Published online 2023 Jan 30. doi: 10.3389/jpps.2023.11136

PMCID:: PMC9990631

Abstract Article PDF–661K

Select item 997639410.

Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences

Yitian Zhou, Lenka Nevosadová, Erik Eliasson, Volker M. Lauschke

Hum Genomics. 2023; 17: 15. Published online 2023 Feb 28. doi: 10.1186/s40246-023-00461-z

PMCID:: PMC9976394

Abstract Article PDF–2.2M

Select item 992368811.

Biotransformation of Bisphenol by Human Cytochrome P450 2C9 Enzymes: A Density Functional Theory Study

Artur Hermano Sampaio Dias, Rolly Yadav, Thirakorn Mokkawes, Asheesh Kumar, Munir S. Skaf, Chivukula V. Sastri, Devesh Kumar, Sam P. de Visser

Inorg Chem. 2023 Feb 6; 62(5): 2244–2256. Published online 2023 Jan 18. doi: 10.1021/acs.inorgchem.2c03984

PMCID:: PMC9923688

Abstract Article PDF–5.5M

Select item 936327312.

The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals

Sigrid Haeggström, Magnus Ingelman-Sundberg, Svante Pääbo, Hugo Zeberg

Pharmacogenomics J. 2022; 22(4): 247–249. Published online 2022 Jul 2. doi: 10.1038/s41397-022-00284-6

PMCID:: PMC9363273

Abstract Article PDF–410K

Select item 932234613.

The Impact of CYP2C9*11 Allelic Variant on the Pharmacokinetics of Phenytoin and (S)‐Warfarin

Maor Wanounou, Chanan Shaul, Zahi Abu Ghosh, Shoshana Alamia, Yoseph Caraco

Clin Pharmacol Ther. 2022 Jul; 112(1): 156–163. Published online 2022 May 5. doi: 10.1002/cpt.2613

PMCID:: PMC9322346

Abstract Article PDF–307K

Select item 925115614.

Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy

Cangsang Song, Xingde Li, Panpan Mao, Wenbing Song, Lu Liu, Yang Zhang

Eur J Hosp Pharm. 2022 Jul; 29(4): 198–201. Published online 2020 Aug 31. doi: 10.1136/ejhpharm-2020-002367

PMCID:: PMC9251156

Abstract Article PDF–222K

Select item 906987315.

CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project

Andrea Gaedigk, Erin C. Boone, Steven E. Scherer, Seung-been Lee, Ibrahim Numanagić, Cenk Sahinalp, Joshua D. Smith, Sean McGee, Aparna Radhakrishnan, Xiang Qin, Wendy Y. Wang, Emily G. Farrow, Nina Gonzaludo, Aaron L. Halpern, Deborah A. Nickerson, Neil A. Miller, Victoria M. Pratt, Lisa V. Kalman

J Mol Diagn. 2022 Apr; 24(4): 337–350. doi: 10.1016/j.jmoldx.2021.12.011

PMCID:: PMC9069873

Abstract Article PDF–1.4M

Select item 881786516.

Genetic Analysis of CYP2C9 with Reference to Drug Response in Epilepsy Patients of Pakistan

Hafsa Maqbool, Tayyaba Saleem, Nadeem Sheikh, Aqsa Ashfaq

Genet Res (Camb) 2022; 2022: 1451007. Published online 2022 Jan 29. doi: 10.1155/2022/1451007

PMCID:: PMC8817865

Abstract Article PDF–1.0M

Select item 850869417.

Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison

Sonia J. Parikh, Sumit Kamat, Margaret Phillips, Samuel P. Boyson, Thomas Yarbrough, Dylan Davie, Qinghai Zhang, Karen C. Glass, Manish B. Shah

Int J Mol Sci. 2021 Oct; 22(19): 10206. Published online 2021 Sep 22. doi: 10.3390/ijms221910206

PMCID:: PMC8508694

Abstract Article PDF–3.3M

Select item 845616718.

Massively parallel characterization of CYP2C9 variant enzyme activity and abundance

Clara J. Amorosi, Melissa A. Chiasson, Matthew G. McDonald, Lai Hong Wong, Katherine A. Sitko, Gabriel Boyle, John P. Kowalski, Allan E. Rettie, Douglas M. Fowler, Maitreya J. Dunham

Am J Hum Genet. 2021 Sep 2; 108(9): 1735–1751. Published online 2021 Jul 26. doi: 10.1016/j.ajhg.2021.07.001

PMCID:: PMC8456167

Abstract Article PDF–4.5M

Select item 838486719.

Impact of genetic and non-genetic factors on hepatic CYP2C9 expression and activity in Hungarian subjects

Ferenc Fekete, Katalin Mangó, Máté Déri, Evelyn Incze, Annamária Minus, Katalin Monostory

Sci Rep. 2021; 11: 17081. Published online 2021 Aug 24. doi: 10.1038/s41598-021-96590-3

PMCID:: PMC8384867

Abstract Article PDF–1.2M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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