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Select item 112586011.

Inhibition of FBP1 expression by KMT5A through TWIST1 methylation is one of the mechanisms leading to chemoresistance in breast cancer

Xue Peng, Lisi Ma, Xuan Chen, Fen Tang, Xiangyun Zong

Oncol Rep. 2024 Aug; 52(2): 110. Published online 2024 Jul 3. doi: 10.3892/or.2024.8769

PMCID:: PMC11258601

Abstract Article PDF–7.1M

Select item 111520092.

Lysine Methyltransferase 5A Promotes the Progression of Growth Hormone Pituitary Neuroendocrine Tumors through the Wnt/β-Catenin Signaling Pathway

Junjun Li, Hao Song, Ting Chen, Sixi Zhang, Chao Zhang, Chen Ma, Lingye Zhang, Tengfei Wang, Yuan Qian, Xingli Deng

Neuroendocrinology. 2024 Jun; 114(6): 589–601. Published online 2024 Apr 2. doi: 10.1159/000538560

PMCID:: PMC11152009

Abstract Article

Select item 109113513.

Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification

Yun Li, Meijuan Cheng, Jingjing Jin, Dongxue Zhang, Shenglei Zhang, Yaling Bai, Jinsheng Xu

Aging (Albany NY) 2024 Feb 15; 16(3): 2438–2456. Published online 2024 Feb 1. doi: 10.18632/aging.205492

PMCID:: PMC10911351

Abstract Article PDF–2.4M

Select item 95403454.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 95132715.

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1

Amelia K. Luciano, Ekaterina D. Korobkina, Scott P. Lyons, John A. Haley, Shelagh M. Fluharty, Su Myung Jung, Arminja N. Kettenbach, David A. Guertin

J Biol Chem. 2022 Oct; 298(10): 102379. Published online 2022 Aug 13. doi: 10.1016/j.jbc.2022.102379

PMCID:: PMC9513271

Abstract Article PDF–2.7M

Select item 94065286.

USP29 Deubiquitinates SETD8 and Regulates DNA Damage-Induced H4K20 Monomethylation and 53BP1 Focus Formation

Yeray Hernández-Reyes, María Cristina Paz-Cabrera, Raimundo Freire, Veronique A. J. Smits

Cells. 2022 Aug; 11(16): 2492. Published online 2022 Aug 11. doi: 10.3390/cells11162492

PMCID:: PMC9406528

Abstract Article PDF–1.9M

Select item 93383137.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 90234928.

KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling

Bo Yu, Jun Su, Qiqi Shi, Qing Liu, Jun Ma, Guoqing Ru, Lei Zhang, Jian Zhang, Xichun Hu, Jianming Tang

Nat Commun. 2022; 13: 2192. Published online 2022 Apr 21. doi: 10.1038/s41467-022-29899-w

PMCID:: PMC9023492

Abstract Article PDF–4.1M

Select item 82661689.

ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy

Lihong Lu, Ziwen Zhong, Jiahui Gu, Ke Nan, Minmin Zhu, Changhong Miao

Mol Med. 2021; 27: 74. Published online 2021 Jul 8. doi: 10.1186/s10020-021-00339-7

PMCID:: PMC8266168

Abstract Article PDF–6.4M

Select item 817992510.

LncRNA LINC00473 is involved in the progression of invasive pituitary adenoma by upregulating KMT5A via ceRNA-mediated miR-502-3p evasion

Junjun Li, Yuan Qian, Chao Zhang, Wei Wang, Yisheng Qiao, Hao Song, Liyan Li, Jiazhi Guo, Di Lu, Xingli Deng

Cell Death Dis. 2021 Jun; 12(6): 580. Published online 2021 Jun 5. doi: 10.1038/s41419-021-03861-y

PMCID:: PMC8179925

Abstract Article PDF–2.3M

Select item 808068011.

SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN

Xuefang Shen, Xiangyuan Chen, Jing Wang, Jing Liu, Zhiyao Wang, Qing Hua, Qichao Wu, Yanguang Su, Huanzhong He, Yuqin Hu, Zhipeng Meng, Wanxia Xiong, Minmin Zhu

Exp Mol Med. 2020 Oct; 52(10): 1715–1729. Published online 2020 Oct 7. doi: 10.1038/s12276-020-00509-3

PMCID:: PMC8080680

Abstract Article PDF–3.8M

Select item 776689412.

Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer

Miku Wada, Asako Kukita, Kenbun Sone, Ryuji Hamamoto, Syuzo Kaneko, Masaaki Komatsu, Yu Takahashi, Futaba Inoue, Machiko Kojima, Harunori Honjoh, Ayumi Taguchi, Tomoko Kashiyama, Yuichiro Miyamoto, Michihiro Tanikawa, Tetsushi Tsuruga, Mayuyo Mori-Uchino, Osamu Wada-Hiraike, Yutaka Osuga, Tomoyuki Fujii

Biomolecules. 2020 Dec; 10(12): 1686. Published online 2020 Dec 16. doi: 10.3390/biom10121686

PMCID:: PMC7766894

Abstract Article PDF–4.0M

Select item 759933813.

Histone methyltransferase SET8 is regulated by miR-192/215 and induces oncogene-induced senescence via p53-dependent DNA damage in human gastric carcinoma cells

Xiaojing Zhang, Yin Peng, Yuan Yuan, Yuli Gao, Fan Hu, Jian Wang, Xiaohui Zhu, Xianling Feng, Yulan Cheng, Yanjie Wei, Xinmin Fan, Yaohong Xie, Yansi Lv, Hassan Ashktorab, Duane Smoot, Song Li, Stephen J. Meltzer, Gangqiang Hou, Zhe Jin

Cell Death Dis. 2020 Oct; 11(10): 937. Published online 2020 Oct 30. doi: 10.1038/s41419-020-03130-4

PMCID:: PMC7599338

Abstract Article PDF–8.3M

Select item 713599814.

The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates α-tubulin

Hang Gyeong Chin, Pierre-Olivier Esteve, Cristian Ruse, Jiyoung Lee, Scott E. Schaus, Sriharsa Pradhan, Ulla Hansen

J Biol Chem. 2020 Apr 3; 295(14): 4748–4759. Published online 2020 Feb 28. doi: 10.1074/jbc.RA119.010951

PMCID:: PMC7135998

Abstract Article PDF–2.5M

Select item 692771015.

SET8 localization to chromatin flanking DNA damage is dependent on RNF168 ubiquitin ligase

Stanimir Dulev, Sichun Lin, Qingquan Liu, Vildan B. Cetintas, Nizar N. Batada

Cell Cycle. 2020; 19(1): 15–23. Published online 2019 Nov 24. doi: 10.1080/15384101.2019.1690231

PMCID:: PMC6927710

Abstract Article PDF–2.8M

Select item 682732016.

The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizing the methyltransferase SET8 and transcriptionally repressing p21

Keishi Fukuura, Yasumichi Inoue, Chiharu Miyajima, Shin Watanabe, Muneshige Tokugawa, Daisuke Morishita, Nobumichi Ohoka, Masayuki Komada, Hidetoshi Hayashi

J Biol Chem. 2019 Nov 1; 294(44): 16429–16439. Published online 2019 Sep 18. doi: 10.1074/jbc.RA119.009006

PMCID:: PMC6827320

Abstract Article PDF–3.6M

Select item 677813717.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 675349518.

SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1

Huifang Zhang, Qinqin Gao, Shuo Tan, Jia You, Cong Lyu, Yunpeng Zhang, Mengmeng Han, Zhaosu Chen, Jialun Li, Hailin Wang, Lujian Liao, Jun Qin, Jiwen Li, Jiemin Wong

Nucleic Acids Res. 2019 Sep 26; 47(17): 9053–9068. Published online 2019 Aug 10. doi: 10.1093/nar/gkz626

PMCID:: PMC6753495

Abstract Article PDF–8.0M

Select item 657952019.

The dynamic conformational landscape of the protein methyltransferase SETD8

Shi Chen, Rafal P Wiewiora, Fanwang Meng, Nicolas Babault, Anqi Ma, Wenyu Yu, Kun Qian, Hao Hu, Hua Zou, Junyi Wang, Shijie Fan, Gil Blum, Fabio Pittella-Silva, Kyle A Beauchamp, Wolfram Tempel, Hualiang Jiang, Kaixian Chen, Robert J Skene, Yujun George Zheng, Peter J Brown, Jian Jin, Cheng Luo, John D Chodera, Minkui Luo

eLife. 2019; 8: e45403. Published online 2019 May 13. doi: 10.7554/eLife.45403