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Select item 112933511.

Intergenic risk variant rs56258221 skews the fate of naive CD4⁺ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis

Tobias Poch, Jonas Bahn, Christian Casar, Jenny Krause, Ioannis Evangelakos, Hilla Gilladi, Lilly K. Kunzmann, Alena Laschtowitz, Nicola Iuso, Anne-Marie Schäfer, Laura A. Liebig, Silja Steinmann, Marcial Sebode, Trine Folseraas, Lise K. Engesæter, Tom H. Karlsen, Andre Franke, Norbert Hubner, Christian Schlein, Eithan Galun, Samuel Huber, Ansgar W. Lohse, Nicola Gagliani, Dorothee Schwinge, Christoph Schramm

Cell Rep Med. 2024 Jul 16; 5(7): 101620. Published online 2024 Jun 19. doi: 10.1016/j.xcrm.2024.101620

PMCID:: PMC11293351

Abstract Article PDF–5.9M

Select item 111481842.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 109216393.

The role of Bach2 in regulating CD8 + T cell development and function

Xinyu Weng, Min Zheng, Yanning Liu, Guohua Lou

Cell Commun Signal. 2024; 22: 169. Published online 2024 Mar 8. doi: 10.1186/s12964-024-01551-8

PMCID:: PMC10921639

Abstract Article PDF–1.0M

Select item 101189424.

The rs11755527 polymorphism in the BACH2 gene and type 1 diabetes mellitus: case control study in a Brazilian population

Cristine Dieter, Natália Emerim Lemos, Luiza Emy Dorfman, Guilherme Coutinho Kullmann Duarte, Taís Silveira Assmann, Daisy Crispim

Arch Endocrinol Metab. 2020 Mar-Apr; 64(2): 138–143. Published online 2020 Mar 18. doi: 10.20945/2359-3997000000214

PMCID:: PMC10118942

Abstract Article PDF–154K

Select item 95296145.

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

Charlotte J. Imianowski, Sarah K. Whiteside, Teresa Lozano, Alexander C. Evans, Jayme D. Benson, Christina J.F. Courreges, Firas Sadiyah, Colleen M. Lau, Nordin D. Zandhuis, Francis M. Grant, Martijn J. Schuijs, Panagiota Vardaka, Paula Kuo, Elizabeth J. Soilleux, Jie Yang, Joseph C. Sun, Tomohiro Kurosaki, Klaus Okkenhaug, Timotheus Y.F. Halim, Rahul Roychoudhuri

J Exp Med. 2022 Dec 5; 219(12): e20211476. Published online 2022 Sep 30. doi: 10.1084/jem.20211476

PMCID:: PMC9529614

Abstract Article PDF–5.6M

Select item 91052356.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 89767477.

CRISPR/Cas9-mediated insertion of HIV LTR within BACH2 promotes expansion of T regulatory-like cells

Michelle L. Christian, Michael J. Dapp, Samuel C. Scharffenberger, Hank Jones, Chaozhong Song, Lisa M. Frenkel, Anthony Krumm, James I. Mullins, David J. Rawlings

J Immunol. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: J Immunol. 2022 Apr 1; 208(7): 1700–1710. Published online 2022 Mar 9. doi: 10.4049/jimmunol.2100491

PMCID:: PMC8976747

Abstract Article PDF–1.6M

Select item 86708428.

BACH2 inhibition reverses β cell failure in type 2 diabetes models

Jinsook Son, Hongxu Ding, Thomas B. Farb, Alexander M. Efanov, Jiajun Sun, Julie L. Gore, Samreen K. Syed, Zhigang Lei, Qidi Wang, Domenico Accili, Andrea Califano

J Clin Invest. 2021 Dec 15; 131(24): e153876. Published online 2021 Dec 15. doi: 10.1172/JCI153876

PMCID:: PMC8670842

Abstract Article PDF–12M

Select item 84402669.

Polymorphism in BACH2 gene is a marker of polyglandular autoimmunity

Marta Fichna, Magdalena Żurawek, Bartosz Słomiński, Marta Sumińska, Agata Czarnywojtek, Natalia Rozwadowska, Piotr Fichna, Małgorzata Myśliwiec, Marek Ruchała

Endocrine. 2021; 74(1): 72–79. Published online 2021 May 8. doi: 10.1007/s12020-021-02743-9

PMCID:: PMC8440266

Abstract Article PDF–463K

Select item 835772710.

Whole genome sequencing identifies variants associated with sarcoidosis in a family with a high prevalence of sarcoidosis

Daan Fritz, Bart Ferwerda, Matthijs C. Brouwer, Diederik van de Beek

Clin Rheumatol. 2021; 40(9): 3735–3743. Published online 2021 Apr 27. doi: 10.1007/s10067-021-05684-w

PMCID:: PMC8357727

Abstract Article PDF–365K

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 805568812.

Up-regulated circBACH2 contributes to cell proliferation, invasion, and migration of triple-negative breast cancer

Xinxing Wang, Bingjian Xue, Yujie Zhang, Guangcheng Guo, Xin Duan, Dongwei Dou

Cell Death Dis. 2021 May; 12(5): 412. Published online 2021 Apr 19. doi: 10.1038/s41419-021-03684-x

PMCID:: PMC8055688

Abstract Article PDF–3.8M

Select item 800904813.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 794845214.

A conserved acetylation switch enables pharmacological control of tubby-like protein stability

Evan M. Kerek, Kevin H. Yoon, Shu Y. Luo, Jerry Chen, Robert Valencia, Olivier Julien, Andrew J. Waskiewicz, Basil P. Hubbard

J Biol Chem. 2021 Jan-Jun; 296: 100073. Published online 2020 Nov 23. doi: 10.1074/jbc.RA120.015839

PMCID:: PMC7948452

Abstract Article PDF–3.6M

Select item 793578115.

BACH2‐mediated FOS confers cytarabine resistance via stromal microenvironment alterations in pediatric ALL

Han Zhang, Ruidong Zhang, Xueling Zheng, Ming Sun, Jia Fan, Chunlian Fang, Xin Tian, Huyong Zheng

Cancer Sci. 2021 Mar; 112(3): 1235–1250. Published online 2021 Jan 22. doi: 10.1111/cas.14792

PMCID:: PMC7935781

Abstract Article PDF–3.1M

Select item 760716716.

Interaction of BACH2 with FUS promotes malignant progression of glioma cells via the TSLNC8–miR‐10b‐5p–WWC3 pathway

Yang Yang, Xiaobai Liu, Jian Zheng, Yixue Xue, Libo Liu, Jun Ma, Ping Wang, Chunqing Yang, Di Wang, Lianqi Shao, Xuelei Ruan, Yunhui Liu

Mol Oncol. 2020 Nov; 14(11): 2936–2959. Published online 2020 Sep 26. doi: 10.1002/1878-0261.12795

PMCID:: PMC7607167

Abstract Article PDF–23M

Select item 716998317.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 701221518.

The Critical Role of Bach2 in Shaping the Balance between CD4⁺ T Cell Subsets in Immune-Mediated Diseases

Lingyi Yang, Shuli Chen, Qiuyu Zhao, Ying Sun, Hong Nie

Mediators Inflamm. 2019; 2019: 2609737. Published online 2019 Dec 30. doi: 10.1155/2019/2609737

PMCID:: PMC7012215

Abstract Article PDF–391K

Select item 694204419.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 682594520.

Variants in the BACH2 and CLEC16A gene might be associated with susceptibility to insulin‐triggered type 1 diabetes

Hiroshi Onuma, Ryoichi Kawamura, Yasuharu Tabara, Masakatsu Yamashita, Jun Ohashi, Eiji Kawasaki, Akihisa Imagawa, Yuya Yamada, Daisuke Chujo, Kenji Takahashi, Tadashi Suehiro, Yasunori Takata, Haruhiko Osawa, Hideichi Makino

J Diabetes Investig. 2019 Nov; 10(6): 1447–1453. Published online 2019 May 14. doi: 10.1111/jdi.13057

PMCID:: PMC6825945

Abstract Article PDF–403K

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