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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 100013722.

Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2

Sophie Broadway-Stringer, He Jiang, Kirsty Wadmore, Charlotte Hooper, Gillian Douglas, Violetta Steeples, Amar J. Azad, Evie Singer, Jasmeet S. Reyat, Frantisek Galatik, Elisabeth Ehler, Pauline Bennett, Jacinta I. Kalisch-Smith, Duncan B. Sparrow, Benjamin Davies, Kristina Djinovic-Carugo, Mathias Gautel, Hugh Watkins, Katja Gehmlich

Cells. 2023 Mar; 12(5): 721. Published online 2023 Feb 24. doi: 10.3390/cells12050721

PMCID:: PMC10001372

Abstract Article PDF–2.7M

Select item 97752253.

Genetic Ablation of Ankrd1 Mitigates Cardiac Damage during Experimental Autoimmune Myocarditis in Mice

Ieva Rinkūnaitė, Egidijus Šimoliūnas, Milda Alksnė, Gabrielė Bartkutė, Siegfried Labeit, Virginija Bukelskienė, Julius Bogomolovas

Biomolecules. 2022 Dec; 12(12): 1898. Published online 2022 Dec 18. doi: 10.3390/biom12121898

PMCID:: PMC9775225

Abstract Article PDF–2.7M

Select item 96553134.

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate

Nour Abou Nader, Amélie Ménard, Adrien Levasseur, Guillaume St-Jean, Derek Boerboom, Gustavo Zamberlam, Alexandre Boyer

Int J Mol Sci. 2022 Nov; 23(21): 13585. Published online 2022 Nov 5. doi: 10.3390/ijms232113585

PMCID:: PMC9655313

Abstract Article PDF–4.1M

Select item 83479365.

A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis

Chun-Hao Hung, Tung-Liang Lee, Anna Yu-Szu Huang, Kang-Chung Yang, Yu-Chiau Shyu, Shau-Ching Wen, Mu-Jie Lu, Shinsheng Yuan, Che-Kun James Shen

Int J Mol Sci. 2021 Aug; 22(15): 8024. Published online 2021 Jul 27. doi: 10.3390/ijms22158024

PMCID:: PMC8347936

Abstract Article PDF–4.4M

Select item 77825896.

QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function

Xinyun Chen, Ying Liu, Chen Xu, Lina Ba, Zhuo Liu, Xiuya Li, Jie Huang, Ed Simpson, Hongyu Gao, Dayan Cao, Wei Sheng, Hanping Qi, Hongrui Ji, Maria Sanderson, Chen-Leng Cai, Xiaohui Li, Lei Yang, Jie Na, Kenichi Yamamura, Yunlong Liu, Guoying Huang, Weinian Shou, Ning Sun

Nat Commun. 2021; 12: 89. Published online 2021 Jan 4. doi: 10.1038/s41467-020-20327-5

PMCID:: PMC7782589

Abstract Article PDF–8.6M

Select item 76581957.

The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling

Sek-Shir Cheong, Khondoker M. Akram, Carlos Matellan, Sally Yunsun Kim, David C. A. Gaboriau, Matthew Hind, Armando E. del Río Hernández, Mark Griffiths, Charlotte H. Dean

Front Cell Dev Biol. 2020; 8: 577201. Published online 2020 Oct 29. doi: 10.3389/fcell.2020.577201

PMCID:: PMC7658195

Abstract Article PDF–8.8M

Select item 64420368.

Myocardial-specific ablation of Jumonji and AT-rich interaction domain–containing 2 (Jarid2) leads to dilated cardiomyopathy in mice

Eunjin Cho, HyunJun Kang, Dae-Ki Kang, Youngsook Lee

J Biol Chem. 2019 Mar 29; 294(13): 4981–4996. Published online 2019 Jan 30. doi: 10.1074/jbc.RA118.005634

PMCID:: PMC6442036

Abstract Article PDF–3.3M

Select item 62429399.

Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement

Guangshuai Jia, Jens Preussner, Xi Chen, Stefan Guenther, Xuejun Yuan, Michail Yekelchyk, Carsten Kuenne, Mario Looso, Yonggang Zhou, Sarah Teichmann, Thomas Braun

Nat Commun. 2018; 9: 4877. Published online 2018 Nov 19. doi: 10.1038/s41467-018-07307-6

PMCID:: PMC6242939

Abstract Article PDF–6.6M

Select item 585436110.

Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Ca_v1.1 converge at E18.5

Dilyana Filipova, Margit Henry, Tamara Rotshteyn, Anna Brunn, Mariana Carstov, Martina Deckert, Jürgen Hescheler, Agapios Sachinidis, Gabriele Pfitzer, Symeon Papadopoulos

PLoS One. 2018; 13(3): e0194428. Published online 2018 Mar 15. doi: 10.1371/journal.pone.0194428

PMCID:: PMC5854361

Abstract Article PDF–29M

Select item 582301111.

YAP/TAZ and Hedgehog coordinate growth and patterning in gastrointestinal mesenchyme

Jennifer L. Cotton, Qi Li, Lifang Ma, Joo-Seop Park, Jiayi Wang, Jianhong Ou, Lihua J. Zhu, Y. Tony Ip, Randy L. Johnson, Junhao Mao

Dev Cell. Author manuscript; available in PMC 2018 Oct 9.

Published in final edited form as: Dev Cell. 2017 Oct 9; 43(1): 35–47.e4. Published online 2017 Sep 21. doi: 10.1016/j.devcel.2017.08.019

PMCID:: PMC5823011

Abstract Article PDF–3.7M

Select item 577540012.

The histone code reader Spin1 controls skeletal muscle development

Holger Greschik, Delphine Duteil, Nadia Messaddeq, Dominica Willmann, Laura Arrigoni, Manuela Sum, Manfred Jung, Daniel Metzger, Thomas Manke, Thomas Günther, Roland Schüle

Cell Death Dis. 2017 Nov; 8(11): e3173. Published online 2017 Nov 23. doi: 10.1038/cddis.2017.468

PMCID:: PMC5775400

Abstract Article PDF–6.2M

Select item 555028213.

Elastic force restricts growth of the murine utricle

Ksenia Gnedeva, Adrian Jacobo, Joshua D Salvi, Aleksandra A Petelski, A J Hudspeth

eLife. 2017; 6: e25681. Published online 2017 Jul 25. doi: 10.7554/eLife.25681

PMCID:: PMC5550282

Abstract Article PDF–11M

Select item 529582114.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 493134315.

MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

Stephan Lange, Katja Gehmlich, Alexander S. Lun, Jordan Blondelle, Charlotte Hooper, Nancy D. Dalton, Erika A. Alvarez, Xiaoyu Zhang, Marie-Louise Bang, Yama A. Abassi, Cristobal G. dos Remedios, Kirk L. Peterson, Ju Chen, Elisabeth Ehler

Nat Commun. 2016; 7: 12120. Published online 2016 Jun 29. doi: 10.1038/ncomms12120

PMCID:: PMC4931343

Abstract Article PDF–2.2M

Select item 493132416.

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

Da-Hye Lee, Jae Oh Park, Tae-Shin Kim, Sang-Kyum Kim, Tack-hoon Kim, Min-chul Kim, Gun Soo Park, Jeong-Hwan Kim, Shinji Kuninaka, Eric N. Olson, Hideyuki Saya, Seon-Young Kim, Ho Lee, Dae-Sik Lim

Nat Commun. 2016; 7: 11961. Published online 2016 Jun 30. doi: 10.1038/ncomms11961

PMCID:: PMC4931324

Abstract Article PDF–3.4M

Select item 456598617.

Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers

Giuseppina Mastrototaro, Xingqun Liang, Xiaodong Li, Pierluigi Carullo, Nicoletta Piroddi, Chiara Tesi, Yusu Gu, Nancy D. Dalton, Kirk L. Peterson, Corrado Poggesi, Farah Sheikh, Ju Chen, Marie-Louise Bang

Cardiovasc Res. 2015 Jul 15; 107(2): 216–225. Published online 2015 May 18. doi: 10.1093/cvr/cvv156

PMCID:: PMC4565986

Abstract Article

Select item 448157218.

Targeted inhibition of ANKRD1 disrupts sarcomeric ERK-GATA4 signal transduction and abrogates phenylephrine-induced cardiomyocyte hypertrophy

Lin Zhong, Manuel Chiusa, Adrian G. Cadar, Angel Lin, Susan Samaras, Jeffrey M. Davidson, Chee C. Lim

Cardiovasc Res. 2015 May 1; 106(2): 261–271. Published online 2015 Mar 13. doi: 10.1093/cvr/cvv108

PMCID:: PMC4481572

Abstract Article PDF–1.0M

Select item 427824319.

Global Deletion of Ankrd1 Results in a Wound-Healing Phenotype Associated with Dermal Fibroblast Dysfunction

Susan E. Samaras, Karinna Almodóvar-García, Nanjun Wu, Fang Yu, Jeffrey M. Davidson

Am J Pathol. 2015 Jan; 185(1): 96–109. doi: 10.1016/j.ajpath.2014.09.018

PMCID:: PMC4278243

Abstract Article PDF–2.2M

Select item 412129420.

Cytosolic CARP Promotes Angiotensin II- or Pressure Overload-Induced Cardiomyocyte Hypertrophy through Calcineurin Accumulation

Ci Chen, Liang Shen, Shiping Cao, Xixian Li, Wanling Xuan, Jingwen Zhang, Xiaobo Huang, Jianping Bin, Dingli Xu, Guofeng Li, Masafumi Kitakaze, Yulin Liao

PLoS One. 2014; 9(8): e104040. Published online 2014 Aug 4. doi: 10.1371/journal.pone.0104040

PMCID:: PMC4121294

Abstract Article PDF–5.7M

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