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Items: 1 to 20 of 62

1.
Knockout mice with pituitary malformations help identify human cases of hypopituitarism
Julian Martinez-Mayer, Michelle L. Brinkmeier, Sean P. O’Connell, Arnold Ukagwu, Marcelo A. Marti, Mirta Miras, Maria V. Forclaz, Maria G. Benzrihen, Leonard Y. M. Cheung, Sally A. Camper, Buffy S. Ellsworth, Lori T. Raetzman, Maria I. Pérez-Millán, Shannon W. Davis
Genome Med. 2024; 16: 75. Published online 2024 May 31. doi: 10.1186/s13073-024-01347-y
PMCID:
PMC11140907
AbstractArticlePDF–4.4M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Inhibition of NADPH Oxidase (NOX) 2 Mitigates Colitis in Mice with Impaired Macrophage AMPK Function
Suhrid Banskota, Huaqing Wang, Yun Han Kwon, Jaya Gautam, Sabah Haq, Jensine Grondin, Gregory R. Steinberg, Waliul I. Khan
Biomedicines. 2023 May; 11(5): 1443. Published online 2023 May 14. doi: 10.3390/biomedicines11051443
PMCID:
PMC10216132
AbstractArticlePDF–2.5M
4.
The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids
Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Serge Ducommun, Matthew J. Sanders, Joshua P. Nederveen, Rebecca J. Ford, Stephen L. Pinkosky, Logan K. Townsend, Robert M. Gutgesell, Rachel Lu, Kei Sakamoto, Gregory R. Steinberg
Proc Natl Acad Sci U S A. 2022 Nov 29; 119(48): e2119824119. Published online 2022 Nov 21. doi: 10.1073/pnas.2119824119
PMCID:
PMC9860314
AbstractArticlePDF–1.5M
5.
Salsalate reduces atherosclerosis through AMPKβ1 in mice
Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Vanessa P. Houde, Stephanie Stypa, Sonia Rehal, Sarka Lhotak, Bruce E. Kemp, Bernardo L. Trigatti, Geoff H. Werstuck, Richard C. Austin, Morgan D. Fullerton, Gregory R. Steinberg
Mol Metab. 2021 Nov; 53: 101321. Published online 2021 Aug 21. doi: 10.1016/j.molmet.2021.101321
PMCID:
PMC8429104
AbstractArticlePDF–1.8M
6.
Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK
Suhrid Banskota, Huaqing Wang, Yun Han Kwon, Jaya Gautam, Pallavi Gurung, Sabah Haq, F M Nazmul Hassan, Dawn M Bowdish, Jung-Ae Kim, David Carling, Morgan D Fullerton, Gregory R Steinberg, Waliul I Khan
Inflamm Bowel Dis. 2021 Jun; 27(6): 914–926. Published online 2020 Nov 30. doi: 10.1093/ibd/izaa305
PMCID:
PMC8128406
AbstractArticlePDF–20M
7.
AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival
Ranjithmenon Muraleedharan, Mruniya V. Gawali, Durgesh Tiwari, Abitha Sukumaran, Nicole Oatman, Jane Anderson, Diana Nardini, Mohammad Alfrad Nobel Bhuiyan, Ivan Tkáč, Amber Lynne Ward, Mondira Kundu, Ronald Waclaw, Lionel M. Chow, Christina Gross, Raghavendra Rao, Stefanie Schirmeier, Biplab Dasgupta
Cell Rep. Author manuscript; available in PMC 2020 Oct 2.
Published in final edited form as: Cell Rep. 2020 Sep 1; 32(9): 108092. doi: 10.1016/j.celrep.2020.108092
PMCID:
PMC7531170
AbstractArticlePDF–4.3M
8.
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1-isoforms
Stephen L. Pinkosky, John W. Scott, Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Rebecca J. Ford, Christopher G. Langendorf, Naomi X. Y. Ling, Tracy L. Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William J. Smiles, Kevin R.W. Ngoei, Michael W. Parker, Yan Yan, Karsten Melcher, Bruce E. Kemp, Jonathan S. Oakhill, Gregory R. Steinberg
Nat Metab. Author manuscript; available in PMC 2021 Jan 27.
Published in final edited form as: Nat Metab. 2020 Sep; 2(9): 873–881. Published online 2020 Jul 27. doi: 10.1038/s42255-020-0245-2
PMCID:
PMC7502547
ArticlePDF–1.6M
9.
Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1
Anusha Seneviratne, Yumeng Han, Eunice Wong, Edward R.H. Walter, Lijun Jiang, Luke Cave, Nicholas J. Long, David Carling, Justin C. Mason, Dorian O. Haskard, Joseph J. Boyle
Circ Res. 2020 Sep 11; 127(7): 928–944. Published online 2020 Jul 2. doi: 10.1161/CIRCRESAHA.119.315528
PMCID:
PMC7478221
AbstractArticlePDF–12M
10.
Autophagy is required for lung development and morphogenesis
Behzad Yeganeh, Joyce Lee, Leonardo Ermini, Irene Lok, Cameron Ackerley, Martin Post
J Clin Invest. 2019 Jul 1; 129(7): 2904–2919. Published online 2019 Jun 4. doi: 10.1172/JCI127307
PMCID:
PMC6597208
AbstractArticlePDF–24M
11.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
12.
CAMKK2 promotes prostate cancer independently of AMPK via increased lipogenesis
Lucy Penfold, Angela Woods, Phillip Muckett, Alexander Yu. Nikitin, Tera R. Kent, Shuai Zhang, Rebecca Graham, Alice Pollard, David Carling
Cancer Res. Author manuscript; available in PMC 2019 Jun 15.
Published in final edited form as: Cancer Res. 2018 Dec 15; 78(24): 6747–6761. Published online 2018 Sep 21. doi: 10.1158/0008-5472.CAN-18-0585
PMCID:
PMC6295249
AbstractArticlePDF–2.0M
13.
AMP Kinase Promotes Glioblastoma Bioenergetics and Tumor Growth
Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang, Georgianne Ciraolo, Xiaoting Chen, Ronald Waclaw, Lionel M. Chow, Zaza Khuchua, Matthew Kofron, Matthew T. Weirauch, Ady Kendler, Christopher McPherson, Nancy Ratner, Ichiro Nakano, Nupur Dasgupta, Kakajan Komurov, Biplab Dasgupta
Nat Cell Biol. Author manuscript; available in PMC 2018 Dec 18.
Published in final edited form as: Nat Cell Biol. 2018 Jul; 20(7): 823–835. Published online 2018 Jun 18. doi: 10.1038/s41556-018-0126-z
PMCID:
PMC6113057
AbstractArticlePDF–4.6M
14.
CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice
Jin Li, Su-Ping Deng, Gang Wei, Peng Yu
Database (Oxford) 2018; 2018: bay012. Published online 2018 Mar 23. doi: 10.1093/database/bay012
PMCID:
PMC5868181
AbstractArticlePDF–653K
15.
The AMP-activated protein kinase beta 1 subunit modulates erythrocyte integrity
Emma L. Cambridge, Zoe McIntyre, Simon Clare, Mark J. Arends, David Goulding, Christopher Isherwood, Susana S. Caetano, Carmen Ballesteros Reviriego, Agnieszka Swiatkowska, Leanne Kane, Katherine Harcourt, The Sanger Mouse Genetics Project, David J. Adams, Jacqueline K. White, Anneliese O. Speak
Exp Hematol. 2017 Jan; 45: 64–68.e5. doi: 10.1016/j.exphem.2016.09.006
PMCID:
PMC5823972
AbstractArticlePDF–1.9M
16.
AMPK β1 reduces tumor progression and improves survival in p53 null mice
Vanessa P. Houde, Sara Donzelli, Andrea Sacconi, Sandra Galic, Joanne A. Hammill, Jonathan L. Bramson, Robert A. Foster, Theodoros Tsakiridis, Bruce E. Kemp, Giuseppe Grasso, Giovanni Blandino, Paola Muti, Gregory R. Steinberg
Mol Oncol. 2017 Sep; 11(9): 1143–1155. Published online 2017 Jun 28. doi: 10.1002/1878-0261.12079
PMCID:
PMC5579332
AbstractArticlePDF–773K
17.
A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5)
Stefan H. Geyer, Lukas Reissig, Julia Rose, Robert Wilson, Fabrice Prin, Dorota Szumska, Ramiro Ramirez‐Solis, Catherine Tudor, Jacqui White, Timothy J. Mohun, Wolfgang J. Weninger
J Anat. 2017 May; 230(5): 710–719. Published online 2017 Feb 9. doi: 10.1111/joa.12590
PMCID:
PMC5382591
AbstractArticlePDF–1.5M
18.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
19.
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
Emilio P. Mottillo, Eric M. Desjardins, Justin D. Crane, Brennan K. Smith, Alex E. Green, Serge Ducommun, Tora I. Henriksen, Irena A. Rebalka, Aida Razi, Kei Sakamoto, Camilla Scheele, Bruce E. Kemp, Thomas J. Hawke, Joaquin Ortega, James G. Granneman, Gregory R. Steinberg
Cell Metab. Author manuscript; available in PMC 2017 Jan 16.
Published in final edited form as: Cell Metab. 2016 Jul 12; 24(1): 118–129. doi: 10.1016/j.cmet.2016.06.006
PMCID:
PMC5239668
AbstractArticlePDF–1.8M
20.
Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1
Brennan K. Smith, Rebecca J. Ford, Eric M. Desjardins, Alex E. Green, Meghan C. Hughes, Vanessa P. Houde, Emily A. Day, Katarina Marcinko, Justin D. Crane, Emilio P. Mottillo, Christopher G.R. Perry, Bruce E. Kemp, Mark A. Tarnopolsky, Gregory R. Steinberg
Diabetes. Author manuscript; available in PMC 2017 Jan 12.
Published in final edited form as: Diabetes. 2016 Nov; 65(11): 3352–3361. Published online 2016 Aug 23. doi: 10.2337/db16-0564
PMCID:
PMC5233442
AbstractArticlePDF–980K

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