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Items: 1 to 20 of 50

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance
Nathalia R.V. Dragano, Edward Milbank, Roberta Haddad-Tóvolli, Pablo Garrido-Gil, Eva Nóvoa, Marcos F. Fondevilla, Valentina Capelli, Ariane Maria Zanesco, Carina Solon, Joseane Morari, Leticia Pires, Ánxela Estevez-Salguero, Daniel Beiroa, Ismael González-García, Olga Barca-Mayo, Carlos Diéguez, Ruben Nogueiras, José L. Labandeira-García, Elisabeth Rexen Ulven, Trond Ulven, Marc Claret, Licio A. Velloso, Miguel López
Mol Metab. 2024 Jan; 79: 101840. Published online 2023 Nov 29. doi: 10.1016/j.molmet.2023.101840
PMCID:
PMC10784317
AbstractArticlePDF–3.3M
3.
GPR40 Deficiency Worsens Metabolic Syndrome-Associated Periodontitis in Mice
Yanchun Li, Zhongyang Lu, Cameron L. Kirkwood, Keith L. Kirkwood, Stephen A. Wank, Ai-Jun Li, Maria F. Lopes-Virella, Yan Huang
J Periodontal Res. Author manuscript; available in PMC 2024 Jun 1.
Published in final edited form as: J Periodontal Res. 2023 Jun; 58(3): 575–587. Published online 2023 Feb 17. doi: 10.1111/jre.13107
PMCID:
PMC10182248
AbstractArticlePDF–1.8M
4.
Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice
Xixi Lin, Like Wang, Xiaojie Lu, Yuanyuan Zhang, Rongying Zheng, Ruijie Chen, Weixi Zhang
Respir Res. 2023; 24: 56. Published online 2023 Feb 17. doi: 10.1186/s12931-023-02361-1
PMCID:
PMC9938616
AbstractArticlePDF–2.4M
5.
Loss of GPR40 in LDL receptor-deficient mice exacerbates high-fat diet-induced hyperlipidemia and nonalcoholic steatohepatitis
Zhongyang Lu, Yanchun Li, Ai-Jun Li, Wing-Kin Syn, Stephen A. Wank, Maria F. Lopes-Virella, Yan Huang
PLoS One. 2022; 17(11): e0277251. Published online 2022 Nov 4. doi: 10.1371/journal.pone.0277251
PMCID:
PMC9635748
AbstractArticlePDF–4.7M
6.
GPR40 deficiency is associated with hepatic FAT/CD36 upregulation, steatosis, inflammation, and cell injury in C57BL/6 mice
Zhongyang Lu, Yanchun Li, Wing-Kin Syn, Ai-Jun Li, W. Sue Ritter, Stephen A. Wank, Maria F. Lopes-Virella, Yan Huang
Am J Physiol Endocrinol Metab. 2021 Jan 1; 320(1): E30–E42. Published online 2020 Oct 26. doi: 10.1152/ajpendo.00257.2020
PMCID:
PMC8436599
AbstractArticle
7.
Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms
Daiane F. Engel, Vanessa C. D. Bobbo, Carina S. Solon, Guilherme A. Nogueira, Alexandre Moura-Assis, Natalia F. Mendes, Ariane M. Zanesco, Athanasios Papangelis, Trond Ulven, Licio A. Velloso
Sci Rep. 2020; 10: 11047. Published online 2020 Jul 6. doi: 10.1038/s41598-020-68110-2
PMCID:
PMC7338363
AbstractArticlePDF–6.2M
8.
A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40
Andreas Spyrantis, Jana Krieger, Katja Stifter, Bernhard Otto Boehm, Reinhold Schirmbeck
Cell Mol Immunol. 2020 Jun; 17(6): 659–661. Published online 2019 Oct 24. doi: 10.1038/s41423-019-0309-y
PMCID:
PMC7264294
ArticlePDF–903K
9.
GPR119 - a major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Co-acting in Synergy with FFA1 (GPR40)
Jeppe P. Ekberg, Maria Hauge, Line V. Kristensen, Andreas N. Madsen, Maja S. Engelstoft, Anna-Sofie Husted, Rasmus Sichlau, Kristoffer Egerod, Timothy Kowalski, Fiona M. Gribble, Frank Reimann, Harald S. Hansen, Andrew D. Howard, Birgitte Holst, Thue W. Schwartz
Endocrinology. Author manuscript; available in PMC 2020 May 11.
Published in final edited form as: Endocrinology. 2016 Dec 1; 157(12): 4561–4569. Published online 2016 Oct 25. doi: 10.1210/en.2016-1334
PMCID:
PMC7212052
AbstractArticlePDF–1.1M
10.
GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells
Ryota Usui, Daisuke Yabe, Muhammad Fauzi, Hisanori Goto, Ainur Botagarova, Shinsuke Tokumoto, Hisato Tatsuoka, Yumiko Tahara, Shizuka Kobayashi, Toshiya Manabe, Yoshihiro Baba, Tomohiro Kurosaki, Pedro Luis Herrera, Masahito Ogura, Kazuaki Nagashima, Nobuya Inagaki
Sci Rep. 2019; 9: 15562. Published online 2019 Oct 29. doi: 10.1038/s41598-019-52048-1
PMCID:
PMC6820554
AbstractArticlePDF–1.2M
11.
GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve
Hikaru Ueno, Ryo Ito, Shin-ichi Abe, Hitomi Ogino, Minoru Maruyama, Hirohisa Miyashita, Yasufumi Miyamoto, Yusuke Moritoh, Yoshiyuki Tsujihata, Koji Takeuchi, Nobuhiro Nishigaki
PLoS One. 2019; 14(9): e0222653. Published online 2019 Sep 16. doi: 10.1371/journal.pone.0222653
PMCID:
PMC6746387
AbstractArticlePDF–2.3M
12.
Taste Preference for Fatty Acids Is Mediated by GPR40 and GPR120
Cristina Cartoni, Keiko Yasumatsu, Tadahiro Ohkuri, Noriatsu Shigemura, Ryusuke Yoshida, Nicolas Godinot, Johannes le Coutre, Yuzo Ninomiya, Sami Damak
J Neurosci. 2010 Jun 23; 30(25): 8376–8382. doi: 10.1523/JNEUROSCI.0496-10.2010
PMCID:
PMC6634626
AbstractArticlePDF–1.6M
13.
FFAR4 Is Involved in Regulation of Neurotensin Release From Neuroendocrine Cells and Male C57BL/6 Mice
Jing Li, Jun Song, Xian Li, Stephanie B Rock, Heather F Sinner, Heidi L Weiss, Todd Weiss, Courtney M Townsend, Jr, Tianyan Gao, B Mark Evers
Endocrinology. 2018 Aug; 159(8): 2939–2952. Published online 2018 May 22. doi: 10.1210/en.2018-00284
PMCID:
PMC6486825
AbstractArticle
14.
GPR40 modulates epileptic seizure and NMDA receptor function
Yong Yang, Xin Tian, Demei Xu, Fangshuo Zheng, Xi Lu, Yanke Zhang, Yuanlin Ma, Yun Li, Xin Xu, Binglin Zhu, Xuefeng Wang
Sci Adv. 2018 Oct; 4(10): eaau2357. Published online 2018 Oct 17. doi: 10.1126/sciadv.aau2357
PMCID:
PMC6192686
AbstractArticlePDF–4.5M
15.
Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms
Madhura Panse, Oliver Kluth, Estela Lorza-Gil, Gabriele Kaiser, Eckhard Mühlbauer, Annette Schürmann, Hans-Ulrich Häring, Susanne Ullrich, Felicia Gerst
PLoS One. 2018; 13(5): e0198016. Published online 2018 May 29. doi: 10.1371/journal.pone.0198016
PMCID:
PMC5973613
AbstractArticlePDF–6.2M
16.
Structural basis for GPR40 allosteric agonism and incretin stimulation
Joseph D. Ho, Betty Chau, Logan Rodgers, Frances Lu, Kelly L. Wilbur, Keith A. Otto, Yanyun Chen, Min Song, Jonathan P. Riley, Hsiu-Chiung Yang, Nichole A. Reynolds, Steven D. Kahl, Anjana Patel Lewis, Christopher Groshong, Russell E. Madsen, Kris Conners, Jayana P. Lineswala, Tarun Gheyi, Melbert-Brian Decipulo Saflor, Matthew R. Lee, Jordi Benach, Kenton A. Baker, Chahrzad Montrose-Rafizadeh, Michael J. Genin, Anne R. Miller, Chafiq Hamdouchi
Nat Commun. 2018; 9: 1645. Published online 2018 Apr 25. doi: 10.1038/s41467-017-01240-w
PMCID:
PMC5917010
AbstractArticlePDF–2.2M
17.
Palmitic Acid Hydroxy Stearic Acids Activate GPR40 Which is Involved in Their Beneficial Effects on Glucose Homeostasis
Ismail Syed, Jennifer Lee, Pedro M. Moraes-Vieira, Cynthia J. Donaldson, Alexandra Sontheimer, Pratik Aryal, Kerry Wellenstein, Matthew J Kolar, Andrew T Nelson, Dionicio Siegel, Jacek Mokrosinski, I. Sadaf Farooqi, Juan Juan Zhao, Mark M. Yore, Odile D. Peroni, Alan Saghatelian, Barbara B. Kahn
Cell Metab. Author manuscript; available in PMC 2019 Feb 6.
Published in final edited form as: Cell Metab. 2018 Feb 6; 27(2): 419–427.e4. doi: 10.1016/j.cmet.2018.01.001
PMCID:
PMC5807007
AbstractArticlePDF–1.3M
18.
20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
Sorin Tunaru, Remy Bonnavion, Isabell Brandenburger, Jens Preussner, Dominique Thomas, Klaus Scholich, Stefan Offermanns
Nat Commun. 2018; 9: 177. Published online 2018 Jan 12. doi: 10.1038/s41467-017-02539-4
PMCID:
PMC5766607
AbstractArticlePDF–1.2M
19.
GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent
Michele J. Pachanski, Melissa E. Kirkland, Daniel T. Kosinski, Joel Mane, Boonlert Cheewatrakoolpong, Jiyan Xue, Daphne Szeto, Gail Forrest, Corin Miller, Michelle Bunzel, Christopher W. Plummer, Harry R. Chobanian, Michael W. Miller, Sarah Souza, Brande S. Thomas-Fowlkes, Aimie M. Ogawa, Adam B. Weinglass, Jerry Di Salvo, Xiaoyan Li, Yue Feng, Daniel A. Tatosian, Andrew D. Howard, Steven L. Colletti, Maria E. Trujillo
PLoS One. 2017; 12(10): e0186033. Published online 2017 Oct 20. doi: 10.1371/journal.pone.0186033
PMCID:
PMC5650142
AbstractArticlePDF–12M
20.
Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance
Sibylle Sabrautzki, Gabriele Kaiser, Gerhard K.H. Przemeck, Felicia Gerst, Estela Lorza-Gil, Madhura Panse, Tina Sartorius, Miriam Hoene, Susan Marschall, Hans-Ulrich Häring, Martin Hrabě de Angelis, Susanne Ullrich
Mol Metab. 2017 Oct; 6(10): 1304–1312. Published online 2017 Jul 18. doi: 10.1016/j.molmet.2017.07.007
PMCID:
PMC5641630
AbstractArticlePDF–867K

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