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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 88910182.

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

Teng Ma, Xiao Tian, Baoding Zhang, Mengqi Li, Yu Wang, Chunyan Yang, Jianfeng Wu, Xiaoyan Wei, Qi Qu, Yaxin Yu, Shating Long, Jin-Wei Feng, Chun Li, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Junjie Chen, Yong Yu, Xi Huang, Ying He, Luming Yao, Lei Zhang, Mingxia Zhu, Wen Wang, Zhi-Chao Wang, Mingliang Zhang, Yuqian Bao, Weiping Jia, Shu-Yong Lin, Zhiyun Ye, Hai-Long Piao, Xianming Deng, Chen-Song Zhang, Sheng-Cai Lin

Nature. 2022; 603(7899): 159–165. Published online 2022 Feb 23. doi: 10.1038/s41586-022-04431-8

PMCID:: PMC8891018

Abstract Article PDF–84M

Select item 83024503.

Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum

Rosanne Wouters, Christine Michiels, Ragna Sannerud, Bertrand Kleizen, Katleen Dillen, Wendy Vermeire, Abril Escamilla Ayala, David Demedts, Randy Schekman, Wim Annaert

J Cell Biol. 2021 Sep 6; 220(9): e201911104. Published online 2021 Jul 22. doi: 10.1083/jcb.201911104

PMCID:: PMC8302450

Abstract Article PDF–7.0M

Select item 71476884.

Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae

Danye Jiang, Courtney A. Burger, Anna Casasent, Nicholas E. Albrecht, Fenge Li, Melanie A. Samuel

J Comp Neurol. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: J Comp Neurol. 2020 Apr 1; 528(5): 729–755. Published online 2019 Oct 31. doi: 10.1002/cne.24784

PMCID:: PMC7147688

Abstract Article PDF–4.0M

Select item 67252095.

APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic Development

Guojun Ma, Tong Li, Donald L. Price, Philip C. Wong

J Neurosci. 2005 Jan 5; 25(1): 192–198. doi: 10.1523/JNEUROSCI.3814-04.2005

PMCID:: PMC6725209

Abstract Article PDF–351K

Select item 66728276.

Moderate Reduction of γ-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities

Tong Li, Hongjin Wen, Cory Brayton, Fiona M. Laird, Guojun Ma, Shiwen Peng, Lisa Placanica, T. C. Wu, Barbara J. Crain, Donald L. Price, Charles G. Eberhart, Philip C. Wong

J Neurosci. 2007 Oct 3; 27(40): 10849–10859. doi: 10.1523/JNEUROSCI.2152-07.2007

PMCID:: PMC6672827

Abstract Article PDF–665K

Select item 64337627.

Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors

Shanshan Cheng, Tingting Liu, Yimin Hu, Yingqian Xia, Jinxing Hou, Chaoli Huang, Xiaochuan Zou, Juan Liang, Yun Stone Shi, Yuanlin Zheng, Jun Lu, Guiquan Chen

J Neurosci. 2019 Mar 20; 39(12): 2195–2207. doi: 10.1523/JNEUROSCI.2523-18.2019

PMCID:: PMC6433762

Abstract Article PDF–9.1M

Select item 63803418.

miR-151-5p modulates APH1a expression to participate in contextual fear memory formation

Xu-Feng Xu, You-Cui Wang, Liang Zong, Xiao-Long Wang

RNA Biol. 2019 Mar; 16(3): 282–294. Published online 2019 Jan 29. doi: 10.1080/15476286.2019.1572435

Correction in:: RNA Biol. 2020; 17(12): 1827.

PMCID:: PMC6380341

Abstract Article PDF–2.6M

Select item 61700149.

Rapid and Integrative Discovery of Retina Regulatory Molecules

Nicholas E. Albrecht, Jonathan Alevy, Danye Jiang, Courtney A. Burger, Brian I. Liu, Fenge Li, Julia Wang, Seon-Young Kim, Chih-Wei Hsu, Sowmya Kalaga, Uchechukwu Udensi, Chinwe Asomugha, Ritu Bohat, Angelina Gaspero, Monica J. Justice, Peter D. Westenskow, Shinya Yamamoto, John R. Seavitt, Arthur L. Beaudet, Mary E. Dickinson, Melanie A. Samuel

Cell Rep. Author manuscript; available in PMC 2018 Oct 3.

Published in final edited form as: Cell Rep. 2018 Aug 28; 24(9): 2506–2519. doi: 10.1016/j.celrep.2018.07.090

PMCID:: PMC6170014

Article PDF–1.2M

Select item 553829710.

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration

Hermien Acx, Lutgarde Serneels, Enrico Radaelli, Serge Muyldermans, Cécile Vincke, Elise Pepermans, Ulrike Müller, Lucía Chávez‐Gutiérrez, Bart De Strooper

EMBO Mol Med. 2017 Aug; 9(8): 1088–1099. Published online 2017 Jun 6. doi: 10.15252/emmm.201707561

PMCID:: PMC5538297

Abstract Article PDF–5.8M

Select item 501302411.

Prostaglandin I₂ upregulates the expression of anterior pharynx‐defective‐1α and anterior pharynx‐defective‐1β in amyloid precursor protein/presenilin 1 transgenic mice

Pu Wang, Pei‐Pei Guan, Jing‐Wen Guo, Long‐Long Cao, Guo‐Biao Xu, Xin Yu, Yue Wang, Zhan‐You Wang

Aging Cell. 2016 Oct; 15(5): 861–871. Published online 2016 May 30. doi: 10.1111/acel.12495

PMCID:: PMC5013024

Abstract Article PDF–2.8M

Select item 482024812.

Antagonistic Effects of BACE1 and APH1B-?-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

Soraia Barão, Annette Gärtner, Eduardo Leyva-Díaz, Galina Demyanenko, Sebastian Munck, Tine Vanhoutvin, Lujia Zhou, Melitta Schachner, Guillermina López-Bendito, Patricia F. Maness, Bart De Strooper

Cell Rep. Author manuscript; available in PMC 2016 Apr 4.

Published in final edited form as: Cell Rep. 2015 Sep 1; 12(9): 1367–1376. Published online 2015 Aug 20. doi: 10.1016/j.celrep.2015.07.059

PMCID:: PMC4820248

Abstract Article PDF–801K

Select item 431955913.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 407328314.

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

Pietro Fazzari, An Snellinx, Victor Sabanov, Tariq Ahmed, Lutgarde Serneels, Annette Gartner, S Ali M Shariati, Detlef Balschun, Bart De Strooper

eLife. 2014; 3: e02196. Published online 2014 Jun 2. doi: 10.7554/eLife.02196

PMCID:: PMC4073283

Abstract Article PDF–2.5M

Select item 396495515.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977