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Items: 1 to 20 of 32

1.
Ring domains are essential for GATOR2-dependent mTORC1 activation
Cong Jiang, Xiaoming Dai, Shaohui He, Hongfei Zhou, Lan Fang, Jianping Guo, Songlei Liu, Tao Zhang, Weijuan Pan, Haihong Yu, Tianmin Fu, Dali Li, Hiroyuki Inuzuka, Ping Wang, Jianru Xiao, Wenyi Wei
Mol Cell. Author manuscript; available in PMC 2024 Apr 19.
Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 74–89.e9. Published online 2022 Dec 16. doi: 10.1016/j.molcel.2022.11.021
PMCID:
PMC11027793
AbstractArticlePDF–3.0M
2.
The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
Lena H Nguyen, Youfen Xu, Maanasi Nair, Angelique Bordey
eLife. 2024; 12: RP91010. Published online 2024 Feb 27. doi: 10.7554/eLife.91010
PMCID:
PMC10942629
AbstractArticlePDF–5.5M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
Reprogramming tumour-associated macrophages to outcompete cancer cells
Xian Zhang, Shun Li, Isha Malik, Mytrang H. Do, Liangliang Ji, Chun Chou, Wei Shi, Kristelle J. Capistrano, Jing Zhang, Ting-Wei Hsu, Briana G. Nixon, Ke Xu, Xinxin Wang, Andrea Ballabio, Laura S. Schmidt, W. Marston Linehan, Ming O. Li
Nature. Author manuscript; available in PMC 2023 Dec 14.
Published in final edited form as: Nature. 2023 Jul; 619(7970): 616–623. Published online 2023 Jun 28. doi: 10.1038/s41586-023-06256-5
PMCID:
PMC10719927
AbstractArticlePDF–5.6M
5.
Perineuronal Nets Degradation and Parvalbumin Interneuron loss in a Mouse Model of DEPDC5-related Epilepsy
Tao Yang, Shuntong Hu, Wei-Chih Chang, Hsin-Yi Kao, Yu Wang
Dev Neurosci. Author manuscript; available in PMC 2023 Feb 15.
Published in final edited form as: Dev Neurosci. 2022; 44(6): 671–677. Published online 2022 May 17. doi: 10.1159/000525039
PMCID:
PMC9669280
AbstractArticlePDF–1.3M
6.
Simultaneous loss of TSC1 and DEPDC5 in skeletal and cardiac muscles produces early-onset myopathy and cardiac dysfunction associated with oxidative damage and SQSTM1/p62 accumulation
Chun-Seok Cho, Yongsung Kim, Sung-Rye Park, Boyoung Kim, Carol Davis, Irene Hwang, Susan V. Brooks, Jun Hee Lee, Myungjin Kim
Autophagy. 2022; 18(10): 2303–2322. Published online 2021 Dec 29. doi: 10.1080/15548627.2021.2016255
PMCID:
PMC9542799
AbstractArticlePDF–9.9M
7.
DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
Christopher J. Yuskaitis, Jinita B. Modasia, Sandra Schrötter, Leigh-Ana Rossitto, Karenna J. Groff, Christopher Morici, Divakar S. Mithal, Ram P. Chakrabarty, Navdeep S. Chandel, Brendan D. Manning, Mustafa Sahin
Cell Rep. Author manuscript; available in PMC 2022 Sep 24.
Published in final edited form as: Cell Rep. 2022 Aug 30; 40(9): 111278. doi: 10.1016/j.celrep.2022.111278
PMCID:
PMC9508617
AbstractArticlePDF–1.7M
8.
Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: novel mouse models for GATORopathy
Saeko Ishida, Di Zhao, Yuta Sawada, Yuichi Hiraoka, Tomoji Mashimo, Kohichi Tanaka
Hum Mol Genet. 2022 May 1; 31(9): 1519–1530. Published online 2021 Nov 20. doi: 10.1093/hmg/ddab337
PMCID:
PMC9071434
AbstractArticlePDF–1.6M
9.
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity
Lingyun Long, Jun Wei, Seon Ah Lim, Jana L. Raynor, Hao Shi, Jon P. Connelly, Hong Wang, Cliff Guy, Boer Xie, Nicole M. Chapman, Guotong Fu, Yanyan Wang, Hongling Huang, Wei Su, Jordy Saravia, Isabel Risch, Yong-Dong Wang, Yuxin Li, Mingming Niu, Yogesh Dhungana, Anil KC, Peipei Zhou, Peter Vogel, Jiyang Yu, Shondra M. Pruett-Miller, Junmin Peng, Hongbo Chi
Nature. Author manuscript; available in PMC 2022 Jun 1.
Published in final edited form as: Nature. 2021 Dec; 600(7888): 308–313. Published online 2021 Nov 18. doi: 10.1038/s41586-021-04109-7
PMCID:
PMC8887674
AbstractArticlePDF–6.5M
10.
Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway
Lin Xu, Xinge Zhang, Yue Xin, Jie Ma, Chenyan Yang, Xi Zhang, Guoqing Hou, Xiaocheng Charlie Dong, Zhaoli Sun, Xiwen Xiong, Xuan Cao
Cell Death Dis. 2021 Jul; 12(7): 710. Published online 2021 Jul 15. doi: 10.1038/s41419-021-03980-6
PMCID:
PMC8282792
AbstractArticlePDF–5.1M
11.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
12.
Prevention of premature death and seizures in a Depdc5 mouse epilepsy model through inhibition of mTORC1
Lindsay K Klofas, Brittany P Short, Chengwen Zhou, Robert P Carson
Hum Mol Genet. 2020 May 28; 29(8): 1365–1377. Published online 2020 Apr 13. doi: 10.1093/hmg/ddaa068
PMCID:
PMC7254848
AbstractArticlePDF–1.2M
13.
Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury
Chun-Seok Cho, Allison H. Kowalsky, Sim Namkoong, Sung-Rye Park, Shuangcheng Wu, Boyoung Kim, Amanda James, Bondong Gu, Ian A. Semple, Mohamed A. Tohamy, Sumeet Solanki, Uhn-Soo Cho, Joel K. Greenson, Yatrik M. Shah, Myungjin Kim, Jun Hee Lee
Cell Discov. 2019; 5: 60. Published online 2019 Nov 19. doi: 10.1038/s41421-019-0131-9
PMCID:
PMC6868011
AbstractArticlePDF–3.5M
14.
Chronic mTORC1 inhibition rescues behavioral and biochemical deficits resulting from neuronal Depdc5 loss in mice
Christopher J Yuskaitis, Leigh-Ana Rossitto, Sarika Gurnani, Elizabeth Bainbridge, Annapurna Poduri, Mustafa Sahin
Hum Mol Genet. 2019 Sep 1; 28(17): 2952–2964. Published online 2019 May 17. doi: 10.1093/hmg/ddz123
PMCID:
PMC6736288
AbstractArticlePDF–2.3M
15.
Skeletal muscle–specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration
Ted G. Graber, Christopher S. Fry, Camille R. Brightwell, Tatiana Moro, Rosario Maroto, Nisha Bhattarai, Craig Porter, Maki Wakamiya, Blake B. Rasmussen
J Biol Chem. 2019 Mar 15; 294(11): 4091–4102. Published online 2019 Jan 11. doi: 10.1074/jbc.RA118.005970
PMCID:
PMC6422100
AbstractArticlePDF–2.3M
16.
Second-hit mosaic mutation in mTORC1 repressor DEPDC5 causes focal cortical dysplasia–associated epilepsy
Théo Ribierre, Charlotte Deleuze, Alexandre Bacq, Sara Baldassari, Elise Marsan, Mathilde Chipaux, Giuseppe Muraca, Delphine Roussel, Vincent Navarro, Eric Leguern, Richard Miles, Stéphanie Baulac
J Clin Invest. 2018 Jun 1; 128(6): 2452–2458. Published online 2018 Apr 30. doi: 10.1172/JCI99384
PMCID:
PMC5983335
AbstractArticlePDF–6.3M
17.
A Mouse Model of DEPDC5-related Epilepsy: Neuronal Loss of Depdc5 Causes Dysplastic and Ectopic Neurons, Increased mTOR Signaling, and Seizure Susceptibility
Christopher J. Yuskaitis, Brandon M. Jones, Rachel L. Wolfson, Chloe E. Super, Sameer C. Dhamne, Alexander Rotenberg, David M. Sabatini, Mustafa Sahin, Annapurna Poduri
Neurobiol Dis. Author manuscript; available in PMC 2019 Mar 1.
Published in final edited form as: Neurobiol Dis. 2018 Mar; 111: 91–101. Published online 2017 Dec 20. doi: 10.1016/j.nbd.2017.12.010
PMCID:
PMC5803417
AbstractArticlePDF–2.3M
18.
Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling
James Hughes, Ruby Dawson, Melinda Tea, Dale McAninch, Sandra Piltz, Dominique Jackson, Laura Stewart, Michael G. Ricos, Leanne M. Dibbens, Natasha L. Harvey, Paul Thomas
Sci Rep. 2017; 7: 12618. Published online 2017 Oct 3. doi: 10.1038/s41598-017-12574-2
PMCID:
PMC5626732
AbstractArticlePDF–5.1M
19.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
20.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M

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