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Items: 1 to 20 of 66

1.
Life-long Restructuring of 3D Genome Architecture in Cerebellar Granule Cells
Longzhi Tan, Jenny Shi, Siavash Moghadami, Bibudha Parasar, Cydney P. Wright, Yunji Seo, Kristen Vallejo, Inma Cobos, Laramie Duncan, Ritchie Chen, Karl Deisseroth
Science. Author manuscript; available in PMC 2024 Apr 30.
Published in final edited form as: Science. 2023 Sep 8; 381(6662): 1112–1119. Published online 2023 Sep 7. doi: 10.1126/science.adh3253
PMCID:
PMC11059189
AbstractArticlePDF–3.5M
2.
Male-Dominant Effects of Chd8 Haploinsufficiency on Synaptic Phenotypes during Development in Mouse Prefrontal Cortex
Robert A. Ellingford, Mizuki Tojo, M. Albert Basson, Laura C. Andreae
ACS Chem Neurosci. 2024 Apr 17; 15(8): 1635–1642. Published online 2024 Apr 1. doi: 10.1021/acschemneuro.3c00690
PMCID:
PMC11027092
AbstractArticlePDF–4.4M
3.
Chd8 haploinsufficiency impacts rearing experience in C57BL/6 mice
Manal Tabbaa, Pat Levitt
Genes Brain Behav. 2024 Apr; 23(2): e12892. Published online 2024 Apr 1. doi: 10.1111/gbb.12892
PMCID:
PMC10982810
AbstractArticlePDF–6.3M
4.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
5.
Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction
Xi Shi, Congyi Lu, Alba Corman, Alexandra Nikish, Yang Zhou, Randy J. Platt, Ivan Iossifov, Feng Zhang, Jen Q. Pan, Neville E. Sanjana
Am J Hum Genet. 2023 Oct 5; 110(10): 1750–1768. Published online 2023 Oct 5. doi: 10.1016/j.ajhg.2023.09.004
PMCID:
PMC10577079
AbstractArticlePDF–4.7M
6.
CHD8 regulates gut epithelial cell function and affects autism-related behaviors through the gut-brain axis
Ipsita Chatterjee, Dmitriy Getselter, Nasreen Ghanayem, Ram Harari, Liron Davis, Shai Bel, Evan Elliott
Transl Psychiatry. 2023; 13: 305. Published online 2023 Oct 2. doi: 10.1038/s41398-023-02611-2
PMCID:
PMC10545671
AbstractArticlePDF–4.9M
7.
Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neurons
Atsuki Kawamura, Masaaki Nishiyama
Commun Biol. 2023; 6: 593. Published online 2023 Jun 2. doi: 10.1038/s42003-023-04968-y
PMCID:
PMC10238509
AbstractArticlePDF–5.5M
8.
Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex
Martin Munz, Arjun Bharioke, Georg Kosche, Verónica Moreno-Juan, Alexandra Brignall, Tiago M. Rodrigues, Alexandra Graff-Meyer, Talia Ulmer, Stephanie Haeuselmann, Dinko Pavlinic, Nicole Ledergerber, Brigitte Gross-Scherf, Balázs Rózsa, Jacek Krol, Simone Picelli, Cameron S. Cowan, Botond Roska
Cell. 2023 Apr 27; 186(9): 1930–1949.e31. doi: 10.1016/j.cell.2023.03.025
PMCID:
PMC10156177
AbstractArticle
9.
Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes
Soo Yeon Lee, Hanseul Kweon, Hyojin Kang, Eunjoon Kim
Front Mol Neurosci. 2023; 16: 1111388. Published online 2023 Feb 16. doi: 10.3389/fnmol.2023.1111388
PMCID:
PMC9978779
AbstractArticlePDF–4.0M
10.
Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency
Manal Tabbaa, Allison Knoll, Pat Levitt
Neuron. Author manuscript; available in PMC 2024 Feb 15.
Published in final edited form as: Neuron. 2023 Feb 15; 111(4): 539–556.e5. Published online 2023 Feb 3. doi: 10.1016/j.neuron.2023.01.009
PMCID:
PMC9960295
AbstractArticlePDF–4.7M
11.
Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis
Chen Dong, Chuntao Zhao, Xiang Chen, Kalen Berry, Jiajia Wang, Feng Zhang, Yunfei Liao, Rong Han, Sean Ogurek, Lingli Xu, Li Zhang, Yifeng Lin, Wenhao Zhou, Mei Xin, Daniel A. Lim, Kenneth Campbell, Masato Nakafuku, Ronald R. Waclaw, Q. Richard Lu
J Neurosci. 2022 Nov 2; 42(44): 8373–8392. doi: 10.1523/JNEUROSCI.2400-21.2022
PMCID:
PMC9653284
AbstractArticlePDF–12M
12.
Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviors
Soo Yeon Lee, Hanseul Kweon, Hyojin Kang, Eunjoon Kim
Front Mol Neurosci. 2022; 15: 1022306. Published online 2022 Oct 25. doi: 10.3389/fnmol.2022.1022306
PMCID:
PMC9641250
AbstractArticlePDF–5.3M
13.
Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities
Stephania Assimopoulos, Christopher Hammill, Darren J. Fernandes, Tara Leigh Spencer Noakes, Yu‐Qing Zhou, Lauryl M. J. Nutter, Jacob Ellegood, Evdokia Anagnostou, John G. Sled, Jason P. Lerch
Autism Res. 2022 Jul; 15(7): 1189–1208. Published online 2022 Apr 21. doi: 10.1002/aur.2728
PMCID:
PMC9325472
AbstractArticlePDF–3.5M
14.
Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling
Zhaowei Tu, Cuiqing Fan, Ashely K. Davis, Mengwen Hu, Chen Wang, Akhila Dandamudi, Katie G. Seu, Theodosia A. Kalfa, Q. Richard Lu, Yi Zheng
Cell Rep. Author manuscript; available in PMC 2022 Jul 21.
Published in final edited form as: Cell Rep. 2022 Jul 12; 40(2): 111072. doi: 10.1016/j.celrep.2022.111072
PMCID:
PMC9302451
AbstractArticlePDF–2.6M
15.
Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model
Jessica A. Jiménez, Jeremy M. Simon, Wenxin Hu, Sheryl S. Moy, Kathryn M. Harper, Chih-Wei Liu, Kun Lu, Mark J. Zylka
Sci Rep. 2022; 12: 5555. Published online 2022 Apr 1. doi: 10.1038/s41598-022-09533-x
PMCID:
PMC8975859
AbstractArticlePDF–1.6M
16.
Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8+/− mouse model of ASD-like behavior
You Yu, Bing Zhang, Peifeng Ji, Zhenqiang Zuo, Yongxi Huang, Ning Wang, Chang Liu, Shuang-Jiang Liu, Fangqing Zhao
Nat Commun. 2022; 13: 1151. Published online 2022 Mar 3. doi: 10.1038/s41467-022-28746-2
PMCID:
PMC8894489
AbstractArticlePDF–3.1M
17.
Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice
Robert A. Ellingford, Martyna J. Panasiuk, Emilie Rabesahala de Meritens, Raghav Shaunak, Liam Naybour, Lorcan Browne, M. Albert Basson, Laura C. Andreae
Mol Psychiatry. 2021; 26(7): 3614–3624. Published online 2021 Apr 9. doi: 10.1038/s41380-021-01070-9
PMCID:
PMC8505247
AbstractArticlePDF–2.4M
18.
Microglial ASD-related genes are involved in oligodendrocyte differentiation
Yuta Takanezawa, Shogo Tanabe, Daiki Kato, Rie Ozeki, Masayo Komoda, Tatsunori Suzuki, Hiroko Baba, Rieko Muramatsu
Sci Rep. 2021; 11: 17825. Published online 2021 Sep 8. doi: 10.1038/s41598-021-97257-9
PMCID:
PMC8426463
AbstractArticlePDF–3.5M
19.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
20.
The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability
Zhaowei Tu, Chen Wang, Ashley K. Davis, Mengwen Hu, Chuntao Zhao, Mei Xin, Q. Richard Lu, Yi Zheng
Blood. 2021 Jul 22; 138(3): 221–233. Prepublished online 2021 Apr 19. doi: 10.1182/blood.2020009997
PMCID:
PMC8310427
AbstractArticle

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