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Select item 110941891.

Dysfunctional adipocytes promote tumor progression through YAP/TAZ-dependent cancer-associated adipocyte transformation

Yaechan Song, Heeju Na, Seung Eon Lee, You Min Kim, Jihyun Moon, Tae Wook Nam, Yul Ji, Young Jin, Jae Hyung Park, Seok Chan Cho, Jaehoon Lee, Daehee Hwang, Sang-Jun Ha, Hyun Woo Park, Jae Bum Kim, Han-Woong Lee

Nat Commun. 2024; 15: 4052. Published online 2024 May 14. doi: 10.1038/s41467-024-48179-3

Correction in:: Nat Commun. 2024; 15: 5623.

PMCID:: PMC11094189

Abstract Article PDF–8.2M

Select item 109319972.

Cisplatin Nephrotoxicity Is Critically Mediated by the Availability of BECLIN1

Tillmann Bork, Camila Hernando-Erhard, Wei Liang, Zhejia Tian, Kosuke Yamahara, Tobias B. Huber

Int J Mol Sci. 2024 Mar; 25(5): 2560. Published online 2024 Feb 22. doi: 10.3390/ijms25052560

PMCID:: PMC10931997

Abstract Article PDF–6.7M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108791754.

BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking

Sharon Tran, Juliani Juliani, Tiffany J. Harris, Marco Evangelista, Julian Ratcliffe, Sarah L. Ellis, David Baloyan, Camilla M. Reehorst, Rebecca Nightingale, Ian Y. Luk, Laura J. Jenkins, Sonia Ghilas, Marina H. Yakou, Chantelle Inguanti, Chad Johnson, Michael Buchert, James C. Lee, Peter De Cruz, Kinga Duszyc, Paul A. Gleeson, Benjamin T. Kile, Lisa A. Mielke, Alpha S. Yap, John M. Mariadason, W. Douglas Fairlie, Erinna F. Lee

Commun Biol. 2024; 7: 209. Published online 2024 Feb 20. doi: 10.1038/s42003-024-05890-7

PMCID:: PMC10879175

Abstract Article PDF–15M

Select item 107877915.

Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy

Weihui Yan, Shanshan Chen, Ying Wang, Yaying You, Ying Lu, Weipeng Wang, Bo Wu, Jun Du, Shicheng Peng, Wei Cai, Yongtao Xiao

Commun Biol. 2024; 7: 94. Published online 2024 Jan 13. doi: 10.1038/s42003-024-05785-7

PMCID:: PMC10787791

Abstract Article PDF–21M

Select item 105917186.

A comparative analysis of microglial inducible Cre lines

Travis E. Faust, Philip A. Feinberg, Ciara O’Connor, Riki Kawaguchi, Andrew Chan, Hayley Strasburger, Maximilian Frosch, Margaret A. Boyle, Takahiro Masuda, Lukas Amann, Klaus-Peter Knobeloch, Marco Prinz, Anne Schaefer, Dorothy P. Schafer

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Sep 26; 42(9): 113031. Published online 2023 Aug 26. doi: 10.1016/j.celrep.2023.113031

PMCID:: PMC10591718

Abstract Article PDF–3.9M

Select item 105896737.

Impairment of serine transport across the blood–brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction

Inna Radzishevsky, Maali Odeh, Oded Bodner, Salman Zubedat, Lihi Shaulov, Maxim Litvak, Kayoko Esaki, Takeo Yoshikawa, Bella Agranovich, Wen-Hong Li, Alex Radzishevsky, Eyal Gottlieb, Avi Avital, Herman Wolosker

Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2302780120. Published online 2023 Oct 9. doi: 10.1073/pnas.2302780120

PMCID:: PMC10589673

Abstract Article PDF–6.8M

Select item 105376368.

Implication of the Autophagy-Related Protein Beclin1 in the Regulation of EcoHIV Replication and Inflammatory Responses

Myosotys Rodriguez, Florida Owens, Marissa Perry, Nicole Stone, Yemmy Soler, Rianna Almohtadi, Yuling Zhao, Elena V. Batrakova, Nazira El-Hage

Viruses. 2023 Sep; 15(9): 1923. Published online 2023 Sep 14. doi: 10.3390/v15091923

PMCID:: PMC10537636

Abstract Article PDF–4.4M

Select item 105034409.

Constitutively active autophagy dampens inflammation through metabolic and post-transcriptional regulation of macrophage cytokine production

Jinjin Xu, Lingjia Kong, Blayne A. Oliver, Bihua Li, Elizabeth A. Creasey, Gaelen Guzman, Monica Schenone, Kimberly L. Carey, Steven A. Carr, Daniel B. Graham, Jacques Deguine, Ramnik J. Xavier

Cell Rep. Author manuscript; available in PMC 2023 Sep 15.

Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112708. Published online 2023 Jun 30. doi: 10.1016/j.celrep.2023.112708

PMCID:: PMC10503440

Abstract Article PDF–1.4M

Select item 1041071710.

Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve

Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylène Brunelle, Nicolas Gévry, Bruce D. Murphy

Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2220849120. Published online 2023 Jul 26. doi: 10.1073/pnas.2220849120

PMCID:: PMC10410717

Abstract Article PDF–3.9M

Select item 1030619211.

Autophagy prevents early proinflammatory responses and neutrophil recruitment during Mycobacterium tuberculosis infection without affecting pathogen burden in macrophages

Rachel L. Kinsella, Jacqueline M. Kimmey, Asya Smirnov, Reilly Woodson, Margaret R. Gaggioli, Sthefany M. Chavez, Darren Kreamalmeyer, Christina L. Stallings

PLoS Biol. 2023 Jun; 21(6): e3002159. Published online 2023 Jun 15. doi: 10.1371/journal.pbio.3002159

PMCID:: PMC10306192

Abstract Article PDF–1.8M

Select item 1028980612.

Beclin-1-Dependent Autophagy but Not Apoptosis Is Critical for Stem Cell Mediated-Endometrial Programming and the Establishment of Pregnancy

Pooja Popli, Suni Tang, Sangappa B. Chadchan, Chandni Talwar, Edmund B. Rucker, III, Xiaoming Guan, Diana Monsivais, John P. Lydon, Christina L. Stallings, Kelle H Moley, Ramakrishna Kommagani

Dev Cell. Author manuscript; available in PMC 2024 May 22.

Published in final edited form as: Dev Cell. 2023 May 22; 58(10): 885–897.e4. Published online 2023 Apr 10. doi: 10.1016/j.devcel.2023.03.013

PMCID:: PMC10289806

Abstract Article PDF–3.3M

Select item 1028344513.

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes

Nivedita Hegdekar, Chinmoy Sarkar, Sabrina Bustos, Rodney M. Ritzel, Marie Hanscom, Prarthana Ravishankar, Deepika Philkana, Junfang Wu, David J. Loane, Marta M. Lipinski

Autophagy. 2023; 19(7): 2026–2044. Published online 2023 Jan 18. doi: 10.1080/15548627.2023.2167689

PMCID:: PMC10283445

Abstract Article PDF–4.3M

Select item 1017524514.

Genetically prolonged beige fat in male mice confers long-lasting metabolic health

Ruifan Wu, Jooman Park, Yanyu Qian, Zuoxiao Shi, Ruoci Hu, Yexian Yuan, Shaolei Xiong, Zilai Wang, Gege Yan, Sang-Ging Ong, Qing Song, Zhenyuan Song, Abeer M. Mahmoud, Pingwen Xu, Congcong He, Robert W. Arpke, Michael Kyba, Gang Shu, Qingyan Jiang, Yuwei Jiang

Nat Commun. 2023; 14: 2731. Published online 2023 May 12. doi: 10.1038/s41467-023-38471-z

PMCID:: PMC10175245

Abstract Article PDF–6.7M

Select item 1014472815.

Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart

Jihoon Nah, Akihiro Shirakabe, Risa Mukai, Peiyong Zhai, Eun Ah Sung, Andreas Ivessa, Wataru Mizushima, Yasuki Nakada, Toshiro Saito, Chengchen Hu, Yong Keun Jung, Junichi Sadoshima

Cardiovasc Res. 2022 Aug; 118(12): 2638–2651. Published online 2022 Jan 9. doi: 10.1093/cvr/cvac003

PMCID:: PMC10144728

Abstract Article PDF–2.0M

Select item 1007901816.

Identification of Ndfip1 as a novel negative regulator for spatial memory formation associated with increased ubiquitination of Beclin 1 and PTEN

Wei-Lun Hsu, Yun-Li Ma, Yan-Chu Chen, Yen-Chen Liu, Kuang-Min Cheng, Eminy H. Y. Lee

PLoS One. 2023; 18(4): e0283908. Published online 2023 Apr 6. doi: 10.1371/journal.pone.0283908

PMCID:: PMC10079018

Abstract Article PDF–2.5M

Select item 1001990017.

Deciphering Functional Roles and Interplay Between Beclin1 and Beclin2 in Autophagosome Formation and Mitophagy

Justin M. Quiles, Rita H. Najor, Eileen Gonzalez, Monica Jeung, Wenjing Liang, Sarah M. Burbach, Erika A. Zumaya, Rachel Y. Diao, Mark A. Lampert, Åsa B. Gustafsson

Sci Signal. Author manuscript; available in PMC 2023 Mar 16.

Published in final edited form as: Sci Signal. 2023 Jan 31; 16(770): eabo4457. Published online 2023 Jan 31. doi: 10.1126/scisignal.abo4457

PMCID:: PMC10019900

Abstract Article PDF–3.6M

Select item 1001631818.

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress

Maria Naama, Shahar Telpaz, Aya Awad, Shira Ben-Simon, Sarina Harshuk-Shabso, Sonia Modilevsky, Elad Rubin, Jasmin Sawaed, Lilach Zelik, Mor Zigdon, Nofar Asulin, Sondra Turjeman, Michal Werbner, Supapit Wongkuna, Rachel Feeney, Bjoern O. Schroeder, Abraham Nyska, Meital Nuriel-Ohayon, Shai Bel

Cell Host Microbe. 2023 Mar 8; 31(3): 433–446.e4. doi: 10.1016/j.chom.2023.01.006

PMCID:: PMC10016318

Abstract Article

Select item 998046019.

BECN1^F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner

Salwa Sebti, Zhongju Zou, Michael U. Shiloh

Autophagy. 2023; 19(3): 957–965. Published online 2022 Aug 21. doi: 10.1080/15548627.2022.2111852

PMCID:: PMC9980460

Abstract Article PDF–3.0M

Select item 997833320.

Beclin-1 dependent autophagy improves renal outcomes following Unilateral Ureteral Obstruction (UUO) injury

Reynold I. Lopez-Soler, Azadeh Nikouee, Matthew Kim, Saman Khan, Lakshmi Sivaraman, Xiangzhong Ding, Qun Sophia Zang

Front Immunol. 2023; 14: 1104652. Published online 2023 Feb 16. doi: 10.3389/fimmu.2023.1104652

PMCID:: PMC9978333

Abstract Article PDF–24M

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