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Items: 1 to 20 of 31

1.
The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage
Claire A. Butler, Adrian Mendoza Arvilla, Giedre Milinkeviciute, Celia Da Cunha, Shimako Kawauchi, Narges Rezaie, Heidi Y. Liang, Dominic Javonillo, Annie Thach, Shuling Wang, Sherilyn Collins, Amber Walker, Kai‐Xuan Shi, Jonathan Neumann, Angela Gomez‐Arboledas, Caden M. Henningfield, Lindsay A. Hohsfield, Mark Mapstone, Andrea J. Tenner, Frank M. LaFerla, Ali Mortazavi, Grant R. MacGregor, Kim N. Green
Alzheimers Dement. 2024 Jul; 20(7): 4914–4934. Published online 2024 Mar 20. doi: 10.1002/alz.13783
PMCID:
PMC11247689
AbstractArticlePDF–5.4M
2.
In vivo validation of late‐onset Alzheimer's disease genetic risk factors
Michael Sasner, Christoph Preuss, Ravi S. Pandey, Asli Uyar, Dylan Garceau, Kevin P. Kotredes, Harriet Williams, Adrian L. Oblak, Peter Bor‐Chian Lin, Bridget Perkins, Disha Soni, Cindy Ingraham, Audrey Lee‐Gosselin, Bruce T. Lamb, Gareth R. Howell, Gregory W. Carter
Alzheimers Dement. 2024 Jul; 20(7): 4970–4984. Published online 2024 Apr 30. doi: 10.1002/alz.13840
PMCID:
PMC11247676
AbstractArticlePDF–3.3M
3.
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism
Keiji Kawatani, Marie-Louise Holm, Skylar C. Starling, Yuka A. Martens, Jing Zhao, Wenyan Lu, Yingxue Ren, Zonghua Li, Peizhou Jiang, Yangying Jiang, Samantha K. Baker, Ni Wang, Bhaskar Roy, Tammee M. Parsons, Ralph B. Perkerson, III, Hanmei Bao, Xianlin Han, Guojun Bu, Takahisa Kanekiyo
Mol Psychiatry. 2024; 29(3): 809–819. Published online 2023 Dec 22. doi: 10.1038/s41380-023-02372-w
PMCID:
PMC11153016
AbstractArticlePDF–6.9M
4.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
5.
Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer’s disease
Abbas Dehghan, Rui Climaco Pinto, Ibrahim Karaman, Jian Huang, Brenan R. Durainayagam, Mohsen Ghanbari, Areesha Nazeer, Qi Zhong, Sonia Liggi, Luke Whiley, Rima Mustafa, Miia Kivipelto, Alina Solomon, Tiia Ngandu, Takahisa Kanekiyo, Tomonori Aikawa, Carola I. Radulescu, Samuel J. Barnes, Gonçalo Graça, Elena Chekmeneva, Stephane Camuzeaux, Matthew R. Lewis, Manuja R. Kaluarachchi, M. Arfan Ikram, Elaine Holmes, Ioanna Tzoulaki, Paul M. Matthews, Julian L. Griffin, Paul Elliott
Proc Natl Acad Sci U S A. 2022 Oct 25; 119(43): e2206083119. Published online 2022 Oct 21. doi: 10.1073/pnas.2206083119
PMCID:
PMC9618092
AbstractArticlePDF–2.3M
6.
ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex
Jahangir Iqbal, Manuel D. Suarez, Pradeep K. Yadav, Meghan T. Walsh, Yimeng Li, Yiyang Wu, Zhengwei Huang, Antonisamy William James, Victor Escobar, Ashwag Mokbe, Adam M. Brickman, José A. Luchsinger, Kezhi Dai, Herman Moreno, M. Mahmood Hussain
J Biol Chem. 2022 Oct; 298(10): 102411. Published online 2022 Aug 23. doi: 10.1016/j.jbc.2022.102411
PMCID:
PMC9513280
AbstractArticlePDF–3.3M
7.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
8.
ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain
Tomonori Aikawa, Yingxue Ren, Yu Yamazaki, Masaya Tachibana, Madeleine R. Johnson, Casey T. Anderson, Yuka A. Martens, Marie-Louise Holm, Yan W. Asmann, Takashi Saito, Takaomi C. Saido, Michael L. Fitzgerald, Guojun Bu, Takahisa Kanekiyo
Proc Natl Acad Sci U S A. 2019 Nov 19; 116(47): 23790–23796. Published online 2019 Nov 5. doi: 10.1073/pnas.1908529116
PMCID:
PMC6876254
AbstractArticlePDF–1.4M
9.
Deletion of Abca7 Increases Cerebral Amyloid-β Accumulation in the J20 Mouse Model of Alzheimer's Disease
Woojin S. Kim, Hongyun Li, Kalani Ruberu, Sharon Chan, David A. Elliott, Jac Kee Low, David Cheng, Tim Karl, Brett Garner
J Neurosci. 2013 Mar 6; 33(10): 4387–4394. doi: 10.1523/JNEUROSCI.4165-12.2013
PMCID:
PMC6704948
AbstractArticlePDF–1.5M
10.
Deletion of Alzheimer’s Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels
Surabhi Bhatia, YuHong Fu, Jen-Hsiang T. Hsiao, Glenda M. Halliday, Woojin Scott Kim
J Alzheimers Dis Rep. 2017; 1(1): 237–247. Prepublished online 2017 Dec 5. Published online 2017 Dec 16. doi: 10.3233/ADR-170029
PMCID:
PMC6159609
AbstractArticlePDF–733K
11.
ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content
Heba N. Nowyhed, Shilpi Chandra, William Kiosses, Paola Marcovecchio, Farah Andary, Meng Zhao, Michael L. Fitzgerald, Mitchell Kronenberg, Catherine C. Hedrick
Sci Rep. 2017; 7: 40273. Published online 2017 Jan 16. doi: 10.1038/srep40273
PMCID:
PMC5238393
AbstractArticlePDF–1.5M
12.
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology
Nobutaka Sakae, Chia-Chen Liu, Mitsuru Shinohara, Jessica Frisch-Daiello, Li Ma, Yu Yamazaki, Masaya Tachibana, Linda Younkin, Aishe Kurti, Minerva M. Carrasquillo, Fanggeng Zou, Daniel Sevlever, Gina Bisceglio, Ming Gan, Romain Fol, Patrick Knight, Miao Wang, Xianlin Han, John D. Fryer, Michael L. Fitzgerald, Yasumasa Ohyagi, Steven G. Younkin, Guojun Bu, Takahisa Kanekiyo
J Neurosci. 2016 Mar 30; 36(13): 3848–3859. doi: 10.1523/JNEUROSCI.3757-15.2016
PMCID:
PMC4812140
AbstractArticlePDF–2.5M
13.
Abca7 deletion does not affect adult neurogenesis in the mouse
Hongyun Li, Tim Karl, Brett Garner
Biosci Rep. 2016 Apr; 36(2): e00308. Prepublished online 2016 Jan 19. Published online 2016 Mar 16. doi: 10.1042/BSR20150308
PMCID:
PMC4793298
AbstractArticlePDF–620K
14.
ATP-binding Cassette Transporter A7 (ABCA7) Loss of Function Alters Alzheimer Amyloid Processing
Kanayo Satoh, Sumiko Abe-Dohmae, Shinji Yokoyama, Peter St George-Hyslop, Paul E. Fraser
J Biol Chem. 2015 Oct 2; 290(40): 24152–24165. Published online 2015 Aug 10. doi: 10.1074/jbc.M115.655076
PMCID:
PMC4591804
AbstractArticlePDF–2.1M
15.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
16.
Endogenous β-glucocerebrosidase activity in Abca12−/−epidermis elevates ceramide levels after topical lipid application but does not restore barrier function
Jorge F. Haller, Paul Cavallaro, Nicholas J. Hernandez, Lee Dolat, Stephanie J. Soscia, Ruth Welti, Gregory A. Grabowski, Michael L. Fitzgerald, Mason W. Freeman
J Lipid Res. 2014 Mar; 55(3): 493–503. doi: 10.1194/jlr.M044941
PMCID:
PMC3934733
AbstractArticlePDF–1.4M
17.
Role of Abca7 in Mouse Behaviours Relevant to Neurodegenerative Diseases
Warren Logge, David Cheng, Rose Chesworth, Surabhi Bhatia, Brett Garner, Woojin Scott Kim, Tim Karl
PLoS One. 2012; 7(9): e45959. Published online 2012 Sep 24. doi: 10.1371/journal.pone.0045959
PMCID:
PMC3454356
AbstractArticlePDF–412K
18.
Effects of Deletion of Macrophage ABCA7 on Lipid Metabolism and the Development of Atherosclerosis in the Presence and Absence of ABCA1
Illiana Meurs, Laura Calpe-Berdiel, Kim L. L. Habets, Ying Zhao, Suzanne J. A. Korporaal, A. Mieke Mommaas, Emmanuelle Josselin, Reeni B. Hildebrand, Dan Ye, Ruud Out, Johan Kuiper, Theo J. C. Van Berkel, Giovanna Chimini, Miranda Van Eck
PLoS One. 2012; 7(3): e30984. Published online 2012 Mar 5. doi: 10.1371/journal.pone.0030984
Correction in:
PLoS One. 2012; 7(5): 10.1371/annotation/577d9009-baf4-46ea-b44e-eda094b604db.
PMCID:
PMC3293875
AbstractArticlePDF–3.6M
19.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
20.
HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7
Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L. Fitzgerald, Shinji Yokoyama
Atherosclerosis. Author manuscript; available in PMC 2012 Aug 1.
Published in final edited form as: Atherosclerosis. 2011 Aug; 217(2): 407–414. Published online 2011 Jun 23. doi: 10.1016/j.atherosclerosis.2011.06.031
PMCID:
PMC3150192
AbstractArticlePDF–1.5M

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