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Items: 1 to 20 of 55

1.
Amino acid transporter SLC7A5 regulates cell proliferation and secretary cell differentiation and distribution in the mouse intestine
Lingyu Bao, Liezhen Fu, Yijun Su, Zuojia Chen, Zhaoyi Peng, Lulu Sun, Frank J. Gonzalez, Chuan Wu, Hongen Zhang, Bingyin Shi, Yun-Bo Shi
Int J Biol Sci. 2024; 20(6): 2187–2201. Published online 2024 Mar 25. doi: 10.7150/ijbs.94297
PMCID:
PMC11008275
AbstractArticlePDF–7.9M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer
Zhiyuan Zhou, Bin Zhang, Yue Deng, Suke Deng, Jie Li, Wenwen Wei, Yijun Wang, Jiacheng Wang, Zishan Feng, Mengjie Che, Xiao Yang, Jingshu Meng, Yan Li, Yan Hu, Yajie Sun, Lu Wen, Fang Huang, Yuhan Sheng, Chao Wan, Kunyu Yang
J Exp Clin Cancer Res. 2024; 43: 34. Published online 2024 Jan 29. doi: 10.1186/s13046-024-02959-3
PMCID:
PMC10823633
AbstractArticlePDF–10M
4.
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders
Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz
Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700
PMCID:
PMC10769350
AbstractArticlePDF–11M
5.
Targeting glutamine metabolic reprogramming of SLC7A5 enhances the efficacy of anti-PD-1 in triple-negative breast cancer
Renhong Huang, Han Wang, Jin Hong, Jiayi Wu, Ou Huang, Jianrong He, Weiguo Chen, Yafen Li, Xiaosong Chen, Kunwei Shen, Zheng Wang
Front Immunol. 2023; 14: 1251643. Published online 2023 Sep 4. doi: 10.3389/fimmu.2023.1251643
PMCID:
PMC10507177
AbstractArticlePDF–35M
6.
Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models
Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai
Sci Rep. 2023; 13: 13943. Published online 2023 Aug 25. doi: 10.1038/s41598-023-41096-3
PMCID:
PMC10457391
AbstractArticlePDF–2.6M
7.
DELE1 is protective for mitochondrial cardiomyopathy
Helen Huynh, Siting Zhu, Sharon Lee, Yutong Bao, Jing Pang, Anh Nguyen, Yusu Gu, Chao Chen, Kunfu Ouyang, Sylvia M. Evans, Xi Fang
J Mol Cell Cardiol. Author manuscript; available in PMC 2023 Jul 30.
Published in final edited form as: J Mol Cell Cardiol. 2023 Feb; 175: 44–48. Published online 2022 Dec 17. doi: 10.1016/j.yjmcc.2022.12.003
PMCID:
PMC10387237
AbstractArticlePDF–661K
8.
SRC2 controls CD4+ T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5
Wencan Zhang, Xu Cao, Xiancai Zhong, Hongmin Wu, Yun Shi, Mingye Feng, Yi-Chang Wang, David Ann, Yousang Gwack, Yate-Ching Yuan, Weirong Shang, Zuoming Sun
Proc Natl Acad Sci U S A. 2023 May 2; 120(18): e2221352120. Published online 2023 Apr 24. doi: 10.1073/pnas.2221352120
PMCID:
PMC10160970
AbstractArticlePDF–2.6M
9.
LAT1 expression influences Paneth cell number and tumor development in ApcMin/+ mice
Yunlong Sui, Namiko Hoshi, Ryuichi Ohgaki, Lingling Kong, Ryutaro Yoshida, Norihiro Okamoto, Masato Kinoshita, Haruka Miyazaki, Yuna Ku, Eri Tokunaga, Yuki Ito, Daisuke Watanabe, Makoto Ooi, Masakazu Shinohara, Kengo Sasaki, Yoh Zen, Takenori Kotani, Takashi Matozaki, Zibin Tian, Yoshikatsu Kanai, Yuzo Kodama
J Gastroenterol. 2023; 58(5): 444–457. Published online 2023 Feb 5. doi: 10.1007/s00535-023-01960-5
Correction in:
J Gastroenterol. 2023; 58(5): 458.
PMCID:
PMC10140238
AbstractArticlePDF–5.2M
10.
l-Type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis
Gyujin Park, Kazuya Fukasawa, Tetsuhiro Horie, Yusuke Masuo, Yuka Inaba, Takanori Tatsuno, Takanori Yamada, Kazuya Tokumura, Sayuki Iwahashi, Takashi Iezaki, Katsuyuki Kaneda, Yukio Kato, Yasuhito Ishigaki, Michihiro Mieda, Tomohiro Tanaka, Kazuma Ogawa, Hiroki Ochi, Shingo Sato, Yun-Bo Shi, Hiroshi Inoue, Hojoon Lee, Eiichi Hinoi
JCI Insight. 2023 Apr 10; 8(7): e154925. Published online 2023 Apr 10. doi: 10.1172/jci.insight.154925
PMCID:
PMC10132163
AbstractArticlePDF–11M
11.
Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease
Elena Puris, Liudmila Saveleva, Izaque de Sousa Maciel, Katja M. Kanninen, Seppo Auriola, Gert Fricker
Mol Neurobiol. 2023; 60(2): 732–748. Published online 2022 Nov 11. doi: 10.1007/s12035-022-03111-y
PMCID:
PMC9849299
AbstractArticlePDF–2.3M
12.
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses
Suzanne H. Hodge, Maria Z. Krauss, Irem Kaymak, James I. King, Andrew J.M. Howden, Gordana Panic, Richard K. Grencis, Jonathan R. Swann, Linda V. Sinclair, Matthew R. Hepworth
J Exp Med. 2023 Mar 6; 220(3): e20221073. Published online 2022 Dec 26. doi: 10.1084/jem.20221073
PMCID:
PMC9794837
AbstractArticlePDF–6.6M
13.
L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production
Janne Tampio, Magdalena Markowicz-Piasecka, Ahmed Montaser, Jaana Rysä, Anu Kauppinen, Kristiina M. Huttunen
Mol Pharm. 2022 Nov 7; 19(11): 3806–3819. Published online 2022 Aug 26. doi: 10.1021/acs.molpharmaceut.2c00328
PMCID:
PMC9644403
AbstractArticlePDF–11M
14.
Mitochondrial stress induces an HRI-eIF2α pathway protective for cardiomyopathy
Siting Zhu, Anh Nguyen, Jing Pang, Jun Zhao, Ze’e Chen, Zhengyu Liang, Yusu Gu, Helen Huynh, Yutong Bao, Sharon Lee, Yuval Kluger, Kunfu Ouyang, Sylvia M Evans, Xi Fang
Circulation. Author manuscript; available in PMC 2023 Sep 27.
Published in final edited form as: Circulation. 2022 Sep 27; 146(13): 1028–1031. Published online 2022 Sep 26. doi: 10.1161/CIRCULATIONAHA.122.059594
PMCID:
PMC9523491
ArticlePDF–1016K
15.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
16.
Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice
Esteban Salazar-Petres, Daniela Pereira-Carvalho, Jorge Lopez-Tello, Amanda Nancy Sferruzzi-Perri
Biol Reprod. 2022 Jun; 106(6): 1292–1311. Published online 2022 Mar 16. doi: 10.1093/biolre/ioac056
PMCID:
PMC9327737
AbstractArticlePDF–3.0M
17.
Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain
Aleyah E. Goins, Kimberly Gomez, Dongzhi Ran, Mitra Afaghpour-Becklund, Rajesh Khanna, Sascha R.A. Alles
Pflugers Arch. Author manuscript; available in PMC 2023 Apr 1.
Published in final edited form as: Pflugers Arch. 2022 Apr; 474(4): 397–403. Published online 2022 Jan 20. doi: 10.1007/s00424-021-02653-9
PMCID:
PMC8930528
AbstractArticlePDF–1.3M
18.
Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2
Eamon Fitzgerald, Jennie Roberts, Daniel A. Tennant, James P. Boardman, Amanda J. Drake
Sci Rep. 2021; 11: 9092. Published online 2021 Apr 27. doi: 10.1038/s41598-021-88757-9
PMCID:
PMC8079390
AbstractArticlePDF–2.2M
19.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
20.
Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice
Ivan Menendez-Montes, Beatriz Escobar, Manuel J. Gomez, Teresa Albendea-Gomez, Beatriz Palacios, Elena Bonzon-Kulichenko, Jose Luis Izquierdo-Garcia, Ana Vanessa Alonso, Alessia Ferrarini, Luis Jesus Jimenez-Borreguero, Jesus Ruiz-Cabello, Jesus Vázquez, Silvia Martin-Puig
iScience. 2021 Feb 19; 24(2): 102124. Published online 2021 Feb 3. doi: 10.1016/j.isci.2021.102124
PMCID:
PMC7900219
AbstractArticlePDF–6.0M

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