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Items: 1 to 20 of 1488

1.
Exploring Molecular Drivers of PARPi Resistance in BRCA1-Deficient Ovarian Cancer: The Role of LY6E and Immunomodulation
Tirzah Braz Petta, Joseph Carlson
Int J Mol Sci. 2024 Oct; 25(19): 10427. Published online 2024 Sep 27. doi: 10.3390/ijms251910427
PMCID:
PMC11477368
AbstractArticlePDF–4.1M
2.
Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection
Ilaria Ceppi, Maria Rosaria Dello Stritto, Martin Mütze, Stefan Braunshier, Valentina Mengoli, Giordano Reginato, Hồ Mỹ Phúc Võ, Sonia Jimeno, Ananya Acharya, Megha Roy, Aurore Sanchez, Swagata Halder, Sean Michael Howard, Raphaël Guérois, Pablo Huertas, Sylvie M. Noordermeer, Ralf Seidel, Petr Cejka
Nature. 2024; 634(8033): 492–500. Published online 2024 Sep 11. doi: 10.1038/s41586-024-07909-9
PMCID:
PMC11464378
AbstractArticlePDF–56M
3.
Hypermethylation of the BRCA2 gene promoter and its co-hypermethylation with the BRCA1 gene promoter in patients with breast cancer
Liliia Fishchuk, Zoia Rossokha, Olga Lobanova, Valeriy Cheshuk, Roman Vereshchako, Viktoriia Vershyhora, Nataliia Medvedieva, Olha Dubitskaa, Natalia Gorovenko
Cancer Biomark. 2024; 40(3-4): 275–283. Prepublished online 2024 Aug 2. Published online 2024 Aug 27. doi: 10.3233/CBM-230458
PMCID:
PMC11380246
AbstractArticlePDF–279K
4.
BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance
Ksenija Nesic, John J. Krais, Yifan Wang, Cassandra J. Vandenberg, Pooja Patel, Kathy Q. Cai, Tanya Kwan, Elizabeth Lieschke, Gwo-Yaw Ho, Holly E. Barker, Justin Bedo, Silvia Casadei, Andrew Farrell, Marc Radke, Kristy Shield-Artin, Jocelyn S. Penington, Franziska Geissler, Elizabeth Kyran, Robert Betsch, Lijun Xu, Fan Zhang, Alexander Dobrovic, Inger Olesen, Rebecca Kristeleit, Amit Oza, Iain McNeish, Gayanie Ratnayake, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, David D. L. Bowtell, Thomas C. Harding, Kevin Lin, Elizabeth M. Swisher, Olga Kondrashova, Clare L. Scott, Neil Johnson, Matthew J. Wakefield
Mol Cancer. 2024; 23: 158. Published online 2024 Aug 5. doi: 10.1186/s12943-024-02048-1
PMCID:
PMC11299415
AbstractArticlePDF–2.4M
5.
BRCA1 and 53BP1 Regulate Reprogramming Efficiency by Mediating DNA Repair Pathway Choice at Replication-associated Double-Strand Breaks
Daniela Georgieva, Ning Wang, Angelo Taglialatela, Stepan Jerabek, Colleen R. Reczek, Pei Xin Lim, Julie Sung, Qian Du, Michiko Horiguchi, Maria Jasin, Alberto Ciccia, Richard Baer, Dieter Egli
Cell Rep. Author manuscript; available in PMC 2024 Jul 25.
Published in final edited form as: Cell Rep. 2024 Apr 23; 43(4): 114006. Published online 2024 Mar 30. doi: 10.1016/j.celrep.2024.114006
PMCID:
PMC11272184
AbstractArticlePDF–2.7M
6.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
7.
Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non‐small‐cell lung cancer
Min Kim, Hyo‐Gyoung Kang, Shin Yup Lee, Hyung Cheol Lee, Eung Bae Lee, Yi Young Choi, Won Kee Lee, Sukki Cho, Guang Jin, Hyo‐Sung Jheon, Ji Woong Son, Myung‐Hoon Lee, Deuk Kju Jung, Seung Ick Cha, Chang Ho Kim, Young Mo Kang, Sin Kam, Tae Hoon Jung, Sanghoon Jheon, Jae Yong Park
Cancer Sci. 2010 Nov; 101(11): 2436–2442. Published online 2010 Jul 31. doi: 10.1111/j.1349-7006.2010.01699.x
PMCID:
PMC11159840
AbstractArticlePDF–209K
8.
BRCA1 contributes to transcription‐coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein
Leizhen Wei, Li Lan, Akira Yasui, Kiyoji Tanaka, Masafumi Saijo, Ayako Matsuzawa, Risa Kashiwagi, Emiko Maseki, Yiheng Hu, Jeffrey D. Parvin, Chikashi Ishioka, Natsuko Chiba
Cancer Sci. 2011 Oct; 102(10): 1840–1847. Published online 2011 Aug 18. doi: 10.1111/j.1349-7006.2011.02037.x
PMCID:
PMC11159811
AbstractArticlePDF–473K
9.
Cross‐sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer
Kokichi Sugano, Seigo Nakamura, Jiro Ando, Shin Takayama, Hiroyuki Kamata, Isao Sekiguchi, Megumi Ubukata, Tetsuro Kodama, Masami Arai, Fujio Kasumi, Yasuo Hirai, Tadashi Ikeda, Hiromitsu Jinno, Masaki Kitajima, Daisuke Aoki, Akira Hirasawa, Yuko Takeda, Kumiko Yazaki, Takashi Fukutomi, Takayuki Kinoshita, Ryuichiro Tsunematsu, Teruhiko Yoshida, Masako Izumi, Shino Umezawa, Hiroshi Yagata, Hiroko Komatsu, Naoko Arimori, Noriko Matoba, Nobuhisa Gondo, Shiro Yokoyama, Yoshio Miki
Cancer Sci. 2008 Oct; 99(10): 1967–1976. Published online 2008 Oct 9. doi: 10.1111/j.1349-7006.2008.00944.x
PMCID:
PMC11158907
AbstractArticlePDF–293K
10.
BRCA1 and XRCC1 polymorphisms associated with survival in advanced gastric cancer treated with taxane and cisplatin
Hyun Jeong Shim, Joo Young Yun, Jun Eul Hwang, Woo Kyun Bae, Sang Hee Cho, Ji Hee Lee, Hee Nam Kim, Min Ho Shin, Sun Seog Kweon, Jae Hyuk Lee, Hyeoung Joon Kim, Ik Joo Chung
Cancer Sci. 2010 May; 101(5): 1247–1254. Published online 2010 Mar 12. doi: 10.1111/j.1349-7006.2010.01514.x
PMCID:
PMC11158840
AbstractArticlePDF–215K
11.
Osteopontin can act as an effector for a germline mutation of BRCA1 in malignant transformation of breast cancer‐related cells
Mohamed K. El‐Tanani, Hiu‐Fung Yuen, Zhanzhong Shi, Angela Platt‐Higgins, Niamh E. Buckley, Paul B. Mullan, Denis Paul Harkin, Patrick G. Johnston, Philip S. Rudland
Cancer Sci. 2010 Jun; 101(6): 1354–1360. Published online 2010 Mar 10. doi: 10.1111/j.1349-7006.2010.01561.x
PMCID:
PMC11158710
AbstractArticlePDF–474K
12.
Aberrant methylation of breast and ovarian cancer susceptibility gene 1 in chemosensitive human ovarian cancer cells does not involve the phosphatidylinositol 3′‐kinase–Akt pathway
Yan‐Qiu Wang, Jia‐Rong Zhang, Shuang‐Di Li, Yin‐Yan He, Yi‐Xia Yang, Xue‐Lian Liu, Xiao‐Ping Wan
Cancer Sci. 2010 Jul; 101(7): 1618–1623. Published online 2010 Mar 17. doi: 10.1111/j.1349-7006.2010.01568.x
PMCID:
PMC11158593
AbstractArticlePDF–568K
13.
BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer
Yanglin Chen, Jing Zhou, Ye Xu, Zhaosheng Li, Xianzi Wen, Lihua Yao, Yuntao Xie, Dajun Deng
Cancer Sci. 2009 Sep; 100(9): 1663–1667. Published online 2009 May 18. doi: 10.1111/j.1349-7006.2009.01225.x
PMCID:
PMC11158407
AbstractArticlePDF–714K
14.
Assessing the Impact of Novel BRCA1 Exon 11 Variants on Pre-mRNA Splicing
Halla Elshwekh, Inas M. Alhudiri, Adam Elzagheid, Nabil Enattah, Yasmine Abbassi, Lubna Abou Assali, Ilenia Marino, Cristiana Stuani, Emanuele Buratti, Maurizio Romano
Cells. 2024 May; 13(10): 824. Published online 2024 May 11. doi: 10.3390/cells13100824
PMCID:
PMC11119505
AbstractArticlePDF–1.8M
15.
Analysis of BRCA1 and BRCA2 mutations in Brazilian breast cancer patients with positive family history
Rozany Mucha Dufloth, Sílvia Carvalho, Juliana Karina Heinrich, Júlia Yoriko Shinzato, César Cabello dos Santos, Luiz Carlos Zeferino, Fernando Schmitt
Sao Paulo Med J. 2005; 123(4): 192–197. Published online 2005 Jul 7. doi: 10.1590/S1516-31802005000400007
PMCID:
PMC11060407
AbstractArticlePDF–435K
16.
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Hilal Ahmad, Asif Ali, Roshan Ali, Ali Talha Khalil, Ishaq Khan, Mah Muneer Khan, Mohammed Alorini
Neoplasia. 2024 May; 51: 100989. Published online 2024 Mar 27. doi: 10.1016/j.neo.2024.100989
PMCID:
PMC11026844
AbstractArticlePDF–23M
17.
Constitutional BRCA1 and MGMT Methylation Are Significant Risk Factors for Triple-Negative Breast Cancer and High-Grade Serous Ovarian Cancer in Saudi Women
Nisreen Al-Moghrabi, Maram Al-Showimi, Amal Alqahtani, Osama Almalik, Hamed Alhusaini, Ghdah Almalki, Ajawhara Saad, Elaf Alsunayi
Int J Mol Sci. 2024 Mar; 25(6): 3108. Published online 2024 Mar 7. doi: 10.3390/ijms25063108
PMCID:
PMC10970267
AbstractArticlePDF–1.0M
18.
Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers
Brant Gracia, Patricia Montes, Angelica Maria Gutierrez, Banu Arun, Georgios Ioannis Karras
Cell Rep. Author manuscript; available in PMC 2024 Mar 15.
Published in final edited form as: Cell Rep. 2024 Feb 27; 43(2): 113803. Published online 2024 Feb 17. doi: 10.1016/j.celrep.2024.113803
PMCID:
PMC10941025
AbstractArticlePDF–2.1M
19.
BRCA1, BRCA2, and TP53 germline and somatic variants and clinicopathological characteristics of Brazilian patients with epithelial ovarian cancer
Caroline Stahnke Richau, Nicole de Miranda Scherer, Bruna Palma Matta, Elvismary Molina de Armas, Fábio Carvalho de Barros Moreira, Anke Bergmann, Claudia Bessa Pereira Chaves, Mariana Boroni, Anna Claudia Evangelista dos Santos, Miguel Angelo Martins Moreira
Cancer Med. 2024 Feb; 13(3): e6729. Published online 2024 Feb 2. doi: 10.1002/cam4.6729
PMCID:
PMC10905552
AbstractArticlePDF–1.0M
20.
Prevalence and spectrum of germline BRCA1 and BRCA2 in a cohort of ovarian cancer patients from the Salento peninsula (Southern Italy): a matter of preventive health
Elisabetta De Matteis, Maria Rosaria Tumolo, Paolo Tarantino, Mariangela Ciccarese, Tiziana Grassi, Francesco Bagordo, Maria Rita De Giorgio, Emanuele Rizzo, Graziana Ronzino
Oncotarget. 2024; 15: 134–141. Published online 2024 Feb 22. doi: 10.18632/oncotarget.28561
PMCID:
PMC10883683
AbstractArticlePDF–412K

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