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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74277972.

An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution

Benyu Liu, Buqing Ye, Xiaoxiao Zhu, Liuliu Yang, Huimu Li, Nian Liu, Pingping Zhu, Tiankun Lu, Luyun He, Yong Tian, Zusen Fan

Nat Commun. 2020; 11: 4076. Published online 2020 Aug 14. doi: 10.1038/s41467-020-17944-5

PMCID:: PMC7427797

Abstract Article PDF–6.5M

Select item 70501033.

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair

Zhen Chen, Chao Wang, Antrix Jain, Mrinal Srivastava, Mengfan Tang, Huimin Zhang, Xu Feng, Litong Nie, Dan Su, Yun Xiong, Sung Yun Jung, Jun Qin, Junjie Chen

Mol Cell Proteomics. 2020 Mar; 19(3): 467–477. Published online 2020 Jan 3. doi: 10.1074/mcp.RA119.001794

PMCID:: PMC7050103

Abstract Article PDF–1.8M

Select item 68265864.

Common Nevus and Skin Cutaneous Melanoma: Prognostic Genes Identified by Gene Co-Expression Network Analysis

Lingge Yang, Yu Xu, Yan Yan, Peng Luo, Shiqi Chen, Biqiang Zheng, Wangjun Yan, Yong Chen, Chunmeng Wang

Genes (Basel) 2019 Oct; 10(10): 747. Published online 2019 Sep 25. doi: 10.3390/genes10100747

PMCID:: PMC6826586

Abstract Article PDF–2.6M

Select item 67409565.

Slick (Slo2.1), a Rapidly-Gating Sodium-Activated Potassium Channel Inhibited by ATP

Arin Bhattacharjee, William J. Joiner, Meilin Wu, Youshan Yang, Fred J. Sigworth, Leonard K. Kaczmarek

J Neurosci. 2003 Dec 17; 23(37): 11681–11691. doi: 10.1523/JNEUROSCI.23-37-11681.2003

PMCID:: PMC6740956

Abstract Article PDF–789K

Select item 66742406.

Opposite Regulation of Slick and Slack K⁺ Channels by Neuromodulators

Celia M. Santi, Gonzalo Ferreira, Bo Yang, Valeswara-Rao Gazula, Alice Butler, Aguan Wei, Leonard K. Kaczmarek, Lawrence Salkoff

J Neurosci. 2006 May 10; 26(19): 5059–5068. doi: 10.1523/JNEUROSCI.3372-05.2006

PMCID:: PMC6674240

Abstract Article PDF–1.7M

Select item 60777227.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 59806568.

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease

SJ Furney, A Simmons, G Breen, I Pedroso, K Lunnon, P Proitsi, A Hodges, J Powell, L-O Wahlund, I Kloszewska, P Mecocci, H Soininen, M Tsolaki, B Vellas, C Spenger, M Lathrop, L Shen, S Kim, AJ Saykin, MW Weiner, S Lovestone

Mol Psychiatry. Author manuscript; available in PMC 2018 May 31.

Published in final edited form as: Mol Psychiatry. 2011 Nov; 16(11): 1130–1138. Published online 2010 Nov 30. doi: 10.1038/mp.2010.123

PMCID:: PMC5980656

Abstract Article PDF–439K

Select item 56878209.

A de novo mutation in the Sodium-Activated Potassium channel KCNT2 alters ion selectivity and causes epileptic encephalopathy

Sushmitha Gururaj, Elizabeth Emma Palmer, Garrett D Sheehan, Tejaswi Kandula, Rebecca Macintosh, Kevin Ying, Paula Morris, Jiang Tao, Kerith-Rae Dias, Ying Zhu, Marcel E. Dinger, Mark J. Cowley, Edwin P Kirk, Tony Roscioli, Rani Sachdev, Michael E Duffey, Ann Bye, Arin Bhattacharjee

Cell Rep. Author manuscript; available in PMC 2017 Nov 15.

Published in final edited form as: Cell Rep. 2017 Oct 24; 21(4): 926–933. doi: 10.1016/j.celrep.2017.09.088

PMCID:: PMC5687820

Abstract Article PDF–1.1M

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 537410611.

Molecular mechanisms of Slo2 K⁺ channel closure

M. Hunter Giese, Alison Gardner, Angela Hansen, Michael C. Sanguinetti

J Physiol. 2017 Apr 1; 595(7): 2321–2336. Published online 2016 Dec 2. doi: 10.1113/JP273225

PMCID:: PMC5374106

Abstract Article PDF–1.1M

Select item 531969712.

Heteromeric Slick/Slack K⁺ channels show graded sensitivity to cell volume changes

Maria A. Tejada, Nadia Hashem, Kirstine Calloe, Dan A. Klaerke

PLoS One. 2017; 12(2): e0169914. Published online 2017 Feb 21. doi: 10.1371/journal.pone.0169914

PMCID:: PMC5319697

Abstract Article PDF–2.4M

Select item 487245913.

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

S Stringer, C C Minică, K J H Verweij, H Mbarek, M Bernard, J Derringer, K R van Eijk, J D Isen, A Loukola, D F Maciejewski, E Mihailov, P J van der Most, C Sánchez-Mora, L Roos, R Sherva, R Walters, J J Ware, A Abdellaoui, T B Bigdeli, S J T Branje, S A Brown, M Bruinenberg, M Casas, T Esko, I Garcia-Martinez, S D Gordon, J M Harris, C A Hartman, A K Henders, A C Heath, I B Hickie, M Hickman, C J Hopfer, J J Hottenga, A C Huizink, D E Irons, R S Kahn, T Korhonen, H R Kranzler, K Krauter, P A C van Lier, G H Lubke, P A F Madden, R Mägi, M K McGue, S E Medland, W H J Meeus, M B Miller, G W Montgomery, M G Nivard, I M Nolte, A J Oldehinkel, Z Pausova, B Qaiser, L Quaye, J A Ramos-Quiroga, V Richarte, R J Rose, J Shin, M C Stallings, A I Stiby, T L Wall, M J Wright, H M Koot, T Paus, J K Hewitt, M Ribasés, J Kaprio, M P Boks, H Snieder, T Spector, M R Munafò, A Metspalu, J Gelernter, D I Boomsma, W G Iacono, N G Martin, N A Gillespie, E M Derks, J M Vink

Transl Psychiatry. 2016 Mar; 6(3): e769. Published online 2016 Mar 29. doi: 10.1038/tp.2016.36

PMCID:: PMC4872459

Abstract Article PDF–1.1M

Select item 477966014.

Hydrophobic interactions between the S5 segment and the pore helix stabilizes the closed state of Slo2.1 potassium channels

Tomoyuki Suzuki, Angela Hansen, Michael C. Sanguinetti

Biochim Biophys Acta. Author manuscript; available in PMC 2017 Apr 1.

Published in final edited form as: Biochim Biophys Acta. 2016 Apr; 1858(4): 783–792. Published online 2015 Dec 23. doi: 10.1016/j.bbamem.2015.12.024

PMCID:: PMC4779660

Abstract Article PDF–1.8M

Select item 450552015.

Identification of the Intracellular Na⁺ Sensor in Slo2.1 Potassium Channels

Steven J. Thomson, Angela Hansen, Michael C. Sanguinetti

J Biol Chem. 2015 Jun 5; 290(23): 14528–14535. Published online 2015 Apr 22. doi: 10.1074/jbc.M115.653089

PMCID:: PMC4505520

Abstract Article PDF–2.4M

Select item 421019616.

Cell Volume Changes Regulate Slick (Slo2.1), but Not Slack (Slo2.2) K⁺ Channels

Maria A. Tejada, Kathleen Stople, Sofia Hammami Bomholtz, Anne-Kristine Meinild, Asser Nyander Poulsen, Dan A. Klaerke

PLoS One. 2014; 9(10): e110833. Published online 2014 Oct 27. doi: 10.1371/journal.pone.0110833

PMCID:: PMC4210196

Abstract Article PDF–737K

Select item 381338217.

Structural basis of ion permeation gating in Slo2.1 K⁺ channels

Priyanka Garg, Alison Gardner, Vivek Garg, Michael C. Sanguinetti

J Gen Physiol. 2013 Nov; 142(5): 523–542. doi: 10.1085/jgp.201311064

PMCID:: PMC3813382

Abstract Article PDF–3.5M

Select item 362598418.

Genetic Factors In Non-smokers with Age-related Macular Degeneration Revealed Through Genome-wide Gene-Environment Interaction Analysis

Adam C. Naj, William K. Scott, Monique D. Courtenay, William H. Cade, Stephen G. Schwartz, Jaclyn L. Kovach, Anita Agarwal, Gaofeng Wang, Jonathan L. Haines, Margaret A. Pericak-Vance

Ann Hum Genet. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Ann Hum Genet. 2013 May; 77(3): 215–231. doi: 10.1111/ahg.12011

PMCID:: PMC3625984

Abstract Article PDF–654K

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 135612920.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

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